Development of Spray-Dried Micelles, Liposomes, and Solid Lipid Nanoparticles for Enhanced Stability by Shradha Dattani, Xiaoling Li, Charina Lampa, Amanda Barriscale, Behzad Damadzadeh, David Lechuga-Ballesteros, Bhaskara R. Jasti

“…The objective of this study was to compare the potential of lipid-based micelles, liposomes, and SLNs for producing stable re-dispersible spray-dried powders with trehalose or a combination of trehalose and L-leucine. This study provides novel insights into the implementation of spray drying as a technique to enhance long-term stability for these lipid-based nanocarriers. …”
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The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of huma... by Manahil M. Bineid, Litai Liu, Eduard F. Ventura, Sakshi Bansal, Katherine Curi-Quinto, Juana del Valle-Mendoza, Gemma E. Walton, Karani Santhanakrishnan Vimaleswaran

“…Oral supplementation with probiotics, prebiotics, and synbiotics is a novel potential complementary therapy for addressing overweight and obesity through gut microbiota modulation. …”
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EZH2 inhibition induces pyroptosis via RHA-mediated S100A9 overexpression in myelodysplastic syndromes by Qi Zhang, Yingwan Luo, Li Ye, Yuxia Wang, Lu Wang, Wenli Yang, Wei Lang, Shuanghong Zhu, Lingxu Jiang, Weimei Jin, Chen Mei, Xinping Zhou, Yanling Ren, Liya Ma, Gaixiang Xu, Bowatte Gedara Lakmal Vimukthi Bandara Bowattage, Hongyan Tong, Jie Sun

“…In summary, our results uncovered a novel pyroptosis pathway induced by EZH2 inhibition and provided a rationale for EZH2 inhibitor treatment in MDS.…”
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Polymeric Multivalent Fc Binding Peptides‐Fabricated Clinical Compounding Bispecific Antibody Potentiates Dual Immunotherapy Targeting PD1 and CTLA‐4 by Zongyu Liu, Hongyu Chu, Weidong Zhao, Chenguang Yang, Tongjun Liu, Na Shen, Zhaohui Tang

“…Thus, these findings provide a novel approach to enhance antitumor therapy using aPD1 and aCTLA‐4.…”
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Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome by Ming-Yuan Liu, Meili Wang, Junjun Liu, An-Qiang Sun, Chang-Shun He, Xin Cong, Wei Kong, Wei Li

“…These insights posit the mTORC1 axis as a strategic target for intervention, offering a novel approach to manage TAAs in MFS and potentially pave insights for current treatment paradigms.…”
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Declining suitability for conversion of drylands to paddy fields in Northeast China: Impact of future climate and socio-economic changes by Jiacheng Qian, Huafu Zhao, Xiaoxiao Wang, Tao Wang, Zhe Feng, Congjie Cao, Xiao Li, Aihui Zhang

“…To fill this knowledge gap, this research developed a novel method for quantifying the suitability of CDPF, based on the MaxEnt model for application in Northeast China. …”
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Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) by Tingyi Liang, Shaochi Zhang, Xiang Zhang, Xiaohan Wang, Xunda Ji, Peiquan Zhao

“…In total, 30.8% of the eyes had a final vision ≥20/200.ConclusionThe presence of retinoschisis (retinal cyst) in Coats disease is strongly associated with retinal telangiectasia and exudation and is indicative of active vascular disease requiring effective ablative treatment. We propose a novel approach, endolaser photocoagulation combined with external drainage of cystic fluid and intravitreal ranibizumab injection, which was effective in achieving final anatomic improvement with retinal cyst resolution.…”
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3-bromo-4-(2-hydroxyethyl)-7-methoxy-2H-chromen-2-one inhibits allergic reactions in IgE-mediated RBL-2H3 cells and a passive cutaneous anaphylaxis mouse model by Moonsu Kim, Huiji Kim, Sun Young Moon, Seong-Ah Shin, Minji Kim, Seyeon Choi, Sugeun Gwon, Jun Hyuck Lee, Hyun Ho Park, Chang Sup Lee

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Advancements in end treatment techniques and applications of acid mine drainage in coal mines: A research review by Qiaohui CHE, Song DU, Degao ZHANG, Yinglin FAN, Xiao ZHANG, Fengli WANG

“…In order to address these challenges in acid mine drainage treatment within coal mines, this review introduces magnetic nanoparticle materials and a novel collaborative treatment method, providing a fresh perspective. …”
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Biaxial Flexural Strength and Vickers Hardness of 3D-Printed and Milled 5Y Partially Stabilized Zirconia by Sebastian Hetzler, Carina Hinzen, Stefan Rues, Clemens Schmitt, Peter Rammelsberg, Andreas Zenthöfer

“…PZ samples were made from a novel ceramic suspension via digital light processing and divided into three subgroups: PZ-HN-ZD (horizontal nesting, printed with Zipro-D Dental), PZ-VN-Z (vertical nesting, printed with Zipro-D Dental) and PZ-VN-Z (vertical nesting, printed with Zipro Dental). …”
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Structure and immunomodulatory activity of Lentinus edodes polysaccharides modified by probiotic fermentation by Jingjing Liang, Meina Zhang, Xiaohan Li, Yuan Yue, Xiaowei Wang, Mengzhen Han, Tianli Yue, Zhouli Wang, Zhenpeng Gao

