Immune-mediated mechanisms in acute osteofascial compartment syndrome: insights from multi-omics analysis by Qinzhen Lu, He Ling, Yonghui Lao, Junjie Liu, Wei Su, Zhao Huang

“…Hence, there is an urgent need for research elucidating AOCS's pathogenic mechanism and exploring novel treatments. Methods To address this, we established a rat model of AOCS, extracting toe flexor muscles from both experimental and control groups. …”
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Vegetation optical depth as a key predictor for fire risk escalation by Dinuka Kankanige, Yi Y. Liu, Ashish Sharma

“…With further improvements, the proposed method can serve as a foundation for developing a novel forecast index solely based on time series data of fire risk and vegetation dynamics.…”
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Ellipsoid Zone Integrity and Visual Acuity Changes during Diabetic Macular Edema Therapy: A Longitudinal Study by Lucy J. Kessler, Gerd U. Auffarth, Dmitrii Bagautdinov, Ramin Khoramnia

“…In addition, our results underlined the potential of EZ parameters as novel OCT biomarkers for prediction of VA outcomes during therapy.…”
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Parametric Design and Mechanical Characterization of a Selective Laser Sintering Additively Manufactured Biomimetic Ribbed Dome Inspired by the Chorion of Lepidopteran Eggs by Alexandros Efstathiadis, Ioanna Symeonidou, Emmanouil K. Tzimtzimis, Dimitrios Avtzis, Konstantinos Tsongas, Dimitrios Tzetzis

“…(Lepidoptera, Nympalidae) and develop design solutions through the implementation of a novel strategy of biomimetic design. Scanning electron microscopy (SEM) analysis of the chorion reveals a medial zone that forms an arachnoid grid resembling a ribbed dome with convex longitudinal ribs and concave transverse ring members. …”
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Laser Welding of Micro-Wire Stent Electrode as a Minimally Invasive Endovascular Neural Interface by Bo Wen, Liang Shen, Xiaoyang Kang

“…To ensure consistent results, a novel micro-wire welding with platinum pad method was introduced during the welding process. …”
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Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice by Gaifen Li, Qiong Wu, Chao Wang, Pin Deng, Jiaxin Li, Zhiguang Zhai, Yubo Li

“…Morris water maze and novel object recognition were used to detect the cognitive function of each mouse. …”
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Efficient photocatalytic degradation of bisphenol A on 2D-3D spherically hierarchical structure Zn5In2S8 by Zongwen Zhang, Yi Zhang, Huili Han, Riyadh Ramadhan Ikreedeegh, Riyadh Ramadhan Ikreedeegh, Syed Shoaib Ahmad Shah, Muhammad Tayyab

“…In this study, we present the synthesis and application of a novel 2D-3D spherically hierarchical Zn5In2S8 (ZIS) photocatalyst for the photocatalytic degradation of BPA under visible light for the first time. …”
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Exploring Echinacea angustifolia for anti-viral compounds against Zika virus RNA-dependent RNA polymerase: a computational study by Mai M. El-Daly, Leena H. Bajrai, Thamir A. Alandijany, Isra M. Alsaady, Hattan S. Gattan, Meshari M. Alhamdan, Vivek Dhar Dwivedi, Esam I. Azhar

“…Our research sheds light on the viability of these E. angustifolia compounds as ZIKV RDRP inhibitors, laying a foundation for further experimental research in developing novel antiviral treatments against ZIKV infections.…”
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Effect of ubiquitin-specific proteinase 43 on ovarian serous adenocarcinoma and its clinical significance by Qin Li, Wenhao Li, Jiahao Wang, Wenjing Shi, Taorong Wang

“…It postulates USP43 as a novel therapeutic target for ovarian cancer treatment.…”
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The Effects of Synthetic Polymers on the Release Patterns of Bupivacaine Hydrochloride from Sodium Hyaluronate Hydrogels by Dorota Wójcik-Pastuszka, Roksana Iwaszkiewicz, Witold Musiał

“…Objectives: The aim of this investigation is to propose a novel HA (sodium hyaluronate)-based hydrogel for intra-articular injection doped with synthetic polymers and incorporated with bupivacaine hydrochloride (Bu) as a local anesthetic. …”
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HPRS: hierarchical potential-based reward shaping from task specifications by Luigi Berducci, Edgar A. Aguilar, Dejan Ničković, Radu Grosu

“…Using a potential-based formulation, we enhance sparse to dense rewards and formally prove this to maintain policy optimality. We call our novel approach hierarchical, potential-based reward shaping (HPRS). …”
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On the Development of Vehicle Dynamics Active Systems: The Handling Stability Ratio as a Strategic Indicator for Integrating Multiple Actuators by Roberto Aratri, Stefano de Pinto, Giuseppe Guastadisegni, Antonio Gonzalez, Aldo Sorniotti, Francesco Bottiglione, Giacomo Mantriota

