Peptide Aptamer–Paclitaxel Conjugates for Tumor Targeted Therapy by Xinyang Shen, Yuan Ma, Hang Luo, Razack Abdullah, Yufei Pan, Yihao Zhang, Chuanxin Zhong, Baoting Zhang, Ge Zhang

“…<b>Results</b>: This analysis highlights the potential of peptide aptamer–paclitaxel conjugates as a novel and effective approach for targeted cancer therapy. …”
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Estimating Seafloor Topography of the South China Sea Using SWOT Wide-Swath Altimetry Data by Fengshun Zhu, Jinbo Li, Yang Li, Jianqiao Xu, Jinyun Guo, Jiangcun Zhou, Heping Sun

“…The surface water and ocean topography (SWOT) wide-swath altimetry satellite was launched in December 2022. The performance of novel wide-swath altimetry in seafloor topography modeling needs to be evaluated. …”
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Impact of power ultrasound on the quality of leafy green produce through a multifrequency, multimode, modulated system by Bin Zhou, J. Atilio de Frias, Yaguang Luo, Jorge M. Fonseca, Hao Feng

“…The present study examined the response of leafy greens to ultrasound treatment as shown by tissue damage and sensory quality, using a novel multifrequency, multimode, modulated (MMM) system to address the issue of nonuniform ultrasound field distribution. …”
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Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…Our findings unveil a novel mechanism by which Blimp-1 modulates macrophage polarization through metabolic regulation, presenting potential therapeutic targets for sepsis. …”
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Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera) by Andrea Becchimanzi, Giovanna De Leva, Rosanna Mattossovich, Serena Camerini, Marialuisa Casella, Giovanni Jesu, Ilaria Di Lelio, Sabrina Di Giorgi, Joachim R. de Miranda, Anna Valenti, Silvia Gigliotti, Francesco Pennacchio

“…Conclusions In summary, these data indicate that DWV modulates the host ArgK through transcriptional regulation and cooptation to enhance its fitness in honey bees. Our findings open novel perspectives on possible new therapies for DWV control by targeting specific host proteins.…”
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Effect of Artemisia annua on anticoccidial action, intestinal microbiota and metabolites of Hu lambs by Shuaiqi Liu, Shiheng Li, Shuqi Cheng, Manyu Liu, Jing Li, Senyang Li, Xiaoying Li, Longxian Zhang, Fuchun Jian

“…Therefore, there is an urgent need to identify novel alternative drugs for the treatment of the lamb coccidia. …”
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Detailed genetic analyses highlight genetic variation and genomic regions for lead tolerance in spring wheat by Amira M. I. Mourad, Amira M. I. Mourad, Ahmed Sallam, Ahmed Sallam, Khaled A. Farghaly, Andreas Börner

“…Interestingly, five significant markers were found to be associated with lead tolerance at the seedling and adult growth stages.DiscussionThe results of this study provide new and novel insights into genetic control and genetic variation in lead tolerance at the early growth stage. …”
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Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018 by Yongchun Xiao, Yong Mou, Yong Mou, Ping Wu, Ke Wang, Tianjun Chen, Zhiwan Chen, Hongsheng Lin, Hua Yang, Zhisheng Ji

“…BackgroundThe Magnesium Depletion Score (MDS) is a novel indicator that integrates multiple factors to assess systemic magnesium depletion. …”
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A 7-Amino Acid Peptide Mimic from Hepatitis C Virus Hypervariable Region 1 Inhibits Mouse Lung Th9 Cell Differentiation by Blocking CD81 Signaling during Allergic Lung Inflammation by Wanzhou Zhao, Conghao Tan, Xi Yu, Ruihe Yu, Qibing Mei, Yun Cheng

“…T helper (Th) cells orchestrate allergic lung inflammation in asthma pathogenesis. Th9 is a novel Th cell subset that mainly produces IL-9, a potent proinflammatory cytokine in asthma. …”
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Risk prediction models for stress urinary incontinence after pelvic organ prolapse (POP) surgery: a systematic review and meta-analysis by Bi Jun Yu, Hao Chong He, Li Wang, Han Mei Shao, Ying Min Liu, Xiao Ying Yan, Jian Liu

“…Future research should follow TRIPOD and PROBAST principles, focus on addressing sources of heterogeneity, improve model development through robust designs, large sample sizes, comprehensive predictors, and novel modelling approaches, and validate tools that can be effectively integrated into clinical decision-making to manage stress urinary incontinence after pelvic floor reconstruction.…”
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Obstacle Avoidance for Ship Navigation Safety Combining Heuristic Search Algorithm and Improved ACO Algorithm by Dan Wang, Yan Jing

“…In complex environments, the proposed algorithm reduces the average path length by 15.7 and 12.4 compared to Particle Swarm Optimisation and Line-of-Sight algorithms, and reduces the number of iterations by 49 and 22.2, respectively. The study proposes a novel obstacle avoidance path planning method by effectively integrating the improved ant colony algorithm with the A* algorithm, which significantly improves the efficiency and accuracy of vessel navigation safety. …”
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Highly Sensitive Non-Dispersive Infrared Gas Sensor with Innovative Application for Monitoring Carbon Dioxide Emissions from Lithium-Ion Battery Thermal Runaway by Liang Luo, Jianwei Chen, Aisn Gioronara Hui, Rongzhen Liu, Yao Zhou, Haitong Liang, Ziyuan Wang, Haosu Luo, Fei Fang

