Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation by Xuan Deng, Lu Chang, Lingyu Tang, Haoqin Jiang, Xiao Xu, Xinju Zhang, Jian Chen, Liu Dong, Qianqian Xu, Ruoshui Cao, Jianbin Xiang, Ming Guan

“…Thus, lncRNA GDIL is a novel target to promote GSH degradation and augment platinum therapy.…”
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Gut microbiota dysfunction in Crohn’s disease by Sylvie Buffet-Bataillon, Sylvie Buffet-Bataillon, Gabriela Durão, Isabelle Le Huërou-Luron, Olivier Rué, Olivier Rué, Yann Le Cunff, Vincent Cattoir, Guillaume Bouguen

“…Here, we investigated metagenomic functions using PICRUSt2 during the course of CD to better understand microbiota-related disease mechanisms and provide new insights for novel therapeutic strategies.MethodsWe performed 16S rRNA-based microbial profiling of 567 faecal samples collected from a cohort of 383 CD patients, including 291 remissions (CR), 177 mild-moderate (CM) and 99 severe (CS) disease states. …”
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Current Perspectives on Treatment of Gram-Positive Infections in India: What Is the Way Forward? by Atul P. Kulkarni, Vasant C. Nagvekar, Balaji Veeraraghavan, Anup R. Warrier, Deepak TS, Jaishid Ahdal, Rishi Jain

“…The most important step is development of newer antimicrobial agents with novel mechanisms of action and favourable pharmacokinetic profile. …”
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Effects of culturally-appropriate group education for migrants with type 2 diabetes in primary healthcare: pre-test-post-test design by Katarina Hjelm, Emina Hadziabdic

“…However, this study is the only to evaluate the effects of a culturally appropriate diabetes intervention for these migrants on diabetes knowledge and health outcomes, adding a novel perspective to the existing literature. The aim of the study was to evaluate the effects on diabetes knowledge, HbA1c, and self-rated health of a previously developed, culturally appropriate diabetes education model, based on individual beliefs about health and illness, underpinned by knowledge, and conducted through focus group discussions. …”
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Non-Redox-Based Electrochemical Detection of Adrenaline: A Simple and Reliable Approach Using Glass Nanopipets by Ralph J. Page, Gene Koifman, Noel Manring, Jessica L. Smeltz, Pavithra Pathirathna

“…The detection of adrenaline (Adr) is essential for monitoring physiological and clinical conditions, including stress response, cardiovascular health, and neurological disorders. We present a novel glass-nanopipet electrode sensor based on a non-redox ion-transfer approach using ion transfer across two immiscible electrolyte solutions (ITIES). …”
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PGTransNet: a physics-guided transformer network for 3D ocean temperature and salinity predicting in tropical Pacific by Song Wu, Senliang Bao, Wei Dong, Senzhang Wang, Xiaojiang Zhang, Chengcheng Shao, Junxing Zhu, Xiaoyong Li

“…In this paper, we proposed PGTransNet, a novel physics-guided transformer network for 3D Ocean temperature and salinity forecasting. …”
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Advanced Driver-Assistance System (ADAS) for Intelligent Transportation Based on the Recognition of Traffic Cones by Liyong Wang, Peng Sun, Min Xie, Shaobo Ma, Boxiong Li, Yuchen Shi, Qinghua Su

“…The result indicates that this novel method could recognize the red, blue, and yellow traffic cones with 85%, 100%, and 100% success rate, respectively, while maintaining 90% accuracy in traffic-cone distance sensing. …”
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Segmental ischemia and indocyanine green navigation: impact on perioperative parameters in laparoscopic vs. open partial nephrectomy by R.M. Molchanov, O.O. Honcharuk, G.G. Khareba, O.B. Blyuss, R.V. Duka

“…The aim of this study is to compare perioperative parameters of laparoscopic partial nephrectomy and open partial nephrectomy in renal tumor management, and to evaluate the effect of using novel method of indocyanine green navigation in segmental ischemia on these parameters. …”
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Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India by Nabeela Usmani, Mukhtar Ahmad, Saba Khan, Mohammad Mustufa Khan, Haseeb Ahsan, Sadaf Parveen, Roshan Alam

“… Background: Coronavirus disease 2019 (Covid-19) is a novel disease caused by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). …”
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High Intestinal and Systemic Levels of Interleukin-23/T-Helper 17 Pathway in Chinese Patients with Inflammatory Bowel Disease by Lu Song, Rui Zhou, Sha Huang, Feng Zhou, Shufang Xu, Wei Wang, Fengming Yi, Xiaobing Wang, Bing Xia

“…Taken together, our results provided evidence that IL-23/Th17 pathway genes may represent important biomarkers of active stage of IBD and serve as novel therapeutic targets for IBD in Chinese population.…”
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Edge-Preserving Probabilistic Downsampling for Reliable Medical Segmentation in Resource-Constrained Environments by Shahzad Ali, Yu Rim Lee, Soo Young Park, Won Young Tak, Soon Ki Jung

