Community knowledge, perceptions and practices around COVID-19 in Sierra Leone: a nationwide, cross-sectional survey by Maike Winters, Helena Nordenstedt, Mohammad B Jalloh, Paul Sengeh, Nance Webber, Ibrahim Ngobeh, Thomas Samba, Harold Thomas

“…Objectives To assess the public’s knowledge, attitudes and practices about the novel coronavirus in Sierra Leone to inform an evidence-based communication strategy around COVID-19.Design Nationwide, cross-sectional Knowledge, Attitudes and Practices survey.Setting 56 randomly selected communities in all 14 districts in Sierra Leone.Participants 1253 adults aged 18 years and older of which 52% were men.Main outcome measures We calculated proportions of core indicators (awareness, knowledge, risk perception, practices). …”
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Electric sampling of soot particles in spreading non-premixed flames: methodology and influence of gravity by Li, Yutao, Bordino, Antoine, Guibaud, Augustin, Montero, David, Citerne, Jean-Marie, Consalvi, Jean-Louis, Torero, Jose, Legros, Guillaume

“…Within this context, a novel technique of soot sampling using electric field is applied to a spreading non-premixed flame at normal and micro-gravity. …”
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ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure) by Marc A Benninga, Morris Gordon, Nikhil Thapar, Osvaldo Borrelli, Vassiliki Sinopoulou, Merit Tabbers, Anil Darbari, Julie Khlevner, Anna de Geus, Marcin Banasiuk, Mary Boruta, Dawn Dore-Stites, Michelle Gould, Juliette Hawa, Kirsten Brooke Jones, Alexandra Kilgore, Hayat Mousa, Samuel Nurko

“…There is a significant range of therapies available to healthcare professionals for this condition, with many novel or recently studied. There is a need for an update to the joint European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines last released in 2014. …”
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Precision Medicine Assessment of the Radiographic Defect Angle of the Intrabony Defect in Periodontal Lesions by Deep Learning of Bitewing Radiographs by Patricia Angela R. Abu, Yi-Cheng Mao, Yuan-Jin Lin, Chien-Kai Chao, Yi-He Lin, Bo-Siang Wang, Chiung-An Chen, Shih-Lun Chen, Tsung-Yi Chen, Kuo-Chen Li

“…This study employed a series of novel image enhancement techniques to significantly improve diagnostic accuracy. …”
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Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets. by Natalia A Ilyushina, Jon P Seiler, Jerold E Rehg, Robert G Webster, Elena A Govorkova

“…Our results suggest that highly pathogenic H5N1 variants carrying mutations within the NA active site that decrease susceptibility to NA inhibitors may possess increased virulence in mammalian hosts compared to drug-sensitive viruses. There is a need for novel anti-influenza drugs that target different virus/host factors and can limit the emergence of resistance.…”
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Enhancing Medical Student Engagement Through Cinematic Clinical Narratives: Multimodal Generative AI–Based Mixed Methods Study by Tyler Bland

“…This innovative method suggests a novel direction for curriculum development that could improve learning outcomes and student satisfaction in medical education. …”
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The Protective Effects of Annexin A1 in Acute Lung Injury Mediated by Nrf2 by Hui Huang, Yuqin Shi, Yuequan Zhou

“…Conclusion Collectively, these findings suggest that AnxA1 alleviates LPS‐induced ALI and might be a promising novel therapeutic agent against LPS‐induced ALI.…”
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A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia by Zhiping Duan, Yunda Huang, Xiaoling Liu, Huiyu Tang, Guihua Jiang, Wei Huang, Runfen Du, Dan Zhou, Hong Yang

“…Atherogenic index of plasma (AIP) is a novel indicator of atherosclerotic status based on triglycerides and high-density lipoprotein cholesterol. …”
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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D by Yang Qin, Li Liu, Yanwen Zhang, Xiaowei Chen, Jiani Zhang, Sunwang Ling, Jianguang Wang, Xinyu Yang

“…In this study, we screen and verify insulin-like growth factor-2 mRNA binding protein 1 (IGF2BP1) as a novel citrullinated protein with significantly elevated citrullinated level in RA. …”
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Cognitive analysis of conceptual metaphor and its types in discourse of Shahrnūsh Pārsipur’s The Dog and the Long Winter based on the theory of Fauconnier and Turner by Parvin Gholamhosseini, Parastoo Karimi, Hamidreza Ghanooni, Jahangir Safari

“…To this end, Pārsipur’s novel was carefully studied, and its metaphors were thoroughly extracted. …”
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Continuous-wave Laser on Er,Yb-Codoped Pentaborate Crystal by K. N. Gorbachenya, V. E. Kisel, R. V. Deineka, A. S. Yasukevich, N. V. Kuleshov, V. V. Maltsev, D. D. Mitina, E. A. Volkova, N. I. Leonyuk