“…To address the gap, this paper introduces and analyzes a novel performance indicator, the Handling Stability Ratio (HSR). …”
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Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie Fauchée, and a Split Papule at the Oral Commissure: Case Report and Review by Walter de Araujo Eyer-Silva, Maria Alessandra Leite Freire, Cecília Angelina Horta-Araujo, Guilherme Almeida Rosa da Silva, Jorge Francisco da Cunha Pinto, Fernando Raphael de Almeida Ferry

“…The oral lesions were considered highly suggestive of secondary syphilis. A novel VDRL assay (which was previously negative) yielded a titer of 1/128. …”
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The use of the Prospector calculator reduces antibiotic therapy in exacerbations of chronic obstructive pulmonary disease by Marcin Paprocki, Szymon Żwirowski, Krzysztof Kuziemski

“…This study was designed to explore the hypothesis that utilization of a novel decision-making tool called Prospector would lead to lower consumption of antibiotics and provide a more rational approach to managing COPD exacerbations versus standard therapy in patients with COPD. …”
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Microwave-Assisted Method for Simultaneous Hydrolysis and Extraction for Preparation of Geniposidic Acid from Eucommia ulmoides Bark Using Basic Imidazolide Ionic Liquid by Lili Li, Yupin Guo, Chunchao Zhao, Mengxia Wei, Junling Liu, Yuangang Zu, Fei Wang, Lei Yang

“…In order to hydrolyze geniposide and extract geniposidic acid, a novel microwave irradiation heating method for simultaneous hydrolysis and extraction for preparation of geniposidic acid from Eucommia ulmoides bark using basic imidazolide ionic liquid was developed in this work. …”
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Photoswitch dissociation from a G protein-coupled receptor resolved by time-resolved serial crystallography by Hannah Glover, Torben Saßmannshausen, Quentin Bertrand, Matilde Trabuco, Chavdar Slavov, Arianna Bacchin, Fabio Andres, Yasushi Kondo, Robin Stipp, Maximilian Wranik, Georgii Khusainov, Melissa Carrillo, Demet Kekilli, Jie Nan, Ana Gonzalez, Robert Cheng, Werner Neidhart, Tobias Weinert, Filip Leonarski, Florian Dworkowski, Michal Kepa, Josef Wachtveitl, Michael Hennig, Joerg Standfuss

“…This innovative approach provides insights into GPCR dynamics at the atomic level, offering potential for developing novel pharmaceuticals.…”
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Androgen Receptor-Target Genes in African American Prostate Cancer Disparities by Bi-Dar Wang, Qi Yang, Kristin Ceniccola, Fernando Bianco, Ramez Andrawis, Thomas Jarrett, Harold Frazier, Steven R. Patierno, Norman H. Lee

“…Chromatin immunoprecipitation confirmed STAT1, RHOA, ITGB5, MAPKAPK2, CSNK2A,1 and PIK3CB genes as novel AR targets in PCa disparities. Moreover, functional screens revealed that androgen-stimulated AR binding and upregulation of RHOA, ITGB5, and PIK3CB genes were associated with increased invasive activity of AA PCa cells, as siRNA-mediated knockdown of each gene caused a loss of androgen-stimulated invasion. …”
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Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort by J. Korduner, P. M. Nilsson, O. Melander, M. J. Gerl, G. Engström, E. Bachus, M. Magnusson, F. Ottosson

“…This unique and extensive biomarker profiling presents novel data on potentially differentiating traits between these two obese phenotypes.…”
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Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells by Zheng Zhang, Huaxiang Xu, Junyi He, Qiangsheng Hu, Yuxin Liu, Zijin Xu, Wenhui Lou, Wenchuan Wu, Lei Zhang, Ning Pu, Chenye Shi, Yaolin Xu, Wenquan Wang, Liang Liu

“…Abstract As a novel form of nonapoptotic cell death, ferroptosis is developing into a promising therapeutic target of dedifferentiating and therapy-refractory cancers. …”
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A review on challenges and future of green charging networks for zero emission electric transportation by Ijaz Ahmed, Muhammad Maaruf, Amjad Ali, Mohammad AlMuhaini, Muhammad Khalid

“…Using independent and interlinked mathematical models, authors examine contemporary computational approaches that manage corporate architectural challenges in novel manners. The aim of this work is to investigate potential avenues for future research, with a focus on attaining sustainable mobility while also promoting the intelligent advancement of microgrids. …”
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