Methylcobalamin-containing nanofiber sheets have better neuroprotective effects than small intestinal submucosa sheets by Yoshiaki Yoshimura, Toru Iwahashi, Taisuke Kasuya, Toshiki Shimada, Katsuyuki Konishi, Atsushi Kamata, Mai Konishi, Arisa Kazui, Ryoya Shiode, Satoshi Miyamura, Kunihiro Oka, Seiji Okada, Hiroyuki Tanaka

“…The use of MeCbl sheets may represent a novel approach for preventing secondary nervous system impairment following inflammation.…”
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A retrospective study on tolvaptan prescription in clinical practice in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) using the Japanese claims... by Daisuke Hagiwara, Miyuki Matsukawa, Junko Tasaki, Yumiko Nakamura, Hiroshi Arima

“…We aimed to survey the status of tolvaptan administration in routine clinical practice since the approval of a novel indication for treating syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in Japan. …”
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Retrotrans-genomics identifies aberrant THE1B endogenous retrovirus fusion transcripts in the pathogenesis of sarcoidosis by Shunsuke Funaguma, Aritoshi Iida, Yoshihiko Saito, Jantima Tanboon, Francia Victoria De Los Reyes, Kyuto Sonehara, Yu-ichi Goto, Yukinori Okada, Shinichiro Hayashi, Ichizo Nishino

“…Single-cell or single-nucleus RNA-seq analyses of sarcoidosis not only confirmed these transcripts but also revealed a novel read-through transcript, SIRPB1-SIRPD, and TREM2.1, predominantly in granuloma-associated macrophages. …”
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Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing by Shumin Pang, Dongwei Wu, Dorian A H Hanaor, Astrid Haibel, Jens Kurreck, Aleksander Gurlo

“…This study introduces a novel strategy that combines rotational three-dimensional (3D) printing technology and sponge replication technique to fabricate bone-mimetic scaffolds based on composite materials comprising copper-substituted diopside and biphasic calcium phosphate. …”
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Exopolysaccharides from camel milk-derived Limosilactobacillus reuteri C66: Structural characterization, bioactive and rheological properties for food applications by A.K.M. Humayun Kober, Mohamed Abdin, Athira Subhash, Shao-Quan Liu, Enes Dertli, Basim Abu-Jdayil, Pau-Loke Show, Mutamed Ayyash

“…The current study highlights that EPS-C66 can enhance the health benefits and rheological properties of foods, contributing to the development of novel functional foods.…”
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Advancing dynamic quantum crystallography: enhanced models for accurate structures and thermodynamic properties by Helena Butkiewicz, Michał Chodkiewicz, Anders Ø. Madsen, Anna A. Hoser

“…While electron-density modelling has seen considerable progress [e.g. the Hansen–Coppens multipole model and Hirshfeld Atom Refinement (HAR)], the treatment of thermal motion has remained largely unchanged. We have developed a novel method that combines the strengths of the advanced charge-density models [Aspherical Atom Models (AAMs), such as HAR or the Transferable Aspherical Atom Model (TAAM)] and the thermal motion model (normal modes refinement, NoMoRe). …”
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Current molecular understanding of central nervous system schwannomas by Takahiro Tsuchiya, Satoru Miyawaki, Yu Teranishi, Kenta Ohara, Yudai Hirano, Shotaro Ogawa, Seiei Torazawa, Yu Sakai, Hiroki Hongo, Hideaki Ono, Nobuhito Saito

“…Main body Recent research has also uncovered novel genetic alterations, such as the SH3PXD2A::HTRA1 fusion gene, VGLL-fusions in intraparenchymal CNS schwannomas, and the SOX10 mutation particularly in non-vestibular cranial nerve schwannomas. …”
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Prediction of Pt, Ir, Ru, and Rh complexes light absorption in the therapeutic window for phototherapy using machine learning by V. Vigna, T. F. G. G. Cova, A. A. C. C. Pais, E. Sicilia

“…While ML models have been used to predict UV–vis properties of organic molecules, applying this to metal complexes is novel. The model is efficient, fast, and resource-light, using decision tree-based algorithms that provide interpretable results. …”
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Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents by Hafez Hend N., Alsalamah Sulaiman A., El-Gazzar Abdel-Rhman B. A.

“…A novel series of carbamothioylamino-benzene-sulfonamide-thiophene-carboxylates 4a-c and thieno[3,2-d]pyrimidin-2-yl-amino-benzene-sulfonamides 5a-c were synthesized in a series of synthetic steps and were used as key intermediates for the synthesis of thienotriazolopyrimidine-benzene-sulfonamide derivatives 6a-c and 7a-c. …”
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‘In the shadows of a giant?’ A spatial analytical method for assessing coastal proximity using R: a case-study from the Bronze Age Saronic Gulf (Greece) by Christopher Nuttall

