Regional Medical Campuses in Canada by Aaron Johnston, Amanda Bell, Kristy Penner, Trushar Patel, Grace Perez

“…We found that the environments of proposed RMCs differed somewhat from existing RMCs and included examples of novel organizational constructs, settings with smaller urban population sizes, smaller hospitals, and settings with smaller and decreasing physician workforce. …”
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First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide by Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo

“…This study underscores the potential of L-PDRN as a multifunctional and sustainable alternative to salmon-derived PDRN, offering enhanced bioactivity, scalability, and environmental benefits. The novel approach of utilizing microbial-derived PDRN opens new avenues for therapeutic applications in oxidative stress management, tissue regeneration, and immune modulation, paving the way for a paradigm shift in PDRN sourcing and functionality.…”
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Survival and prognostic factors for primary lung extranodal NK/T-cell lymphoma: a retrospective study of data from China and the SEER database by Qiuyu Li, Haoyu Zuo, Chengyang Liu, Jing Yang, Nini Dai

“…Future research should focus on understanding the molecular and immunological drivers of this disease, with an emphasis on discovering novel therapeutic approaches. Large-scale multicenter studies are needed to improve diagnostic and treatment strategies for primary lung ENKTL.…”
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Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research by Cheol-Kyu Park, MD, PhD, Maryam Khalil, BSc, Nhu-An Pham, PhD, Stephanie Wong, BSc, Dalam Ly, PhD, Adrian Sacher, MD, FRCPC, Ming-Sound Tsao, MD, FRCPC

“…Given the unmet need for improved predictive models in immuno-oncology, humanized mouse models which are co-engrafted with both human tumors and immune system components have been used to investigate novel immunotherapeutics. These models have similarly been used to predict immune-related adverse events and to develop predictive biomarkers. …”
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Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation by Min Liao, Xiao-Ru Wu, Jia-Ning Hu, Xing-Zhou Lin, Tang‑yuan‑meng Zhao, Hu Sun

“…Abstract Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin. …”
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A Machine Learning Approach Using Topic Modeling to Identify and Assess Experiences of Patients With Colorectal Cancer: Explorative Study by Kelly Voigt, Yingtao Sun, Ayush Patandin, Johanna Hendriks, Richard Hendrik Goossens, Cornelis Verhoef, Olga Husson, Dirk Grünhagen, Jiwon Jung

“…ObjectiveThis study aims to identify and assess patient experiences on a large scale using a novel machine learning–supported approach, leveraging data from patient forums. …”
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Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats by Omnia A. Moselhy, Nahed Abdel-Aziz, Azza El-bahkery, Said S. Moselhy, Ehab A. Ibrahim

“…In conclusion, CNPs ameliorated the neurotoxicity of γ radiation and hold promise as a novel agent to delay cellular senescence via their combined antioxidant, anti-inflammatory, and mitochondrial-enhancing properties.…”
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TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma by Ziqing Yu, Lihua Zhong, Wangyang Tang, Wenfang Zhang, Ting Lin, Weifeng Zhu, Gang Chen, Jianchao Wang

“…Therapeutic strategies aimed at targeting 5hmC modification or TET2 may offer a novel approach for the management of ALCL.…”
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Beyond the storms: Exploring predictors of posttraumatic stress and posttraumatic growth among survivors of hurricanes Irma and Maria in Puerto Rico by Marie-Claire Meadows, Noelle Serino, Dahianira M. Camacho-Monclova, Kaumudi Joshipura, Sarah R. Lowe

“…Conclusion: These findings provide novel evidence that different disaster-related exposures have distinct associations with the different PTG domains in Puerto Rico. …”
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Global prevalence of platelet-type von Willebrand disease by Omid Seidizadeh, Andrea Cairo, Maha Othman, Flora Peyvandi

“…Conclusion: This population-based genetic epidemiology analysis indicates a substantially higher than expected frequency of PT-VWD. This novel finding suggests that a large number of PT-VWD patients are still under- or misdiagnosed.…”
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Pretransplant Immune- and Apoptosis-Related Gene Expression Is Associated with Kidney Allograft Function by Dorota Kamińska, Katarzyna Kościelska-Kasprzak, Paweł Chudoba, Oktawia Mazanowska, Mirosław Banasik, Marcelina Żabinska, Maria Boratyńska, Agnieszka Lepiesza, Agnieszka Gomółkiewicz, Piotr Dzięgiel, Marian Klinger

