The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-<span style="font-variant: small-caps">d</span>-Xylulose 5-Phosphate Reductoisomeras... by Sana Takada, Mona A. Abdullaziz, Stefan Höfmann, Talea Knak, Shin-ichiro Ozawa, Yasumitsu Sakamoto, Thomas Kurz, Nobutada Tanaka

“…Recent biochemical studies have demonstrated that novel reverse fosmidomycin analogs with phenylalkyl substituents at the hydroxamate nitrogen exhibit inhibitory activities against <i>Pf</i>DXR at the nanomolar level. …”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect by Daniel de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Cor Lieftink, Joyce J. I. Catsman, Shirley Ormel, Matilda Ayidah, Bas Pilzecker, Olimpia Alessandra Buoninfante, Paul C. M. van den Berk, Roderick L. Beijersbergen, Heinz Jacobs

“…The unique characteristics of type 3 deletions implicate the existence of a novel deletion pathway in mice and humans that is counteracted by DDT. …”
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Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion by Mehul Vora, Jonathan Dietz, Zachary Wing, Karen George, Jun Kelly Liu, Christopher Rongo, Cathy Savage-Dunn

“…Functional analysis of target genes revealed a novel role in body size for genes involved in one-carbon metabolism and in the endoplasmic reticulum (ER) secretory pathway, including the disulfide reductase dpy-11. …”
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Immunological Aspects of Fulminant Type 1 Diabetes in Chinese by Zhen Wang, Ying Zheng, Yiting Tu, Zhijie Dai, Jian Lin, Zhiguang Zhou

“…Fulminant type 1 diabetes (FT1D) is a novel subtype of type 1 diabetes characterized by extremely rapid onset and complete deficiency of insulin due to the destruction of pancreatic β cells. …”
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Adaptive polarimetric optimization for ground deformation monitoring using multi-temporal InSAR with dual-polarization sentinel-1 by Leixin Zhang, Feng Zhao, Yunjia Wang, Jordi J. Mallorqui, Teng Wang, Yuxuan Zhang, Zhongbo Hu, Sen Du, José Fernández

“…To address these challenges, we propose an adaptive coherency matrix decomposition method for PolMTI (ADCMD-PolMTI), a novel algorithm that adaptively and effectively optimizes phase of both PS and DS pixels. …”
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Simultaneous Quantification of 25-Hydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3 in Rats Shows Strong Correlations between Serum and Brain Tissue Levels by Ying Xue, Xin He, Huan-De Li, Yang Deng, Miao Yan, Hua-Lin Cai, Mi-Mi Tang, Rui-Li Dang, Pei Jiang

“…Therefore, we developed a novel analysis method by using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to simultaneously quantify the concentrations of 25-hydroxyvitamin D3 (25(OH)D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) in the serum and brain of rats fed with different dose of vitamin D3. …”
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Osteoblastic Differentiation and Mitigation of the Inflammatory Response in Titanium Alloys Decorated with Oligopeptides by Aroa Álvarez-López, Raquel Tabraue-Rubio, Rafael Daza, Luis Colchero, Gustavo V. Guinea, Martine Cohen-Solal, José Pérez-Rigueiro, Daniel González-Nieto

“…These results highlight the potential of peptide decoration on R-THAB^® functionalized surfaces to expedite the development of novel metallic biomaterials with enhanced biocompatibility properties, thereby advancing the field of regenerative medicine.…”
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Transcatheter aortic valve implantation complexity score by Christopher Malkin, Daniel J Blackman, Noman Ali, Amr Abdelrahman, Michael Cunnington, Paul Bamford, Sacchin Arockiam, Suleman Aktaa, Rowan Hall

“…A significant limitation to increasing TAVI capacity is the availability of cardiac catheterisation laboratory time. We have developed a novel complexity scoring system (TAVI ComplEXity; TEX score) which can aid in planning lists with appropriate case selection. …”
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Influence of Alkali Treatment and Maleated Polypropylene (MAPP) Compatibilizer on the Dry-Sliding Wear and Frictional Behavior of Borassus Fruit Fine Fiber (BFF)/Polypropylene (PP)... by Sumit Nijjar, P. Sudhakara, Shubham Sharma, Sanjeev Saini, Aklilu Teklemariam, V. Mariselvam, Satheesh Kumar Sampath, J. I. Song

“…Tribological properties of the novel Borassus fruit fine fiber- (BFF-) reinforced polypropylene (PP) composites with respect to fiber matrix surface modifications have been described. …”
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Nanoparticle-mediated gene delivery techniques in plant systems by Kuber Shivashakarappa, Sureshbabu Marriboina, Korsi Dumenyo, Ali Taheri, Zeinab Yadegari

