Radiation-induced impacts on mitochondrial DNA and the transgenerational genomic instability by Ryosuke Seino, Haruka Kubo, Kai Nishikubo, Hisanori Fukunaga

“…Furthermore, to our knowledge, this is first to demonstrate the hereditary effects of radiation on the regulation of mitochondrial genome. These provide novel insights into the significance of radiation protection and preventive medicine for not only pre-pregnancy females but also the next generation.…”
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Multi-stage harmonic cascade at seeded free-electron lasers by Li Zeng, Yong Yu, Xiaofan Wang, Qinming Li, Jitao Sun, Xinmeng Li, Zhigang He, Jiayue Yang, Guorong Wu, Weiqing Zhang, Xueming Yang

“…This paper presents a novel method for generating coherent X-ray FEL pulses in the water window region based on the HGHG scheme with multi-stage harmonic cascade. …”
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Impact fracturing of rock-like material using carbon dioxide under different temperatures and pressures by Shaobin Hu, Zhengyong Yan, Chun Zhu, Manchao He, Shuogang Pang

“…This paper introduces a novel method of supercritical energetic fluid thermal shock fracturing. …”
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Remotely‐Sensed Game Trails Are a Behavioral Footprint That Explains Patterns of Herbivore Habitat Use by Keenan Stears, Melissa H. Schmitt, Mike J. Peel, Tsumbedzo Ramalevha, Douglas J. McCauley, Dave I. Thompson, Deron E. Burkepile

“…Ultimately, we show that game trails are a novel data source that can be used to identify broadly‐occurring patterns of herbivore habitat use over large spatial scales.…”
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An Explanatory Study on User Behavior in Discovering Aggregated Multimedia Web Content by Abdur Rehman Khan, Umer Rashid, Naveed Ahmed

“…The results confirmed previous user studies and suggest novel research recommendations statistically significant in multimedia information exploration-related endeavors.…”
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ML-NIC: accelerating machine learning inference using smart network interface cards by Raghav Kapoor, David C. Anastasiu, Sean Choi

“…To fulfill such a need, this work introduces a novel framework, called ML-NIC, for deploying trained machine learning models onto programmable network devices' data planes. …”
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Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects by Sang Eon Park, Hyeong Seop Kim, Soo Jin Kwon, Min-Jeong Kim, Suk-joo Choi, Soo-young Oh, Gyu Ha Ryu, Hong Bae Jeon, Duk L. Na, Jong Wook Chang

“…Further, these data suggest that human WJ-MSCs exposed to an AD environment may represent a promising and novel therapy for AD.…”
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Liver diseases: epidemiology, causes, trends and predictions by Can Gan, Yuan Yuan, Haiyuan Shen, Jinhang Gao, Xiangxin Kong, Zhaodi Che, Yangkun Guo, Hua Wang, Erdan Dong, Jia Xiao

“…Recent advances in understanding the pathogenesis of liver diseases hold critical implications and translational value for the development of novel therapeutic strategies.…”
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Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study by Bram Rochwerg, Jason H. Cheung, Christine M. Ribic, Faraz Lalji, France J. Clarke, Susheel Gantareddy, Nischal Ranganath, Aziz Walele, Ellen McDonald, Maureen O. Meade, Deborah J. Cook, Trevor T. Wilkieson, Catherine M. Clase, Peter J. Margetts, Azim S. Gangji

“…Bioimpedance analysis (BIA) is a novel method of assessing a patient’s volume status. …”
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Designing of an innovative conserved multiepitope subunit vaccine targeting SARS-CoV-2 glycoprotein and nucleoprotein through immunoinformatic by Temitope Isaac Adelusi, Abdeen Tunde Ogunlana, Moyosoluwa Precious Oyewole, Taiwo Ooreoluwa Ojo, Olamide Tosin Olaoba, Elijah Kolawole Oladipo, Shopnil Akash, Samir Ibenmoussa, Mohammed Bourhia, Yousef A. Bin Jardan, Baye Sitotaw

“…Therefore, our objective is to develop a novel vaccine candidate targeting the dominant T-cell and B-cell epitopes of the immune system. …”
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lncRNA NEAT1 Downregulation Ameliorates the Myocardial Infarction of Mice by Regulating the miR-582-5p/F2RL2 Axis by Zhenhua Wu, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Yaobang Bai, Zhigang Guo

“…NEAT1 downregulation ameliorates MI by regulating the miR-582-5p/F2RL2 axis, providing novel biomarkers for MI treatment.…”
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Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…The successful implementation of this novel approach in discovery PK studies eliminates the need for tedious and costly generation of specific immunocapturing reagents for the LAGA mutants. …”
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Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

“…Results We proposed a novel strategy using Large Language Models (GPT-4) to analyze all clinical trials on prostate cancer and systematically identify true negatives. …”
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IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network by Ruifen Cao, Qiangsheng Li, Pijing Wei, Yun Ding, Yannan Bin, Chunhou Zheng

“…In this study, we propose a novel IL-6-inducing peptide prediction method called DGIL-6, which integrates 3D structural information with graph neural networks. …”
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Correlation between MDA Level and Chitotriosidase-1 Activity in Seminal Fluid of Iraqi Infertile Males by Ali S. Abdul Aziz, Hedef D. Elyaseen, Hussain K. Kadhem

“…Conclusion: There is a correlation between seminal fluid Chitotriosidase-1 activity and malondialdehyde level in the Asthenospermia Group. Novel diagnostic and therapeutic approaches for the treatment of male infertility may result from our growing understanding of the roles played by Chitotriosidase-1 and malondialdehyde in male reproductive health. …”
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Landfill site selection in hilly terrains: An integrated RS-GIS approach with AHP and VIKOR by Shobhit Chaturvedi, Naimish Bhatt, Vatsal Shah, Keval H. Jodhani, Dhruvesh Patel, Sudhir Kumar Singh

“…This paper presents a novel integrated Geographic Information System-Multi-Criteria Decision Making (GIS-MCDM) framework for evaluating landfill site suitability in Shimla, India, a rapidly urbanizing hill station. …”
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Electrical brain activations in preadolescents during a probabilistic reward-learning task reflect cognitive processes and behavior strategies by Yu Sun Chung, Yu Sun Chung, Berry van den Berg, Kenneth C. Roberts, Armen Bagdasarov, Marty G. Woldorff, Marty G. Woldorff, Michael S. Gaffrey, Michael S. Gaffrey, Michael S. Gaffrey

“…These findings provide novel insights into the neural processes underlying RL in preadolescents.…”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…Therefore, there is an urgent need for more research on the pathogenesis of N. fowleri and the identification of novel targets for intervention. With the advances in genomic and proteomic technologies, new opportunities have emerged to explore the molecular biology of N. fowleri and its host response. …”
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Hybrid Modeling of an Induction Machine to Support Bearing Diagnostics by Praneet Amitabh, Dimitar Bozalakov, Frederik De Belie

“…In this article, a novel hybrid model of an induction machine is proposed that can emulate the response of a machine with a faulty bearing. …”
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The association between visceral fat metabolic score and stroke: mediation by declining kidney function by Yue Cao, Weixing Wen, Hao Zhang, Weiwen Li, Guolin Huang, Yuli Huang

“…Metabolic Score for Visceral Fat (METS-VF), a metric of visceral obesity, has emerged as a novel predictor of metabolic diseases. However, its association with stroke remains unclear. …”
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