“…In this study, we introduce a novel CO₂ gas sensor based on the advanced pyroelectric single-crystal lead niobium magnesium titanate (PMNT), which exhibits exceptionally high pyroelectric properties compared to commercially available materials, such as lithium tantalate single crystals and lead zirconate titanate ceramics. …”
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Synthesis and Spatial Structure of 3-Phenylacrylic Acid Octahydroquinolizin-1-Ylmethyl Ester and 2-(Octahydroquinolizin-1-Ylmethyl)Isoindole-1,3-Dione by Zh.S. Nurmaganbetov, O.A. Nurkenov, S.D. Fazylov, D.M. Turdybekov, Ye.V. Minayeva, G. Khabdolda, A.M. Ibraybekova, Zh.S. Tilla, K.M. Turdybekov

“…The values of chemical shifts, multiplet and integrated intensity of 1H and 13C signals in one-dimensional NMR spectra of the novel compounds were determined. The crystal structures of 3-phenylacrylic acid octahydroquinolizin-1-ylmethyl ester and 2-(octahydroquinolizin-1-ylmethyl)isoindole-1,3-dione were elucidated through X-ray analysis. …”
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Description of a new surgical approach for elbow arthroplasty: Selective Triceps-On Medial Paraolecranon (STOMP) approach by Carlos Prada, MD, Sirat Khan, MBBS, PhD, Thomas Goetz, MD, Bashar Alolabi, MD, MSc

“…We present here the operative technique, indications, and initial outcomes of a novel Selective Triceps-On Medial Paraolecranon (STOMP) approach for TEA, which allows both preservation of the triceps function and excellent exposure to the proximal ulna with minimal risk to the ulnar nerve. …”
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Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Deliver miR-21 to Promote Corneal Epithelial Wound Healing through PTEN/PI3K/Akt Pathway by Xiaolong Liu, Xuran Li, Guangyuan Wu, Pengfei Qi, Yanyan Zhang, Zhiyu Liu, Xinyue Li, Yu Yu, Xiangmei Ye, Yang Li, Dongguang Yang, Yueqiu Teng, Ce Shi, Xin Jin, Sen Qi, Yuting Liu, Shudan Wang, Ying Liu, Fenglin Cao, Qingran Kong, Zhenkun Wang, Hong Zhang

“…HUMSC-sEVs could enhance the recovery of corneal epithelial wounds though restraining PTEN by transferring miR-21 and may represent a promising novel therapeutic agent for corneal wound repair.…”
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Convolutional Attention Based Mechanism for Facial Microexpression Recognition by Hafiz Khizer Bin Talib, Kaiwei Xu, Yanlong Cao, Yuan-Ping Xu, Zhijie Xu, Muhammad Zaman, Adnan Akhunzada

“…Using the ConvMixer architecture, we Proposed a novel technique for facial microexpression identification based on convolutional attention mechanism. …”
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Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1 by Yanbin Zhang, Peng Lv, Qing Zhang, Wei Xiang, Xiaobing Jiang, Zijun Guo, Tao Zhang

“…Together, this study demonstrated that exosomal miR-21-5p from GAMSC promoted GBM proliferation, migration, invasion, and glycolysis by targeting PDHA1, which provided novel insights into the metabolic interactions between GAMSCs and GBM cells, emphasizing the importance of exosome-mediated communication in tumor progression.…”
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A High-Quality Phased Genome Assembly of Stinging Nettle (<i>Urtica dioica</i> ssp. <i>dioica</i>) by Kaede Hirabayashi, Christopher R. Dumigan, Matúš Kučka, Diana M. Percy, Gea Guerriero, Quentin Cronk, Michael K. Deyholos, Marco Todesco

“…Using a combination of PacBio HiFi, Oxford Nanopore, and Illumina sequencing, as well as Hi-C long-range interaction data (using a novel Hi-C protocol presented here), we assembled two haplotypes of 574.9 Mbp (contig N50 = 10.9 Mbp, scaffold N50 = 44.0 Mbp) and 521.2 Mbp (contig N50 = 13.5 Mbp, scaffold N50 = 48.0 Mbp), with assembly BUSCO scores of 92.6% and 92.2%. …”
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Efficient and Rapid Microfluidics Production of Bio-Inspired Nanoparticles Derived from <i>Bombyx mori</i> Silkworm for Enhanced Breast Cancer Treatment by Muhamad Hawari Mansor, Zijian Gao, Faith Howard, Jordan MacInnes, Xiubo Zhao, Munitta Muthana

“…This study aimed to fabricate silk fibroin particles (SFPs) using a novel swirl mixer previously presented by our group, evaluating their characteristics and suitability for drug delivery applications, including magnetic nanoparticles and dual-drug encapsulation with curcumin (CUR) and 5-fluorouracil (5-FU). …”
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Tumor Microenvironment‐Responsive Nanoparticles Enhance IDO1 Blockade Immunotherapy by Remodeling Metabolic Immunosuppression by Mengna Wang, Yuhong Liu, Yanshi Li, Tao Lu, Min Wang, Zhaobo Cheng, Lin Chen, Tongling Wen, Min Pan, Guohua Hu

“…This study highlights a novel nano‐platform that simultaneously improves metabolism and enhances ICB efficacy to achieve a new and efficient antitumor strategy.…”
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