Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels by Nathalie Idlin, Sivakumar Krishnamoorthy, Magdalena Wolczyk, Mouad Fakhri, Michal Lechowski, Natalia Stec, Jacek Milek, Pratik Kumar Mandal, Jaroslaw Cendrowski, Christos Spanos, Magdalena Dziembowska, Katarzyna Mleczko-Sanecka, Juri Rappsilber, Gracjan Michlewski

“…Conclusions These findings uncover novel posttranscriptional mechanisms governed by HuR and its inhibitor, elucidating pathways relevant to HuR-mediated regulation and molecular therapies aimed at targeting this protein.…”
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Efficacy and safety of cardiac myosin inhibitors for symptomatic hypertrophic cardiomyopathy: a meta-analysis of randomized controlled trials by Anas Abunada, Madiha Shah, Ateesh Kumar, Syeda Lamiya Mir, Dinesh Kumar, Saboor Ahmed, Muhammad Tanzeel, Vikash Kumar, Aashish Meghjiani, Muhammad Basit Ali Siddiqui, Govinda Khatri, Aneesh Rai, Fnu Deepak, Ayush Kumar

“…Traditional treatments address symptoms but not the underlying disease mechanism, highlighting the need for novel therapies. Cardiac myosin inhibitors such as mavacamten and aficamten present potential new treatment options.MethodsA meta-analysis of randomized controlled trials (RCTs) was conducted following PRISMA guidelines. …”
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Two studies in one: A propensity-score-matched comparison of fingolimod versus interferons and glatiramer acetate using real-world data from the independent German studies, PANGAEA... by Jonathan Alsop, Jennie Medin, Christian Cornelissen, Stefan Viktor Vormfelde, Tjalf Ziemssen

“…<h4>Methods and findings</h4>Patients with active MS who previously received BRACE were identified from German prospective, observational studies, PANGAEA and PEARL. A novel methodology was developed to compare outcomes between propensity-score-matched cohorts (3:1 ratio) from the independent single-arm studies. …”
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How far? Travel burdens for children admitted to hospitals in the Western Cape Province of South Africa by M Richards, D le Roux, D Pienaar

“…Conclusion: Using a large health dataset, this study demonstrates in a novel way for South Africa, the distances children travel to access admission facilities. …”
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Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation by Md Ruhul Amin, Lakhan Khara, Joshua Szaszkiewicz, Andrew M. Kim, Trevor J. Hamilton, Declan W. Ali

“…Adult zebrafish tested in the open field test and novel object approach test demonstrated no differences in locomotion, anxiety-like behavior, nor boldness, compared to controls. …”
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Real world experience with [99mTc]Tc-HYNIC-iPSMA SPECT prostate cancer detection: interim results from the global NOBLE registry by Pete Tually, Virginia García Quinto, Yehia Omar, Fuad Novruzov, Ryan Yudistiro, Mike Sathekge, Geoffrey Currie, Paul Galette, Neel Patel, Tracey Brown, Gabriel Bolland, Rebecca Lo Bue, David Cade

“…Abstract Purpose [99mTc]Tc-HYNIC-iPSMA is a novel technetium-99m-labelled small molecule inhibitor of the prostate-specific membrane antigen (PSMA) for detecting prostate cancer (PC). …”
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SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model by Xiaodong Zou, Tong Wu, Jianjiao Lin, Tao Su, Hui Xiao, Chuyan Ni, Lijuan Hu, Wenchu Lin, Weilin Chen, Richard D. Ye, Li Xiang

“…Collectively, our results shed novel lights on regulating SAA3 in intestinal fibrosis and indicate the potential to develop therapeutic strategies for IBD patients.…”
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The <i>MCPH7</i> Gene Product STIL Is Essential for Dendritic Spine Formation by Tohru Matsuki, Hidenori Tabata, Masashi Ueda, Hideaki Ito, Koh-ichi Nagata, Yumi Tsuneura, Shima Eda, Kenji Kasai, Atsuo Nakayama

“…Based on these findings, we concluded that the centrosomal protein STIL is a novel regulatory factor essential for spine formation/maintenance by activating Rac and its downstream pathway, possibly through the association with ARHGEF7.…”
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Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis by Rongjiong Zheng, Songsong Xie, Qiong Zhang, Ling Cao, Shaniya Niyazi, Xiaobo Lu, Lihua Sun, Yan Zhou, Yuexin Zhang, Kai Wang

“…These results indicate that peripheral T lymphocyte immunity was involved in patients with brucellosis and represents a target for the preclinical and clinical assessment of novel immunomodulating therapeutics. The patients’ immune function had not completely recovered in a short period of time during convalescence, so long-term follow-up of convalescent patients is needed.…”
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A medical insurance fund operation performance evaluation system under the DRG payment mode reform by Zijian Wang, Zijian Wang, Zijian Wang, Weifu Chang, Weifu Chang, Aijing Luo, Aijing Luo, Aijing Luo

