Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet by Qinqin Yang, Yanyun Xu, Liye Shen, Yongming Pan, Junjie Huang, Quanxin Ma, Chen Yu, Jiaojiao Chen, Yu Chen, Minli Chen

“…Guanxinning tablet (GXNT) is a novel Chinese medicine formula, which has been clinically used to treat coronary heart disease for many years. …”
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LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer by Viola Melone, Domenico Palumbo, Luigi Palo, Noemi Brusco, Annamaria Salvati, Antonietta Tarallo, Giorgio Giurato, Francesca Rizzo, Giovanni Nassa, Alessandro Weisz, Roberta Tarallo

“…Abstract RNA-based therapeutics highlighted novel approaches to target either coding or noncoding molecules for multiple diseases treatment. …”
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Mitochondrial ROS modulate presynaptic plasticity in the drosophila neuromuscular junction by Irina Stavrovskaya, Bethany Kristi Morin, Stephen Madamba, Cliyahnelle Alexander, Alexis Romano, Samia Alam, Lucas Pavlov, Erna Mitaishvili, Pablo M. Peixoto

“…These findings establish a novel framework for understanding the signaling role of mROS in presynaptic structural and functional plasticity, providing insights into redox-based mechanisms of neuronal communication.…”
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Ultra‐Broad Emission Copper Halide Scintillator‐Based X‐Ray Imager by Haocheng Lv, Wenyi Shao, Haifeng Chen, Guoyang Zhu, Yao Wang, Zhenzhong Zhang, Hongwei Liang

“…Abstract Lead‐free metal‐halide scintillators are gaining considerable attention as more eco‐friendly and superior alternatives to their lead‐based counterparts. However, novel broad‐emission band scintillators like the state‐of‐the‐art CsI: Tl scintillator, which can generate high signals due to its strong compatibility with the spectral responsivity of regular photodiode arrays, are still less investigated. …”
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Progress in research on strain glass transition in Ni-Ti based alloys by ZHAO Xinqing, WANG Kai, LYU Chao, ZHANG Kaichao, HOU Huilong

“…In the present paper，the proposition, novel properties and the research progress of the strain glass transition in Ni-Ti based alloys were reviewed. …”
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Investigating Energy Performance Criteria in Compliance with Iranian National Building Regulations: The Role of Residential Building Envelope Adjacency by Payam Soltan Ahmadi, Ahmad Khoshgard, Hossein Ahmadi Danesh Ashtiani

“…This study fills a critical research gap by estimating energy consumption indices through a novel methodology that combines regression analysis and Monte Carlo simulation for the three energy classifications specified in Article 19 of the Iranian National Building Regulations. …”
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Safety and Efficacy of Topical Lotilaner Ophthalmic Solution 0.25% for the Treatment of Demodex Blepharitis: A Pilot Study by Roberto Gonzalez-Salinas, Elizabeth Yeu, Mark Holdbrook, Stephanie N. Baba, Juan Carlos Ceballos, Martha Massaro-Corredor, Claudia Corredor-Ortega, Nallely Ramos-Betancourt, Hugo Quiroz-Mercado

“…Topical lotilaner ophthalmic solution, 0.25% for 4 weeks, showed promising efficacy for the treatment of Demodex blepharitis. This novel treatment appears to be safe and well tolerated. …”
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3D Localization of FRB 20190425A for Its Potential Host Galaxy and Implications by Da-Chun Qiang, Zhi-Qiang You, Sheng Yang, Zong-Hong Zhu, Ting-Wan Chen

“…In this paper, we introduce a novel approach to identifying potential host galaxies in three-dimensional space. …”
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Clinical symptoms and functional impairment in attention deficit hyperactivity disorder (ADHD) co-morbid tic disorder (TD) patients: a cluster-based investigation by Zhongliang Jiang, Hui Xu, Anyi Zhang, Liping Yu, Xianbin Wang, Wenyan Zhang, Yonghua Cui, Ying Li

“…Cluster analysis provides a novel perspective on the heterogeneity of these commonly observed clinical disorders. …”
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Hypercalcemia and co-occurring TBX1 mutation in Glycogen Storage Disease Type Ib: case report by Zakaria Kasmi, Imane Ain El Hayat, Zahra Aadam, Abderrahmane Errami, Ibtihal Benhsaien, Jalila EL Bakkouri, Dalal Ben Sabbahia, Meryem Atrassi, Ahmed Aziz Bousfiha, Fatima Ailal

