Potential of the CLARA test facility for VHEE radiotherapy research by Deepa Angal-Kalinin, Deepa Angal-Kalinin, Deepa Angal-Kalinin, Stewart Boogert, Stewart Boogert, James Kevin Jones, James Kevin Jones

“…A new beam line has been designed to maximise the exploitation of the CLARA facility in a variety of scientific fields, including novel acceleration and new modalities of radiotherapy. …”
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Fault current handling in large-scale MMC-HVDC systems: an improved approach with DC circuit breaker and fault current limiter by Rashid Hussain Chandio, Madad Ali Shah, Abdul Aziz Memon, Khawaja Haider Ali, Jahangeer Badar Soomro, Basem Alamri, Ahmed Althobaiti, Mohammed Alqarni

“…This paper presents a novel Hybrid FCL for the protection of large scale VSC-HVDC. …”
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The efficacy and safety of MARS-PD: Meridian activation remedy system for Parkinson's disease-A single-center, assessor and statistician-blinded, parallel-group randomized, control... by Miso S Park, SangSoo Park, Jie-Yoon Kang, In Chul Jung, HoRyong Yoo

“…To address this unmet need, we developed a novel therapeutic approach that integrates acupuncture and exercise: the Meridian Activation Remedy System for PD patients (MARS-PD). …”
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The resilience of parents and carers who administer medicines to children at home: a qualitative systematic review protocol by Stephen Morris, Simon Pini, Beth Fylan, Franki Wilson, Helen Faulkner, David P. Alldred

“…Discussion This protocol describes a novel method to address an important patient safety issue. …”
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Energy-Efficient and Trust-Based Autonomous Underwater Vehicle Scheme for 6G-Enabled Internet of Underwater Things by Altaf Hussain, Shuaiyong Li, Tariq Hussain, Razaz Waheeb Attar, Ahmed Alhomoud, Reem Alsagri, Khalid Zaman

“…This paper introduces a novel energy-efficient lightweight, void hole avoidance, localization, and trust-based scheme, termed as Energy-Efficient and Trust-based Autonomous Underwater Vehicle (EETAUV) protocol designed for 6G-enabled underwater acoustic sensor networks (UASNs). …”
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Soluble ST2 does not change cardiovascular risk prediction compared to cardiac troponin T in kidney transplant candidates. by Mira T Keddis, Ziad El-Zoghby, Bruce Kaplan, Jeffrey W Meeusen, Leslie J Donato, Fernando G Cosio, D Eric Steidley

“…<h4>Background</h4>Solubility of Tumorigenicity 2 (sST2) is a novel biomarker that better stratifies risk of cardiovascular events (CVE) compared to cardiac troponin T(cTnT) in heart failure. …”
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Synthesis and Characterization of Green Zinc Oxide Nanoparticles with Antiproliferative Effects through Apoptosis Induction and MicroRNA Modulation in Breast Cancer Cells by Amir Hossein Aalami, Mohammad Mesgari, Amirhossein Sahebkar

“…Biological properties such as the antioxidant and antimicrobial activity of these novel ZnO-NPs were considered. MTT assays showed that the inhibitory concentration (IC50) of ZnO-NPs after 24 h was 11.16 μg/mL, 60.08 μg/mL, and 26.3 μg/mL on MCF7, MDA-MB-231, and HFF cells, respectively. …”
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Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, m... by Prithwish Banerjee, Guy A MacGowan, Frans H Rutten, Iacopo Olivotto, Petar M Seferović, Jonathan Mant, Djordje G Jakovljevic, Oscar Fernandez, Josep Darbà, Nduka C Okwose, Jose Zamorano, Duncan Edwards, David Sinclair, Lazar Velicki, Amy Groenewegen, Lars S Maier, Dimitris Fotiadis, Sarah Jane Charman, Annamaria Del Franco, Maria Tafelmeier, Andrej Preveden, Cristina Garcia Sebastian, Amy S Fuller, Anne Pauline Nelissen, Petros Malitas, Aikaterini Zisaki, Zoran Bosnic, Petar Vracar, Fausto Barlocco, Marta Jiménez-Blanco Bravo, Nenad Filipovic, Bano Fatima, Williams Kate, Fornaro Alessandra, Milovancev Aleksandra, Ascanio Meritxell, Aguera Ainoa, Pičulin Matej, Flis Borut, Boucharas Dimitrios, Manousos Dimitris, Tsiknakis Manolis, Kassiotis Thomas, Sustersic Tijana, Milicevic Bogdan, Hobbs FD Richard, Kaagman Onno

