Ellagic acid ameliorates cisplatin-induced acute kidney injury by regulating inflammation and SIRT6/TNF-α signaling by Yuqi Gao, Kezheng Peng, Yida Wang, Yannan Guo, Chenye Zeng, Rui Hua, Qingfei Liu, Xue Li, Ying Qiu, Zhao Wang

“…For this reason, finding novel targeted therapies to attenuate the nephrotoxicity of cisplatin should be pretty significant. …”
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An endoscopic ultrasound-based interpretable deep learning model and nomogram for distinguishing pancreatic neuroendocrine tumors from pancreatic cancer by Nan Yi, Shuangyang Mo, Yan Zhang, Qi Jiang, Yingwei Wang, Cheng Huang, Shanyu Qin, Haixing Jiang

“…These methodologies contributed substantial net benefits to clinical decision-making processes. A novel interpretable DL model and nomogram were developed and validated using EUS images, cooperating with machine learning algorithms. …”
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Tumor Microenvironment Responsive Key Nanomicelles for Effective Against Invasion and Metastasis in Ovarian Cancer Using Mice Model by Liu Y, Kong L, Yu Y, Zang J, Zhang L, Guo RB, Li ST, Cheng L, Li XT, Chen YQ

“…The effectiveness of conventional chemoradiotherapy remains limited. Nano-particles, as a novel drug delivery system, have significant potential for improving therapeutic efficacy and overcoming these challenges.Methods: According to the high expression level of matrix metalloproteinase-2 (MMP-2) in the tumor microenvironment, MMP-2 responsive nano-particles (PVGLIG-MTX-D/T-NMs) containing docetaxel and triptolide were prepared by the thin-film dispersion method. …”
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Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma by Yuli Zhang, Dinggui Chen, Miaomiao Yang, Xianfeng Qian, Chunmei Long, Zhongwei Zheng

“…Survival analysis demonstrated that 2 lncRNAs (EGOT and SERHL), 4 miRNAs, and 40 mRNAs were significantly associated with the overall survival of HCC patients. Two novel regulatory pathways, EGOT-miR-32-5p-XYLT2 axis and SERHL-miR-1269a/miR-193b-3p-BCL2L1/SYK/ARNT/CHST3/LPCAT1 axis, were built up and contribute to the underlying mechanism of HCC pathogenesis. …”
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Detection of Antimicrobial Resistance Genes Associated with Carbapenem Resistance from the Whole-Genome Sequence of Acinetobacter baumannii Isolates from Malaysia by Mohan Rao, Fairuz A. Rashid, Surianti Shukor, Rohaidah Hashim, Norazah Ahmad

“…A total of 6 sequence types (STs) of the Oxford scheme were identified, including 4 reported STs and 2 novel STs. Eleven isolates were classified into clonal complex 92 (CC92/ICII), among which ST195 and ST208 were the most prevalent STs. …”
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Essential contribution of habitats in non-protected areas to climate-driven species migration in China by Jie Su, Fanhua Kong, Haiwei Yin, Michael E. Meadows, Liding Chen, Hong S. He, Hui Sun, Zhenya Li, Kejing Zhou, Bin Chen

“…The disappearing climate index (DCI) and novel climate index (NCI) results show that some 17 % of the subdivided climate classes within the PAs have changed. …”
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Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin by Xingyuan Ma, Xingyuan Ma, Chao Sun, Xiao Ding, Yuhang Zhang, Yuhang Zhang, Tingzhen Deng, Tingzhen Deng, Yatao Wang, Yatao Wang, Haijun Yang, Haijun Yang, Ruiwen Ding, Ruiwen Ding, Haotian Li, Haotian Li, Dawen Wang, Dawen Wang, Maohua Zheng, Maohua Zheng

“…This review provides a comprehensive analysis of metformin’s molecular mechanisms in glioma treatment and highlights its potential as a novel therapeutic strategy, especially for treatment-resistant gliomas.…”
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Conjugates of Phthalocyanines With Oligonucleotides as Reagents for Sensitized or Catalytic DNA Modification

“…These results suggest the possible use of phthalocyanine-oligonucleotide conjugates as novel artificial regulators of gene expression and therapeutic agents for treatment of cancer.…”
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Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages by Qi Wang, Juqing Huang, Yafeng Zheng, Xuefang Guan, Chenchun Lai, Huiying Gao, Chi-Tang Ho, Bin Lin

“…Collectively, our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases.…”
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Targeting ASK1 by CS17919 alleviates kidney‐ and liver‐related diseases in murine models by Guoqiang Liao, Qianjiao Yang, Xuhua Mao, Yiru Zhao, Beizhong Chen, Kun Zhang, Yu Zhang, Ping Zhang, Zhengli Chen, Shengjian Huang

“…In this study, we designed and synthesized a novel selective ASK1 inhibitor, CS17919, and investigated its pharmacological effects in various animal models of metabolic injury. …”
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Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program. by Allison E Ashley-Koch, Nathan A Kimbrel, Xue J Qin, Jennifer H Lindquist, Melanie E Garrett, Michelle F Dennis, Lauren P Hair, Jennifer E Huffman, Daniel A Jacobson, Ravi K Madduri, Hilary Coon, Anna R Docherty, Jooeun Kang, Niamh Mullins, Douglas M Ruderfer, VA Million Veteran Program (MVP), MVP Suicide Exemplar Workgroup, International Suicide Genetics Consortium, Philip D Harvey, Benjamin H McMahon, David W Oslin, Elizabeth R Hauser, Michael A Hauser, Jean C Beckham

