Cadaveric simulation versus standard training for postgraduate trauma and orthopaedic surgical trainees: protocol for the CAD:TRAUMA study multicentre randomised controlled educati... by Damian Griffin, Hannah K James, Giles T R Pattison, Joanne D Fisher

“…A pragmatic approach to sample size is taken in lieu of a formal power calculation as this is novel exploratory work with no a priori estimate of effect size to reference. …”
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Identification of prognostic biomarker of non-small cell lung cancer based on mitochondrial permeability transition-driven necrosis-related genes and determination of anti-tumor ef... by Zhifei Ma, Wen Chen, Aiping Zhang, Xiaokang Shen, Lin Zheng

“…Recent evidence suggests that activation of MPTND can effectively induce cancer cell death and may represent a novel therapeutic strategy for cancer. Yet, the role of MPTDN-related genes in non-small cell lung cancer (NSCLC) remains unrevealed. …”
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Decentralized clinical trials are better for the participants and for the planet: the case study of a double-blind randomized controlled trial in Singapore (PROMOTE study) by Lisa R. Fries, Nadia Khaled, Ivan Viveros Santos, Elvira Suniega-Tolentino, Motshewa Sesing, Melissa P. S. Toh, Chui Yuen Yang, Shiao Yng Chan, Shiao Yng Chan, Sara Colombo Mottaz

“…IntroductionNovel technologies have enabled the decentralization of many aspects of clinical trials, but little research has been done on the impact of these changes on the participant experience, trial operations, or the environment.MethodsA fully decentralized clinical trial conducted in Singapore is used as a case study to evaluate the operational outcomes, environmental impact (via life cycle assessment), and participants experience (qualitative interviews) of the decentralized model compared to a traditional study with in-person visits.ResultsThe decentralized study achieved high participant retention rates (97%) and high completion rates for clinical data, even for biological samples. …”
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A data driven approach for soft tissue biomarker identification linked to Chiari-like malformation and syringomyelia by Jake Cumber, Jake Cumber, Emma Scales-Theobald, Emma Scales-Theobald, Clare Rusbridge, Clare Rusbridge, Clare Rusbridge, Kevin Wells, Kevin Wells

“…This research aimed to identify cranial and spinal pathologies and neural morphologies linked to CM-P and SM in dogs using MRI scans and machine learning with the aim of identifying novel data driven biomarkers which could confirm CM-P and identify dogs at risk of developing SM. …”
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Impact of Cyclosporine A on Cognitive Functions and Neuronal Oxidative Stress, Apoptosis and Inflammatory Markers in Rats by Awyed Batah Almutairi, Abdulaziz Arif A. Alshammari, Arshad Husain Rahmani, Ali Yousif Babiker, Long Chiau Ming, Maha A. Aldubayan, Ahmad H. Alhowail, Vasudevan Mani

“…Behavioural assessments included the elevated plus maze (EPM) and novel object recognition (NOR) tests used to evaluate memory capabilities and recognition memory respectively, and the Y-maze assessed the exploration of a new environment and navigational skills. …”
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The antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm by Tiantian Guo, Dai Wang, Sherry Shiqian Gao

“…Abstract Background To investigate the antibiofilm effect and mechanism of the silver nanowire (AgNW)-modified glass ionomer cement (GIC) against multi-species oral biofilm, and to examine the mechanical and biochemical properties of this novel GIC material. Methods Conventional GIC was incorporated with different concentrations of AgNW and silver nanoparticles (AgNP). …”
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Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions by Pengjie Huang, Weichang Li, Jiezhong Guan, Yibing Jia, Dan Wang, Yurun Chen, Niu Xiao, Songyue Ou, Yan Wang, Bo Yang

“…As a result, there is a growing need for novel drug delivery systems that can enhance therapeutic efficacy, reduce side effects, and improve treatment outcomes. …”
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Multi-omic spatial effects on high-resolution AI-derived retinal thickness by V. E. Jackson, Y. Wu, R. Bonelli, J. P. Owen, L. W. Scott, S. Farashi, Y. Kihara, M. L. Gantner, C. Egan, K. M. Williams, B. R. E. Ansell, A. Tufail, A. Y. Lee, M. Bahlo

“…Analysis of common genomic variants, metabolomic, blood and immune biomarkers, disease PheCodes and genetic scores across a fine-scale macular thickness grid, reveals multiple novel genetic loci including four on the X chromosome; retinal thinning associated with many systemic disorders including multiple sclerosis; and multiple associations to correlated metabolites that cluster spatially in the retina. …”
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Effectiveness of the ARTHE-e app for exercise adherence in people with knee osteoarthritis: protocol for a randomised controlled trial by Bruno Pereira, Charlotte Lanhers, Emmanuel Coudeyre, Lech Dobija, Mathilde Pelletier-Visa, Alexis Bonhomme

“…In response, we have developed a novel smartphone-based m-health application, ARTH-e, specifically designed to enhance adherence to adapted physical activity in individuals with knee osteoarthritis. …”
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Elucidating the emotional persona in the Romanian university students’ academic discourse: a corpus-based exploration by Diana Paula Dudău, Diana Paula Dudău, Madalina Chitez, Florin Alin Sava