“…We propose to address this global challenge by developing the STRATIFYHF artificial intelligence-driven decision support system (DSS), which uses novel analytical methods in determining the risk, diagnosis and prognosis of HF. …”
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Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn’s disease by Lisa Budzinski, Gi-Ung Kang, René Riedel, Toni Sempert, Leonie Lietz, René Maier, Janine Büttner, Bettina Bochow, Marcell T. Tordai, Aayushi Shah, Amro Abbas, Tanisha Momtaz, Jannike L. Krause, Robin Kempkens, Katrin Lehman, Gitta A. Heinz, Anne E. Benken, Stefanie Bartsch, Kathleen Necke, Ute Hoffmann, Mir-Farzin Mashreghi, Robert Biesen, Tilmann Kallinich, Tobias Alexander, Bosse Jessen, Carl Weidinger, Britta Siegmund, Andreas Radbruch, Anja Schirbel, Benjamin Moser, Hyun-Dong Chang

“…We here present the proof-of-concept demonstrating that multi-parameter single-cell bacterial phenotyping by mMFC could be a novel tool with high translational potential to expand current microbiome investigations by phenotyping of bacteria to identify disease- and therapy-associated cellular alterations and to reveal novel target properties of bacteria for functional assays and therapeutic approaches.…”
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CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment by Yu Wang, Haiyan Xu, Li Cai, Yang Sun, Liwei Wang, Ming Yue, Xiaofei Zhang, Yanling Wang, Shumin Li, Shengbai Xue, Jingyu Ma, Tiebo Mao, Weiyu Ge, Daiyuan Shentu, Wenxin Lu, Yongchao Wang, Jiong Hu, Jiujie Cui

“…This study aims to investigate the biological function and mechanism of how a novel UPR sensor, CREB3L1 works in PDAC and further evaluate its clinical application prospect.Methods We tested UPR signaling including CREB3L1 in Thapsigargin-treated PDAC cells. …”
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Development and evaluation of a CRISPR/Cas12a-based diagnostic test for rapid detection and genotyping of HR-HPV in clinical specimens by Lijuan Yin, Ziqian Zhao, Chunhua Wang, Caihong Zhou, Xiuzhen Wu, Baoxue Gao, Liangyuan Wang, Shuli Man, Xinkuan Cheng, Qiankun Wu, Siqi Hu, Hongxia Fan, Long Ma, Hui Xing, Liang Shen

“…Based on these findings, our CRISPR/Cas-based HR-HPV detection platform holds promise as a novel clinical detection tool, offering a visually intuitive and expedited alternative to existing HPV infection diagnostics and providing fresh perspectives for clinical cervical cancer screening.IMPORTANCEThis study developed a novel high-risk human papillomavirus (HR-HPV) detection platform based on CRISPR/Cas12a technology. …”
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Supercharged nanoadhesive through co-assembly of recombinant protein and tetrahedral DNA for corneal transplantation by Jing Zhao, Feng Zhang, Zhe Zhang, Zhenhua Li, Yanze Yu, Bingqing Sun, Binghong Yu, Yong Ma, Xuan Ding, Liyin Wang, Lifei Zheng, Wenguo Cui, Xingtao Zhou

“…To address this, we developed a novel cornea-specific nanoadhesive constructed through protein-DNA co-assembly and applied it to corneal transplantation. …”
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Real-time holographic camera for obtaining real 3D scene hologram by Zhao-Song Li, Chao Liu, Xiao-Wei Li, Yi Zheng, Qian Huang, Yi-Wei Zheng, Ye-Hao Hou, Chen-Liang Chang, Da-Wei Zhang, Song-Lin Zhuang, Di Wang, Qiong-Hua Wang

