Proteomic profiling of serum in cats with naturally occurring degenerative joint disease and co-morbid conditions by B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, Rakesh Ponnala, Steven G. Kamerling, Tracey Williams

“…Further, these data could be leveraged to identify novel therapeutic targets to address the gap in our ability to manage DJD, pain, and CKD in cats. …”
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Effect of Inflammation on Gingival Mesenchymal Stem/Progenitor Cells’ Proliferation and Migration through Microperforated Membranes: An In Vitro Study by M. Al Bahrawy, K. Ghaffar, A. Gamal, K. El-Sayed, V. Iacono

“…Regenerative periodontal approaches, employing gingival mesenchymal stem/progenitor cells in combination with these novel membranes, would occur mostly in inflamed microenvironmental conditions intraorally. …”
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Prognostic Value of Tumor Regression Grade Combined with Pathological Lymph Node Status in Initially Node-Positive Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy by Dakui Luo, Yajie Chen, Zhouyu Luo, Huangbo Gong, Qingguo Li, Xinxiang Li

“…TRG combined with ypN status was an independent predictor for both DFS and OS in multivariate analysis.Conclusion TRG combined with ypN status is a novel prognostic factor in cN + rectal cancer following neoadjuvant chemoradiotherapy, which assists clinicians make appropriate decisions regarding postoperative treatment and surveillance.…”
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A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy by Abdelbaset Mohamed Elasbali, Farah Anjum, Osama A. AlKhamees, Waleed Abu Al-Soud, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…Six substitutions (N26H, N26K, G47W, D98G, G109A, and G109R) were predicted to decrease protein solubility and were located in minimally frustrated regions, potentially compromising Dystrophin functionality and contributing to DMD pathogenesis.ConclusionThis study provides novel insights into the molecular mechanisms of DMD, highlighting specific mutations that disrupt Dystrophin’s solubility and function. …”
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Purification, Characterization and Antibacterial Mechanism of Plantaricin 2-1 by Mengyang LI, Xiaoxue CHE, Qingshen SUN

“…Results showed that plantaricin P2-1 was a novel bacteriocin with the molecular weight of 983.564 Da. …”
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Development and in vitro evaluation of biomimetic injectable hydrogels from decellularized human nerves for central nervous system regeneration by Gopal Agarwal, Kennedy Moes, Christine E. Schmidt

“…Human brain neurons had higher neuronal differentiation within iHPN compared to TCP or collagen hydrogels. Overall, iHPN is a novel injectable hydrogel that has potential for minimally invasive CNS applications, such as a carrier for cell or drug delivery and/or a biomaterial to support axonal growth.…”
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Unlocking the Potential of Buckwheat Hulls, Sprouts, and Extracts: Innovative Food Product Development, Bioactive Compounds, and Health Benefits – a Review by Zhibek Atambayeva, Almagul Nurgazezova, Kumarbek Amirkhanov, Zhanna Assirzhanova, Altyngul Khaimuldinova, Haykuhi Charchoghlyan, Meruyert Kaygusuz

“…The review underscores the need for further research to optimize the use of buckwheat less-utilized parts and to better understand their health impacts. By highlighting the novel uses and health benefits of buckwheat hulls, sprouts, and extracts, the review contributes to the growing field of sustainable food practices and the development of functional foods.…”
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FathomDEM: an improved global terrain map using a hybrid vision transformer model by Peter Uhe, Chris Lucas, Laurence Hawker, Malcolm Brine, Hamish Wilkinson, Anthony Cooper, Alex A Saoulis, James Savage, Christopher Sampson

“…We present here, FathomDEM, a new global 30 m DEM produced using a novel application of a hybrid vision transformer model. …”
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A Smart Nanomedicine Unleashes a Dual Assault of Glucose Starvation and Cuproptosis to Supercharge αPD‐L1 Therapy by Yiming Xu, Yuan Wu, Xinjie Zheng, Dongxue Wang, Hangqi Ni, Weiyu Chen, Kai Wang

“…Thus, an intelligent biomimetic nano‐delivery system is synthesized by camouflaging lung cancer cell membranes onto glucose oxidase‐loaded Cu‐LDHs (CMGCL) for cancer metabolism targeted interference. Such novel nanomedicine is able to induce lung cancer cell cuproptosis and PD‐L1 upregulation significantly via self‐amplified cascade reactions. …”
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Exploring Zinc C295 as a Dual HIV-1 Integrase Inhibitor: From Strand Transfer to 3′-Processing Suppression by Sharif Karim Sayyed, Marzuqa Quraishi, D. S. Prabakaran, Balaji Chandrasekaran, Thiyagarajan Ramesh, Satish Kumar Rajasekharan, Chaitany Jayprakash Raorane, Tareeka Sonawane, Vinothkannan Ravichandran

