Personalized Therapy in a Patient With EGFR-Mutated NSCLC Developing Sequential CCDC6-RET Fusion and BRAF V600E Mutation as Bypass Resistance Mechanisms by Arianna Marinello, MD, Claudia Parisi, MD, Damien Vasseur, PhD, David Combarel, PharmD, Juliette Bihoreau, NP, Pernelle Lavaud, MD, Rémy Ezzedine, MD, Lodovica Zullo, MD, Luc Friboulet, PhD, Gerard Zalcman, MD, PhD, Antoine Italiano, MD, PhD, Benjamin Besse, MD, PhD, Mihaela Aldea, MD, PhD

“…After the identification of CCDC6-RET fusion, the patient received a combination of selpercatinib and osimertinib with prolonged benefit and manageable toxicity. When a novel BRAF V600E mutation was detected at progression, the molecular tumor board suggested the administration of triple therapy, adding trametinib (anti-MEK). …”
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A multigene phylogeny toward a new phylogenetic classification of Leotiomycetes by Peter R. Johnston, Luis Quijada, Christopher A. Smith, Hans-Otto Baral, Tsuyoshi Hosoya, Christiane Baschien, Kadri Pärtel, Wen-Ying Zhuang, Danny Haelewaters, Duckchul Park, Steffen Carl, Francesc López-Giráldez, Zheng Wang, Jeffrey P. Townsend

“…To fill some of the taxonomic gaps in the 15-gene phylogeny, we further present an ITS gene tree, particularly targeting ex-type specimens of generic type species. A small number of novel taxa are proposed: Marthamycetales ord. nov., and Drepanopezizaceae and Mniaeciaceae fams. nov. …”
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Transcutaneous vagus nerve stimulation for Parkinson’s disease: a systematic review and meta-analysis by Jiatong Shan, Jiatong Shan, Jiatong Shan, Zehong Li, Minxiu Ji, Miao Zhang, Caidi Zhang, Yikang Zhu, Zhen Feng

“…BackgroundTranscutaneous vagus nerve stimulation (tVNS) has emerged as a novel noninvasive adjunct therapy for advanced Parkinson’s disease (PD), yet no quantitative analysis had been conducted to assess its therapeutic effect.ObjectivesThis review aimed to investigate the efficacy of tVNS on motor function, other potential clinical targets and its safety in various treatment conditions.MethodsWe searched six databases for randomized controlled trials (RCTs) that involved treating PD patients with tVNS. …”
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Glioblastoma drives protease-independent extracellular matrix invasion of microglia by Chia-Wen Chang, Ashwin Bale, Rohit Bhargava, Brendan A.C. Harley

“…Improved physicochemical understanding of microglia activation and invasion may provide novel GBM therapeutic strategies essential for improving long-term treatment efficacy. …”
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Factors influencing malnutrition among adolescent girls in The Gambia: a mixed-methods exploratory study by Haddy Jallow-Badjan, Tanefa A. Apekey, Maria J. Maynard

“…Conclusion This exploratory study provides novel data to inform larger-scale research to understand and address malnutrition among adolescent females in The Gambia. …”
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Almond cold-pressed oil by-product as ingredient for cookies with potential health benefits: Chemical and sensory evaluation by João C.M. Barreira, M. Antónia Nunes, Beatriz Vieira da Silva, Filipa B. Pimentel, Anabela S.G. Costa, M. Alvarez-Ortí, J.E. Pardo, M. Beatriz P.P. Oliveira

“…Accordingly, the incorporation of PDAF might represent an effective way of adding value to an industrial by-product, while providing a pleasant novel cookie formulation. Keywords: By-products, Almond, Food security, Cookie formulation, Principal component analysis…”
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Quantitative relationships between elastic modulus of rod and biomechanical properties of transforaminal lumbar interbody fusion: a finite element analysis by Jie Li, Zengfeng Du, Shuai Cao, Teng Lu, Zhongwei Sun, Hongyu Wei, Haopeng Li, Ting Zhang

“…BackgroundCurrently, some novel rods with lower elastic modulus have the potential as alternatives to traditional titanium alloy rods in lumbar fusion. …”
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Machine learning model and nomogram to predict the risk of heart failure hospitalization in peritoneal dialysis patients by Liping Xu, Fang Cao, Lian Wang, Weihua Liu, Meizhu Gao, Li Zhang, Fuyuan Hong, Miao Lin

“…For all the above endpoints, the ML models demonstrated better discrimination than Cox regression.Conclusions We developed and validated a novel method to predict the risk factors of HF and all-cause mortality that integrates readily available clinical, laboratory, and electrocardiographic variables to predict the risk of HF among PD patients.…”
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Non-medical treatment for late age-related macular degeneration by A.K. Drakon, A.G. Kurguzova, V.M. Sheludchenko, N.B. Korchazhkina

“…A myriad of studies is currently underway to discover cutting-edge, effective therapeutic modalities. Gene therapy is a novel alternative to regular intravitreal injections of anti-VEGF agents for late wet AMD. …”
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Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a M... by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz

