Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk by Fahad M. Aldakheel, Hadeel Alnajran, Shatha A. Alduraywish, Ayesha Mateen, Mohammed S. Alqahtani, Rabbani Syed

“…There is a pressing need for novel biomarkers to enhance precision medicine approaches for PCa. …”
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Fractional-order PID feedback synthesis controller including some external influences on insulin and glucose monitoring by Kottakkaran Sooppy Nisar, Muhammad Farman, Khadija Jamil, Saba Jamil, Evren Hincal

“…The article aims to develop a fractional-order proportional integral derivative (PID) controller to monitor insulin and glucose levels in humans under the influences of stress, excitement, and trauma. A novel fractional-order diabetes mellitus model is proposed, incorporating a nonsingular, nonlocal kernel (Mittag-Leffler function) to account for the effect of epinephrine on suppressing insulin secretion and the dynamics of beta-cell mass. …”
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MicroVi: A Cost-Effective Microscopy Solution for Yeast Cell Detection and Count in Wine Value Chain by Ismael Benito-Altamirano, Sergio Moreno, David M. Vaz-Romero, Anna Puig-Pujol, Gemma Roca-Domènech, Joan Canals, Anna Vilà, Joan Daniel Prades, Ángel Diéguez

“…We demonstrate that this novel microscopy setup is able to measure the same type of samples as an optical microscopy system, but with smaller size equipment and with automated cell count configuration. …”
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Preschool and Me: Educational-clinical linkage to improve health equity for children with developmental delays and disabilities from historically marginalized communities by Tina L. Schuh, Kathleen R. Diviak, Sarai Coba-Rodriguez, Emily Pela, Raphael Kinney, Michael L. Berbaum, Amanda Klemas, Kruti Acharya, Molly Martin, Reshma Shah

“…To address this issue, we developed Preschool and Me (PreM), a community-clinical linkage (CCL) implemented within healthcare settings serving historically marginalized communities. This novel CCL, an educational-medical linkage model, aims to increase access to school-based services for PCw/DD. …”
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Structure-based identification of HNF4α agonists: Rosmarinic acid as a promising candidate for NAFLD treatment by Xi Chen, Xinqi Zhu, Gang Wu, Xiaobo Wang, Yu Zhang, Nan Jiang

“…Collectively, these findings suggest that rosmarinic acid is a promising HNF4α agonist which is more effective to activate the P1 isoform of HNF4α and holds potential as an effective treatment for NAFLD, providing a foundation for the development of novel lipid-lowering drugs with enhanced efficacy and reduced side effect. …”
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Simultaneous exposure to microplastics and heavy metal lead induces oxidative stress, histopathological damage, and immune dysfunction in marine mussel Mytilus coruscus by Chuanyue Chen, Xueer Wang, Yingrong Jin, Yinchang Yao, Suchang Li, Zhi Liao, Xiaolin Zhang, Xiaojun Yan

“…Furthermore, the TLR/MyD88/NFκB signaling pathway is involved in the immune response of mussels to environmental stress. This study provides novel perspectives on the toxicity of MPs combined with Pb in marine animals, as well as the molecular mechanisms underlying their ecotoxicological effects.…”
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Dietary addition of compound organic acids improves the growth performance, carcass trait, and body health of broilers by Fang Cai, Meiping Huang, Wei Liu, Xiaoling Wan, Kai Qiu, Xiao Xu

“…Despite their promising effects in other animal species, the impact of this novel compound organic acidifier on broiler performance, metabolism, and immune response has not been fully elucidated. …”
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Complement inhibition targets a rich-club within the neuroinflammatory network after stroke to improve radiographic and functional outcomes by Youssef M. Zohdy, Tomas Garzon-Muvdi, Jonathan A. Grossberg, Daniel L. Barrow, Brian M. Howard, Gustavo Pradilla, Firas H. Kobeissy, Stephen Tomlinson, Ali M. Alawieh

“…Similar findings were observed with functional and cognitive outcomes, showing R2 values of 0.58, 0.7, 0.54, and 0.7 for neurological severity scores, corner tasks, passive avoidance, and novel object recognition tasks, respectively (P < 0.001). …”
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A life stage resolved habitat model for guiding seagrass restoration in coastal lagoons by Sherry Y. Zhai, Michelle Waycott, Ryan Lewis, Emma O’Loughlin, Paul L.A. Erftemeijer, Peisheng Huang, Justin D. Brookes, Claire Sims, Zhenming Zhang, Matthew R. Hipsey

“…This study aimed to develop a novel phenology-based habitat suitability model for quantifying the overall probability of reproductive success, based on salinity, water depth, light availability, temperature and filamentous algae presence. …”
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Innovative Zein-derived inks: Towards sustainable 3D printing solutions by Derniza-Elena Cozorici, Erika Blanzeanu, Ionut-Cristian Radu, Marian Nicolae Verziu, Cristina Stavarache, Minodora Marin, Rafael Luque, Catalin Zaharia

“…This study highlights the development of a biodegradable, zein-based bio-ink derived from corn gluten meal as a promising candidate for extrusion-based 3D printing applications. A novel two-step functionalization strategy was employed, involving the esterification of zein to introduce hydroxyl groups, followed by methacrylation with methacrylic acid to create a UV-curable ink formulation. …”
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WDR36 Regulates Trophectoderm Differentiation During Human Preimplantation Embryonic Development Through Glycolytic Metabolism by Shiyu An, Shuyue Hou, Feifei Xu, Huanyu Yan, Wenyi Zhang, Jinfeng Xiang, Haoran Chen, Hanwen Zhang, Lingling Dong, Xiaobin Sun, Ran Huo, Yun Chen, Xi Wang, Yang Yang

