The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development by Zhenxing Cheng, Simon T. Abrams, James Austin, Julien Toh, Susan Siyu Wang, Zhi Wang, Qian Yu, Weiping Yu, Cheng Hock Toh, Guozheng Wang

“…Understanding the roles of DNA sensors and signal pathways will pave the way for novel therapeutic strategies in many diseases, particularly in sepsis.…”
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Research on tire tread abrasion performance considering the patten and slippage with verification by Huaqiao Liu, Yao Xiao, Kongshuo Wang, Yukun Zhou, Huiguang Bian, Chuansheng Wang

“…This study introduces a novel method for assessing wear by calculating the tire slippage. …”
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Selective state models are what you need for animal action recognition by Edoardo Fazzari, Donato Romano, Fabrizio Falchi, Cesare Stefanini

“…This study introduces Mamba-MSQNet, a novel architecture family for multilabel Animal Action Recognition using Selective Space Models. …”
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Optimization of corrosion resistance of AZ31 Mg alloy through hydration-driven interaction between quinolin-8-ol and plasma electrolytic oxidation-formed MgO layer by Mosab Kaseem, Talitha Tara Thanaa, Ananda Repycha Safira, Alireza Askari, Arash Fattah-alhosseini

“…This study presents a novel approach to improving the anticorrosive performance of AZ31 Mg alloy by exploiting the role of the hydration reaction to induce interactions between Quinolin-8-ol (8HQ) molecules and the porous MgO layer formed via plasma electrolytic oxidation (PEO). …”
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Remineralising Effects of L-arginine Fluoride Mouthwash versus Sodium Fluoride Mouthwash: A Protocol of an In-vitro Study by Anjori Ajinkya Raut, Punit Ratnakar Fulzele

“…Despite breakthroughs in preventive dentistry, oral infections and tooth decay remain common among children, highlighting the need for novel and efficient preventive interventions. Although fluoride is a proven preventive measure against tooth decay, L-arginine, a naturally occurring amino acid, has shown promising results in enhancing remineralisation and has gained interest due to its role in maintaining oral health. …”
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A hybrid CNN-Bi-LSTM model with feature fusion for accurate epilepsy seizure detection by Xiaoshuai Cao, Shaojie Zheng, Jincan Zhang, Wenna Chen, Ganqin Du

“…In recent years, advancements in the analysis of electroencephalogram (EEG) signals have garnered widespread attention, particularly in the area of seizure recognition. Methods A novel hybrid deep learning approach that combines feature fusion for efficient seizure detection is proposed in this study. …”
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The role of the microbiota and metabolites in the treatment of pulmonary fibrosis with UC-MSCs: Integrating fecal metabolomics and 16S rDNA analysis. by Yukai Luo, Shuang Zhou, Xiaojing Zhang, Yijian Lin, Jun Liu, Wenzhao Cheng, Yiming Zeng

“…<h4>Conclusion</h4>Umbilical cord-derived mesenchymal stem cells (UC-MSCs) ameliorate bleomycin-induced pulmonary fibrosis symptoms in mice by exerting anti-inflammatory effects and mitigating pulmonary fibrosis through the modulation of gut microbiota disorders and their metabolism. These findings offer novel insights into the potential mechanisms and clinical utility of stem cell therapy for pulmonary fibrosis.…”
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Spinal presentations in children with type 1 spinal muscular atrophy on nusinersen treatment across the SMA-REACH UK network: a retrospective national observational study by Francesco Muntoni, Giovanni Baranello, Pinki Munot, Mariacristina Scoto, Adnan Manzur, Marion Main, Evelin Milev, Lianne Abbott, Victoria Selby, Amy Wolfe, Annemarie Rohwer, Catherine Rye, Sarah Gregson, Grainne NicFhirleinn, Rosanna Raab, Heather McMurchie, Angela Topping, Faye Mason, Jennie Sheehan, Felicity Vann, Steph Wadsworth, José Longatto, Lindsey Pallant, Nick Emery, Jenny Moustoukas, Sarah D’Urso, Kay White, Efthymia Panagiotopoulou

“…Background Prior to the introduction of disease-modifying treatments (DMTs), children with type 1 spinal muscular atrophy (SMA) typically did not survive beyond the age of 2 years; management was mainly palliative. Novel therapies have made this a treatable condition, resulting in increased life expectancy and more time spent upright. …”
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The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism by Xue Wang, Chunyou Ning, Xingyi Cheng, Zhengzhong Wu, Dongbo Wu, Xuemei Ding, Cunxiang Ju, Zhihang Zhou, Lingfeng Wan, Wei Zhao, Peiliang Shi

“…Conclusions We successfully constructed a novel mouse model for liver fibrosis. This GSDMD‐NT‐induced fibrosis may be mediated by abnormal lipid metabolism. …”
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Treatment decision regret after precision prostatectomy: An analysis of patient‐reported outcomes predicting decision regret by Kaushik P. Kolanukuduru, Wooju Jeong, Larisa Pistin, Firas Abdollah, Ash K. Tewari, Mani Menon