“…Thus, the regulation of the nonclassical axis of RAS forms part of a novel protective effect of fenofibrate in myocardial ischemia.…”
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Experimental and numerical analysis of pGFRP and wood cross-arm in latticed tower: a comprehensive study of mechanical deformation and flexural creep by Amir Abd Latif, Mohamad Ridzwan Ishak, Muhammad Rizal Razman, Noorfaizal Yidris, Mohamed Yusoff Mohd Zuhri, Muhammad Asyraf Muhammad Rizal, Zuliskandar Ramli

“…Abstract The adoption of pultruded glass fibre-reinforced polymer (pGFRP) composites as a substitute for traditional wooden cross-arms in high transmission towers represents a relatively novel approach. These materials were selected for their high strength-to-weight ratio and lightweight properties. …”
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H. Pylori‐Facilitated TERT/Wnt/β‐Catenin Triggers Spasmolytic Polypeptide‐Expressing Metaplasia and Oxyntic Atrophy by Lijiao He, Xiao Zhang, Shengwei Zhang, Yi Wang, Weichao Hu, Jie Li, Yunyi Liu, Yu Liao, Xue Peng, Jianjun Li, Haiyan Zhao, Liting Wang, Yang‐Fan Lv, Chang‐Jiang Hu, Shi‐Ming Yang

“…Mechanism study revealed that CagA elevated TERT abundance by disrupting the interaction between TERT and its novel E3 ligase, SYVN1. Interestingly, Nitazoxanide effectively relieved SPEM via inhibition of the Wnt/β‐Catenin signaling in vivo. …”
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Inferior Outcomes of Fludarabine–Cyclophosphamide–Rituximab Chemotherapy in Korean Chronic Lymphocytic Leukemia Patients with Concurrent Thrombocytopenia and Anemia by Tong-Yoon Kim, Gi-June Min, Young-Woo Jeon, Seung-Ah Yahng, Seok-Goo Cho, Jong-Mi Lee, Myungshin Kim, Ki-Seong Eom

“…In the Republic of Korea, where insurance limits coverage to novel agents, FCR therapy should be carefully considered for patients with CLL. …”
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Transcription Factor E2F-1 Is Upregulated in Human Gastric Cancer Tissues and Its Overexpression Suppresses Gastric Tumor Cell Proliferation by Qiang Xiao, Lei Li, Yubo Xie, Ning Tan, Changqing Wang, Junyi Xu, Keyi Xia, Kevin Gardner, Qingdi Q. Li

“…These findings suggest that E2F-1, a stable and conservative gene during the oncogenesis and progression of stomach cancers, may potentially serve as a biomarker for clinical diagnosis of gastric carcinomas and as a target for the development of novel therapeutic interventions to treat this disease.…”
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A comparative study of the performance of ten metaheuristic algorithms for parameter estimation of solar photovoltaic models by Adel Zga, Farouq Zitouni, Saad Harous, Karam Sallam, Abdulaziz S. Almazyad, Guojiang Xiong, Ali Wagdy Mohamed

“…This study conducts a comparative analysis of the performance of ten novel and well-performing metaheuristic algorithms for parameter estimation of solar photovoltaic models. …”
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Quality Evaluation of Muffins Enriched With Blueberry and Cranberry Powders by Njomza Gashi, Endrit Hasani, Salih Salihu

“…This was the main objective of this study, to improve the nutritional profile of muffins through berries’ incorporation and evaluate the consumers’ acceptability for these novel products. In this study, the muffins were enriched with cranberries and blueberries in powder form at concentrations of 3%, 6%, and 9%. …”
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Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTE... by Behnam Nazarzadeh, Saeedeh sadat Ghazanfari, Farzaneh Karimi, Seyed ali Moezibady, Fatemeh Salmani, Kazem Dastjerdi, Hamidreza Mohammadi

“…ABSTRACT Background and Aims Mounting evidence have implicated that rs1801131 and rs1801133, located in the Methylenetetrahydrofolate reductase (MTHFR) gene, may emerge as novel biomarkers for coronary artery disease (CAD). …”
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The Feasibility and Acceptability of an HIV Web- Based Screening Program in Iran by Roya Sahebi, Hossein Dehghanian, Alireza Mirahmadizadeh, Leyla Sahebi, Reza Yousefi Farkhad, Simin Khayatzadeh-Safaie, Nazila Sattari, Leila Jahangiry, Hamid Sharifi

“…A web-based screening programcould provide a novel approach to address this challenge. This study aimed to evaluate the feasibility and acceptability of a web-based HIV screening program for identifying individuals with high-risk HIV behaviors in Iran.Methods: A cross-sectional study was conducted using an educational website where individuals could anonymously complete a risk assessment questionnaire. …”
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Biomass and Yield in Solanum lycopersicum Expressing a Synthetic Photorespiration Pathway by Laura Dougherty, Bret Cooper, James Bunce, Bryan Vinyard, John Stommel

“…The current study investigated whether a novel synthetic photorespiratory pathway demonstrated to reduce photorespiratory metabolic energy demands and increase plant vegetative biomass in model species could boost tomato crop yield, notably yield of marketable fruit. …”
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Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function by Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer, Brooke Harmon

“…The development of specific, safe, and potent monoclonal antibodies (Abs) has led to novel therapeutic options for infectious disease. …”
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