“…In contrast, the Romanian corpus, characterized by a third cluster, presents less clear-cut patterns: humanities texts span both emotionally expressive and neutral tones, while research and academic papers frequently exhibit an achievement-oriented or entrepreneurial style, though a significant subset also reflects a highly disengaged profile.DiscussionBy integrating machine learning, network analysis, and automatic language analysis, this study offers a novel perspective on how language, genre, and discipline-specific conventions shape emotional expression in academic writing. …”
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Application of Magnetic Aquatic Plant Biochar for Efficient Removal of Antimony from Water: Adsorption Properties and Mechanism by Luyi Nan, Yuting Zhang, Min Liu, Liangyuan Zhao, Yuxuan Zhu, Xun Zhang

“…In the present research, a novel type of efficient adsorbent material for the magnetic recovery of Sb was proposed: the magnetic aquatic plant biochar. …”
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Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…The DrugBank screening resulted in three promising drugs—triamterene, phenazopyridine, and CRA_1801—with predicted pIC50 values greater than 7, warranting further investigation as novel PD treatments. Molecular docking and molecular dynamics simulations were performed to provide a comprehensive understanding of the interactions between LRRK2 and the inhibitors in the data set and best molecules of the screening. …”
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Ball Point Game: Playing or Learning Agile Project Management? by Maria Lydia Fioravanti, Gustavo M. N. Avellar, Bruna Oliveira Romeiro, Bruna Goncalves Rezende, Ellen Francine Barbosa, Ana M. Moreno

“…The study highlights the potential of educational games to bridge the gap between theoretical knowledge and hands-on activities, making them valuable tools in Agile management education. Our work has as novel element the integration of both game-based learning and experience-based learning approaches to teach Agile project management.…”
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Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered by Michael Griessmair, Michael Griessmair, Claire Delbridge, Claus Zimmer, Eva Mayr, Arthur Wagner, Julian Canisius, Marie-Christin Metz, Benedikt Wiestler, Benedikt Wiestler

“…Better understanding this molecular cascade might help to identify novel targets for individualized therapies.…”
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Facile construction of polyoxometalate-modified polyaryletherketone-based hybrid membranes with enhanced proton conductivity by Bo Hu, Qiuchen Du, Yang Yang, Dengdeng Li, Jiawang Fu, Bailing Liu, Hong-Ying Zang, Yangguang Li, Haiming Xie, Zhongmin Su

“…The development of novel proton exchange membranes (PEMs) with high proton conductivity and good mechanical performance as alternatives to Nafion is crucial. …”
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Assessing the Capabilities of Generative Pretrained Transformer-4 in Addressing Open-Ended Inquiries of Oral Cancer by Kaiyuan Ji, Jing Han, Guangtao Zhai, Jiannan Liu

“…Introduction and aims: In the face of escalating oral cancer rates, the application of large language models like Generative Pretrained Transformer (GPT)-4 presents a novel pathway for enhancing public awareness about prevention and early detection. …”
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Electronic and photophysical properties of copper (II) Complexes: Insights into solvatochromic Effects, Photoreduction, and fluorescence behavior by Haja Tar, Lama M. Alhomaidan, Lotfi Beji, Abrar S. Alnafisah, Noura Kouki, Sabri Messaoudi, Fahad M. Alminderej, Azizah A. Algreiby, Lotfi M. Aroua

“…Photolysis experiments underpin the complexes’ behavior under light irradiation, revealing reversible photoreduction processes and the formation of novel photoproducts. Notably, the addition of triethylamine influences photolysis kinetics, elucidating complex interactions. …”
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Identification of a pathogenic founder variant in the WFS1 gene that causes Wolfram syndrome in the Druze population by Inbal Halabi, Inbal Halabi, Yardena Tenenbaum-Rakover, Yardena Tenenbaum-Rakover, Lena Sagi-Dain, Lena Sagi-Dain, Lena Sagi-Dain, Ilana Koren, Ilana Koren, Ilana Koren

“…Early diagnosis of WS is important for therapeutic approaches, especially since novel medications are becoming available.…”
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Modeling vegetation density with remote sensing, normalized difference vegetation index and biodiversity plants in watershed area by R.Z. Ekaputri, T. Hidayat, H.K. Surtikanti, W. Surakusumah

“…Spatial data encompass maps and field data.FINDING: By employing normalized difference vegetation index data, the study pioneers a novel approach to environmental monitoring, setting an example for effective resource management and ecological conservation in watershed regions. …”
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Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential by Rushikesh Girase, Nayan A. Gujarathi, Amey Sukhia, Sri Sai Nikitha Kota, Tulshidas S. Patil, Abhijeet A. Aher, Yogeeta O. Agrawal, Shreesh Ojha, Charu Sharma, Sameer N. Goyal

“…It highlights the pathophysiology of RA, explores selective targeting sites, and elucidates diverse mechanisms of novel liposomal types and their applications. Furthermore, the targeting strategies of pH-sensitive, flexible, surface-modified, PEGylated, acoustic, ROS-mediated, and biofunctionalized liposomes are addressed. …”
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