PZS‐Net: Incorporating of Frame Sequence and Multi‐Scale Priors for Prostate Zonal Segmentation in Transrectal Ultrasound by Jianguo Ju, Qian Zhang, Pengfei Xu, Tiange Liu, Cheng Li, Ziyu Guan

“…To overcome the limitation, a novel Prostate Zonal Segmentation Network (PZS‐Net), based on U‐Net, which learns critical cross‐frame information and multi‐scale features from sequential frames, is proposed. …”
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Construction process optimisation of graphene-basalt fibre asphalt mixtures by Huzhu Zhang, Wenjia Yang, Huimin Li, Chunyu Zheng, Lijuan Sun

“…Graphene-basalt fibre asphalt mixture (GBFAM) is a novel composite-modified material. However, there is currently a lack of an effective basis for selecting appropriate construction processes and parameters in practical engineering applications. …”
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Graph Deep Active Learning Framework for Data Deduplication by Huan Cao, Shengdong Du, Jie Hu, Yan Yang, Shi-Jinn Horng, Tianrui Li

“…To fill this research gap, we propose a novel graph deep active learning framework for data deduplication, which is based on similarity algorithms combined with the bidirectional encoder representations from transformers (BERT) model to extract the deep similarity features of multi-source data records, and first introduce the graph active learning strategy to build a clean graph to filter the data that needs to be labeled, which is used to delete the duplicate data that retain the most information. …”
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A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines by Linghong Huang, Xinyuan Sun, Qinhua Zuo, Ting Song, Ning Liu, Zonghua Liu, Wei Xue

“…This antigen capture system provides a novel strategy to improve the anti-tumor efficacy of in situ tumor vaccines.…”
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Restriction of mitochondrial oxidation of glutamine or fatty acids enhances intracellular growth of Mycobacterium abscessus in macrophages by Ho Won Kim, Ji Won Lee, Hoe Sun Yoon, Hwan-Woo Park, Young Ik Lee, Sung Ki Lee, Jake Whang, Jong-Seok Kim

“…These insights advance our understanding of Mab’s impact on host cell metabolism and propose a novel avenue for therapeutic intervention. By manipulating host mitochondrial metabolism, we identify a potential host-directed therapeutic strategy against Mab, offering a promising alternative to conventional treatments beleaguered by drug resistance. …”
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A Sentinel-2-Based System to Detect and Monitor Oil Spills: Demonstration on 2024 Tobago Accident by Emilio D’Ugo, Ashish Kallikkattilkuruvila, Roberto Giuseppetti, Alejandro Carvajal, Abdou Mbacke Diouf, Matteo Tucci, Federico Aulenta, Alessandro Ursi, Patrizia Sacco, Deodato Tapete, Giovanni Laneve, Fabio Magurano

“…In this paper, we analyze the serious environmental accident caused by a massive oil spill on 7 February 2024, off the island of Tobago, using two separate algorithms, namely, the established visible near-red index (VNRI) algorithm and the novel IVI visible reflectance ratio index (IVI), both applied to Sentinel-2 satellite images. …”
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Expert Comment Generation Considering Sports Skill Level Using a Large Multimodal Model with Video and Spatial-Temporal Motion Features by Tatsuki Seino, Naoki Saito, Takahiro Ogawa, Satoshi Asamizu, Miki Haseyama

“…To address this issue, we propose a novel approach to generate skill-level-aware expert comments by leveraging a Large Multimodal Model (LMM) and spatial-temporal motion features. …”
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What is the NCD service capacity and disruptions due to COVID-19? Results from the WHO non-communicable disease country capacity survey in the Americas region by Anselm Hennis, Silvana Luciani, Roberta Caixeta, Carolina Chavez, Dolores Ondarsuhu

“…Mitigation strategies to ensure continuity of care for people with NCDs were deployed in many countries and included triaging patients, telemedicine and teleconsultations, and electronic prescriptions and other novel prescribing practices.Conclusions The findings from this regional survey suggest significant and sustained disruptions, affecting all countries regardless of the country’s level of investments in healthcare or NCD burden.…”
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Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 21: Suitability of taxonomic... by EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Juan Evaristo Suarez, Ingvar Sundh, Angela Botteon, Barizzone Fulvio, Sandra Correia, Lieve Herman

“…Of 54 microorganisms notified to EFSA between April and September 2024 (33 as feed additives, 17 as food enzymes or additives, 4 as novel foods), 50 were not evaluated because: 12 were filamentous fungi, 1 was Enterococcus faecium and 8 were Escherichia coli (all excluded from the QPS evaluation), and 29 were TUs that already have a QPS status. …”
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Survivin is Highly Expressed and Promotes Cell Survival in Malignant Peritoneal Mesothelioma by Nadia Zaffaroni, Aurora Costa, Marzia Pennati, Cinzia De Marco, Emanuela Affini, Maria Madeo, Roberta Erdas, Antonello Cabras, Shigeki Kusamura, Dario Baratti, Marcello Deraco, Maria Grazia Daidone

