Synthesis, evaluation of the biological activity against Trypanosoma cruzi and Leishmania donovani. Preliminary in silico ADMET studies of 5-nitroimidazole derivatives by Miguel A. Rodríguez, Ali Mijoba, Nereida J. Parra-Giménez, Zuleyma Blanco, Katiuska Chávez, Alirica I. Suárez, Esteban Fernandez-Moreira, Hegira Ramírez, Jaime E. Charris

“…The toxicity (ADME/Tox) assessment study were carried out to predict the molecular properties associated with pharmacokinetic aspects of novel compounds. The trypanocidal and leishmanicidal activities of all synthesized hybrids were evaluated, compounds 7a and 8b were active against the epimastigote form of T. cruzi. …”
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Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation by Shushu Xue, Junrong Jiao, Si Miao, Lijun Wang, Yang Liu, Qingjie Zhang, Qiyue Wang, Yu Xi, Yuanyuan Zhang

“…In a word, DP‐BNF@Lat‐MPs could be a novel inhalable integrated microsphere that provides a new possibility for thermoradiotherapy of LMBC.…”
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Facial expression recognition through muscle synergies and estimation of facial keypoint displacements through a skin-musculoskeletal model using facial sEMG signals by Lun Shu, Victor R. Barradas, Zixuan Qin, Yasuharu Koike

“…This study introduces a novel framework using surface electromyography (sEMG) signals from facial muscles to recognize facial expressions and estimate the displacement of facial keypoints during the execution of the expressions. …”
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Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease by Zachary Kostamo, Manuel A. Ortega, Chavonna Xu, Patricia R. Feliciano, Elizabeth Budak, Daisy Lam, Valerie Winton, Rebecca Jenkins, Archita Venugopal, Margaret Zhang, John Jamieson, Brent Coisman, Kennedy Goldsborough, Britney Hernandez, Celeste K. Kanne, Erica N. Evans, Jordan Zgodny, Yankai Zhang, Jawa Darazim, Ashwin Patel, Michael A. Pendergast, John Manis, Adam J. Hartigan, Giuseppe Ciaramella, Seung-Joo Lee, S. Haihua Chu, Vivien A. Sheehan

“…Our results highlight the importance of functionally assessing the mature red cell environment when evaluating novel gene editing strategies for hematologic disorders.…”
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Asthma Biologics Across the T2 Spectrum of Inflammation in Severe Asthma: Biomarkers and Mechanism of Action by Lindsley AW, Lugogo N, Reeh KAG, Spahn J, Parnes JR

“…Indeed, many negative results challenge current assumptions about the etiology of non-T2 asthma and raise doubts about the viability of targeting popular alternative inflammatory pathways, such as T17. Novel data have emerged from the use of biologics to treat various inflammatory mediators and have furthered our understanding of pathogenic mechanisms that drive asthma. …”
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Transcatheter Approach for Critical Pulmonary Stenosis or Pulmonary Atresia with Intact Ventricular Septum in Young Infants Using the Simmons Catheter by Jian Wang, Jing Sun, Jian Shen, Jianping Yang, Ling Yang, Pengjun Zhao, Sun Chen

“…In this study, we introduced a novel transcatheter approach with the Simmons catheter to reach the RVOT and compared its efficacy and safety with those of the approaches using a floating catheter and the Judkins right coronary catheter. …”
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Genomic and transcriptomic insights into vitamin A-induced thermogenesis and gene reuse as a cold adaptation strategy in wild boars by Mingpeng Zhang, Aleksei Traspov, Jiawen Yang, Min Zheng, Veronika R. Kharzinova, Huashui Ai, Natalia A. Zinovieva, Lusheng Huang

“…Further pathway and transcriptomic analyses reveal a novel cold resistance mechanism centered on enhanced vitamin A metabolism and catalysis, involving the reuse of UGT2B31 and rhythm regulation by ANGPTL8, RLN3 and ZBTB20. …”
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A Bore-Integrated Patch Antenna Array for Whole-Body Excitation in Ultra-High-Field Magnetic Resonance Imaging by Svetlana S. Egorova, Nikolai A. Lisachenko, Egor I. Kretov, Yang Gao, Xiaotong Zhang, Stanislav B. Glybovski, Georgiy A. Solomakha

“…The same approach faces difficulties in fast and reliable SAR evaluation, precise positioning, and patient comfort in the clinical environment. Recently, a novel bore-integrated array of stripline antenna elements with substantial free space was introduced for whole-body imaging at 7 T, showing, however, insufficient transmission efficiency (the level of <inline-formula> <tex-math notation="LaTeX">$B_{1}^{+}$ </tex-math></inline-formula> at the unit input power). …”
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Autoregulatory Feedback Mechanism of P38MAPK/Caspase-8 in Photodynamic Therapy-Hydrophilic/Lipophilic Tetra-α-(4-carboxyphenoxy) Phthalocyanine Zinc-Induced Apoptosis of Human Hepa... by Yu Wang, Chunhui Xia, Wei Chen, Yuhang Chen, Yiyi Wang, Tao Li

“…Photodynamic therapy (PDT) is a novel and promising antitumor treatment. Our previous study showed that hydrophilic/lipophilic tetra-α-(4-carboxyphenoxy) phthalocyanine zinc- (TαPcZn-) mediated PDT (TαPcZn-PDT) inhibits the proliferation of human hepatocellular carcinoma Bel-7402 cells by triggering apoptosis and arresting cell cycle. …”
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The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver by J. Chamouton, F. Hansmannel, J. A. Bonzo, M. C. Clémencet, G. Chevillard, M. Battle, P. Martin, T. Pineau, S. Duncan, F. J. Gonzalez, N. Latruffe, S. Mandard, V. Nicolas-Francès