“…The pretransplant IFNG and CASP3 and FAS and IL-18 genes’ expression in the recipients’ peripheral blood is the possible candidate for novel biomarker of short- and long-term allograft function.…”
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Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the Eye by Federica Bertoli, Daniele Veritti, Carla Danese, Francesco Samassa, Valentina Sarao, Nicolò Rassu, Tommaso Gambato, Paolo Lanzetta

“…The novel pandemic coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has challenged the medical community. …”
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Real-World Parkinson’s Hand Tremor Detection Using Ensemble Learning Techniques by Sungwook Hur, Jieming Zhang, Moon-Hyun Kim, Tai-Myoung Chung

“…In this paper, we propose a novel approach to detect Parkinsonian hand tremor at walking state by exploiting the periodic synchronization between arm swings and leg steps that is observed in natural walking, specifically by using a wrist-worn sensor to capture the characteristic hand tremor that is induced during walking in Parkinson’s patients. …”
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The protective effects of peptides from Chinese baijiu on AAPH-induced oxidative stress in HepG2 cells via Nrf2-mediated signaling pathway by Jiaying Huo, Yuezhang Ming, Huifeng Li, Anjun Li, Jiwen Zhao, Mingquan Huang, Weizheng Sun, Jihong Wu, Jinglin Zhang

“…However, only a few reports have been published examining the antioxidant peptides derived from Chinese baijiu. In this study, 6 novel peptides derived from Chinese baijiu were identified successfully using high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (HPLC-QTOF-MS) with a concentration of 0.835–24.540 µg/L. …”
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Comprehensive performance evaluation of satellite-based and reanalysis rainfall estimate products in Ethiopia: For drought, flood, and water resources applications. by Desta Yoseph Wodebo, Assefa M Melesse, Tekalegn Ayele Woldesenbet, Kirubel Mekonnen, Ahmed Amdihun, Diriba Korecha, Hailay Zeray Tedla, Gerald Corzo, Asaminew Teshome

“…This study offers multiple novel perspectives for selecting location-specific suitable rainfall products as decision-support information for water resources, flood risk management, and drought monitoring in Ethiopia. …”
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The Efficient Integration of Dust and Numerical Weather Prediction for Renewable Energy Applications by Xi Chen, Mei Chong, Shian‐Jiann Lin, Zhi Liang, Paul Ginoux, Yuan Liang, Bihui Zhang, Qian Song, Shengkai Wang, Jiawei Li, Yimin Liu

“…Using iDust, global 12.5‐km 10‐day hourly dust storm forecast simulations initiated at 00UTC can produce results by 06UTC, enabling timely forecasting of severe dust storms with concentrations exceeding 1,000 μg/m3. This novel capability of iDust can meet the urgent forecasting needs of the renewable energy industry for extreme dust conditions, supporting the green energy transition.…”
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…Novel engineered IL-2 agonists strive to increase the therapeutic window of aldesleukin (human IL-2) by increasing selectivity toward effector over regulatory T cells and reducing dose-limiting toxicities. …”
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…Methods This study evaluated a novel approach to OA treatment by combining adipose tissue-derived MSCs (AD-MSCs) with rapamycin, a clinically approved immunosuppressive drug with anti-senescence properties. …”
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Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches by Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim

“…Furthermore, we leveraged a novel 15N-Met labeling technique of the antibody to directly observe structural perturbations at the oxidation sites. …”
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Automatic Detection of the Aortic Annular Plane and Coronary Ostia from Multidetector Computed Tomography by Patricio Astudillo, Peter Mortier, Johan Bosmans, Ole De Backer, Peter de Jaegere, Francesco Iannaccone, Matthieu De Beule, Joni Dambre

“…In this work, we propose a novel automatic method to detect the relevant aortic landmarks from MDCT images using deep learning techniques. …”
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