“…Abstract Objectives This study aimed to assess postoperative decision regret (DR) after precision prostatectomy (PP), a novel subtotal surgical technique for prostate cancer (PCa) that involves the preservation of the unilateral capsule and seminal vesicle, and to identify factors predictive of DR after PP. …”
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Structural basis for the inhibition of coronaviral main proteases by PF-00835231 by Zhou Xuelan, Lu Xiaolu, Lin Cheng, Zou Xiaofang, Li Wenwen, Zeng Xiangyi, Wang Jie, Zeng Pei, Wang Weiwei, Zhang Jin, Jiang Haihai, Li Jian

“…Given the importance of the main protease for the treatment of coronaviral infection, structural insights into M^pro inhibition by PF-00835231 can accelerate the design of novel antivirals with broad-spectrum efficacy against different human coronaviruses.…”
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Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice by Daoyong Li, Daoyong Li, Mingyu Bai, Mingyu Bai, Zhanpeng Guo, Yang Cui, Yang Cui, Xifan Mei, Xifan Mei, He Tian, He Tian, Zhaoliang Shen

“…These results were confirmed in the SCI mouse model, where zinc ions also reduced inflammation and cell death.DiscussionOur findings highlight a novel mechanism by which zinc ions regulate inflammation in SCI by upregulating IKBα and inhibiting NF-κB activation. …”
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Osteoarthritis-like changes in rat temporomandibular joint induced by unilateral anterior large overjet treatment by Xinru Xie, Rui Chao, Yi Mao, Tianhao Wan, Yexin Wang, Yan Zhu, Weifeng Xu, Xuzhuo Chen, Yong Wang, Zhigui Ma, Shanyong Zhang

“…The current study provides a novel and reliable rat model suitable for TMJOA research and offers insights into the disease’s potential mechanistic pathways and molecular targets, contributing to a deeper understanding of TMJOA.…”
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Efficient evidence selection for systematic reviews in traditional Chinese medicine by Yizhen Li, Zhe Huang, Zhongzhi Luan, Shujing Xu, Yunan Zhang, Lin Wu, Darong Wu, Dongran Han, Yixing Liu

“…In this study, we introduce a novel precision-preferred comprehensive information extraction and selection procedure to enhance both the efficiency and accuracy of evidence selection for TCM practitioners. …”
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Expanded granular sludge bed bioreactor in wastewater treatment by A. Cruz-Salomón, E. Ríos-Valdovinos, F. Pola-Albores, S. Lagunas-Rivera, R. Meza-Gordillo, V.M. Ruíz-Valdiviezo, K.C. Cruz-Salomón

“…According to the review, it is concluded that the EGSB bioreactor is a novel sustainable alternative to treat different types of wastewaters and consequently change the paradigm of wastewater management from "treatment and disposal" to "beneficial use" as well as "profitable effort".…”
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Implementation and comprehensive investigation of gate engineered Si0.1Ge0.9/GaAs charged plasma based JLTFET for improved analog/ RF performance by Pranita Soni, Aditya Jain, Kaushal Kumar, Lokesh Kumar Soni, Ajay Kumar, Neha Gupta, Amit Kumar Goyal, Rakesh Saroha

“…This study introduces the Variable Length Dual Dielectric Material-Gate Spacer Engineering Heterostructure Junction-Less Tunnel Field-Effect Transistor (VLDD-GSE-HJLTFET), a novel device that integrates advanced bandgap engineering, dual-dielectric gate configuration, and heterostructure design using Si0.1Ge0.9/GaAs layers. …”
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Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis by Hang Han, Guojiang Zhang, Yuanyuan Yang, Chenxi Li, Xiandeng Li, Ling Zhong, Zan Chen, Jianxia Xiong, Tao Cai, Lingjuan Zhang, Xiao Zhang, Qinjian Zhao

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Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease by Guangming Su, Ping Huang, Dan Liu, Guorui Xing, Ruochun Guo, Shenghui Li, Shao Fan, Lin Cheng, Qiulong Yan, Wei Yang

“…Our results provide valuable insights into the complex interplay between gut fungi and bacteria in ACVD, paving the way for novel therapeutic approaches.…”
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Preparation and evaluation of Brucella T4SS recombinant proteins in serodiagnosis of human brucellosis based on TMT-based proteomics technology by Qi Wu, Chen Sun, Liping Guo, Yujia Xie, Jinpeng Zhang, Jinpeng Zhang, Dehui Yin, Dehui Yin

“…Cross-reactivity was observed in a limited number of serum samples from febrile patients without brucellosis.ConclusionsThe study highlights the potential of VirB proteins as novel diagnostic antigens for human brucellosis. …”
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Exploring the purpose and stages of patient and public involvement and engagement (PPIE) in audiology research: a case study approach by Helen Pryce, Nisha Dhanda, Jean Straus

“…The methods sought to engage volunteer PPIE contributors who might otherwise have not known about or contributed views of research methods. Specifically, our novel methods for engagement meant reaching out deliberately to marginalised communities and using individual, relationship building approaches, rather than relying on previously described focus group style meetings. …”
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