Quantitative analysis of amino acid excretion by Methanothermobacter marburgensis under N2-fixing conditions by Barbara Reischl, Benjamin Schupp, Hayk Palabikyan, Barbara Steger-Mähnert, Christian Fink, Simon K.-M. R. Rittmann

“…To quantify N2-fixation rates in a mass balance setting a novel method has been established. The method utilizes the pressure drop below a certain threshold pressure in closed batch cultivation mode – the threshold pressure for N 2 -fixation (THpN2fix). …”
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Efficacy and safety of Xiongzhitongluo granules in the treatment of acute ischemic stroke: study protocol for a randomized controlled trial by Yunmeng Chen, Jingjing Wei, Xiao Liang, Yue Liu, Lina Miao, Di Zhao, Yunfan Zhang, Hongxi Liu, Yunling Zhang

“…However, their efficacy is often limited by stringent time constraints and contraindications, restricting accessibility for certain patient populations. Investigating novel therapeutic strategies is, therefore, crucial. …”
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circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression by Yue Ma, Yanyi Ren, Huitao Wen, Chengcheng Cui

“…Our study identified circCOL1A1 as a novel oncogenic circRNA and will provide more information for gastric cancer therapy.…”
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Small molecules targeting the eubacterial β-sliding clamp discovered by combined in silico and in vitro screening approaches by Alessia Caputo, Gian Marco Elisi, Elisabetta Levati, Giulia Barotti, Sara Sartini, Jerome Wagner, Dominique Y. Burnouf, Simone Ottonello, Silvia Rivara, Barbara Montanini

“…Protein-protein interactions (PPIs), owing to their pivotal role in microbial physiology, emerge as novel and attractive targets. Particularly promising is the α-subunit/β-sliding clamp interaction, crucial for the replicative competence of bacterial DNA polymerase III holoenzyme. …”
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Exploiting Cancer Dormancy Signaling Mechanisms in Epithelial Ovarian Cancer Through Spheroid and Organoid Analysis by Emily J. Tomas, Yudith Ramos Valdes, Jennifer Davis, Bart Kolendowski, Adrian Buensuceso, Gabriel E. DiMattia, Trevor G. Shepherd

“…We speculate that EOC cells modify their biology between tumour and spheroid states during cancer dormancy, although the specific mechanisms underlying this transition remain unknown. Here, we present novel findings from direct comparisons between cultured EOC spheroids and organoids. …”
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Evaluation of an assistive exosuit for alleviating neck and shoulder muscle fatigue during prolonged flexed neck posture by Hang Man Cho, Jae-Ryeong Choi, Jung-Hwan Moon, Kyu-Jin Cho, Seung-Won Kim

“…This research presents a novel assistive exosuit, characterized by its slim and lightweight structure and intuitive control without the use of hands, designed to mitigate muscle fatigue in the neck and shoulders during prolonged flexed neck posture. …”
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Improved Performance and Voltage Stability of Islanded Inverters Using Single-Loop PI-Lead Controller by Mohammed E. Benzoubir, Abderezak Lashab, Khaled Rayane, Mohammed Benmiloud, Mohamed Bougrine, Atallah Benalia, Mohamed Trabelsi, Hani Vahedi

“…This paper introduces a novel single-loop control scheme for voltage regulation in islanded inverters, using a proportional-integral-lead (PI-Lead) controller designed within the synchronous reference frame (SRF) through a loop-shaping approach. …”
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Proteome differences of dental stem cells between permanent and deciduous teeth by data-independent acquisition proteomics by Zhang Suping, Liu Yuqing, Dong Jin, Jiao Min, Gu Yongchun, Chen Liling, Yuan Na, Wang Jianrong, Yang Dezhao, Meng Fanwen

“…To address this gap, we employed a novel data-independent acquisition (DIA) proteomics approach to compare the protein expression profiles of DPSC and SHED. …”
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Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development by Yue-Wei Chen, Qiu-Rong Du, Yu-Juan He, Wen-Shu Chen, Wen-Yang Jiang, Qi Gui, Cheng-Cheng Xu, Wei Wang, Hong-Yun Cheng

“…Our findings may provide novel targets for diagnosis and therapeutic intervention in lung cancer patients.…”
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Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascend... by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…The effects of NX210c on claudin-5 and biomarkers influencing BBB integrity—and the overarching brain protection it offers—provide a novel therapeutic strategy targeting an underlying driver of neurodegenerative conditions for which disease-modifying treatments are limited or not available.…”
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Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs by William W. Muir, Carlos L. del Rio, Yukie Ueyama, Bradley L. Youngblood, Robert S. George, Carl W. Rausch, Billy S. H. Lau, Robert L. Hamlin

