Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review by Chang Gao, Yan-Jun Liu, Jing Yu, Ran Wang, Jin-Jin Shi, Ru-Yi Chen, Guan-Jun Yang, Jiong Chen

“…Such insights may pave the way for novel strategies in cancer diagnosis and treatment, enhancing our understanding of UBE2T’s role in cancer biology and supporting the development of innovative therapeutic approaches.…”
Get full text

Bioprocess exploitation of microaerobic auto-induction using the example of rhamnolipid biosynthesis in Pseudomonas putida KT2440 by Jakob Grether, Holger Dittmann, Leon Willems, Tabea Schmiegelt, Elvio Henrique Benatto Perino, Philipp Hubel, Lars Lilge, Rudolf Hausmann

“…Conclusions Utilizing the inherent tolerance of P. putida to microaerobic conditions in combination with the application of homologous, low-oxygen inducible promoters is a novel and efficient strategy to control bioprocesses. …”
Get full text

Mouse Umbilical Cord Mesenchymal Stem Cell Paracrine Alleviates Renal Fibrosis in Diabetic Nephropathy by Reducing Myofibroblast Transdifferentiation and Cell Proliferation and Upr... by Hongde Li, Pengfei Rong, Xiaoqian Ma, Wei Nie, Yan Chen, Juan Zhang, Qiong Dong, Min Yang, Wei Wang

“…Transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) is currently considered a novel therapeutic strategy for diabetic nephropathy (DN). …”
Get full text

Photostimulation decreases fearfulness, but improves growth performance and egg quality of breeder Pekin ducks by E.M. Oluwagbenga, J.M. Schober, M.M. Bergman, D.M. Karcher, C. Chavez, G.S. Fraley

“…Eggs laid were recorded daily from weeks 20 to 31. Novel object test (NOT) was done at weeks 1, 5, 10, 19, and 29, transect welfare scoring at week 30, egg quality assessment at weeks 28 and 29, and fertility was determined at weeks 28 and 29. …”
Get full text

Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma by Giuseppina De Filpo, Elisa Contini, Viola Serio, Andrea Valeri, Massimiliano Chetta, Daniele Guasti, Daniele Bani, Massimo Mannelli, Elena Rapizzi, Michaela Luconi, Mario Maggi, Tonino Ercolino, Letizia Canu

“…After surgery, the normetanephrine levels decreased very slowly and a suspected abdominal lymph node was detected. We found a novel germline KIF1Bβ gene mutation, c.4052C > T, p. …”
Get full text

Unique Biomarker Characteristics in Gestational Diabetes Mellitus Identified by LC-MS-Based Metabolic Profiling by Xingjun Meng, Bo Zhu, Yan Liu, Lei Fang, Binbin Yin, Yanni Sun, Mengni Ma, Yuli Huang, Yuning Zhu, Yunlong Zhang

“…Our findings were helpful to develop novel biomarkers for precision or personalized diagnosis for GDM. …”
Get full text

Assessment of maternal health and behavior during pregnancy in the HEALthy Brain and Child Development Study: Rationale and approach by Kelly K. Gurka, Heather H. Burris, Lucia Ciciolla, Claire D. Coles, Suena H. Massey, Sharlene Newman, Vidya Rajagopalan, Lynne M. Smith, Anna Zilverstand, Gretchen Bandoli

“…Pregnancy, chronic and acute health conditions, family mental health, and healthcare utilization were assessed using existing and novel measures. Maternal mental health was assessed with the Edinburgh Postpartum Depression Scale, select items in the DSM-5 Self-Rated Level-1 and −2 Cross-Cutting Symptom Measures, and the National Stressful Events Survey-PTSD Short Scale. …”
Get full text

Chlorotoxin-functionalized mesoporous silica nanoparticles for pH-responsive paclitaxel delivery to Glioblastoma multiforme by Mirjana Mundžić, Amelia Ultimo, Minja Mladenović, Aleksandra Pavlović, Oliviero L. Gobbo, Eduardo Ruiz-Hernandez, Maria Jose Santos-Martinez, Nikola Ž. Knežević

