Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening by Beenish Majeed, Supannikar Tawinwung, Lance S. Eberson, Timothy W. Secomb, Nicolas Larmonier, Douglas F. Larson

“…To study the role of immune inhibitory cells, CD4+CD25+Foxp3+ regulatory T cells (Tregs), on vascular stiffness, we stimulated the proliferation of Treg lymphocytes in vivo using a novel cytokine immune complex of Interleukin-2 (IL-2) and anti-IL-2 monoclonal antibody clone JES6-1 (mAbCD25). …”
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Surface roughness and material removal of Si3N4 cylindrical rollers using double-side grinding with diamond film pads by Fenfen Zhou, Yongkang Jin, Qi Shao, Weifeng Yao, Hongyun Wang

“…This study introduces a novel double-side grinding method using Diamond Film Pads (DFPs) to process Si3N4 cylindrical rollers. …”
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Hybrid optimized artificial neural network using Latin hypercube sampling and Bayesian optimization for detection, classification and location of faults in transmission lines by Abdul Yussif Seidu, Elvis Twumasi, Emmanuel Assuming Frimpong

“…This paper introduces a novel hybrid approach that integrates Latin hypercube sampling (LHS) and Bayesian optimization for optimizing artificial neural networks (ANNs) in fault detection, classification, and location for transmission lines. …”
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Optimal WSN Deployment to Measure Air Quality in Dynamic Multi-Source Dispersion Scenarios: A Case Study in Arequipa by Alexander Hilario-Tacuri, Alberth Tamo, Marco Pinares-Mamani, Walter Butron, Romel Jimenez

“…Thus, to address this public health challenge, this article introduces a novel dynamic multi-source dispersion model that accounts for variations in wind velocity and direction over time, recognizing that air pollution is influenced by rapidly changing environmental factors. …”
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Effects of Dietary Protein to Lipid Ratio and Insect Meal on Growth Performance, Feed Utilization, and the Gut Microbiome of Lake Whitefish (Coregonus clupeaformis) by Rebecca Lawson, Yubing Chen, Junyu Zhang, Marcia A. Chiasson, Jennifer Ellis, Dominique Bureau, Richard D. Moccia, David Huyben

“…The gut microbiome was dominated by Proteobacteria, specifically by the genera of Shewanella and Aeromonas, although feeding high-lipid diets resulted in the lowest alpha diversity, but was not significant. These results are novel for this species, and we recommend that lake whitefish diets should be formulated to have a minimum 54:18 protein-to-lipid ratio. …”
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Automated Phenotypic Analysis of Mature Soybean Using Multi-View Stereo 3D Reconstruction and Point Cloud Segmentation by Daohan Cui, Pengfei Liu, Yunong Liu, Zhenqing Zhao, Jiang Feng

“…This study develops a novel pipeline for acquiring the phenotypic traits of mature soybeans based on three-dimensional (3D) point clouds. …”
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MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation by Benshuai You, Can Jin, Jiaxin Zhang, Min Xu, Wenrong Xu, Zixuan Sun, Hui Qian

“…In conclusion, our results imply that MSC-derived EVs could be utilized as an effective nanovehicle to deliver L-PGDS for gastric cancer treatment, which provides a novel idea for the EV-based cancer therapy.…”
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Aspiration of acidified milk induces milk allergy by activating alveolar macrophages in mice by Akiko Nakaoka, Takayasu Nomura, Atsushi Suzuki, Kazuyoshi Ozeki, Hirohito Kita, Shinji Saitoh

“…Conclusions: We have developed a novel mouse model for CMA that utilizes the natural antigen and follows the physiological airway sensitization pathway, thus potentially resembling clinical scenarios. …”
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Exploration of interstitial fluid proteome in Homo sapiens forearm through a cutting edge intradermal microdialysis and high-throughput proteomics approach: a pilot study by Yu Sakamoto, Naoto Fujii, Junko Shibato, Ravi Gupta, Cheol Woo Min, Sun Tae Kim, Ranjith Kumar Bakku, Randeep Rakwal

“…This pilot study collected intradermal dialysate, reflective of ISF conditions, from human dorsal forearm (n = 1) using a novel vented-intradermal microdialysis probe, to analyze proteins, isolate them, and characterize their functions. …”
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CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. by John T Loffredo, Thomas C Friedrich, Enrique J León, Jason J Stephany, Denise S Rodrigues, Sean P Spencer, Alex T Bean, Dominic R Beal, Benjamin J Burwitz, Richard A Rudersdorf, Lyle T Wallace, Shari M Piaskowski, Gemma E May, John Sidney, Emma Gostick, Nancy A Wilson, David A Price, Esper G Kallas, Helen Piontkivska, Austin L Hughes, Alessandro Sette, David I Watkins