“…We determined the dose-dependent effects of OC99, a novel, stabilized hemoglobin-based oxygen-carrier, on hemodynamics, systemic and pulmonary artery pressures, surrogates of tissue oxygen debt (arterial lactate 7.2±0.1 mM/L and arterial base excess −17.9 ± 0.5 mM/L), and tissue oxygen tension (tPO2) in a dog model of controlled severe oxygen-debt from hemorrhagic shock. …”
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High Body Roundness Index Is Associated With Unhealthy Sleep Patterns: Insights From NHANES (2007–2014) by Pingchuan Liu, Yuding Luo, Xing He, Jiali Zhang, Fanzhou Ren, Bingyang Zhang, Bo Zheng, Jian Wang

“…However, research investigating sleep patterns in relation to novel anthropometric indices is limited. Therefore, we conducted a cross‐sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2014 to examine the relationship between the body roundness index (BRI) and unhealthy sleep patterns. …”
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Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis by Zhihui Jin, Wei Xiang, Xiaowen Shi, Fenglin Jiang, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Xianzhi Huang, Li Xu

“…Real-time qPCR and Western blotting were used for mRNA and protein level analysis. Results Two novel active compounds, Kuwanon H and Morusin, and the known Kuwanon G, were identified. …”
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Mobilization of subcutaneous fascia contributes to the vascularization and function of acellular adipose matrix via formation of vascular matrix complex by Han Yang, Yidan Xu, Sousan Cheong, Cuiying Xie, Yufan Zhu, Shujie Xu, Feng Lu, Yunfan He

“…Our findings highlight the crucial role of subcutaneous fascia mobility in facilitating the vascularization of AAM implants, offering a novel direction and target for guaranteeing long-term survival and function of regenerative biomaterials in vivo.…”
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Effective BCDNet-based breast cancer classification model using hybrid deep learning with VGG16-based optimal feature extraction by Meenakshi Devi P., Muna A., Yasser Ali, Sumanth V.

“…Hence, the paper presents a novel deep learning model, BCDNet, for classifying breast tumors as benign or malignant using ultrasound images. …”
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Insights into the photocatalytic removal of malachite green organic pollutant by highly efficient hard responsive Ba1 − xCoxDyyFe12−yO19 catalysts by Himanshi, Basant Lal, Ankit Verma, Suman, Jahangeer Ahmed, Arunima Singh, Chan Choon Kit, Rohit Jasrotia, Natrayan Lakshmaiya, Varun Mehra, Abhishek Kandwal

“…To tackle such environmental issues, we are synthesizing a novel catalyst of composition, Ba1 − xCoxDyyFe12−yO19 (x = y = 0.02–0.06) using sol-gel auto-combustion (SGAC) for the photocatalytic eradication of malachite green dye (MGD). …”
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Performance improvements and increased ruminal microbial interactions in Angus heifers via supplementation with native rumen bacteria during high-grain challenge by Fan Yang, Madison T. Henniger, Andrew S. Izzo, Emily A. Melchior, Brooke A. Clemmons, Mary A. Oliver, James R. Gaffney, Cameron Martino, Taylor B. Ault-Seay, Miranda L. Striluk, Jordan J. Embree, Juan F. Cordero-Llarena, Pierre-Yves Mulon, David E. Anderson, Mallory M. Embree, Phillip R. Myer

“…Abstract Feedlot cattle may be subjected to digestive disorders, including ruminal acidosis, due to high concentration of grain in their diet. Therefore, novel feeding strategies are required to maximize animal performance and mitigate economic losses in the operation. …”
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An Electronic Slime-Based Epidermal Electrode Using Carbon Nanocomposites for Biosignal Sensing by Yu Feng, Hui Sun, Meng Chen, Cong Wu, Jiankun Li, Zhi Li, Kremena Makasheva, Na Liu, Guanglie Zhang, Wen Jung Li

“…This work introduces a novel strategy for the design and fabrication of epidermal electrodes, offering high conformability, low impedance, and superior signal quality, which holds significant promise for applications in intelligent healthcare monitoring and human-machine interfaces.…”
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Association between triglyceride-glucose index and clinical outcomes among patients with chronic kidney disease: a meta-analysis by Jinli Tuo, Zhong Li, Linshen Xie

“…Conclusion High TyG index predicts poor clinical outcomes and might serve as a novel prognostic indicator among CKD patients. However, more studies are still needed to verify above findings.…”
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Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human u... by Ye Zhu, Junxiu Wei, Xin Yang, Wei Zhu

“…Notably, the use of the JNK inhibitor SP600125, the PI3K inhibitor LY294002, and the ERK1/2 inhibitor U0126 antagonized the protective effects of DHEA, with SP600125 showing the most significant impact on both HVSMCs and HUVECs.ConclusionOur study has identified a novel mechanism underlying the cardioprotective effects of DHEA. …”
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