“…Glioblastoma multiforme (GBM) is a highly aggressive brain cancer associated with poor survival rates. We developed novel mesoporous silica nanoparticles (MSNs)-based nanocarriers for pH-responsive delivery of a therapeutic drug Paclitaxel (PTX) to GBM tumor cells. …”
Get full text

Glycosylation Patterns in <i>Meccus (Triatoma) pallidipennis</i> Gut: Implications for the Development of Vector Control Strategies by Elia Torres-Gutiérrez, Frida Noelly Candelas-Otero, Olivia Alicia Reynoso-Ducoing, Berenice González-Rete, Mauro Omar Vences-Blanco, Margarita Cabrera-Bravo, Martha Irene Bucio-Torres, Paz María Silvia Salazar-Schettino

“…Understanding glycosylation patterns provides critical insights into vector–pathogen interactions that could eventually inform novel control approaches. Furthermore, the potential use of lectins as insecticidal agents highlights the broader implications of glycoprotein research in the future development of strategies on vector control to disrupt <i>T. cruzi</i> transmission.…”
Get full text

Dynamic Key Replacement Mechanism for Lightweight Internet of Things Microcontrollers to Resist Side-Channel Attacks by Chung-Wei Kuo, Wei Wei, Chun-Chang Lin, Yu-Yi Hong, Jia-Ruei Liu, Kuo-Yu Tsai

“…To address this critical vulnerability, this study proposes a novel dynamic key replacement mechanism specifically designed for lightweight IoT microcontrollers. …”
Get full text

Expression of LINC00847 in Peripheral Blood Mononuclear Cells of Children with Asthma and Its Prediction between Asthma Exacerbation and Remission by Jiaying Hu, Zhike Wang, Suzhen Han, Kai Chen

“…The study demonstrates that increased LINC00847 expression may be associated with the development and progression of asthma, possibly serving as a novel biomarker for predicting asthma exacerbation from asthma remission.…”
Get full text

Discovery of a New Cyanobacterial Genus (<em>Paludothrix</em> gen. nov.) from the Sanyang Wetland in Eastern China, Reflecting the Latest Taxonomic Status in Coleofasciculaceae by Yangyang Wu, Yao Cheng, He Zhang, Ruozhen Geng, Peng Xiao, Baiyu Cui, Renhui Li

“…This research, which is part of a larger investigation into soil biocrust algae diversity in the Sanyang Wetland located in Zhejiang Province, China, introduces a novel taxon of non-heterocystous filamentous cyanobacteria employing a polyphasic approach for cyanobacterial classification, integrating morphological, molecular, ecological, and biogeographical considerations. …”
Get full text

Integrating microplastic research in sustainable agriculture: Challenges and future directions for food production by Marcelo Illanes, María-Trinidad Toro, Mauricio Schoebitz, Nelson Zapata, Diego A. Moreno, María Dolores López-Belchí

“…Currently, the application of omics technologies, including genomics, transcriptomics, and metabolomics, offers novel insights into molecular mechanisms that enable the identification of specific biomarkers associated with MP exposure. …”
Get full text

Foliar application of nano biochar solution elevates tomato productivity by counteracting the effect of salt stress insights into morphological physiological and biochemical indice... by Javeria Shahzadi, Zaib-un-Nisa, Naila Ali, Muhammad Iftikhar, Anis Ali Shah, M. Yasin Ashraf, Chen Chao, Shifa Shaffique, Mansour K. Gatasheh

“…Abstract Nano-biochar considers a versatile and valuable sorbent to enhance plant productivity by improving soil environment and emerged as a novel solution for environmental remediation and sustainable agriculture in modern era. …”
Get full text

