Pain management in trauma: the need for trauma-informed opioid prescribing guidelines by Ben L Zarzaur, Suresh Agarwal, Colleen Trevino, Amelia Baltes, David M Horton, Julia Malicki, Randall T Brown

“…As part of the parent study, focus groups were conducted at each study site to explore the facilitators and barriers of implementing a novel screening tool, as well as to examine the current opioid prescribing guidelines, trainings, and resources available for trauma and acute care providers. …”
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Clinicopathological features of Lynch syndrome pedigrees with MSH2 c.351G>A gene variant by Shuai Zhang, Guanyu Fu, Gongping Sun, Yuanxin Tang, Jin Meng, Zhigang Wang, Rongjun Su, Wei Liu, Xiaoxia Li

“…Abstract Background Lynch syndrome (LS) is an autosomal‐dominant disorder that increases the risk of many cancers. To identify novel or rare pathogenic variants of MMR genes associated with LS, especially in Chinese pedigrees. …”
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Bias in Discontinuous Elevational Transects for Tracking Species Range Shifts by Shixuan Li, Jiannan Yao, Yang Lin, Siyu Wu, Zhongjie Yang, Chao Jin, Yuhan Zhang, Zhen Wang, Jinliang Liu, Guochun Shen, Mingjian Yu

“…To address this concern, we utilized species distribution data from a novel continuous elevational transect to evaluate the accuracy of discontinuous transect methods. …”
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Identification of a Ferroptosis-Related Signature Associated with Prognosis and Immune Infiltration in Adrenocortical Carcinoma by Xi Chen, Lijun Yan, Feng Jiang, Yu Lu, Ni Zeng, Shufang Yang, Xianghua Ma

“…In addition, we discovered that the expressional levels of hub genes were linked to six immune cells’ infiltration in ACC tumor. ssGSEA revealed that contents of most immune cells significantly decreased in the high-risk group. In conclusion, the novel ferroptosis risk signature could be useful in predicting prognosis and reflecting immune infiltration in ACC. …”
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Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma by Chuyu He, Xuejuan Wang, Yi-Shiou Chiou, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie

“…Herein, the function and mechanism of TFF3 in ER+HER2+ MC were delineated; and novel combinatorial therapeutic strategies were identified. …”
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Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study by Hang Zhang, Jing-jing Zuo, Si-si Dong, Yuan Lan, Chen-wei Wu, Guang-yun Mao, Chao Zheng

“…This study is aimed at determining novel sensitive and specific biomarkers to distinguish DKD from their counterparts effectively based on the widely targeted metabolomics approach. …”
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Interference of Celastrol with Cell Wall Synthesis and Biofilm Formation in <i>Staphylococcus epidermidis</i> by Leandro de León Guerra, Nayely Padilla Montaño, Laila Moujir

“…<b>Background</b>: The emergence of antibiotic-resistant bacteria, including <i>Staphylococcus epidermidis</i>, underscores the need for novel antimicrobial agents. Celastrol, a natural compound derived from the plants of the Celastraceae family, has demonstrated promising antibacterial and antibiofilm properties against various pathogens. …”
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Microstructure evolution and mechanical properties of ZK61 magnesium alloy fabricated via friction stir additive manufacturing by Yichen Xiao, Lei Shi, Chuansong Wu, Shengli Li, Ji Chen, Wenjian Ren

“…Friction stir additive manufacturing (FSAM) is a novel solid-phase AM method which enables AM of Mg alloy components to achieve excellent mechanical properties. …”
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Incremental long-term benefit of drug therapies for chronic obstructive pulmonary disease in quality of life but not mortality: a network meta-analysis by Qiong Pan, Jiongzhou Sun, Shiyuan Gao, Zian Liu, Yiwen Huang, Yixin Lian

“…Conclusions The incremental use of combinations of conventional and novel drugs contributed to the long-term benefits in acute exacerbation but not death in COPD. …”
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Identification and characterization of Faecalibacterium prophages rich in diversity-generating retroelements by Anastasia Gulyaeva, Lei Liu, Sanzhima Garmaeva, Marloes Kruk, Rinse K. Weersma, Hermie J. M. Harmsen, Alexandra Zhernakova

