The Prognostic Value of Peripheral Blood Inflammatory Markers in Hepatocellular Carcinoma Treated with Lenvatinib Combined with PD-1 Inhibitors by Xin Y, Liu N, Peng G, Huang X, Cao X, Zhou X

“…The factors related to treatment response and survival outcomes were analyzed through logistic regression and Cox regression, respectively. A novel preoperative prognostic nomogram was constructed based on inflammatory indexes, and the predictive efficacy of the nomogram and BCLC staging was compared by the area under the ROC curve.Results: 156 eligible patients with unresectable HCC were included, with median OS and PFS of 23.8 and 11.5 months, respectively, and ORR of 48.7%. …”
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Mechanistic insights into Y-Box binding protein-1 mediated regulation of lipid metabolism and oxidative stress in NAFLD via INHBE/TNF-β pathway by Zhi Ren, Rui Wang, Jun Wei, Zhenzeng Ma, Xiquan Ke

“…These findings provide valuable insights into novel therapeutic strategies for managing NAFLD. …”
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Leveraging Deep Learning and Multimodal Large Language Models for Near-Miss Detection Using Crowdsourced Videos by Shadi Jaradat, Mohammed Elhenawy, Huthaifa I. Ashqar, Alexander Paz, Richi Nayak

“…This study introduces a novel AI-based framework designed to detect and analyze near-miss and crash events in crowdsourced dashcam footage. …”
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A Generic AI-Based Technique for Assessing Student Performance in Conducting Online Virtual and Remote Controlled Laboratories by Ahmed M. Abd El-Haleem, Mohab Mohammed Eid, Mahmoud M. Elmesalawy, Hadeer A. Hassan Hosny

“…The study has been applied to a novel dataset built by the course instructors and students simulating a circuit on TinkerCad. …”
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Current conceptions and promising tools to prevent cataractogenesis by M.A. Kovalevskaya, Yu.V. Vladimirova, L.A. Filina, V.L. Kokorev

“…This therapy is preferable for the prevention and treatment of lens opacities due to less financial costs and ease of use. A novel strategy of the medical treatment for cataract was developed. …”
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Genetic Testing Distinguishes Multiple Chondroid Chordomas with Neuraxial Bone Metastases from Multicentric Tumors by Hiroshi Kobayashi, Masahiro Shin, Naohiro Makise, Aya Shinozaki-Ushiku, Masachika Ikegami, Yuki Taniguchi, Yusuke Shinoda, Shinji Kohsaka, Tetsuo Ushiku, Katsutoshi Oda, Kiyoshi Miyagawa, Hiroyuki Aburatani, Hiroyuki Mano, Sakae Tanaka

“…Multiple presentations of chordoma imply systemic dissemination of tumor cells, and novel efficient systemic therapy is required to treat this disease.…”
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Stabilization of metal-doped magnesium oxide nanoparticles with PAMAM dendrimers to improve alpha-amylase enzyme inhibition by Jaison Jeevanandam, Mara Gonçalves, Rita Castro, Juan Gallo, Manuel Bañobre-López, João Rodrigues

“…These findings led to a novel mechanism that has not been proposed in previous studies.…”
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PolyRes-Net: A Polyhierarchical Residual Network for Decoding Anatomical Complexity in Medical Image Segmentation by Amr Magdy, Khalid N. Ismail, Marghny H. Mohamed, Mahmoud Hassaballah, Haitham Mahmoud, Mohammed M. Abdelsamea

“…In this paper, we introduce a novel architectural framework, which we refer to as the Polyhierarchical Residual Network (PolyRes-Net). …”
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Preimplantation genetic testing for four families with severe combined immunodeficiency: Three unaffected livebirths by Lingyun Zhang, Lei Feng, Hao Shi, Wenbin Niu, Yanchi Wang, Bei Bu, Yidong Liu, Xiao Bao, Wenyan Song, Haixia Jin, Yingpu Sun

“…Results We identified three novel variants (case1: IL2RG c.720_726delGAGCCAC; case 3: RAG2 c.770 C > T; and case 4: LIG4 c.1347 A > T). …”
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Ritonavir loaded solid lipid nanoparticles for oral drug delivery and bioavailability enhancement by Ananda Kumar Chettupalli, Sarad Pawar Naik Bukke, Shaik Abdul Rahaman, Aziz Unnisa, Madhumitha Adepu, Marati Kavitha, Molakpogu Ravindra Babu, Bayapa Reddy Narapureddy, Hope Onohuean

“…The results of the present study can become a promising platform for the enhancement of oral bioavailability by novel nano carriers. Graphical abstract…”
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Impact of A1 segment asymmetry on hemodynamic conditions around the circle of Willis and anterior communicating artery aneurysm formation by Joonho Lee, Seul-Ki Jeong, Ji Man Hong, Ji Man Hong

