Aroma profiling of long shelf-life yoghurt from milk with varying acidity: Insights from sensory evaluation and instrumental analysis by Jia Wang, Dongjie Zhang, Jie Li, Tingting Zou, Rong Wen, Yaqiong Hou, Huanlu Song, Hongliang Li, Hairan Ma, Jiao Shi

“…These findings provide novel insights into the effect of milk acidity on the aroma components of long shelf-life yoghurt.…”
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Structure and function of a β-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium by Yutaka Nakazawa, Masumi Kageyama, Tomohiko Matsuzawa, Ziqin Liang, Kaito Kobayashi, Hisaka Shimizu, Kazuki Maeda, Miho Masuhiro, Sei Motouchi, Saika Kumano, Nobukiyo Tanaka, Kouji Kuramochi, Hiroyuki Nakai, Hayao Taguchi, Masahiro Nakajima

“…In this study, we identify a β-galactosidase with novel substrate specificity from Bacteroides xylanisolvens, an intestinal bacterium. …”
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Morphological and molecular characterization of a Sarcocystis bovifelis-like sarcocyst in American beef by Aditya Gupta, Larissa S. de Araujo, Andrew Hemphill, Asis Khan, Benjamin M. Rosenthal, Jitender P. Dubey

“…Results Molecular evaluation revealed 100% identity with S. bovifelis-like sarcocysts from naturally infected cattle from Germany and Argentina; although the condition of the frozen material precludes complete characterization by TEM, we noted morphological features which differed from the S. bovifelis originally described from experimentally infected cattle from Germany. Conclusions A novel Sarcocystis species is described from beef from the USA but not named until further evaluation. …”
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Social Structure Analysis in Management of South Sumatra Inland Waters by Fevi Rahma Dwi Putri, Arif Satria, Rilus A. Kinseng, Taryono Taryono

“… • Structure of the working relationship formed is an asymmetric patron-client relationship but with novel theories such as the stratified distribution of rights model, dual status, multi-stage patronage, and the positive function of patronage…”
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Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma by Leonardo do Prado Lima, Carla Jorge Machado, João Bernardo Sancio Rocha Rodrigues, Leonardo de Souza Vasconcellos, Eduardo Paulino Junior, Paula Vieira Teixeira Vidigal, Vivian Resende

“…The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to investigate the immunohistochemical expression of EpCAM and alpha-fetoprotein (AFP) in HCC patients and their association with clinicopathological characteristics. …”
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Development of Antimicrobial Biopolymer Film Incorporated with a Mixture of Sodium Lactate and Diacetate and Studying its Efficacy Against Listeria monocytogenes and Microbiologica... by Katherine Sierra, Luis Guzman, Vianca Tashiguano, Micah T. Black, Payten Leeds, Jakob Doster, Laura J. Garner, Sungeun Cho, Yucheng Peng, Amit Morey

“…The integration of biomolecules derived from agricultural waste has the potential to enhance the mechanical properties of these novel packaging materials. Additionally, incorporating antimicrobial agents can improve food safety and extend shelf life, thereby increasing the market acceptance of these environmentally friendly packaging solutions. …”
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Spatial metabolomics in mental disorders and traditional Chinese medicine: a review by Chaofang Lei, Jiaxu Chen, Zhigang Chen, Chongyang Ma, Xudong Chen, Xiongxing Sun, Xukun Tang, Jun Deng, Shiliang Wang, Junlin Jiang, Dahua Wu, Le Xie

“…Spatial metabolomics is an emerging technology that integrates mass spectrometry imaging (MSI) with metabolomics, offering a novel visual perspective for traditional metabolomics analysis. …”
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An Efficient and Hybrid Deep Learning-Driven Model to Enhance Security and Performance of Healthcare Internet of Things by Muhammad Babar, Muhammad Usman Tariq, Basit Qureshi, Zabeeh Ullah, Fahim Arif, Zahid Khan

“…Furthermore, reducing superfluous data and identifying effective fog nodes are difficult tasks. We provide a novel Software-Defined Networking (SDN)- driven Deep Learning (DL) approach to develop a secure, intelligent, and efficient framework for smart H-CIoT networks in order to address the aforementioned challenges. …”
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Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking by Peduri Suresh Reddy, Thuraka Sekhar, Pinnu Thriveni, Gandla Mahesh Kumar, Allaka Tejeswara Rao, Mohammad Raish, Tota Giridhar, Gudipati Srinivasulu

“…Novel 1,3,4-thiadiazole-based pyrazolo[3,4-d]pyrimidine derivatives (7a–7 l) were synthesised in this study, and their structures were ascertained utilizing a range of spectroscopic methods, including HREI-MS, IR, and NMR (1H/13C). …”
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Finite Element Analysis of Horizontal Bearing Capacity for the Composite Diaphragm Wall Anchor Foundation by Qian Yin, Leyong Wei, Xiaojuan Li, Weiming Gong, Xueying Yang, Guoliang Dai, Shunkai Peng