“…The purpose of this work was to study the growth technique, spectroscopic properties and continuous-wave laser performance of Er3+,Yb3+:YMgB5O10 novel crystal. Absorption and luminescence spectra as well as kinetics of luminescence decay were studied. …”
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Comparison of the safety of remimazolam and propofol during general anesthesia in elderly patients: systematic review and meta-analysis by Xianchun Liu, Longyi Zhang, Li Zhao, Xuelei Zhou, Wei Mao, Linlin Chen, Hongyu Zhu, Ying Xie, Linji Li

“…BackgroundRemimazolam is a novel sedative drug approved for procedural sedation and general anesthesia. …”
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Dietary and plasma atherogenic and thrombogenic indices and cardiometabolic risk factors among overweight and individuals with obesity by Reyhaneh Mokhtari, Mahdieh Abbasalizad Farhangi

“…Conclusion This research introduces a novel field of investigation and emphasizes the possible importance of TI, AI, and AIP indices in regulating cardiometabolic risk factors.…”
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Small Extracellular Vesicles Secreted by iPSC-Derived MSCs Ameliorate Pulmonary Inflammation and Lung Injury Induced by Sepsis through Delivery of miR-125b-5p by Wei Peng, Yun Yang, Jiaquan Chen, Zeyao Xu, Yuanlei Lou, Qi Li, Ning Zhao, Kejian Qian, Fen Liu

“…Our findings demonstrated that iMSC-sEV treatment protects against septic lung injury and exerts anti-inflammatory effects on AMs at least partially through miR-125b-5p, suggesting that iMSC-sEV may provide a novel cell-free strategy for the treatment of septic lung injury.…”
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Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage by Mira Hanna, Ahmed M. A. Akabawy, Mohamed Mansour Khalifa, Mohamed Mansour Khalifa, Marawan Abd Elbaset, Reda Abdelnasser Imam, Hanan Seddiek

“…Finally, early introduced therapy to target free iron during sepsis is a proposed novel solution for protecting the renal tissue from acute injury due to macrophage activation that may end up with chronic kidney injury, if not mortality.…”
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An Approach to Reduce Tuning Sensitivity in the PIC-Based Optoelectronic Oscillator by Controlling the Phase Shift in Its Feedback Loop by Vladislav Ivanov, Ivan Stepanov, Grigory Voronkov, Ruslan Kutluyarov, Elizaveta Grakhova

“…This paper presents a novel approach for continuously controlling the output frequency of an optoelectronic oscillator (OEO) based on integrated photonics. …”
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Targeting KRAS‐mutant pancreatic cancer through simultaneous inhibition of KRAS, MEK, and JAK2 by Satoru Miyazaki, Masato Kitazawa, Satoshi Nakamura, Makoto Koyama, Yuta Yamamoto, Nao Hondo, Masahiro Kataoka, Hirokazu Tanaka, Michiko Takeoka, Daisuke Komatsu, Yuji Soejima

“…The Kirsten rat sarcoma (KRAS) oncogene was considered “undruggable” until the development of sotorasib, a KRASG12C selective inhibitor that shows favorable effects against lung cancers. MRTX1133, a novel KRASG12D inhibitor, has shown promising results in basic research, although its effects against pancreatic cancer are limited when used alone. …”
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Tumor-associated-fibrosis and active collagen-CD44 axis characterize a poor-prognosis subtype of gastric cancer and contribute to tumor immunosuppression by Yingqi Yang, Haohan Sun, Hongkai Yu, Luyao Wang, Chang Gao, Haokun Mei, Xiaomeng Jiang, Minghui Ji

“…The Collagen-CD44 signaling axis has the potential to serve as a novel therapeutic target for gastric cancer by enhancing immune cell-mediated tumor suppression. …”
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Autoantibodies in systemic sclerosis: From disease bystanders to pathogenic players by Aurélien Chepy, Aurore Collet, David Launay, Sylvain Dubucquoi, Vincent Sobanski

“…Secondly, we emphasize the necessity for novel quantitative techniques to track Aab levels over time by gathering data regarding the timing of Aab occurrence relative to SSc symptoms and the relationships between Aab concentrations and disease severity. …”
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Multi-Trait Index-Based Selection of Drought Tolerant Wheat: Physiological and Biochemical Profiling by Mohammed Mohi-Ud-Din, Md. Alamgir Hossain, Md. Motiar Rohman, Md. Nesar Uddin, Md. Sabibul Haque, Mahmudul Hasan Tahery, Mirza Hasanuzzaman

“…Overall, the strategic approaches have yielded novel insights into genotype screening that can be directly applied to deepen our understanding of drought tolerance mechanisms in wheat.…”
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