ISCOM-type matrix from beta-escin and glycyrrhizin saponins by V. Petkov, S. Tsibranska, I. Manoylov, L. Kechidzhieva, K. Ilieva, S. Bradyanova, N. Ralchev, N. Mihaylova, N. Denkov, A. Tchorbanov, S. Tcholakova

“…Background and aims: Nanotechnology provides the opportunity for construction of modern transport devices such as nanoparticles for a variety of applications in the field of medicine. A novel experimental protocol for the formation of saponin-cholesterol-phospholipid nanoparticles of vesicular structure has been developed and applied to prepare stable nanoparticles using escin or glycyrrhizin as saponins. …”
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Application of Enhanced Weighted Least Squares with Dark Background Image Fusion for Inhomogeneity Noise Removal in Brain Tumor Hyperspectral Images by Jiayue Yan, Chenglong Tao, Yuan Wang, Jian Du, Meijie Qi, Zhoufeng Zhang, Bingliang Hu

“…By analyzing the source of the instrument noise, this work first created a novel non-uniform noise removal method for a spatial dimensional push sweep hyperspectral imaging system. …”
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Mechanistic insights into 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targeting lipogenesis via the OLR1-Wnt/β-catenin pathway by Jia Yan, Linglin Zhang, Qingyu Zeng, Yitao Qian, Ke Li, Xiaojing Liu, Yun Wu, Yu Yan, Haiyan Zhang, Szeman Cheung, Jia Liu, Ronald Sroka, Xiuli Wang, Lei Shi

“…This study elucidates a novel mechanistic pathway in ALA-PDT-mediated acne treatment, highlighting OLR1 as a promising target for future therapeutic strategies.…”
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An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection by Yuhao Zheng, Shu Wang, Wenhe Jin, Zhuoxuan Li, Guoju Yang, Xiaoxu Li, Ning Li, Yue Wang, Fan Sheng, Zhiming Song

“…This work highlights potential application methods for fabricating novel antibacterial hybrid piezoelectric scaffolds and engineering macrophages with immunoregulatory antibacterial activity.…”
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Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism by Yanxin Wang, Mingxia Ma, Yumeng Huang, Siqing Fan, Jie Peng, Shiming Li, Xiurong Su, Yanbo Wang, Chenyang Lu

“…The current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting, increased the knowledge about strategies to search antihyperuricemia peptides with definite structure, and emphasized the necessity of combining computer-aided approaches and activity evaluations. In addition, novel action mechanism mediated by gut microbiota was discussed, providing different insights from classical mechanism. …”
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Deploying the Qline System for a QKD Metropolitan Network on the Berlin OpenQKD Testbed by Matheus Sena, Georg Harder, Ronny Doring, Ralf-Peter Braun, Michaela Ritter, Oliver Holschke, Marc Kaplan, Marc Geitz

“…In this study, we present a novel approach to address these issues by introducing a trusted-node-free design on a metropolitan scale for the seamless integration of a QKD system into the Berlin OpenQKD optical fiber testbed. …”
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Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives by Zou Xun-Zhong, Feng An-Sheng, Zeng Fu-Ran, Lai Min-Cheng, Liao Yan-Zhi, Mei Meng, Li Yu

“…The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.…”
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A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review by Giustino Varrassi, Martina Rekatsina, Matteo Luigi Giuseppe Leoni, Marco Cascella, Gabriele Finco, Salvatore Sardo, Chiara Corno, Domenico Tiso, Vittorio Schweiger, Diego Maria Michele Fornasari, Antonella Paladini

“…It seems to introduce novel advancements that can potentially enhance the therapeutic effectiveness of PEA in terms of its anti-inflammatory, antioxidant, and analgesic properties. …”
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Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity by Jisun So, Olivia Strobel, Jamie Wann, Kyungchan Kim, Avishek Paul, Dominic J Acri, Luke C Dabin, Jungsu Kim, Gang Peng, Hyun Cheol Roh

“…Our study establishes a robust snRNA-seq method, providing novel insights into the biological processes involved in adipose tissue remodeling during obesity, with broader applicability across diverse biological systems.…”
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Exploration and characterization of lipid-degrading bacteria from palm oil mill effluent by P. Periadnadi, N. Nurmiati, F.W. Siregar, T.W. Edelwis

“…BACKGROUND AND OBJECTIVES: Lipid-degrading bacteria found in processing ponds of palm oil mill effluent are recognized for the capacity to break down lipid using lipase enzyme. Identifying novel strains of these bacteria with high bioremediation potential contributes valuable insights to the sustainable management of palm oil mill effluent. …”
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A techno-economic perspective on efficient hybrid renewable energy solutions in Douala, Cameroon’s grid-connected systems by Reagan Jean Jacques Molu, Serge Raoul Dzonde Naoussi, Mohit Bajaj, Patrice Wira, Wulfran Fendzi Mbasso, Barun K. Das, Milkias Berhanu Tuka, Arvind R. Singh