“…A composite diaphragm wall anchor foundation (CDWAF) is a novel type of anchor foundation, but research on its bearing performance remains limited. …”
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Biochemical properties and substrate specificity of GOB-38 in Elizabethkingia anophelis by Ren Liu, Yang Liu, Jiehui Qiu, Qun Ren, Chunping Wei, Dejin Pan, Jianglong Shi, Peng Liu, DanDan Wei, Tianxin Xiang, Na Cheng

“…Abstract The novel pathogen, Elizabethkingia anophelis, has gained attention due to its high mortality rates and drug resistance facilitated by its inherent metallo-β-lactamases (MBLs) genes. …”
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Unveiling the biological activities of Heliotropium indicum L. plant extracts: anti-inflammatory activities, GC–MS analysis, and in-silico molecular docking by Mst. Sadia Afroz Shoily, Md. Ekramul Islam, Nur Mohammad Rasel, Shahnaz Parvin, Jaytirmoy Barmon, Aqibul Hasan Aqib, Debendra Nath Roy, Mst. Shahnaj Parvin

“…The study depicts the first and novel report of GC–MS compounds on in silico analysis. …”
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Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study by Christoph Schindler, Jacek Mikosiński, Pawel Mikosiński, Hanna-Riikka Kärkkäinen, Mirka Sanio, Jere Kurkipuro, Igor Mierau, Wesley Smith, Aki Vartiainen, Laurent Décory, Dirk Weber, Thomas Wirth, Juha Yrjänheikki, Sebastian Schellong, Haritha Samaranayake

“…AUP1602-C, a topical four-in-one gene therapy medicinal product (GTMP), consisting of a Lactococcus cremoris strain that produces fibroblast growth factor-2, interleukin-4, and colony-stimulating factor-1, is a promising novel treatment for DFU. Objectives: The aim of this first-in-human study was to investigate whether AUP1602-C is safe and effective in improving wound healing and quality of life (QoL) in patients with non-healing DFU (nhDFU), and to determine the recommended phase II dose. …”
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Cell-Based Therapies for the Treatment of Shoulder and Elbow Tendinopathies: A Scoping Review by Berardo Di Matteo, Riccardo Ranieri, Angelo Manca, Simone Cappato, Maurilio Marcacci, Elizaveta Kon, Alessandro Castagna

“…However, the lack of high-level evidence and the presence of controversial issues, such as interproduct variability, harvest source, and application strategies, do not allow standardization of these novel biologic approaches, whose efficacy needs to be confirmed with properly designed randomized trials.…”
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H₂S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine β-Synthase and Antioxidant Proteins by Rahib K. Islam, Erinn Donnelly, Erminia Donnarumma, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam

“…The present study was undertaken to investigate the effects of a novel H₂S prodrug, SG-1002, on stress induced hypertrophic signaling in murine HL-1 cardiac muscle cells. …”
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Association between the Plasma-Glycosylated Hemoglobin A1c/High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis: A Retrospective Study by Xiangming Hu, Wei Li, Chenyang Wang, Haotian Zhang, Haoyu Lu, Guang Li, Yingling Zhou, Haojian Dong

“…Moreover, the association of HbA1c/HDL-C with atherosclerosis remained significant in a subsample of patients with and without DM. Conclusion. As a novel compound indicator for evaluating blood glucose homeostasis and dyslipidemia, the HbA1c/HDL-C ratio was positively correlated with carotid atherosclerosis evaluated using the mean and maximum cIMT as well as the carotid artery plaque burden.…”
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Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis by Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun, Huating Wang

“…Altogether, our study demonstrates the critical role of MuSCs in actively shaping their niche and provides novel insight into the therapeutic intervention of muscle dystrophy.…”
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Exploring salivary gene expression clusters: A bioinformatics approach for advanced diagnosis and prognosis in head and neck squamous cell carcinoma by Rajesh Parsanathan, Rishaba Byju, D.S. Prabakaran

“…Ultimately, the hypothesis anticipates the discovery of novel molecular signatures in saliva, potentially enhancing early detection and prognostic precision in head and neck squamous cell carcinoma. …”
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Environmental risk factors for self-harm during imprisonment: A pilot prospective cohort study. by Thomas Stephenson, Imogen Harris, Charlotte Armstrong, Seena Fazel, Roxanna Short, Nigel Blackwood

“…The finding regarding frequent cellmate changes predicting self-harm is novel. Findings regarding prisoner-staff ratio and self-harm most likely reflect a reverse causal relationship. …”
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Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice by Ying Huang, Haiying Hu, Ling Liu, Jing Ye, Zhen Wang, Bin Que, Wenjing Liu, Ying Shi, Tao Zeng, Lei Shi, Qingwei Ji, Chao Chang, Yingzhong Lin

“…Interleukin- (IL-) 35, a novel functional cytokine of regulatory T cells (Treg) comprised of the IL-12p35 subunit and the other subunit Epstein-Barr virus-induced gene 3 (EBI3), regulates the activity of CD4+ T cells and macrophages, thereby playing a critical role in inflammatory and autoimmune diseases. …”
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