“…This study introduces a novel approach, Edge-Preserving Probabilistic Downsampling (EPD), designed to retain critical details and bridge the performance gap between networks trained on original and downsampled resolutions. …”
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Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-κB Signaling by Xiaokang Zeng, Kai Xu, Ji Wang, Yunqi Xu, Shaogang Qu

“…Hence, our findings elucidate a novel protective mechanism of AA in astrocytes.…”
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Light and dark biofilm adaptation impacts larval settlement in diverse coral species by Paul A. O’Brien, Sara C. Bell, Laura Rix, Abigail C. Turnlund, Shannon R. Kjeldsen, Nicole S. Webster, Andrew P. Negri, Muhammad A. Abdul Wahab, Inka Vanwonterghem

“…Conclusions Our work identifies novel microbial groups that significantly influence coral larval settlement, which can be targeted for the discovery of settlement-inducing metabolites for implementation in reef restoration programs. …”
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Health State Utility Values in Children and Adolescents with Disabilities: A Systematic Review by Lucy Kanya, PhD, Nana Anokye, PhD, Ahmad Hecham Alani, PharmD, Nandini Jayakumar, MSc, Jennifer M. Ryan, PhD

“…Studies quality was assessed using a novel tool derived from 3 validated checklists. Results: Of the 3541 screened articles, 31 met inclusion criteria. …”
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CXCL8 modulates M0 macrophage proliferation and polarization to influence tumor progression in cervical cancer by Xiyan Zhao, Li Yang, Jigang Pan, Zhirui Zeng, Tuo Zhang, Yushi Yang, Jingjing Zhang, Tengxiang Chen, Ziwen Xiao, Wei Pan

“…These findings position M0 macrophages as central regulators within the TME and suggest that targeting pathways like CXCL8 could provide novel therapeutic strategies for improving outcomes in CESC patients.…”
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e-GLR Score Predicts Early Graft Loss in Adult Live-Donor Liver Transplantation by Viniyendra Pamecha, MS, MRCS, FRCS, FEBS, Nilesh Sadashiv Patil, MS, MCh, Tharun Gattu, MS, Guresh Kumar, MSc, MPhil, PhD, Bramhadatta Pattnaik, MS, MCh, Nihar Mohapatra, MS, MCh, Gaurav Sindwani, MD, PDCC, Ashok Choudhury, MD, DM

“…Internal cross-validation revealed a high predictive value (C-statistic = 0.858). Conclusions:. Our novel risk score can efficiently predict early allograft loss following graft dysfunction, which enables donor-recipient matching, evaluation, and prognostication simply and reliably in adult LDLT.…”
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Biodiversity reporting: Comparing listed entities in the United Kingdom and South Africa by Dino Da Mata, Timothy Lai, Dusan Ecim, Warren Maroun, Dannielle Cerbone

“…First, it provides one of the first comparative analyses of biodiversity reporting between a developing and developed economy, offering novel insights into how different jurisdictional contexts influence reporting practices. …”
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Quantification of modal mineralogy in molybdenite-bearing drill-core samples by laser-induced breakdown spectroscopy by Jonnathan Álvarez, Germán Velásquez, Iván Arévalo, Jorge Yáñez, Claudio Sandoval-Muñoz, Benjamín Sepúlveda

“…This study assesses conventional procedures to quantify modal mineralogy, that includes an initial drill-core logging, followed by petrographic descriptions and SEM-based automated mineralogy analyses performed in selected regions of interest, against a novel approach using laser-induced breakdown spectroscopy (LIBS). …”
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COph100: A comprehensive fundus image registration dataset from infants constituting the “RIDIRP” database by Yan Hu, Mingdao Gong, Zhongxi Qiu, Jiabao Liu, Hongli Shen, Mingzhen Yuan, Xiaoqing Zhang, Heng Li, Hai Lu, Jiang Liu

“…To address this gap, we introduce COph100, a novel and challenging dataset known as the Comprehensive Ophthalmology Retinal Image Registration dataset for infants with a wide range of image quality issues constituting the public “RIDIRP” database. …”
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Revisiting the Link Between HLA‐DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non‐Shared Epitope Alleles *09 and *15 With High Levels of Anti–Citrullinate... by Denis Lagutkin, Luis Panaifo, Ahmad‐Fauzi Nurul‐Aain, Lena Israelsson, Monika Hansson, Karin Lundberg, Lars Alfredsson, Johan Askling, RACI consortium, Lars Klareskog, Chun‐Lai Too, Leonid Padyukov

“…Results Our data show that non‐shared epitope alleles HLA‐DRB1*09 and *15 exhibit significant associations with ACPA levels. Notably, these novel associations were independent of ethnicity. …”
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