“…Using time-of-flight magnetic resonance angiography (TOF-MRA), the research introduces a novel approach to assessing shear stress in A1 segments to uncover the hemodynamic factors contributing to AcomA formation.MethodAn observational study was conducted over 6 years at a tertiary university hospital’s outpatient clinic. …”
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Efficient Method for Robust Backdoor Detection and Removal in Feature Space Using Clean Data by Donik Vrsnak, Marko Subasic, Sven Loncaric

“…Furthermore, detection methods that rely on the input data suffer from the fact that they are constrained to the modality of the input and cannot apply to different modalities. In this work, a novel method for backdoor detection and removal for classification tasks using features extracted by the attacked model called FEAT-IN is proposed. …”
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Kinetics of Sphalerite Leaching by MnO₂-KI Oxidation System in Sulfuric Acid by Mladen Bugarčić, Aleksandar Jovanović, Dimitrije Anđić, Ivana Jelić, Milica Miletić, Branislav Marković, Miroslav Sokić

“…In this study, we developed a novel oxidation system using manganese dioxide (MnO₂) as the primary oxidizing agent and potassium iodide (KI) as a supporting material to create an I₂/I⁻ oxidation cycle in a sulfuric acid medium, at an atmospheric pressure between 40 °C and 80 °C. …”
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Biophysical Insights into Cancer Transformation and Treatment by Jiří Pokorný, Alberto Foletti, Jitka Kobilková, Anna Jandová, Jan Vrba, Jan Vrba, Martina Nedbalová, Aleš Čoček, Andrea Danani, Jack A. Tuszyński

“…Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function.…”
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Obtaining strength-ductility combination in a laser additive manufactured (FeCoNi)86Al7Ti7 high-entropy alloy at cryogenic temperature by Kaiqiang Xie, Yacheng Fang, Pan Ma, Hong Yang, Shiguang Wan, Konda Gokuldoss Prashanth, Piter Gargarella, Yongkun Mu, Gang Wang, Yandong Jia

“…High-entropy alloys (HEAs) are known for their distinctive microstructural features, outstanding performance, and potential applications, establishing them as novel metallic materials. Studies indicate that face-centered cubic HEAs generally offer increased strength and toughness at lower temperatures, suitable for cryogenic applications. …”
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Development of HfO₂-Based Solar-Blind SAW UV-C Sensor for Corona Discharge Detection Application by Hyunho Lee, Faisal Nawaz, Eeunsun Shim, Jinjae Lee, Cheol Choi, Keekeun Lee

“…This study presents a novel surface acoustic wave (SAW)-based solar-blind ultraviolet-C (UV-C) corona sensor, marking the first reported use of HfO₂ as a sensing material for UV-C corona sensing. …”
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NCAPD3‐mediated AKT activation regulates prostate cancer progression by Yi Zhang, Wanlin Xie, Xicui Zong, Yuanyuan Fang, Jia Ren, Zuolei Jing, Yong Wei, Shan Lu, Qingyi Zhu, Ping Liu

“…NCAPD3, as an oncogene, promoted PCa progression by phosphorylating and activating AKT, which suggests a novel functional pathway of NCAPD3 in promoting PCa progression.…”
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Antioxidant Stability of Moringa Leaves Extract Powders Obtained by Cocrystallization, Vacuum Drying, and Plating by Bambang Nurhadi, Fatsyarien Citra Angiputri, Robi Andoyo, Riksfardini Annisa Ermawar, Rudy Adi Saputra

“…Cocrystallization and vacuum drying are two relatively novel, less common techniques offering a simpler and more cost-effective method, but their effect on the antioxidant stability of moringa leaves extract has not yet been studied. …”
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SiC MOSFET with Integrated SBD Device Performance Prediction Method Based on Neural Network by Xiping Niu, Ling Sang, Xiaoling Duan, Shijie Gu, Peng Zhao, Tao Zhu, Kaixuan Xu, Yawei He, Zheyang Li, Jincheng Zhang, Rui Jin

“…This study introduces a novel approach utilizing neural network machine learning to predict the static and dynamic characteristics of the SBD-MOSFET. …”
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Patients' perspectives on buprenorphine subcutaneous implant: a case series by Claudio Pierlorenzi, Marco Nunzi, Sabino Cirulli, Giovanni Francesco Maria Direnzo, Lucia Curatella, Sandra Liberatori, Annalisa Pascucci, Edoardo Petrone, Generoso Ventre, Concettina Varango, Maria Luisa Pulito, Antonella Varango, Cosimo Dandolo, Brunella Occupati, Roberta Marenzi, Claudio Leonardi

“…Thus, the purpose of the study is to evaluate how the introduction of a novel OAT approach influences these key factors in the management of OUD. …”
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