“…Initial management included a lactose-free and galactose-free diet, multivitamin supplementation, and granulocyte colony-stimulating factor (G-CSF) therapy to address neutropenia. A novel aspect of this case involves hypercalcemia as an unusual finding in GSD-Ib and the co-occurrence of a variant in the TBX1 gene, which is not typically associated with the disease but may contribute to the patient’s clinical presentation. …”
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Impact of advanced lung cancer inflammation index on all-cause mortality among patients with heart failure: a systematic review and meta-analysis with reconstructed time-to-event d... by Ahmed Mazen Amin, Ramy Ghaly, Hossam Elbenawi, Abdelrahman Ewis, Ubaid Khan, Khaled S. M. Elshaer, Mohamed Abuelazm, Basel Abdelazeem, Brijesh Patel, Farris K. Timimi, Islam Y. Elgendy

“…The advanced lung cancer inflammation index (ALI) is a novel inflammatory and nutritional biomarker. We aimed to investigate the prognostic role of ALI in patients with HF. …”
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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis by Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge

“…Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepatocyte-like cells expressing functional drug metabolizing enzymes open up possibilities for novel, more relevant human cell based toxicity models. …”
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Exploring the paradigm shift towards sustainability: A systematic literature review on circular economy and eco-innovation by Ruchira R N Ghormare, Sana Fatima, Priya Grover, Nidhi Phutela, Vinay Kandpal, Ernesto D. R. Santibanez Gonzalez

“…Therefore, this research is novel, and we explored the role of circular economy and eco-innovation towards sustainability through a systematic literature review. …”
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High-Coercivity Ferrimagnet Co₂FeO₂BO₃: XMCD Insights into Charge-Ordering and Cation Distribution by Mikhail S. Platunov

“…This XMCD study opens the door to the production of novel high-coercivity, lanthanide-free magnetic materials by showing that targeted substitution at specific crystallographic sites can significantly enhance the magnetic properties of such materials.…”
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Phenolic compounds from Chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-κB and MAPK pathways by Fuxia Hu, Chao Liu, Fengqin Wang, Changxin Zhou, Maotong Zhu, Dongxiao Sun-Waterhouse, Zhaosheng Wang

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Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…These findings offer valuable insights that could inform early detection strategies and the development of novel therapeutic approaches. Further exploration and validation of PAQR11 are essential, highlighting the need for its integration into future oncological research and treatment strategy development. …”
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Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy by Emma Ortiz-Islas, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Talía Sánchez-Barbosa, Diego Pichardo-Rojas, Cecilia Zavala-Tecuapetla, Karla Carvajal-Aguilera, Victoria Campos-Peña

“…Faced with this challenge and in line with advances in the understanding of the pathophysiology of this neurodegenerative condition, various innovative therapeutic strategies have been explored. Here, we review novel approaches inspired by advanced knowledge of the underlying pathophysiological mechanisms of the disease. …”
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High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response by Tianzhu Tao, Lulong Bo, Teng Li, Longbao Shi, Hui Zhang, Bo Ye, Yuhai Xu, Qingqing Ma, Xiaoming Deng, Guorong Zhang

“…The present study identified VISTA as a novel immune checkpoint in the regulation of T cell and macrophage response during sepsis. …”
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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…These results suggest that targeting GPN3 could serve as a novel prognostic biomarker and therapeutic strategy for NSCLC treatment.…”
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IUENNA – openIng the soUthErn jauNtal as a micro-regioN for future Archaeology: A «para-description» by Hagmann, Dominik, Reiner, Franziska

“…IUENNA is a collaborative effort in digital archaeology and digital humanities: It involves a diverse set of stakeholders, including the State Museum for Carinthia (kärnten.museum), the Austrian Archaeological Institute (ÖAI) at the Austrian Academy of Sciences (ÖAW), the Austrian Centre for Digital Humanities and Cultural Heritage (ACDH-CH) at the ÖAW, the Austrian Federal Monuments Authority (BDA), and the archaeological service company ARDIG. The project marks a novel initiative in Austrian Classical studies by providing a robust model for the active and sustainable long-term archiving of digital archaeological data. …”
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