Bilayer 3D co‐culture platform inducing the differentiation of normal fibroblasts into cancer‐associated fibroblast like cells: New in vitro source to obtain cancer‐associated fibr... by Yeon Ju Kim, Hyeon Song Lee, Dohyun Kim, Hwa Kyung Byun, Woong Sub Koom, Won‐Gun Koh

“…Abstract This study presents a novel in vitro bilayer 3D co‐culture platform designed to obtain cancer‐associated fibroblasts (CAFs)‐like cells. …”
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Kinect-Based Correction of Overexposure Artifacts in Knee Imaging with C-Arm CT Systems by Johannes Rausch, Andreas Maier, Rebecca Fahrig, Jang-Hwan Choi, Waldo Hinshaw, Frank Schebesch, Sven Haase, Jakob Wasza, Joachim Hornegger, Christian Riess

“…Objective. To demonstrate a novel approach of compensating overexposure artifacts in CT scans of the knees without attaching any supporting appliances to the patient. …”
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Targeted Inhibition of the miR-199a/214 Cluster by CRISPR Interference Augments the Tumor Tropism of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Hypoxic Con... by Yumei Luo, Xuehu Xu, Xiuli An, Xiaofang Sun, Shu Wang, Detu Zhu

“…These findings suggest a novel application of CRISPRi in NSC-based tumor-targeted gene therapy.…”
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Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis by Yao Zhang, Nan Mu, Shun Qi, Chuanzhu Sun, Yang Rao, Xinyi Yang, Jianying Guo, Yunfeng Mu

“…There is an urgent need for clarifying the pathogenesis and developing novel treatment methods.MethodsSubjects were recruited for the collection of Magnetic Resonance Imaging data and clinical scales. …”
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The consensus rye microsatellite map with EST-SSRs transferred from wheat by D. O. Vidakovic, D. Perovic, T. V. Semilet, A. Börner, E. K. Khlestkina

“…One of the sources of novel SSR markers in rye are microsatellites transferable from the wheat genome. …”
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Maximum Mixture Correntropy Criterion-Based Variational Bayesian Adaptive Kalman Filter for INS/UWB/GNSS-RTK Integrated Positioning by Sen Wang, Peipei Dai, Tianhe Xu, Wenfeng Nie, Yangzi Cong, Jianping Xing, Fan Gao

“…To tackle these challenges, this paper proposes a novel tightly coupled INS/UWB/GNSS-RTK integrated positioning system framework, leveraging a variational Bayesian adaptive Kalman filter based on the maximum mixture correntropy criterion. …”
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The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages by Hwa-Jin Chung, Wonil Koh, Won Kyung Kim, Joon-Shik Shin, Jinho Lee, Sang Kook Lee, In-Hyuk Ha

“…Shinbaro3 exerted anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophage cells through modulation of the TLR4/MyD88 pathways, suggesting that Shinbaro3 is a novel anti-inflammatory therapeutic candidate in the field of pharmacopuncture.…”
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Variants of the Sliding Mode Control in Presence of External Disturbance for Quadrotor by Irfan Ahmad, Muwaida Liaquat, Fahad Mumtaz Malik, Hameed Ullah, Usman Ali

“…The main focus of this article is to design two flight control strategies for a quadrotor. Firstly, a novel IIPRERL-SMC is designed through Improved Integral Sliding Mode Control (II-SMC) via proper gain scheduling by system Eigenvalues. …”
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Combination of inflammatory proteins in serum can be used to diagnose papillary thyroid carcinoma with lymph node metastasis by Yongqin Pan, Guanghao Wang, Delin Chen, Zhihui Wu, Yimwing Kei, Mingxi Xu

“…These findings provide a novel set of diagnostic markers for PTC-LNM based on serum inflammatory protein levels.…”
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Bidimensionally partitioned online sequential broad learning system for large-scale data stream modeling by Wei Guo, Jianjiang Yu, Caigen Zhou, Xiaofeng Yuan, Zhanxiu Wang

“…To address these issues, we propose a novel bidimensionally partitioned online sequential broad learning system (BPOSBLS) in this paper. …”
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Allelic variation in an expansin, MdEXP-A1, contributes to flesh firmness at harvest in apples by Qiufang Su, Yifeng Feng, Xianglu Li, Zidun Wang, Yuanwen Zhong, Zhengyang Zhao, Huijuan Yang