“…Recent advancements in nanotechnology have introduced novel gene-delivery systems, utilizing micro and nanoparticles, which can overcome many limitations of conventional plant gene delivery methods by exhibiting superior transformation efficiency, demonstrate compatibility with biological systems, offer protection to different cargoes, and hold significant capability for enhancing plant regeneration. …”
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SFSCDNet: A Deep Learning Model With Spatial Flow-Based Semantic Change Detection From Bi-Temporal Satellite Images by K. S. Basavaraju, N. Sravya, Vibha Damodara Kevala, Shilpa Suresh, Shyam Lal

“…To overcome these limitations, this paper proposes a novel network called the Spatial Flow-based Semantic Change Detection Network. …”
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Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders by Emanuela Castiglioni, Dario Finazzi, Stefano Goldwurm, Gianni Pezzoli, Gianluca Forni, Domenico Girelli, Federica Maccarinelli, Maura Poli, Maurizio Ferrari, Laura Cremonesi, Paolo Arosio

“…In the search of DNA sequence variations affecting the individual predisposition to develop movement disorders, we scanned by DHPLC the exons and intronic boundary regions of ceruloplasmin, iron regulatory protein 2, hemopexin, hepcidin and hemojuvelin genes in cohorts of subjects affected by Parkinson's disease and idiopathic neurodegeneration with brain iron accumulation (NBIA). Both novel and known sequence variations were identified in most of the genes, but none of them seemed to be significantly associated to the movement diseases of interest.…”
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H. Wendl Leaf Metabolites Potentiate the Radiosensitivity of Hepatocellular Carcinoma Through Ki67 and PARP Inhibition by Nabil M. Selim PhD, Seham S. El-Hawary PhD, Soheir M. El Zalabani PhD, Rehab Nabil Shamma PhD, Nariman El Sayed Mahdy PhD, Noheir H. Sherif PhD, Khayrya A. Youssif PhD, Usama Ramadan Abdelmohsen PhD, Mai H. Mekkawy PhD, Hanan A. Fahmy PhD

“…Conclusion: NE of W. robusta extract may possess a radiosensitizing novel impact and provide a new strategy to combat HCC in clinical practices.…”
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Redo Aortic Valve Replacement After Prior Transcatheter versus Surgical Aortic Valve Replacement: Insights from Western Experience by Arber Aliu, Klodiana Durici, Ira Lazo, Altin Veshti

“…This article presents a novel perspective on the risks associated with surgical aortic valve replacement (SAVR) after prior TAVR or SAVR. …”
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Detection and safety assessment of bonding defects in architectural decorative surface layer based on the variation of vibration acceleration amplitude by Zhide Wang, Xiaogen Liu, Dake Cao, Detian Wan, Shaoshan Wei

“…To minimize the risk of finish layer detachment and ensure its safety, this study presents a novel non-destructive testing technique that detects bonding defects in the decorative surface layer by analyzing variations in vibration acceleration amplitude. …”
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Anterior Cruciate Ligament Mechanical Response to Load in the Setting of Changes to the Medial Meniscus by Angela Hussain, Muffaddal Madraswala, Jason Koh, Farid Amirouche

“…The anterior cruciate ligament (ACL) is a major ligament in the knee joint, and its function is crucial for both the movement and stability of the knee. Our research takes a novel approach by investigating the effect of meniscus tears on the ACL, how such tears will impact the stress on the ACL, and its overall compensation in response to the changes in the meniscus. …”
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Improving remote sensing dehazing quality through local hybrid correction and optimization of atmospheric attenuation model based on wavelength by Daihong Zhao, Kun Shi, Zheng Li, Zheng Li, Meixiang Chen

“…To address these limitations, we propose a novel hybrid correction method, local hybrid correction (LHC), which integrates gamma correction for high-contrast regions and logarithmic correction for low-contrast regions within a dehazed image. …”
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Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer by Parik Kakani, Shruti Ganesh Dhamdhere, Deepak Pant, Rushikesh Joshi, Sachin Mishra, Anchala Pandey, Dimple Notani, Sanjeev Shukla

“…Specifically, disrupting the HIF1α-CTCF-COL5A1exon64A axis through the dCas9-DNMT3A system alleviates the EMT in hypoxic cancer cells and may represent a novel therapeutic target in breast cancer.…”
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Development of Prone Position Ventilation Device and Study on the Application Effect of Combined Life Support Technology in Critically Ill Patients by Yufeng Li, Qiaoqiao Hu, Wenjie Wang, Changhong Du, Siwen Fan, Linlin Xu, Songmei Li, Bei Chen

“…This study aims to evaluate a novel prone position ventilation device designed to enhance patient safety, improve comfort, and reduce adverse events, facilitating prolonged tolerance in critically ill patients. …”
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Traditional Knowledge and Efficacy Analysis of an Emerging Medicinal Food Plant: <i>Disporopsis aspersa</i> by Qingyu Chen, Miaomiao Wang, Xian Hu, Jihai Zhang, Qing Zhang, Congli Xu, Chunlin Long

“…<i>D. aspersa</i> has the potential to be developed into a novel anti-hypertensive food, nutraceutical, or dietary supplement in western Yunnan and neighboring regions, promoting local development.…”
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