“…Conclusion: Our results show for the first time that survivin, as well as other IAPs, is largely expressed in clinical MPMs and suggest that strategies aimed at down-regulating survivin may provide a novel approach for the treatment of the malignancy.…”
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Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito <i>Anopheles stephensi</i> and Its Capacity to Mobilize Pantothenate and Biotin by Jun Isoe, Brendan F. Riske, Megan E. Dobson, Hannah L. Kaylor, Jessica C. Brady, Yared Debebe, Laura M. Saavedra, Shirley Luckhart, Michael A. Riehle

“…We previously demonstrated that Pan is not only essential for mosquito survival, but also for the development of malaria parasites within the mosquito, suggesting that targeting Pan and CoA biosynthesis may be a novel approach for malaria control. However, little is known about how Pan is acquired and mobilized within the mosquito. …”
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Manganese Inhalation as a Parkinson Disease Model by José Luis Ordoñez-Librado, Verónica Anaya-Martínez, Ana Luisa Gutierrez-Valdez, Laura Colín-Barenque, Enrique Montiel-Flores, Maria Rosa Avila-Costa

“…The present study examines the effects of divalent and trivalent Manganese (Mn2+/Mn3+) mixture inhalation on mice to obtain a novel animal model of Parkinson disease (PD) inducing bilateral and progressive dopaminergic cell death, correlate those alterations with motor disturbances, and determine whether L-DOPA treatment improves the behavior, to ensure that the alterations are of dopaminergic origin. …”
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Towards Reliable Participation in UAV-Enabled Federated Edge Learning on Non-IID Data by Youssra Cheriguene, Wael Jaafar, Halim Yanikomeroglu, Chaker Abdelaziz Kerrache

“…Hence, we propose in this article a novel client selection scheme that enhances convergence by prioritizing fast UAVs with high-reliability scores, while eliminating malicious UAVs from training. …”
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SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling by Antonio Michelucci, Luigi Sforna, Riccardo Focaia, Maria Vittoria Leonardi, Angela Di Battista, Giorgia Rastelli, Simone Vespa, Simona Boncompagni, Manlio Di Cristina, Luigi Catacuzzeno

“…Finally, ORF3a expression in HEK293 cells leads to lysosomal volume increase, mitochondrial damage, and accumulation of intracellular membranes, all alterations reverted by the N82W mutation. We propose a novel function for ORF3a as a lysosomal water-permeable channel, essential for lysosome deacidification and inactivation, key steps to promote virus egress.…”
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Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential by Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu, Yu-ming Xu, Yu-ming Xu

“…Based on the available studies, we propose that targeting PGC-1α could serve as a promising novel therapeutic strategy for one or more neurological diseases.…”
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Classifying tumour infiltrating lymphocytes in oral squamous cell carcinoma histopathology using joint learning framework by Barun Barua, Genevieve Chyrmang, Kangkana Bora, Gazi N. Ahmed, Lopamudra Kakoti, Manob Jyoti Saikia

“…To address these limitations, we propose OralTILs-ViT, a novel joint representation learning framework that integrates cellular and tissue-level information. …”
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miR-142-3p Contributes to Early Cardiac Fate Decision of Embryonic Stem Cells by Zhong-Yan Chen, Fei Chen, Nan Cao, Zhi-Wen Zhou, Huang-Tian Yang

“…However, the miRNAs and their targets involved in the regulation of cardiac lineage specification are largely unexplored. Here, we report novel functions of miR-142-3p in the regulation of cardiomyocyte differentiation from mouse embryonic stem cells (mESCs). …”
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Systemic Inflammation and Oxidative Stress in Childhood Obesity: Sex Differences in Adiposity Indices and Cardiovascular Risk by Tjaša Hertiš Petek, Evgenija Homšak, Mateja Svetej, Nataša Marčun Varda

“…We also aimed to assess the potential of the interferon-inducible T-cell alpha chemoattractant (I-TAC/CXCL11) as a novel biomarker. <b>Methods:</b> Eighty children (36 girls) aged 5–18 years with overweight, obesity, or normal weight were analyzed. …”
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New approach to identifying elite winter sport athletes’ risk of relative energy deficiency in sport (REDs) by Leigh Gabel, Steven K Boyd, Emily M Smith, Kelly Drager, Erik M Groves, Lauren A Burt

“…Using advanced imaging to explore REDs risk in a population of winter high-performance athletes is novel.…”
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Spatiotemporal Variance Image Reconstruction for Thermographic Inspections by Logan M. Wilcox, Emily M. Johnson, Emma T. Bohannon, Catherine E. Johnson, Kristen M. Donnell

“…To this end, this work proposes a novel image reconstruction technique for nonuniform excitation/heating and is referred to as spatiotemporal variance reconstruction (STVR). …”
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