“…One promising method of obtaining novel phages for experimental characterization is through induction of the prophages integrated into the genomes of cultured gut bacteria. …”
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Machine learning assisted radiomics in predicting postoperative occurrence of deep venous thrombosis in patients with gastric cancer by Yuan Zeng, Yuhao Chen, Dandan Zhu, Jun Xu, Xiangting Zhang, Huiya Ying, Xian Song, Ruoru Zhou, Yixiao Wang, Fujun Yu

“…Conclusion ML algorithms based on imaging information may prove to be novel non-invasive models for predicting postoperative occurrence of DVT in GC patients.…”
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Exploring diazotrophic diversity: unveiling Nif core distribution and evolutionary patterns in nitrogen-fixing organisms by Bruno Thiago de Lima Nichio, Roxana Beatriz Ribeiro Chaves, Fábio de Oliveira Pedrosa, Roberto Tadeu Raittz

“…Finally, we cataloged 662 species with Nif core, of which 52 were novel. Our analysis generated 10,076 Nif proteins from these species and revealed some Nif core duplications. …”
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PortNet: Achieving lightweight architecture and high accuracy in lung cancer cell classification by Kaikai Zhao, Youjiao Si, Liangchao Sun, Xiangjiao Meng

“…This study aims to develop a novel deep learning model to provide efficient, accurate, and cost-effective auxiliary diagnosis for the pathological types of lung cancer cells. …”
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Orofacial Pain during Mastication in People with Dementia: Reliability Testing of the Orofacial Pain Scale for Non-Verbal Individuals by Merlijn W. de Vries, Corine Visscher, Suzanne Delwel, Jenny T. van der Steen, Marjoleine J. C. Pieper, Erik J. A. Scherder, Wilco P. Achterberg, Frank Lobbezoo

“…The aim of this study was to establish the reliability of the “chewing” subscale of the OPS-NVI, a novel tool designed to estimate presence and severity of orofacial pain in nonverbal patients. …”
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VIBE: an R-package for VIsualization of Bulk RNA Expression data for therapeutic targeting and disease stratification by Indu Khatri, Saskia D. van Asten, Leandro F. Moreno, Brandon W. Higgs, Christiaan Klijn, Christiaan Klijn, Francis Blokzijl, Iris C. R. M. Kolder

“…With this tool, researchers can enhance indication selection and potentially accelerate the development of novel targeted therapies with the goal of precision, personalization, and ensuring treatments align with an individual patient’s disease state across a spectrum of disorders. …”
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Naming the untouchable – environmental sequences and niche partitioning as taxonomical evidence in fungi by Faheema Kalsoom Khan, Kerri Kluting, Jeanette Tångrot, Hector Urbina, Tea Ammunet, Shadi Eshghi Sahraei, Martin Rydén, Martin Ryberg, Anna Rosling

“…Based on the combination of phylogenetic and ecological evidence, we identify two novel species for which we provide molecular diagnostics and propose names. …”
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Development of a TSR-based method for understanding structural relationships of cofactors and local environments in photosystem I by Lujun Luo, Tarikul I. Milon, Elijah K. Tandoh, Walter J. Galdamez, Andrei Y. Chistoserdov, Jianping Yu, Jan Kern, Yingchun Wang, Wu Xu

“…Results The key contributions and important findings include: (i) a novel TSR-based method for representing 3D structures of pigments as well as for quantifying pigment structures was developed; (ii) the results revealed that the redox cofactor, P700, are structurally conserved and different from other redox factors. …”
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A cell-penetrating bispecific antibody suppresses hepatitis B virus replication and secretion by Chongwei Xie, Bing Zhou, Da Yao, Xin Wang, Lihong Zhong, Chuanghua Qiu, Junfang Zhang

“…This cell-penetrating bispecific antibody is a novel approach to suppressing HBV replication and secretion and is a promising anti-HBV therapeutic antibody candidate.…”
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Blue sclerae and their association with glaucoma (a review and case report) by T.A. Beletskaya, E.V. Kozina, D.V. Dmitrenko, Yu.I. Gavrilova

“…The combination of osteogenesis imperfecta type 1 and primary open-angle glaucoma is a novel phenotypic association. The most effective way of controlling intraocular pressure (IOP) in this condition is surgical intervention. …”
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Agent-Based Intelligent Fuzzy Traffic Signal Control System for Multiple Road Intersection Systems by Tamrat D. Chala, László T. Kóczy

“…This paper presents a novel agent-based fuzzy traffic control system for multiple road intersections. …”
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