“…Conditional analysis on PTSD and MDD attenuated most pan-ancestry and EA GWS signals for SI without SA to nominal significance, with the exception of EXD3 which remained GWS. Our novel findings support a polygenic and complex architecture for SI without SA which is largely shared with SA and overlaps with psychiatric conditions frequently comorbid with suicidal behaviors.…”
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Cohort profile: maternal and child health and parenting practices during the COVID-19 pandemic in Ceará, Brazil: birth cohort study (Iracema-COVID) by Marcia C Castro, Márcia Maria Tavares Machado, Simone Farías-Antúnez, David Augusto Batista Sá Araújo, Ana Luiza Penna, Francisco Ariclene Oliveira, Camila Machado de Aquino, Antônio Silva Lima Neto, Geziel dos Santos de Sousa

“…Results of this prospective cohort will generate novel knowledge on the impact of the COVID-19 pandemic on maternal and child health and parenting practices in a population of women and children living in fifth largest city of Brazil.…”
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Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML by Zhanglin Zhang, Xiang Lin, Yaling Yang, Xuemei Wang, Yi Wang, Xianbao Huang, Miao Hong, Wei Gao, Hua He, M. James You, Yi Yang, Guangyao Kong

“…Altogether, these results suggest that targeting USP48 may represent a novel therapeutic strategy in AML.…”
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A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response by Minghan Li, Chang Su, Qianru Wang, Yuetong Chen, Di Jiang, Weijia Wang, Shunjin Chen, Xiangping Li, Ming Fu, Juan Lu

“…Our results highlight the important role of ZNF32 in tumorigenesis and provide novel perspectives for potential cancer treatment strategies.…”
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Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology by Robin Christ, Devon Siemes, Shuo Zhao, Lars Widera, Philippa Spangenberg, Julia Lill, Stephanie Thiebes, Jenny Bottek, Lars Borgards, Andreia G. Pinho, Nuno A. Silva, Susana Monteiro, Selina K. Jorch, Matthias Gunzer, Bente Siebels, Hannah Voss, Hartmut Schlüter, Olga Shevchuk, Jianxu Chen, Daniel R. Engel

“…Analysis of microglial populations using a novel human-in-the-loop deep learning algorithm for the segmentation of microscopic imaging data indicated specific morphological changes, which were reduced to healthy condition after inhibition of TNF-α. …”
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A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors by Umberto Cillo, Caterina Lonati, Alessandra Bertacco, Lucrezia Magnini, Michele Battistin, Liver NMP Consortium, Lara Borsetto, Francesco Dazzi, David Al-Adra, Enrico Gringeri, Maria Laura Bacci, Andrea Schlegel, Daniele Dondossola

“…This proof-of-concept study presents a novel MSC-based liver NMP platform that could reduce the deleterious effects of ischemia/reperfusion before transplantation.…”
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Estimating the Prevalence of Schizophrenia in the General Population of Japan Using an Artificial Neural Network–Based Schizophrenia Classifier: Web-Based Cross-Sectional Survey by Pichsinee Choomung, Yupeng He, Masaaki Matsunaga, Kenji Sakuma, Taro Kishi, Yuanying Li, Shinichi Tanihara, Nakao Iwata, Atsuhiko Ota

“…This study demonstrates the capability of an ANN-based model to improve the estimation of schizophrenia prevalence in the general population, offering a novel approach to public health analysis.…”
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Isotype diversity of antibodies specific for component allergens in the context of allergic diseases: eosinophilic esophagitis (EoE), asthma, and the alpha-gal syndrome (AGS) by Thomas A. E. Platts-Mills, Matthew H. MacCallum, Jeffrey M. Wilson, Lisa J. Workman, Elizabeth A. Erwin

“…Today it is clear that this tolerance depends on high levels of IgG4 antibodies and there is increasing evidence that the IgG4 response is primarily against Fel d 1. The most recent novel allergic disease is the alpha-gal syndrome (AGS). …”
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Fast perceptual learning induces location-specific facilitation and suppression at early stages of visual cortical processing by Yajie Wang, Zhe Qu, You Wang, Mingze Sun, Mengting Mao, Yulong Ding

“…Although location specificity is generally considered as a hallmark of visual PL, it remains unclear whether it involves both facilitation of trained locations and suppression of untrained locations. Here we developed a novel experimental design to investigate the cognitive neural mechanism of location specificity of fast PL. …”
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Are Suggested Hiking Times Accurate? A Validation of Hiking Time Estimations for Preventive Measures in Mountains by Marco Vecchiato, Nicola Borasio, Emiliano Scettri, Vanessa Franzoi, Federica Duregon, Sandro Savino, Andrea Ermolao, Daniel Neunhaeuserer

“…This study aims to evaluate the variability in hiking time estimates from different methods and assess the potential of a novel algorithm, MOVE, to enhance accuracy and safety. …”
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