“…<h4>Methods and findings</h4>Here we show that three ECs in that study made at least seven robust CD8+ T cell responses directed against novel epitopes in Vif, Rev, and Nef restricted by the MHC class I molecule Mamu-B*08. …”
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Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease by Goh Eun Chung, Jeong Yoon Yim, Donghee Kim, Min-Sun Kwak, Jong In Yang, Su Jin Chung, Sun Young Yang, Joo Sung Kim

“…This finding provides novel evidence indicating that serum WBC counts may be potential surrogate markers of NAFLD.…”
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A scoping review of transmission models for soil-transmitted helminth infections to underpin the development of a transmission model for Strongyloides stercoralis by Mackrina Winslow, Juan Pablo Villanueva-Cabezas, Vito Colella, Patricia T. Campbell

“…A total of 47 studies presenting a new model or novel adaptation of an existing model to human STH infection transmission were identified: only one described S. stercoralis transmission in humans. …”
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The Integration of The Indonesian Stock Market With Developed Stock Markets: Pre- and Post-Covid-19 Pandemic by Tri Purwani, Rahmat Budi Santoso, Ana Kadarningsih

“…Originality/Value: This research offers a novel comparative analysis of stock market integration, highlighting Indonesia’s persistent market segmentation despite global shifts before and after the Covid-19 pandemic. …”
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Controlling the formation of microstructure at the melt-pool boundaries during directed energy deposition of aluminum alloy with a modified continuous growth restriction factor by Shanshan Xu, Bo Yin, Jiale Wang, Liquan Jin, Yu Yin, Zhenhua Li, David H. StJohn, Petro Pavlenko, Yueling Guo

“…This study fills the gap left by the inability of Q to explain the influence of solutes on the microstructure during DED, and presents a novel approach for analyzing the formation mechanism of solidified microstructure adjacent to the fusion boundary of the melt pool.…”
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Bismuth-Remaining Cupellation Fire Assay Preconcentration Combined with Inductively Coupled Plasma Mass Spectrometry for the Simultaneous Determination of Ultratrace Au, Pt, Pd, Ru... by Wenshan Ni, Xiangju Mao, Mingxing Yao, Qiliang Sun, Xiaorui Guo, Hongli Zhang, Lu Liu

“…In this work, a novel method of bismuth fire assay (Bi-FA) combined with inductively coupled plasma mass spectrometry (ICP-MS) simultaneous determination of ultratrace gold (Au), platinum (Pt), palladium (Pd), ruthenium (Ru), rhodium (Rh), and iridium (Ir) in geologic samples was established. …”
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New Platform Technology for Comprehensive Serological Diagnostics of Autoimmune Diseases by Annika Willitzki, Rico Hiemann, Vanessa Peters, Ulrich Sack, Peter Schierack, Stefan Rödiger, Ursula Anderer, Karsten Conrad, Dimitrios P. Bogdanos, Dirk Reinhold, Dirk Roggenbuck

“…To address the limitations of IIF and to meet the demand for cost-efficient autoantibody screening, automated IIF methods employing novel pattern recognition algorithms for image analysis have been introduced recently. …”
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Inorganic polyphosphate and the stringent response coordinately control cell division and cell morphology in Escherichia coli by Christopher W. Hamm, Michael J. Gray

“…Our results indicate that these systems, normally studied as stress-response mechanisms, play a coordinated and novel role in regulating cell division, morphology, and metabolism even under non-stress conditions.…”
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DeepRetention: A Deep Learning Approach for Intron Retention Detection by Zhenpeng Wu, Jiantao Zheng, Jiashu Liu, Cuixiang Lin, Hong-Dong Li

“…Here we present DeepRetention, a novel approach for IR detection by modeling the pattern of sequencing depth of introns. …”
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A Spontaneous Complexation–Exfoliation Strategy for a Flexible Anode Towards Superior Durable and Ultrafast Lithium-Ion Batteries by Heying Chu, Jingchuan Zhang, Pengsen Zhao, Yong Li, Zhaoxia Liu, Hongzhou Zhang

“…However, their inherent low conductivity, large volume effect, and poor cycling performance limit their applications. Herein, we report a novel “spontaneous complexation and exfoliation” strategy for the fabrication of flexible MnO NCs@rGO thin-film electrodes, which overcomes the aforementioned drawbacks and pushes the mechanical flexibility and lithium-ion (Li⁺) storage performance to a higher level. …”
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Eliciting Emotions: Investigating the Use of Generative AI and Facial Muscle Activation in Children’s Emotional Recognition by Manuel A. Solis-Arrazola, Raul E. Sanchez-Yanez, Ana M. S. Gonzalez-Acosta, Carlos H. Garcia-Capulin, Horacio Rostro-Gonzalez

“…This study explores children’s emotions through a novel approach of Generative Artificial Intelligence (GenAI) and Facial Muscle Activation (FMA). …”
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