“…These findings provide novel insight into the genetic control of flesh firmness by MdEXP-A1.…”
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Squamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus by Jordan M. Sampson, Kimberly A. Morrissey, Kieran J. Mikolajova, Kourtney M. Zimmerly, Neil J. Gemmell, Michael G. Gardner, Terry Bertozzi, Terry Bertozzi, Robert D. Miller

“…Our analyses include a putative new TCR locus. This novel locus contains V, D, and J gene segments that undergo V(D)J recombination, albeit with a limited number of gene segments in most squamate species. …”
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HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells by Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

“…Our findings reveal a novel mechanism of action of HDAC1-3 inhibitors in MDSCs and suggest a potential synergistic immunotherapy strategy for clinical benefit in HCC.…”
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Derivation of Sa-MoDEI score from DEI. Tak for prognostication in Buerger's Disease - Preliminary data of a prospective observational cohort by Gregory Pathrose, Albert A Kota, Prabhu Premkumar, Prasanna Samuel, Shivraj Padiyar, Deepak Selvaraj, Prasanta Padhan, Debashish Danda

“…Hence, our aim was to prognosticate outcomes in patients with diagnosed Buerger's disease using Sa-MoDEI score, a novel disease extent index (DEI) derived and modified from DEI. …”
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Patients outcomes in lung adenocarcinoma transforming to small-cell lung cancer after tyrosine kinase inhibitor therapy by Shuai Wang, Yongsen Wang, Xuan Wu, Li Yang, Xiaoju Zhang

“…It carries a worse prognosis. Exploring novel therapeutic strategies for transformed SCLC is imperative.…”
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Predictors of HBsAg seroclearance in HBeAg-negative chronic hepatitis B patients treated with nucleotide analogs plus polyethylene glycol interferon by Yan Peng, Mingzhe Ma, Ting Liu, Wenmin He, Shutao Lin, Wa Zhong, Xiaohui Min

“…Moreover, for the first time, we found ALT change values from baseline to week 24 (dALT2) could act as a novel independent clinical efficacy predictors in the forementioned population.…”
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Enhancing Telemarketing Success Using Ensemble-Based Online Machine Learning by Shahriar Kaisar, Md Mamunur Rashid, Abdullahi Chowdhury, Sakib Shahriar Shafin, Joarder Kamruzzaman, Abebe Diro

“…To address the above issues, this paper proposes an ensemble machine learning model with feature selection and oversampling techniques to identify potential customers more accurately. A novel online learning method is proposed for model retraining when new samples are available over time. …”
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Development of the RP-HPLC Method for Simultaneous Determination and Quantification of Artemether and Lumefantrine in Fixed-Dose Combination Pharmaceutical Dosage Forms by Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Desmond Asamoah Bruce Otu, Denis Dekugmen Yar, Yaa Asantewaa Osei

“…The current study developed a novel, simple, sensitive, precise, accurate, and cost-effective RP-HPLC method for the simultaneous determination and quantification of artemether and lumefantrine in pharmaceutical dosage forms. …”
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Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials by George A Wells, Kevin Emery Boczar, Sheojung Shin, Kathryn A Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A Fehlmann, Sarah Visintini, Rob Beanlands

“…Introduction Inflammation is emerging as an important risk factor for atherosclerotic cardiovascular disease and has been a recent target for many novel therapeutic agents. However, comparative evidence regarding efficacy of these anti-inflammatory treatment options is currently lacking.Methods and analysis This systematic review will include randomised controlled trials evaluating the effect of anti-inflammatory agents on cardiovascular outcomes in patients with known cardiovascular disease. …”
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A Cross-Layer FL-Based Clustering Protocol to Support Multicast Routing in IoT-Enabled MANETs With CF-mMIMO by Amalia Amalia, Yushintia Pramitarini, Ridho Hendra Yoga Perdana, Kyusung Shim, Beongku An

“…This paper proposes a novel cross-layer federated learning (FL)-based clustering (CFLC) protocol to support multicast routing in internet of things (IoT)-enabled mobile ad hoc networks (MANETs) with cell-free massive multiple-input multiple-output (CF-mMIMO). …”
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