The influence of Hermetia illucens L. frass on the health, stress, and development of barley by Monika Grzanka, Łukasz Sobiech, Dominika Radzikowska-Kujawska, Zuzanna Sawinska, Przemysław Łukasz Kowalczewski, Stanisław Świtek, Grzegorz Skrzypczak, Przemysław Kardasz

“…As climate change continues to pose challenges to agriculture, incorporating such novel fertilizers may offer a promising avenue for sustainable crop production.…”
Get full text

Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats by Jianmin Ran, Gang Xu, Huixuan Ma, Hailing Xu, Yan Liu, Rongshao Tan, Ping Zhu, Jun Song, Gancheng Lao

“…In this study, we aimed to investigate the effects of febuxostat, a novel inhibitor of xanthine oxidase (XO), on renal damage in streptozotocin- (STZ-) induced diabetic rats. …”
Get full text

Wnt3a Enhances Mesenchymal Stem Cell Engraftment and Differentiation in a Chronic Obstructive Pulmonary Disease Rat Model by Wu H, Zhong Y, Li Y, Zhou X, Zhao T, Wan D, Zhu Y, Zhang Z, Li X, Gan X

“…Huala Wu,1,&ast; Yulan Zhong,2,&ast; Yangjingsi Li,3 Xiangxiang Zhou,2 Tiantian Zhao,1 Daomou Wan,1 Yuanzhe Zhu,1 Zhiyan Zhang,1 Xiaolei Li,1,4 Xin Gan1,4 1Department of Respiratory and Critical Care Medicine, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Chest Hospital of Jiangxi Province, Nanchang, Jiangxi, 330006, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, 330006, People’s Republic of China; 4China-Japan Friendship Jiangxi Hospital, National Regional Center for Respiratory Medicine, Nanchang, Jiangxi, 330200, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xin Gan; Xiaolei Li, Email ganxin1207@126.com; xiaoleili1225@163.comBackground: Bone marrow mesenchymal stem cell (BMSC) therapy is a novel approach for treating COPD. However, the difficulty in engraftment and easy clearance of BMSCs in vivo has hindered their clinical application. …”
Get full text

A comparative filling materials study on microstructure and mechanical properties of welded joints of dissimilar Al–Mg–Si alloys using CMT-laser beam oscillation hybrid welding by H.Y. Shen, J.M. Yu, L. Wang, F. Vogel, C.J. Li, H. Nagaumi

“…In contrast, the ER5183 joint demonstrated superior tensile strength (226.76 MPa) and lower crack sensitivity, rendering it more suitable for high-performance structural applications. Our findings provide novel insights into optimizing filler materials and welding techniques for high-strength aluminum alloy joints.…”
Get full text

Efficacy of Larimichthys crocea TASOR protein-derived peptide FAM286 against Staphylococcus aureus by Ritian Jin, Guanglei Wei, Rong Lin, Wenfeng Lin, Jude Juventus Aweya, Duo Liang, Wuyin Weng, Shen Yang

“…Antimicrobial peptides, as emerging antimicrobial agents, are gradually replacing traditional agents due to their highly effective and safe antimicrobial activity. In this study, a novel peptide, designated as FAM286, was identified from TASOR protein of Larimichthys crocea, which had a strong antimicrobial activity against S. aureus with a minimum bactericidal concentration (MBC) of 3.9 μg/mL and completed bacteria killing by treatment for 1.5 h. …”
Get full text

Intraoperative Hyperspectral Imaging Predicts Early Allograft Dysfunction and Overall Survival in Liver Transplantation by Andri Lederer, MD, Antonia Alina Geisler, MD, Robert Sucher, MD, Daniel Seehofer, MD, Hans-Michael Hau, MD, Uwe Scheuermann, PD, Sebastian Rademacher, MD

“…This study explored the novel application of hyperspectral imaging (HSI) for in vivo allograft perfusion assessment during liver transplantation (LT) and its potential value for predicting early allograft dysfunction (EAD), graft, and overall survival (OS). …”
Get full text