Intranasal Immunization with DNA Vaccine HA-CCL19/Polyethylenimine/Chitosan Composite Provides Immune Protection Against H7N9 Infection by Yuqing Xiang, Hongbo Zhang, Youcai An, Ze Chen

“…Background/Objectives: The H7N9 avian influenza virus (AIV) constitutes a novel subtype of influenza virus that has emerged within the past decade. …”
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Precision Adverse Drug Reactions Prediction with Heterogeneous Graph Neural Network by Yang Gao, Xiang Zhang, Zhongquan Sun, Payal Chandak, Jiajun Bu, Haishuai Wang

“…Traditional machine learning‐based methods primarily focus on predicting potential ADRs for drugs, but they often fall short of capturing the complexity of individual demographics and the variations in ADRs experienced by different people. In this study, a novel framework called Precise Adverse Drug Reaction (PreciseADR) for patient‐level ADR prediction is proposed. …”
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Validation of cantilever-enhanced photoacoustic particle-size-resolved light absorption measurement using nigrosin reference particles and Mie modelling by J. Kuula, J. Kuula, J. Karhu, J. Karhu, T. Mikkonen, P. Grahn, A. Virkkula, A. Virkkula, H. Timonen, T. Hieta, T. Hieta, M. Vainio, M. Vainio

“…To investigate the lensing effect, this study introduces and validates a novel method for size-resolved light absorption measurements using nigrosin particles as a model system. …”
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Clinical Characteristics and Outcomes of COVID-19 in Children in Northern Iran by Leila Shahbaznejad, Hamed Rouhanizadeh, Mohammad Reza Navaeifar, Fatemeh Hosseinzadeh, Faeze Sadat Movahedi, Mohammad Sadegh Rezai

“…Since December 2019, the coronavirus disease 2019 (COVID-19) has been spread rapidly all over the world, infecting all age groups with this novel virus. In this manuscript, we report characteristics of children with COVID-19 in Mazandaran province, northern Iran. …”
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Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: Molecular mechanisms and targeted therapies by Pinglian Yang, Xiaoling Rong, Zhechang Gao, Jiaojiao Wang, Zhiping Liu

“…Fundamental studies that elucidate the mechanisms by which metabolic and epigenetic regulation of macrophage polarization influence atherosclerosis will pave the way for novel therapeutic approaches.…”
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Clinical Characteristics of COVID-19 Patients with and without Diabetes in Wuhan Red Cross Hospital by Guozhen Li, Qin Deng, Jiali Feng, Fang Li, Nian Xiong, Qiong He

“…Since the end of December 2019, novel coronavirus- (SARS-CoV-2-) infected pneumonia (COVID-19) has spread rapidly in China. …”
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Optimizing personalized psychological well-being interventions through digital phenotyping: results from a randomized non-clinical trial by Giulia Rocchi, Giulia Rocchi, Emanuela Vocaj, Simone Moawad, Alessandro Antonucci, Carlo Grigioni, Vincenzo Giuffrida, Joy Bordini

“…Digital phenotyping, which involves the collection of behavioral and physiological data using smartphones, offers a novel way to understand and monitor mental health. …”
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Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction by Li T, Yang B, Liu X, Shi D, Wang Z, Chen Y, Shen C

“…This study aims to develop selenium-quantum-dot-loaded porous silica nanospheres (Se@PSN) as a novel therapeutic approach to address IR injury.Patients and Methods: Se@PSN were synthesized and tested for their reactive oxygen species (ROS) scavenging capabilities and biocompatibility. …”
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Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome by Eva Drnovsek, Mojca Jensterle, Katja Goričar, Sara Redenšek, Andrej Janež, Irina Milisav, Vita Dolžan

“…Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS). …”
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Effect over coagulation and fibrinolysis parameters of a prolonged release 24 + 4 daily use regime contraceptive formulation containing 2 mg dienogest/0.02 mg ethinylestradiol... by Pedro-Antonio Regidor, Alicyoy Angulo, Enrico Colli

“…Background A prolonged release combined oral contraceptive (COC) pill, containing 2 mg dienogest (DNG)/0.02 mg ethinylestradiol (EE) in a 24 + 4 daily dosing regimen has recently been approved in Europe.Objective To determine if this COC impacts coagulation and fibrinolytic factors in comparison to an immediate release COC containing 3 mg drospirenone (DRSP)/0.02 mg EE.Method Forty-four patients received the novel product, and forty-seven the comparator (immediate release formulation) during nine complete cycles. …”
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Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat by John Garcia, Claire Mennan, Helen S. McCarthy, Sally Roberts, James B. Richardson, Karina T. Wright