“…<b>Background</b>: The global AIDS pandemic highlights the urgent need for novel antiretroviral therapies (ART). In our previous work, Zinc C295 was identified as a potent HIV-1 integrase strand transfer (ST) inhibitor. …”
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Expectorant Effects of <i>Atractylodes japonica</i> Koidz. ex Kitam Root Extracts on Particulate Matter-Induced Pulmonary Injury in Mice by Junho Lee, Sana Mansoor, Jeongjun Lee, Hunsuk Chung, Young-Sam Kwon, Khawaja Muhammad Imran Bashir, Jae-Suk Choi, Sae-Kwang Ku

“…This study investigated the growing environmental concern of particulate matter (PM)-induced pulmonary injury and explored novel preventive strategies. In particular, it evaluated the protective effects of <i>Atractylodes japonica</i> Koidz. ex. …”
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N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatoce... by Ronghuan Fang, Zhigang Jia, Yuhang Xin, Kai Zhao, Wei Qin, Haoran Lu, Yi Zhou, Yongsheng Yang, He Fang

“…These findings provide a theoretical basis for the potential discovery of new HCC oncogenes, as well as the identification of effective targets and development of novel anti-HCC drugs and clinical applications.…”
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Importance of OsRac1 in Signalling of Pigm-1 Mediated Resistance to Rice Blast Disease by Dewei Yang, Niqing He, Fenghuang Huang, Jialin Chen, Minxiang Yu, Yidan Jin, Shaojun Lin, Shengping Li

“…Additionally, a transcriptional activator, RAI1, acts as an essential Pigm-1 interactor for blast resistance. Furthermore, a novel material 9311(<i>Pigm-1</i>) was prepared by using two-line restorer line 9311 as receptor and Shuangkang 77009 as donor with molecular marker-assisted technology, which improved blast resistance and yield. …”
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Polymorphisms in genes related to inflammation and endothelial function are associated with ischemic stroke and other vascular events in populations at high risk of stroke by Hong Chen, Hua Luo, Ju Zhou, Ming Yu, Ting Qing, Yanfen Wang, Minjie Shao, Wei Wei, Xingyang Yi

“…Out of these, 118 individuals (4.4%) had a novel IS, 24 (0.9%) suffered a hemorrhagic stroke (HS), 53 (2.0%) developed myocardial infarction (MI), and 33 (1.2%) passed away. …”
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Comparative technoeconomic analysis of centralised and decentralised water source heat pump systems using CATHeaPS by Orestis Angelidis, Anastasia Ioannou, Daniel Friedrich, Alan Thomson, Gioia Falcone

“…This study aims to help stakeholders and decision makers in two ways. It introduces a novel, easy-to-use open access technoeconomic tool that enables a high-level analysis of energy, hydraulic and economic factors for any project area. …”
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Deciphering In Vitro and In Vivo Pharmacological Properties of Seed and Fruit Extracts of Flacourtia jangomas (Lour.) Raeusch by Farhana Alam Ripa, Fowzia Alam, Fahmida Haque Riya, Yesmin Begum, Sharmin Akter Eti, Nusratun Nahar, Zebunnesa Ahmed, Sabrina Sharmin

“…These findings can serve as a reference for future endeavors to isolate pure bioactive compounds from this plant for the development of novel phytomedicines.…”
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FedDrip: Federated Learning With Diffusion-Generated Synthetic Image by Karin Huangsuwan, Timothy Liu, Simon See, Aik Beng Ng, Peerapon Vateekul

“…In this work, we propose a novel framework called &#x201C;FedDrip (Federated Learning with Diffusion Reinforcement at Pseudo-site)&#x201D; that utilizes diffusion-generated synthetic data to alleviate these challenges in non-IID environments. …”
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Hepatovirus infections in juvenile seals from the North Sea by Monica Mirolo, Bianca Kühl, Melvin Daniel Roji, Ana Rubio-García, Valéria Andrade Lima, Christina Puff, Byron Martina, Andreas Beineke, Peter Wohlsein, Wolfgang Baumgärtner, Martin Ludlow, Albert Osterhaus

“…Abstract The discovery of several novel hepatovirus species in marine and terrestrial mammals has expanded the recognised members of the genus Hepatovirus and has provided better understanding on the evolutionary origins of human hepatovirus A (HAV). …”
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CD300E+ macrophages facilitate liver regeneration after splenectomy in decompensated cirrhotic patients by Tao Yang, Yuan Zhang, Chujun Duan, Hui Liu, Dong Wang, Qingshan Liang, Xiao Chen, Jingchang Ma, Kun Cheng, Yong Chen, Ran Zhuang, Jikai Yin

“…CD300E+ macrophages are anticipated to emerge as a novel therapeutic strategy for the treatment of liver cirrhosis.…”
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Multi-scale fracture characterization method for transitional shale reservoir based on post-stack multi-attribute ant-tracking fusion and pre-stack wide-azimuth gathers AVAZ analys... by Hongjie Peng, Jingtao Zhao, Zhen Qiu, Qin Zhang, Wen Liu, Weiliang Kong, Wanli Gao, Tongjie Sheng, Wenyu Li, Yugang Yang

“…The results of the fracture prediction are analyzed and validated. A novel and reliable methodology, designed specifically for the challenges of transitional shale reservoirs, has been developed for combined pre-stack and post-stack seismic multi-scale fracture prediction. …”
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