Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB... by Yuan Xu, Naiyuan Shao, Feng Zhi, Ronghua Chen, Yilin Yang, Jiahui Li, Ying Xia, Ya Peng

“…Our in-vitro studies further confirmed that DOR overexpression mitigated microglial inflammatory response and rescued neurons from AD injury via HMGB1-NF-κB signaling pathway. Conclusions These novel findings uncover previously unappreciated roles of DOR in neuroprotection against AD injury via modulating microglia-related inflammatory responses.…”
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Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity by Shin Koike, Hideo Kimura, Yuki Ogasawara

“…This study identified a novel mechanism for the activation of the PERK–eIF2α–ATF4 pathway through persulfidation by polysulfides and persulfides. …”
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Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies by Hongping Wan, Xinyi Zhong, Shinong Yang, Jiarong Deng, Xu Song, Yong Liu, Yuanfeng Li, Zhongqiong Yin, Xinghong Zhao

“…Consequently, there is an urgent need for novel therapeutics targeting antibiotic‐resistant pathogens. …”
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Design and numerical simulation of CuBi2O4 solar cells with graphene quantum dots as hole transport layer under ideal and non-ideal conditions by Muhammad Panachikkool, E. T. Aparna, Perumal Asaithambi, T. Pandiyarajan

“…Abstract The simulation of ideal and non-ideal conditions using the SCAPS-1D simulator for novel structure Ag/FTO/CuBi2O4/GQD/Au was done for the first time. …”
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Simultaneous Determination of Mineral Nutrients and Toxic Metals in M. stenopetala from Southern Ethiopia: A Comparative Study of Three Cultivating Areas Using MP-AES by Ashenafi Shemnsa, Wondimeneh Dubale Adane, Merid Tessema, Endale Tesfaye, Gizaw Tesfaye

“…The samples were collected during the arid season, in 2019 from the three main M. stenopetala growing areas in southern Ethiopia (Chano Mile Kebele, Nechisar Kebele, and Konso Special Woreda). A novel digestion method for leaf and seed samples was developed using an optimized acid mixture (2.5 : 0.75 : 0.5 of HNO3, HClO4, and H2O2) at 240°C for 2 hrs and 30 min, resulting in clear and colorless solutions. …”
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Detecting anomalies in smart wearables for hypertension: a deep learning mechanism by C. Kishor Kumar Reddy, Vijaya Sindhoori Kaza, R. Madana Mohana, Mohammed Alhameed, Fathe Jeribi, Shadab Alam, Mohammed Shuaib

“…This research aims to address the limitations of current healthcare systems, particularly in remote areas, by leveraging deep learning techniques in Smart Health Monitoring (SHM).MethodsThis paper introduces a novel neural network architecture, ResNet-LSTM, to predict BP from physiological signals such as electrocardiogram (ECG) and photoplethysmogram (PPG). …”
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Establishing a GRU-GCN coordination-based prediction model for miRNA-disease associations by Kai-Cheng Chuang, Ping-Sung Cheng, Yu-Hung Tsai, Meng-Hsiun Tsai

“…After preprocessing, data was trained with a novel model combining gated recurrent units (GRU) and graph convolutional network (GCN) to predict the level of miRNA-disease associations. …”
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The Histone Demethylase KDM3B Promotes Osteo-/Odontogenic Differentiation, Cell Proliferation, and Migration Potential of Stem Cells from the Apical Papilla by Chen Zhang, Xiao Han, Yuncun Liang, Huina Liu, Zhipeng Fan, Jianpeng Zhang

“…In brief, we discovered that KDM3B promoted the osteo-/odontogenic differentiation, cell proliferation, and migration potential of SCAPs and provided a novel target and theoretical basis for regenerative medicine.…”
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Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery by Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman, Philip A. Leighton

“…Heavy chain-only antibodies with their single antigen-binding domain offer the advantage of a smaller size and higher stability relative to conventional antibodies, and thus, the potential for novel targeting modalities. Domain antibodies have commonly been sourced from camelids with ex-vivo humanization or transgenic rodents expressing heavy chains without light chains, but these host species are all mammalian, limiting their capacity to elicit robust immune responses to conserved mammalian targets. …”
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Enhancing Power Grid Reliability With Machine Learning and Auxiliary Classifier Generative Adversarial Networks: A Study on Fault Detection Using the Georgia Electric System Load D... by Hafeez Ur Rehman Siddiqui, Robert Brown, Adil Ali Saleem, Muhammad Amjad Raza, Sandra Dudley

“…This study introduces a novel integration of machine learning and data augmentation techniques for fault detection and classification, addressing gaps in data diversity and imbalance. …”
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Assessing moisture content in XLPE power cables using frequency-dependent tangent delta measurements by Babu Naik Gugulothu, Sanjay Lakshminarayanan, Madhu Palati, Suresh Haleyur Lakshmegowda, Mahipal Bukya

