RETRACTED ARTICLE: CKS2 induces autophagy-mediated glutathione metabolic reprogramming to facilitate ferroptosis resistance in colon cancer by Leilei Yang, Chengfeng Fang, Jiaju Han, Yufeng Ren, Zaiping Yang, Lingyan Shen, Dinghai Luo, Ruili Zhang, Yan Chen, Shenkang Zhou

“…Abstract Background Ferroptosis, a form of cell death characterized by lipid peroxidation, plays a crucial role in tumor suppression, offering novel avenues for cancer therapy. Previous studies have indicated that high levels of cyclin-dependent kinase subunit 2 (CKS2) promote the progression of various cancers. …”
Get full text

Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing by Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel

“…This study aimed to investigate this interaction, providing the first systematic demonstration of MR binding to the Fc region of mAbs with high-mannose N-glycans. Two novel analytical methods, MR surface plasmon resonance and MR affinity chromatography, were developed and applied to investigate the MR-mAb interaction. …”
Get full text

Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis by Yao Wang, Lin Sun, Zhenglin Dong, Tianyu Zhang, Leining Wang, Yihui Cao, Hui Xu, Chenglei Liu, Bo Chen

“…In summary, this study highlights the combination of genetic engineering and hydrophobic diacylglycerol insertion as a novel targeted therapeutic approach for SROP.…”
Get full text

A scoping review of the impacts of forest cover dynamics on acari-borne diseases: Beyond forest fragmentation by Nolwenn Blache, Karine Chalvet-Monfray, Christophe Déprés, Serge Morand

“…Finally, our review identifies a notable absence of studies on scrub typhus.This scoping review provides a novel and comprehensive overview of global literature on the impacts of forest cover dynamics on Acari vectors and the infectious agents they transmit. …”
Get full text

Algorithm of Behaviour of Virtual Avatars During Public Speaking Training in a VR Environment by Karol Jędrasiak, Robert Robert Wolański, Damian Bereska

“…Conclusions: The research conducted in an “e-Zawody” project concludes that the integration of VR and virtual avatars significantly enhances public speaking training, offering a novel, effective and engaging approach. The development of the algorithm marks a pivotal advancement in educational technology, providing a platform that surpasses traditional training methods. …”
Get full text

Blockchain-Assisted Hierarchical Attribute-Based Encryption Scheme for Secure Information Sharing in Industrial Internet of Things by A. Sasikumar, Logesh Ravi, Malathi Devarajan, A. Selvalakshmi, Abdulaziz Turki Almaktoom, Abdulaziz S. Almazyad, Guojiang Xiong, Ali Wagdy Mohamed

“…To address the need to exchange data between logistics networks, we proposed a novel decentralized hierarchical attribute-based encryption (HABE) scheme combining edge computing and blockchain. …”
Get full text

Cross-education: motor unit adaptations mediate the strength increase in non-trained muscles following 8 weeks of unilateral resistance training by Edoardo Lecce, Alessandra Conti, Alessandro Del Vecchio, Francesco Felici, Alessandro Scotto di Palumbo, Massimo Sacchetti, Ilenia Bazzucchi

“…The present results underscore the role of motor unit adaptations in the transfer of strength gains to non-trained muscles, offering novel insights into the neural mechanisms underlying cross-education.…”
Get full text

Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration by Xing Xiao, Gagik Yeghiazaryan, Fynn Eggersmann, Anna Lena Cremer, Heiko Backes, Peter Kloppenburg, Anne Christine Hausen

“…Deletion of Ox1R increased locomotor activity and exploration during exposure to novel environments or when intracerebroventricularely injected with orexin A. …”
Get full text

Acoustic Transmitted Decellularized Fish Bladder for Tympanic Membrane Regeneration by Hong Chen, Hui Zhang, Guangjie Zhu, Long Cao, Chenjie Yu, Maoli Duan, Xiaoyun Qian, Xia Gao, Yuanjin Zhao

“…Developing advanced tissue-engineered membranes with biocompatibility, suitable mechanical qualities, and anti-fibrotic and anti-inflammatory actions is important for tympanic membrane (TM) repair. Here, we present a novel acoustically transmitted decellularized fish swim bladder (DFB) loaded with mesenchymal stem cells (DFB@MSCs) for TM perforation (TMP) repair. …”
Get full text

Τhiazolidine-4-One Derivatives with Variable Modes of Inhibitory Action Against DPP4, a Drug Target with Multiple Activities and Established Role in Diabetes Mellitus Type II by Dionysia Amanatidou, Phaedra Eleftheriou, Anthi Petrou, Athina Geronikaki, Theodoros Lialiaris

“…While a number of drugs with competitive inhibitory action and covalent binding capacity are available, undesired side effects exist partly attributed to drug kinetics, and research for finding novel, potent, and safer compounds continues. Despite the research, a low number of uncompetitive and non-competitive inhibitors, which could be of worth for pharmaceutical and mechanism studies, was mentioned. …”
Get full text