“…Regression analysis further indicates that medical service capability is the key determinant influencing the operational performance of medical insurance funds.ConclusionThis study develops a novel evaluation system for measuring medical insurance funds’ operational performance. …”
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Assessing the Direct Impact of Typhoons on Vegetation Canopy Structure and Photosynthesis by Yaoyao Zheng, Simin Zhan, Zaichun Zhu, Sen Cao, Jiana Chen, Pengjun Zhao, Weimin Wang, Ranga B. Myneni

“…This study proposes a novel framework for quantifying typhoons’ immediate and long-term impacts on vegetation canopy structure and photosynthesis. …”
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Enhanced bulk and interfacial charge transfer in Fe:VOPO4 modified Mo:BiVO4 photoanodes for photoelectrochemical water splitting by Bing He, Yu Cao, Kaijie Lin, Mingjie Wu, Yunhai Zhu, Xun Cui, Liang Hu, Yingkui Yang, Xueqin Liu

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Harnessing national data systems to understand circumstances surrounding veteran suicide: linking Department of Veterans Affairs and National Violent Death Reporting System Data by Claire A. Hoffmire, Alexandra L. Schneider, Laurel A. Gaeddert, Joseph Logan, Julie A. Kittel, Ryan Holliday, Lindsey L. Monteith

“…This study aimed to link VA and CDC’s National Violent Death Reporting System (NVDRS) data to create a novel data source to characterize the circumstances precipitating and preceding suicide among Veterans, including among those who did not use VA healthcare. …”
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Stem Cell Therapy for the Treatment of Amyotrophic Lateral Sclerosis: Comparison of the Efficacy of Mesenchymal Stem Cells, Neural Stem Cells, and Induced Pluripotent Stem Cells by Lauren Frawley, Noam Tomer Taylor, Olivia Sivills, Ella McPhillamy, Timothy Duy To, Yibo Wu, Beek Yoke Chin, Chiew Yen Wong

“…NSCs, isolated from the fetal spinal cord or brain, demonstrate promise in animal models but face functional integration and ethical challenges. iPSCs, created by reprogramming patient-specific somatic cells, offer a novel approach by potentially replacing or supporting neurons. iPSC therapy addresses ethical issues related to embryonic stem cells but encounters challenges regarding genotoxicity and epigenetic irregularities, somatic cell sources, privacy concerns, the need for extensive clinical trials, and high reprogramming costs. …”
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Characterizing out-of-distribution generalization of neural networks: application to the disordered Su–Schrieffer–Heeger model by Kacper Cybiński, Marcin Płodzień, Michał Tomza, Maciej Lewenstein, Alexandre Dauphin, Anna Dawid

“…However, ML models are also known for their black-box construction, which hinders understanding of what they learn from the data and makes their application to novel data risky. Moreover, the central challenge of ML is to ensure its good generalization abilities, i.e. good performance on data outside the training set. …”
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Surface functionalization of microscaffolds produced by high-resolution 3D printing: A new layer of freedom by Oliver Kopinski-Grünwald, Stephan Schandl, Jegor Gusev, Ourania Evangelia Chamalaki, Aleksandr Ovsianikov

“…Scaffolded-spheroids represent novel building blocks for bottom-up tissue assembly, allowing to produce constructs with high initial cell density. …”
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An In Vitro Model of Diabetic Retinal Vascular Endothelial Dysfunction and Neuroretinal Degeneration by Qiyun Wang, Xinyuan Zhang, Kaiyue Wang, Ling Zhu, Bingjie Qiu, Xiaosi Chen, Xiao Lin, Yao Nie

“…Proper in vitro DR models are crucial for exploring pathophysiology and identifying novel therapeutic targets. This study establishes a rational in vitro diabetic retinal neuronal-endothelial dysfunction model and a comprehensive downstream validation system. …”
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Complex Variant of Philadelphia Translocation Involving Chromosomes 9, 12, and 22 in a Case with Chronic Myeloid Leukaemia by F. Malvestiti, C. Agrati, S. Chinetti, A. Di Meco, S. Cirrincione, M. Oggionni, B. Grimi, F. Maggi, G. Simoni, F. R. Grati

“…In cases with variant Ph translocation a deletion on der(9) may be more frequently observed than in cases with the classical one. Herein we describe a novel case of CML with complex variant Ph translocation involving chromosomes 9, 12, and 22. …”
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S100A8/A9 Molecular Complexes Promote Cancer Migration and Invasion via the p38 MAPK Pathway in Nasopharyngeal Carcinoma by Ning Xu, Bei-Bei Zhang, Xia-Ning Huang, Xiang Yi, Xue-Min Yan, Yan Cai, Qin He, Zi-Jian Han, Yuan-Jiao Huang, Wei Liu, Ai-Jun Jiao

“…This may shed light on the mechanism understanding of NPC prognosis and provide more novel clues for NPC diagnosis and therapy.…”
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CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation by Jingjing Yang, Jingjing Yang, Qiqi Fan, Yiyun Wang, Yuanyue Liu, Xiaoning Xu, Yeqi Liang, Jiakang Xie, Jiajie Li, Fengting Ai, Yong Cao, Shangzhen Yu, Jinman Liu

“…In recent years, circular RNAs (circRNAs), a novel class of non-coding RNA molecules, have emerged as a research focus due to their unique stability and functional roles. …”
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