“…The findings from this study have significant clinical implications for the refinement and development of novel cell-based cartilage repair strategies.…”
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Genetic Variation of the DGAT1 gene in Dual-Purpose Dairy Cows and its Influence on Economically Important Breeding Traits by Mark E Armitage, Emma Swan, Denise O'Meara

“…MethodsDNA was extracted from hair samples, and the genotypes of the DGAT1 gene were determined using a combination of conventional PCR, restriction fragment length polymorphism (RFLP), gel electrophoresis, DNA sequencing and novel real-time PCR assays. ResultsThe three genotypes within the herd were: KK (n = 5), AA (n = 10), KA (n = 8). …”
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Accelerated development of multi-component alloys in discrete design space using Bayesian multi-objective optimisation by Osman Mamun, Markus Bause, Bhuiyan Shameem Mahmood Ebna Hai

“…However, the application of these protocols in materials science, particularly in the design of novel alloys with multiple targeted properties, remains constrained by computational complexity and the absence of reliable and robust acquisition functions for multiobjective optimisation. …”
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Plant genetic resources in India: management and utilization by K. Singh, K. Gupta, V. Tyagi, S. Rajkumar

“…Presently, our focus is on characterization of ex situ conserved germplasm and detailed evaluation of prioritized crops for enhanced utilization; assessment of impact of on-farm conservation practices on genetic diversity; genome-wide association mapping for identification of novel genes and alleles for enhanced utilization of PGR; identification and deployment of germplasm/landraces using climate analog data; validation of trait-specific introduced germplasm for enhanced utilization.…”
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All-Optically Controlled Memristive Device Based on Cu2O/TiO2 Heterostructure Toward Neuromorphic Visual System by Jun Xie, Xuanyu Shan, Ningbo Zou, Ya Lin, Zhongqiang Wang, Ye Tao, Xiaoning Zhao, Haiyang Xu, Yichun Liu

“…The optoelectronic memristor integrates the multifunctionalities of image sensing, storage, and processing, which has been considered as the leading candidate to construct novel neuromorphic visual system. In particular, memristive materials with all-optical modulation and complementary metal oxide semiconductor (CMOS) compatibility are highly desired for energy-efficient image perception. …”
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Pyrolysis and Dioxin Production Characteristics of Mineralized Waste in Landfills by Jian-Ying Fu, Han-Cheng Ma, Wen-Tao Jiao, Xu Xu, Xiao-Qing Lin, Xiao-Dong Li, Ming-Xiu Zhan

“…The experimental results of this study provide novel technical guidance for the resource utilization of MW.…”
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SAR Image Simulation for Crater Terrain Using Formation Theory-Based Modeling and Hybrid Ray-Tracing by Ya-Ting Zhou, Yongsheng Zhou, Qiang Yin, Fei Ma, Fan Zhang

“…To overcome these limitations, this article introduces a novel approach to simulating SAR images of crater terrain. …”
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Isolation of Cellulose from Wheat Straw Using Alkaline Hydrogen Peroxide and Acidified Sodium Chlorite Treatments: Comparison of Yield and Properties by Umair Qasim, Zulfiqar Ali, Muhammad Shahid Nazir, Sadaf Ul Hassan, Sikander Rafiq, Farrukh Jamil, Ala’a H. Al-Muhtaseb, Muzaffar Ali, Muhammad Bilal Khan Niazi, Nasir M. Ahmad, Sami Ullah, Ahmad Mukhtar, Sidra Saqib

“…Environmental concerns due to excessive use of synthetic or petroleum-based materials have encouraged scientists to develop novel, sustainable, and multifunctional material using abundant lignocellulosic biomass. …”
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Using maternal sepsis patient journeys to map and prioritise barriers to quality maternal healthcare in Malawi: a multidisciplinary stakeholder consultation workshop by Yamikani Chimwaza, Dalisto Ndaferankhande, Leonard Mndala, Chifundo Ndamala, Emily Lifa, Mercy Machilika, Esther Mwagomba, Bernard Dossie, Meliya Kwelepeta, Bertha Maseko, David Lissauer, Maria Lisa Odland

“…Conclusions Patient journeys are a novel tool for capturing the experience of care in Malawi. …”
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In silico tools for mechanical analysis of extra‐ and intra‐luminal artificial urinary sphincters by Gianluca Mazzucco, Paola Pirini, Chiara Giulia Fontanella, Alice Berardo, Maria Vittoria Mascolini, Ilaria Toniolo, Leonardo Marziale, Tommaso Mazzocchi, Gioia Lucarini, Nicolò Spiezia, Emanuele Luigi Carniel

“…Conclusions The activities define and demonstrate the effectiveness of a novel in silico approach to the design and reliability assessment of AUS devices, increasing the investigative possibilities and reducing the time, ethical and economic costs.…”
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