“…Transactivation and gel shift experiments identified a novel PPAR response element within intron 3 of the Thb gene, by which PPARα but not HNF4α transactivates. …”
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Large Pretrained Foundation Model for Key Performance Indicator Multivariate Time Series Anomaly Detection by Xu Wang, Qisheng Xu, Kele Xu, Ting Yu, Bo Ding, Dawei Feng, Yong Dou

“…Furthermore, to address the multivariate challenge, we introduce a novel feature extraction method based on channel independence to optimize information processing across multidimensional features. …”
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Accurately Tunable AuNC‐ZIF Content Architecture Based on Coordination‐Dissociation Mechanism Enables Highly Brightness Dual‐Site Fluorescent Biosensor by Junyang Chen, Yuqian Wang, Runpu Shen, Wei Li, Sainan Gao, Zhikang Xiao, Qiyan Lv, Xiaojie Song, Jianzhong Xu, Gaoxiang Xu, Huifang Cui, Zhaohui Li

“…This approach demonstrates broad applicability and maintains strong fluorescence across different ZIFs. Additionally, a novel nanocomposite, Au‐ZIF@carbon‐dots (CDs), is synthesized by encapsulating CDs into the inner cavity of Au‐ZIF. …”
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Immunization of cattle with a Rhipicephalus microplus chitinase peptide containing predicted B-cell epitopes reduces tick biological fitness by María Martina Esperanza Perez-Soria, Daniel Gustavo López-Díaz, Rafael Jiménez-Ocampo, Gabriela Aguilar-Tipacamú, Massaro W. Ueti, Juan Mosqueda, Ala Tabor

“…An immunological strategy based on vaccines offers an alternative approach to tick control. To develop novel tick vaccines, it is crucial to identify and evaluate antigens capable of generating protection in cattle. …”
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Develop Reusable Carbon Sub‐Micrometer Composites with Record‐High Cd(II) Removal Capacity by Mengke Cui, Huiting Jiao, Shijie Yuan, Bin Dong, Zuxin Xu

“…Nevertheless, achieving ultra‐efficient and cost‐effective treatment of trace amounts of heavy metals remains a major challenge. Herein, the novel carbon sub‐micrometer composites (CSMCs) supported Fe0@γ‐Fe2O3 core‐shell clusters nanostructures are designed and synthesized through a series of universally applicable methods. …”
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In-vitro accuracy of the virtual patient model with maxillomandibular relationship at centric occlusion using 3D-printed customized transfer key by Anh Ho-Quynh Nguyen, Nam Cong-Nhat Huynh, Oanh Ngoc-Hoang Nguyen, Nhat Dinh-Minh Nguyen, Hai Hoang Phan, Jong-Eun Kim, Gan Jin, Khanh Hung Nguyen, Hung Trong Hoang

“…Conclusions The 3D-printed customized transfer key effectively enhanced the virtual patient model’s accuracy, surpassing traditional trueness and precision methods. This novel approach offers a streamlined, patient-friendly solution for digital dental workflows.…”
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Prognostic impact of coronary microvascular dysfunction assessed by AMR in acute coronary syndrome patients with chronic kidney disease by Ziyu Guo, Yike Li, Qiang Chen, Jingang Zheng, Jingang Zheng

“…BackgroundAngiography-derived microcirculatory resistance (AMR) is proposed as a novel, pressure- temperature-wire-free and less-invasive method to evaluate coronary microvascular dysfunction (CMD). …”
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Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis by Cheng Tang, Su-Xia Sun, Chao Gu, Chao-Juan Li, Jin Xu, Ke-Lei Su, Dan-Dan Zhou, Kuai Yu, Qing-Ling Xiao, Xiao-Li Chen

“…Abstract Background Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. …”
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Validation of energy valley optimization for adaptive fuzzy logic controller of DFIG-based wind turbines by Basem E. Elnaghi, Ahmed M. Ismaiel, Fathy El Sayed Abdel-Kader, M. N. Abelwhab, Reham H. Mohammed

“…Abstract This study presents a novel optimization algorithm known as the Energy Valley Optimizer Approach (EVOA) designed to effectively develop six optimal adaptive fuzzy logic controllers (AFLCs) comprising 30 parameters for a grid-tied doubly fed induction generator (DFIG) utilized in wind power plants (WPP). …”
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The Bile Acid Metabolism of Intestinal Microorganisms Mediates the Effect of Different Protein Sources on Muscle Protein Deposition in <i>Procambarus clarkii</i> by Xiaodi Xu, Xiaochuan Zheng, Qunlan Zhou, Cunxin Sun, Aimin Wang, Aimin Zhu, Yuanyuan Zhang, Bo Liu

“…Our results demonstrated that the ‘<i>Bacteroides</i>-TCDCA-<i>MSTN</i>’ axis may mediate the effects of different protein sources on muscle development and protein deposition in <i>P. clarkii</i>, which was anticipated to represent a novel target for the muscle quality modulation in crustaceans.…”
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Geological disaster risk assessment based on ecological niche model: A case study of Longhui County, Shaoyang City by Yun ZHANG, Feng ZI, Jiehua GUO, Yunjiang CAO, Jiuling DUAN, Zhigang GUO, Long TANG

“…This study introduces a novel method for the risk assessment of geological disasters in Longhui County and provides a theoretical basis for the government’s risk management strategy.…”
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