“…However, the real-time acquisition of 3D scenes and high-fidelity reconstruction technology has not yet made a breakthrough, which has seriously hindered the development of holography. Here, a novel holographic camera is proposed to solve the above inherent problems completely. …”
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Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Mela... by Mengqi Zhang, Lulu Wang, Wan Liu, Tian Wang, Francesco De Sanctis, Lifang Zhu, Guizhong Zhang, Jian Cheng, Qin Cao, Jingying Zhou, Aldo Tagliabue, Vincenzo Bronte, Dehong Yan, Xianchun Wan, Guang Yu

“…These findings indicate that ART controls the functional polarization of MDSCs and targeting MDSCs by ART provides a novel therapeutic strategy to enhance anti-PD-L1 cancer immunotherapy.…”
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Total synthesis and target identification of marine cyclopiane diterpenes by Tian Li, Shan Jiang, Yuanhao Dai, Xia Wu, Huihui Guo, Liang Shi, Xueli Sang, Li Ren, Jie Wang, Lili Shi, Wenming Zhou, Houhua Li, Hong-Dong Hao

“…Abstract Marine cyclopianes are a family of diterpenoid with novel carbon skeleton and diverse biological activities. …”
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Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor rati... by Dongyu Li, Dongyu Li, Shaolei Li, Hongbing Zhang, Chunqiu Xia, Xiaoyong Nan, Hongyu Liu, Jun Chen, Jun Chen

“…The model showed good calibration (Hosmer–Lemeshow (HL) P value = 0.680) with an area under the receiver operating characteristic curve (AUC) = 0.890 (95% confidence interval (CI): 0.808–0.972) in the validation cohort.ConclusionsWe developed and validated a novel and effective model that predicted the probability of LNM for individual patients with peripheral NSCLC who had a tumor diameter ≤ 2.0 cm and CTR &gt; 0.5. …”
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Deep Brain Stimulation in the treatment of disorders of consciousness by Joanna Olszak, Karolina Zalewa, Lidia Bartoszek, Dominika Orłowska, Wojciech Kapłan, Mikołaj Poleszczuk, Karol Poleszczuk, Alicja Milewska, Anna Czuba, Marta Kaus

“…Conclusions  DBS offers a novel and potentially effective treatment for patients with disorders of consciousness, especially those in a minimally conscious state. …”
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Reprogramming of Adult Retinal Müller Glial Cells into Human-Induced Pluripotent Stem Cells as an Efficient Source of Retinal Cells by Amélie Slembrouck-Brec, Amélie Rodrigues, Oriane Rabesandratana, Giuliana Gagliardi, Céline Nanteau, Stéphane Fouquet, Gilles Thuret, Sacha Reichman, Gael Orieux, Olivier Goureau

“…This advanced maturation of photoreceptors not only supports the possibility to use 3D retinal organoids for studying photoreceptor development but also offers a novel opportunity for disease modeling, particularly for inherited retinal diseases.…”
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Advancing Anaesthetist Rostering Quality: A Practical Approach Toward Fairness and Efficiency by Norizal Abdullah, Masri Ayob, Meng Chun Lam, Nasser R. Sabar, Graham Kendall, Liu Chian Yong

“…To address this challenge, we propose a novel mixed-integer linear programming model with updated constraints, parameters, and an enhanced evaluation function. …”
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RETRACTED: Modern Subtype Classification and Outlier Detection Using the Attention Embedder to Transform Ovarian Cancer Diagnosis by S. M. Nuruzzaman Nobel, S M Masfequier Rahman Swapno, Md. Ashraful Hossain, Mejdl Safran, Sultan Alfarhood, Md. Mohsin Kabir, M. F. Mridha

“…This study highlights how machine learning can revolutionize the medical field’s ability to classify ovarian cancer subtypes and identify outliers, giving doctors a valuable tool to lessen the severe effects of the disease. Adopting this novel method is likely to improve the practice of medicine and give people living with ovarian cancer worldwide hope.…”
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