“…Taken together, the study has established a mechanistic connection between WDR36, glucose metabolism, and cell fate determination during early embryonic lineage commitment, which may provide potential insights into novel therapeutic targets for early adverse pregnancy interventions.…”
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A Double Resistive–Capacitive Approach for the Analysis of a Hybrid Battery–Ultracapacitor Integration Study by Adrian Chmielewski, Piotr Piórkowski, Krzysztof Bogdziński, Paweł Krawczyk, Jakub Lorencki, Artur Kopczyński, Jakub Możaryn, Ramon Costa-Castelló, Stepan Ozana

“…This study proposes a novel approach to analysing the set of differential equations of a substitute model of HESS and validates a model-based approach to investigate the performance of an HESS composed of a Valve-Regulated Lead Acid (VRLA) Absorbent Glass Mat (AGM) battery and a Maxwell ultracapacitor in a parallel configuration. …”
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Biofabrication of copper oxide nanoparticles using Dalbergia sisso leaf extract for antibacterial, antibiofilm and antioxidant activities by Muhammad Hussnain Siddique, Maimona Sadia, Saima Muzammil, Muhammad Saqalein, Asma Ashraf, Sumreen Hayat, Saba Saba, Arif Muhammad Khan, Abeer Hashem, Graciela Dolores Avila-Qezada, Elsayed Fathi Abd-Allah

“…One of the most promising and novel approaches to combat these pathogens is utilization of nanomaterials as antimicrobial agents. …”
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Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans by Michela Palmieri, Spyridoula Maraka, Horace J. Spencer, Jeff D. Thostenson, Katherine Dishongh, Micheal Knox, Betty Ussery, Jesse Byrd, Jacqueline K. Kuipers, Sanaz Abedzadeh-Anaraki, Chitharanjan Duvoor, Yuanjie Mao, Lakshmi Menon, James S. Williams, Stavros C. Manolagas, Robert L. Jilka, Elena Ambrogini

“…These results raise the possibility that higher levels of anti-PC IgM in patients with lower BMD reflect exposure to higher levels of PC-OxPLs, which are known to affect bone mass, and could be a novel risk marker for osteoporosis.…”
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Circ_0001084/miR-181c-5p/PTPN4 Axis Mitigates Cardiomyocyte Injury by Modulating the TLR4/NF-&kappa;B Pathway: Insights into Therapeutic Potential for Myocardial Reperfusion Injury by Deng H, Fan Q, Huang L, Ouyang W, Zhu W

“…Notably, circ_0001084 was identified as absorbing miR-181c-5p, reducing its interaction with PTPN4 and subsequent pathway activation. This suggests a novel therapeutic pathway for myocardial I/R injury treatment, highlighting the interplay between non-coding RNAs and cellular stress responses.Conclusion: circ_0001084 acts as a competing endogenous RNA for miR-181c-5p, enhancing PTPN4 expression and inhibiting the TLR4/NF-κB signaling pathway. …”
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Guidewire Ablation within the Coronary Venous System for Epicardial or Intramural Ventricular Arrhythmia: A Preclinical Study of Biophysical Characterization by Fengqi Xuan, Zhongyin Zuo, Jie Zhang, Shibei Zhang, Zichen Liu, Yunfan Meng, Kuo Sun, Yaling Han, Ming Liang, Zulu Wang

“…In the in vivo phase, effective ablation lesions with maximum and minimum diameters of 3.2 ± 0.3 and 2.8 ± 0.5 mm, respectively, were created by the guidewires during the 10-day observation period after ablation. Conclusion. This novel radiofrequency guidewire ablation technique can feasibly create effective lesions within the CVS, which may improve the efficacy of catheter ablation for challenging epicardial or intramural VA.…”
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Carthamin yellow-loaded glycyrrhetinic acid liposomes alleviate interstitial fibrosis in diabetic nephropathy by Yifei Wang, Wenfang He, Peiyao Ren, Li Zhao, Danna Zheng, Juan Jin

“…The inhibitory effects were stronger than CY alone and were mediated by the inactivation of the TGFBR1/Smad2/Smad3 pathway, as confirmed by TGFBR1 overexpression studies.Conclusions CY-loaded GA liposomes demonstrated significant therapeutic efficacy in alleviating renal interstitial fibrosis in DN by targeting the TGFBR1/Smad2/Smad3 pathway. This novel drug delivery system provides a promising approach for the treatment of DN.…”
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Relation between occupation, gender dominance in the occupation and workplace and suicide in Sweden: a longitudinal study by Gun Johansson, Theo Bodin, Anette Linnersjö, Vladimir Carli, Gergö Hadlaczky, Nuria Matilla Santander, Bianca Blazevska

“…The results of our study are novel and are worth exploring in future qualitative studies.…”
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Characteristics of climate resource utilization and economic benefits in new planting pattern for fresh faba bean and fresh maize in Yangtze River Delta by Bo Li, Qingming Ren, Xiaoxu Shi, Wenyuan Shen, Yafeng Wei, Fei Xiong

“…In this research, we aimed to construct a novel planting pattern for faba bean and maize with high-efficiency utilization of climate resources for application in production. …”
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Development of Personas and Journey Maps for Artificial Intelligence Agents Supporting the Use of Health Big Data: Human-Centered Design Approach by Yoon Heui Lee, Hanna Choi, Soo-Kyoung Lee

“…This research aims to help accelerate the development of novel human-AI interfaces for AI agents that support the analysis and use of HBD, which will be urgently needed in the near future. …”
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