“…Plant-based fermentations provide an untapped source for novel biotechnological applications. In this study, a probiotic named Lactobacillus fermentum 21828 was introduced to ferment Lentinus edodes. …”
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Augmented Reality Navigation System Enhances the Accuracy of Spinal Surgery Pedicle Screw Placement: A Randomized, Multicenter, Parallel‐Controlled Clinical Trial by Yichao Ma, Jiangpeng Wu, Yanlong Dong, Hongmei Tang, Xiaojun Ma

“…This study aims to evaluate the differences in accuracy between novel AR‐guided pedicle screw insertion and conventional surgery techniques. …”
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Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects by Zahid Rafiq, Mingyo Kang, Hampartsoum B. Barsoumian, Gohar S. Manzar, Yun Hu, Carola Leuschner, Ailing Huang, Fatemeh Masrorpour, Weiqin Lu, Nahum Puebla-Osorio, James W. Welsh

“…The convergence of LDRT with other disciplines holds immense potential for developing novel radiotherapy-combined modalities, paving the way for more effective and personalized treatment strategies in melanoma and beyond. …”
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Dynamic simulation of landscape ecological risk in Gansu’s farming-pastoral ecotone based on topographic gradients by Le Yang, Jixuan Yan, Guang Li, Weiwei Ma, Tao Li, Pengcheng Gao, Qiang Li, Xiangdong Yao, Jie Li, Wenning Wang

“…Consequently, land-use planning should be tailored to local conditions, and a long-term monitoring mechanism should be established. This study provides novel insights into the spatiotemporal changes in landscape ecological risk in ecologically vulnerable areas, focusing on topographic gradients.…”
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Long Noncoding RNA HCG9 Promotes Osteosarcoma Progression through RAD51 by Acting as a ceRNA of miR-34b-3p by Lu Wang, ShuangQing Li, Lin Qi, Lin Ling

“…We discovered that lncRNA HCG9 promoted the proliferation of osteosarcoma cells via suppressing miR-34b-3p. Our study provides novel biomarkers and potential therapeutic targets for osteosarcoma treatment.…”
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ERG mediates the differentiation of hepatic progenitor cells towards immunosuppressive PDGFRα+ cancer-associated fibroblasts during hepatocarcinogenesis by Haoran Bai, Xinyu Zhu, Lu Gao, Shiyao Feng, Hegen Li, Xiaoqiang Gu, Jiahua Xu, Chen Zong, Xiaojuan Hou, Xue Yang, Jinghua Jiang, Qiudong Zhao, Lixin Wei, Li Zhang, Zhipeng Han, Wenting Liu, Jianxin Qian

“…These insights contribute to our understanding of the mechanisms underlying the establishment of an immunosuppressive microenvironment in HCC, paving the way for the exploration of novel immunotherapeutic strategies tailored for HCC treatment.…”
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Investigation of TGFβ1-Induced Long Noncoding RNAs in Endothelial Cells by Krishna K. Singh, Pratiek N. Matkar, Adrian Quan, Laura-Eve Mantella, Hwee Teoh, Mohammed Al-Omran, Subodh Verma

“…These observations may reveal potential new targets of TGFβ in endothelial cells and novel therapeutic avenues for cardiovascular disease-associated endothelial dysfunction.…”
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Opening up Corpus FinSL: enriching corpus analysis with linguistic ethnography in a study of constructed action by Puupponen Anna, Hodge Gabrielle, Anible Benjamin, Salonen Juhana, Wainio Tuija, Keränen Jarkko, Hernández Doris, Jantunen Tommi

“…This article outlines a novel interview method developed to enrich the original Corpus of Finnish Sign Language (Corpus FinSL) with additional ethnographic information eight years after it was first documented and archived with standard IMDI corpus metadata. …”
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Identification of Cytosolic DNA Sensor cGAS-STING as Immune-Related Risk Factor in Renal Carcinoma following Pan-Cancer Analysis by Zheng Wu, Ying Lin, Li-Min Liu, Yan-Li Hou, Wei-Ting Qin, Lei Zhang, Shu-Heng Jiang, Qin Yang, Yong-Rui Bai

“…We constructed a cGAS-STING gene signature to predict survival and tumor immunity across human cancers, which can serve as a novel prognostic indicator and therapeutic target, especially in KIRC and KIRP.…”
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Multiscale Attention Feature Fusion Based on Improved Transformer for Hyperspectral Image and LiDAR Data Classification by Aili Wang, Guilong Lei, Shiyu Dai, Haibin Wu, Yuji Iwahori

“…This article proposes a novel multiscale attention feature fusion network, composed of hierarchical convolutional neural networks and transformer to enhance joint classification accuracy of hyperspectral image (HSI) and light detection and ranging (LiDAR) data. …”
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