“…This paper meticulously assesses a novel hybrid energy system specifically engineered to meet the diverse energy needs of Douala, Cameroon. …”
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Impact of HVDC link and electric vehicle on multi-area power system using MOA optimized I-TD2N controller by Tirumalasetty Chiranjeevi, B.S.S. Ganesh Pardhu, Naladi Ram Babu, Sumana Das, Kareem M. AboRas, Wulfran Fendzi Mbasso, Pamarthi Sunitha, Adireddy Ramesh, Pradeep Jangir, Mohammad Khishe

“…The suggested system features with EVs, HVDC link a thermal unit. A novel controller, termed the integral minus tilt double derivative (I-TD2N), has been developed as an auxiliary controller. …”
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Scalable Manufacturing Method for Model Protein-Loaded PLGA Nanoparticles: Biocompatibility, Trafficking and Release Properties by Selin Akpinar Adscheid, Marta Rojas-Rodríguez, Salma M. Abdel-Hafez, Francesco S. Pavone, Marc Schneider, Akif E. Türeli, Martino Calamai, Nazende Günday-Türeli

“…<b>Methods</b>: We prepared blank and model-protein-loaded (albumin–FITC and wheat germ agglutinin-488 (WGA-488)) fluorescent PLGA NPs using the traditional double-emulsion method combined with the micro-spray-reactor system, a novel approach that enables fine particle production enabling scale-up applications. …”
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Effects of UV-B light exposure during automatic milking on vitamin D levels in Holstein Friesian cows by Jaka Jakob Hodnik, Jaka Jakob Hodnik, Marko Jankovec, Jožica Ježek, Žiga Krušič, Stefan Mitterhofer, Jože Starič

“…UV-B exposure during automatic milking offers a novel, non-disruptive method for enhancing vitamin D levels in dairy cows.…”
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Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights by Bantayehu Addis Tegegne, Tesfa Begashaw, Wubetu Yihunie Belay, Mengistie Kassahun Tariku, Tirsit Ketsela Zeleke, Mohammed Jemal, Mamaru Getinet, Agumas Alemu Alehegn, Abebe Dagne

“…This study seeks to inspire researchers to quickly discover and isolate the key active metabolites found in Kleinia taxa, thereby promoting the development of novel, safe, and effective therapies for a variety of illnesses. …”
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Yield, Quality, Antioxidants, and Mineral Composition of Traditional Italian Storage Onion Cultivars in Response to Protein Hydrolysate and Microalgae Biostimulation by Alessio Vincenzo Tallarita, Otilia Cristina Murariu, Tomas Kopta, Florin Daniel Lipșa, Leonardo Gomez, Eugenio Cozzolino, Pasquale Lombardi, Silvio Russo, Gianluca Caruso

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Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism by Xin Liu, Junling Wang, Huiyun Zhang, Mengmeng Zhan, Hanqiu Chen, Zeman Fang, Chiyan Xu, Huifang Chen, Shaoheng He

“…In conclusion, provocation of mast cell accumulation by mast cell tryptase suggests a novel self-amplification mechanism of mast cell accumulation. …”
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Exploring the factors influencing the co-pyrolysis of walnut shells, pistachio shells, and polypropylene based on thermal behavior, kinetics and reaction mechanism by Zhigang Huang, Tong Zhang, Chen Wang, Wenbo Xiao, Zihan Wang, Obid Tursunov, Jiahui Wu, Yuguang Zhou, Xiaolong Yao, Gang Li

“…By integrating thermogravimetric, kinetic, and product analyzes, this study establishes a comprehensive characterization system for understanding pyrolysis processes at multiple scale levels, providing a novel approach for optimizing pyrolysis conditions while providing theoretical guidance for designing efficient and selective pyrolysis processes.…”
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Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS by Mingqun Deng, Han Wu, Miao Yu, Yi Tian, Yuxiu Li, Xinhua Xiao

“…This study indicated that DIHS/DRESS could lead to APS, especially APS III, providing novel insights into the etiological factors of APS.…”
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Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis by Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, Monica Chinellato, Riccardo Mezzetti, Alessandro Grinzato, Francesco Filippini, Lorenzo Maso, Arjen J. Jakobi, Laura Cendron

“…These results provide the groundwork for designing novel antimicrobial strategies and exploring the potential translation of Escherichia coli-derived approaches, to address the implications of P. aeruginosa infections.…”
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