“…Highlights: • The study introduces novel methods in spatial analysis to reinterpret long-standing archaeological theories about settlement distribution • Spatial analysis reveals fluctuating proximity of Bronze Age settlements to the coast in the Saronic Gulf, influenced by socio-cultural and climatic changes…”
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Administration of PDE4 Inhibitors Suppressed the Pannus-Like Inflammation by Inhibition of Cytokine Production by Macrophages and Synovial Fibroblast Proliferation by Katsuya Kobayashi, Toshio Suda, Haruhiko Manabe, Ichiro Miki

“…These results indicate this model makes it easy to evaluate the effect of drugs on various cytokine productions in a granuloma without any purification step and may be a relevant model for evaluating novel antirheumatic drugs on pannus formation in RA. …”
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Multifidelity co-kriging metamodeling based on multivariate data fusion for dynamic fit improvement of injection mechanism in squeeze casting by Dongdong You, Zhekai Lin, Fenglei Li, Wenbin Pang

“…To improve the dynamic fit the injection mechanism in a squeeze casting machine, this paper proposes a novel multifidelity co-kriging (MFCK) metamodeling method, which fuses high-fidelity measured data with low-fidelity simulated data and considers data uncertainty and multivariate correlation influence to accurately predict response values when experimental sample data are insufficient. …”
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Well Pattern and Well Spacing Optimization of Large Volume Water Injection in a Low-Permeability Reservoir with Pressure Sensitivity by Jie Zhan, Yafei Tian, Chao Fan, Xianlin Ma, Ren-Shi Nie, Dongqi Ji, Teng Li, Hongyan Yu

“…Thus, the conventional well spacing of certain well pattern is not suitable for the novel injection scheme. In the paper, the optimal well pattern and well spacing for the large volume water injection scheme to develop a pressure-sensitive low-permeability reservoir is investigated. …”
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Silk-engineered bioactive nanoparticles for targeted alleviation of acute inflammatory disease via macrophage reprogramming by Renfeng Liu, Erkang Zhao, Yejing Wang, Hua Zuo, Lanlan Li, Qingyou Xia, Huawei He

“…Herein, we introduce a novel silk-based bioactive material, TPSF, developed by sequentially conjugating Tempol and phenylboronic acid pinacol ester to silk fibroin. …”
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Effect of Lacticaseibacillus rhamnosus Yoba Fermentation on Physicochemical Properties, Amino Acids, and Antioxidant Activity of Cowpea-Peanut Milk by Armistice Chawafambira, Talknice Zvamaziva Jombo, Tafadzwa Mkungunugwa

“…This study evaluated the probiotic potential, physicochemical, and sensory properties of novel fermented cowpea-peanut milk with Lacticaseibacillus rhamnosus Yoba. …”
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PARP inhibitors as therapy for small cell lung carcinoma: A systematic review and meta-analysis of clinical trials by Samuel Pratama, Lowilius Wiyono, Martien Silviandy Setiawan, Brigitta Cindy Lauren

“…Poly ADP-Ribose Polymerase inhibitors (PARPi) are novel anti-cancer agents that induce DNA damages and cause cell death in tumor cells with impaired DNA repair, known as the synthetic lethality concept. …”
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PBVit: A Patch-Based Vision Transformer for Enhanced Brain Tumor Detection by Pratikkumar Chauhan, Munindra Lunagaria, Deepak Kumar Verma, Krunal Vaghela, Ghanshyam G. Tejani, Sunil Kumar Sharma, Ahmad Raza Khan

“…In PBvit we presents a novel brain tumor detection framework, the Patch Base Vision Transformer (PBVit). …”
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A Deep Learning-Based Approach for the Detection of Various Internet of Things Intrusion Attacks Through Optical Networks by Nouman Imtiaz, Abdul Wahid, Syed Zain Ul Abideen, Mian Muhammad Kamal, Nabila Sehito, Salahuddin Khan, Bal S. Virdee, Lida Kouhalvandi, Mohammad Alibakhshikenari

“…This research introduces XIoT, which is a novel explainable IoT attack detection model designed to address these challenges. …”
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The Effect of Mesenchymal Stem Cell-Derived Exosomes and miR17-5p Inhibitor on Multicellular Liver Fibrosis Microtissues by Farnaz Sani, Mina Soufi Zomorrod, Negar Azarpira, Masoud Soleimani

“…Therefore, we propose this novel MLM model to understand fibrosis mechanisms better and develop new drugs.…”
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Newly isolated halotolerant Gordonia terrae S-LD serves as a microbial cell factory for the bioconversion of used soybean oil into polyhydroxybutyrate by Song Xu, Ruiqin Han, Lidan Tao, Zhipeng Zhang, Junfei Gao, Xinyuan Wang, Wei Zhao, Xiaoxia Zhang, Zhiyong Huang

“…In addition, the whole genome was sequenced, and the PHB biosynthetic pathway and quantitative expression of key genes were delineated in the novel isolated strain. In conclusion, this research introduces the first instance of polyhydroxyalkanoate (PHA) production by Gordonia terrae using used soybean oil as the exclusive carbon source, which will enrich strain resources for future PHB biosynthesis.…”
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