“…The study employed frequency domain spectroscopy to examine the dielectric properties of XLPE cable samples with varying moisture content levels. A novel predictive formula was derived to estimate moisture content using dielectric frequency response (DFR) supported by validation through sweep frequency response analysis (SFRA) tests. …”
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Non-thermal plasma as promising anti-cancer therapy against bladder cancer by inducing DNA damage and cell cycle arrest by Jojanneke Stoof, Zakaria Kalmoua, Ana Sobota, Ruud H. Brakenhoff, Marijke Stigter, Thang V. Pham, Sander R. Piersma, Alex Henneman, Tonny Lagerweij, Richard de Goeij-de Haas, R. Jeroen A. van Moorselaar, Connie R. Jimenez, Irene V. Bijnsdorp

“…We investigated non-thermal plasma’s potential as a novel anti-cancer therapy, focusing on plasma-activated solution (PAS), created by exposing saline to non-thermal plasma. …”
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Serum microRNAs as Diagnostic Markers in Polycystic Ovary Syndrome: A Narrative Review by K Lavanya, N Palaniappan, VM Vinodhini, Santhi Silambanan

“…Since serum microRNAs are present in various bodily fluids, they are novel markers for diseases like PCOS. The microRNA profile constantly changes depending on the pathogenic stage of the disease. …”
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Machine learning-driven analysis of heat transfer in chemically reactive fluid flow considering Soret-Dufour effects by Shazia Habib, Saleem Nasir, Zeeshan Khan, Abdallah S. Berrouk, Waseem, Saeed Islam

“…This study positions the Gaussian Neural Networks framework as a robust computational instrument, providing a foundation for subsequent investigations into intricate geometries, multi-physics phenomena, and magnetohydrodynamic systems for novel technology applications.…”
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Fucoidan alleviated colitis aggravated by fiber deficiency through protecting the gut barrier, suppressing the MAPK/NF-κB pathway, and modulating gut microbiota and metabolites by Weiyun Zheng, Shuangru Tang, Xiaomeng Ren, Xiaomeng Ren, Shuang Song, Shuang Song, Chunqing Ai, Chunqing Ai

“…This study suggests that UPF has the potential to be developed as a novel prebiotic agent to enhance human health.…”
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Effects of self-monitoring physical activity with wearable activity trackers on perceived joint function and health-related quality of life in people with hip and knee osteoarthrit... by Elin Östlind, Frida Eek, Kjerstin Stigmar, Eva Ekvall Hansson

“…Wearable activity trackers (WATs) offer a novel approach to promote PA but could also aid in finding a sustainable PA level over time. …”
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Lens-Free On-Chip Quantitative Phase Microscopy for Large Phase Objects Based on a Biplane Phase Retrieval Method by Yufan Chen, Xuejuan Wu, Yang Chen, Wenhui Lin, Haojie Gu, Yuzhen Zhang, Chao Zuo

“…To address these challenges, we propose a novel biplane phase retrieval (BPR) method that integrates phase unwrapping results obtained at different propagation distances to achieve accurate absolute phase reconstruction. …”
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Cytokine and Chemokine Responses of Peripheral Blood Mononuclear Cells from Dogs Infected with <i>Mycobacterium bovis</i> by Tyler Morrison, Danielle A. Gunn-Moore, Jayne C. Hope, Conor O’Halloran

“…Serum samples were tested to further classify dogs as seropositive or seronegative for circulating antibodies against <i>M. bovis</i> using the DPP^® VetTB Assay, Idexx <i>M. bovis</i> antibody ELISA, and a novel purified protein derivative ELISA. Isolated PBMCs were stimulated with mycobacterial proteins (PPDB or ESAT-6/CFP-10), and 13 cytokines/chemokines were measured in the supernatant. …”
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The role of the extracellular matrix in cardiac regeneration by Xiying Wang, Shuo Yu, Lan Xie, Meixiang Xiang, Hong Ma

“…The present review offers a complete overview of the existing information and novel discoveries regarding the involvement of the ECM in heart regeneration from both mechanical and biochemical perspectives. …”
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Magnetohydrodynamic Peristaltic Propulsion of Casson Nanofluids With Slip Effects Over Heterogeneous Rough Channel by Hanumesh Vaidya, Fateh Mebarek‐Oudina, Rakesh Kumar, C. Rajashekhar, Kerehalli Vinayaka Prasad, Sangeeta Kalal, Kottakkaran Sooppy Nisar

“…In this context, the aim of the present work focuses on modeling the magnetohydrodynamic peristaltic slip flow of Casson nanofluid and analyzing the role of multiple slip effects over a non‐uniform rough channel. A novel rough non‐uniform model is effectively governed by a set of nonlinear coupled governing partial differential equations, which are simplified under long wavelength and creeping flow approximations. …”
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