Disentangling the effects of intermittent faecal shedding and imperfect test sensitivity on the microscopy-based detection of gut parasites in stool samples. by Lana C E Ferreira-Sá, Eleuza R Machado, Rodrigo Gurgel-Gonçalves, Fernando Abad-Franch

“…Separate estimation (and modelling) of true test sensitivity, moreover, may cast new light on the performance of diagnostic tests and procedures, whether novel or routine-practice.…”
Get full text

Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan by Ting Zheng, Xinxin Liu, Yingying Wei, Xinlu Li, Bing Zheng, Quan Gong, Lingli Dong, Jixin Zhong

“…Background. Novel coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly progressed to a global pandemic. …”
Get full text

Towards using virtual acoustics for evaluating spatial ecoacoustic monitoring technologies by Neel P. Le Penru, Becky E. Heath, Jamie Dunning, Lorenzo Picinali, Robert M. Ewers, Sarab S. Sethi

“…We developed an ambisonic virtual sound environment (VSE) for simulating real natural soundscapes to evaluate spatial PAM technologies. We validated this novel approach using a PAM recorder with a six‐microphone array, from which we extracted a typical suite of ecoacoustic metrics, including acoustic indices and avian species predictions and localisations from the software BirdNET and HARKBird, respectively. …”
Get full text

Synthesis and Characterization of TiO2 Modified with Polystyrene and Poly(3-chloro-2-hydroxypropyl Methacrylate) as Adsorbents for the Solid Phase Extraction of Organophosphorus Pe... by Enrique Alejo-Molina, A. Rafael Vilchis-Néstor, David Muñoz-Rodríguez, Cristian Carrera-Figueiras

“…Novel hybrid TiO2 particles were developed and assessed as an adsorbent for solid phase extraction (SPE) of organophosphorus pesticides (fensulfothion, parathion methyl, coumaphos, and diazinon) from spiked water. …”
Get full text

Using Large Language Models to Detect and Understand Drug Discontinuation Events in Web-Based Forums: Development and Validation Study by William Trevena, Xiang Zhong, Michelle Alvarado, Alexander Semenov, Alp Oktay, Devin Devlin, Aarya Yogesh Gohil, Sai Harsha Chittimouju

“…The launch of open-access DDE datasets has the potential to stimulate further research and novel discoveries in this field.…”
Get full text

Investigation of the Feasibility and Safety of a Highly Intensive Penetration Technique for Recanalization in Severe Calcified Femoropopliteal Occlusive Lesions: A Retrospective Ob... by Shinsuke Mori, Keisuke Hirano, Yusuke Setonaga, Toshihiko Kishida, Tomoya Fukagawa, Kohei Yamaguchi, Masafumi Mizusawa, Masakazu Tsutsumi, Norihiro Kobayashi, Yoshiaki Ito

“…To address this issue, we employed a novel highly intensive penetration (HIP) technique. …”
Get full text

Evaluation of the effects of short-term PM2.5 exposure on triglyceride-glucose metrics in a population in eastern China by Zhenpeng Guo, Chenchen Yang, Qiang Zhang, Xinling Shi, Xiaona Li, Qun Zhang, Jianming Wang

“…Abstract Context The triglyceride-glucose (TyG) index, a novel health indicator, has been widely employed to assess insulin resistance (IR). …”
Get full text

Acute and prolonged toxicity assessment of Cannabis sativa extract in rodents and lagomorphs by Alana C. Costa, Arquimedes Gasparotto, Jr., Alana A.K. Garcia, Cícero A.C. Pereira, Emerson L.B. Lourenço, Helena P.G. Joaquim

“…Cannabinoids offer a novel pharmacotherapeutic approach and can complement other medications to address unmet clinical needs in numerous patients, which has led to a global increase in the use of these products. …”
Get full text

Genotype-phenotype correlations for 17 Chinese families with inherited retinal dystrophies due to homozygous variants by Xue Fan, Zhen Li, Lingzhi Sha, Xunlun Sheng, Weining Rong

“…According to 12 patients (70.6% ), they had the best corrected visual acuity (monocular) < 0.3. 3 were blind, 9 with moderate to severe visual impairment, and 2 with mild visual impairment. 16 homozygous variants were detected in 9 different genes, of which 7 were novel homozygous variants, including frameshift variants, missense variants, and a copy number variant. …”
Get full text

The prognostic importance of the pan-immune-inflammation value in patients with septic shock by Yasemin Bozkurt Turan

“…Abstract Introduction The purpose of this study was to determine whether the pan-immune-inflammation value (PIV), a novel biomarker combining neutrophil platelet, monocyte, and lymphocyte counts, some of the most widespread indicators of systemic inflammation, can predict mortality and prognosis in patients admitted to the intensive care unit (ICU) with septic shock. …”
Get full text