Zebularine Promotes Hepatic Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells by Interfering with p38 MAPK Signaling by Yong-Heng Luo, Juan Chen, En-Hua Xiao, Qiu-Yun Li, Yong-Mei Luo

“…The present study investigated the effects of zebularine on hepatic differentiation of rabbit BMMSCs, as well as the role of p38 on DNMT1 and hepatic differentiation, with the aim of developing a novel strategy for improving derivation of hepatocytes. …”
Get full text

Probiotic Potential of Lactobacillus Strains with Antifungal Activity Isolated from Animal Manure by Soundharrajan Ilavenil, Hyung Soo Park, Mayakrishnan Vijayakumar, Mariadhas Valan Arasu, Da Hye Kim, Sivanesan Ravikumar, Ki Choon Choi

“…Thus, KCC-25, KCC-26, KCC-27, and KCC-28 could have the survival ability in the harsh condition of the digestive system in the gastrointestinal tract. In conclusion, novel L. plantarum KCC-25, KCC-26, KCC-27, and KCC-28 could be considered as potential antimicrobial probiotic strains.…”
Get full text

Ion‐Permeable Electrospun Scaffolds Enable Controlled In‐Vitro Electrostimulation Assay of Myoblasts by Serafina Pacilio, Francesco Decataldo, Roberta Costa, Tobias Cramer, Beatrice Fraboni, Giovanna Cenacchi, Maria Letizia Focarete

“…However, in‐vitro assays permitting reliable electrical stimulation of cell contractile activity still require technological development. Here, a novel approach to electrically stimulate differentiated muscular cell contractility is reported exploiting the ionic conductivity and mechanical flexibility of 3D nanofibrous scaffolds. …”
Get full text

System Design for a Prototype Acoustic Network to Deter Avian Pests in Agriculture Fields by Destiny Kwabla Amenyedzi, Micheline Kazeneza, Ipyana Issah Mwaisekwa, Frederic Nzanywayingoma, Philibert Nsengiyumva, Peace Bamurigire, Emmanuel Ndashimye, Anthony Vodacek

“…Further development of this novel integrated and sustainable solution will add another tool for dealing with pest birds.…”
Get full text

Characterization of YdgH: a mediator of beta-lactam susceptibility in Enterobacterales by Jacob E. Lazarus, Matthew K. Waldor, David C. Hooper

“…In a previous screen for novel genetic mediators affecting beta-lactam susceptibility, we discovered that deletion of ydgH, a conserved gene of unknown function, leads to increased resistance to beta-lactams, as well as increased susceptibility to detergent compounds. …”
Get full text

A Modified Quadrature Birdcage Coil Incorporated With a Curved Feature for <italic>In Ovo</italic> MR Imaging by Chang-Hoon Choi, Maximilian Bruch, Suk-Min Hong, Sandra Krause, Carina Stegmayr, Stefan Schwan, Wieland A. Worthoff, Jorg Felder, N. Jon Shah

“…<italic>Goal:</italic> This study presents a novel MRI coil design approach explicitly tailored for chick embryo measurements, with the primary objective of improving sensitivity and coverage. …”
Get full text

Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect by Coralia Cuadrado, Alex Mantilla, Luis Hidalgo, Diego Punina

“…This study focuses on the development of two novel nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated within a biocompatible poly(VCL-co-PEGDA) hydrogel. …”
Get full text

Systemic Proteomic Analysis Reveals Distinct Exosomal Protein Profiles in Rheumatoid Arthritis by Qiu Qin, Ronghua Song, Peng Du, Chaoqun Gao, Qiuming Yao, Jin-an Zhang

“…These proteins not only take important parts in the vicious circle in the pathogenic process of RA but also serve as novel biomarkers in RA diagnosis and prognosis.…”
Get full text

Reforming the innovation system to deliver affordable medicines: a conceptual framework of pharmaceutical innovation as a complex adaptive system (forest) and theory of change by Suerie Moon, Adrian Alonso Ruiz, Marcela C. F. Vieira, Kaitlin E. Large, Iulia Slovenski

“…Methods We inductively developed a novel conceptual framework of the PIS as a complex adaptive system (CAS) analogous to a forest. …”
Get full text

RETRACTED ARTICLE: Quadratic multiple regression model and spectral relaxation approach for carreau nanofluid inclined magnetized dipole along stagnation point geometry by Sayed M. El Din, Adil Darvesh, Assad Ayub, Tanveer Sajid, Wasim Jamshed, Mohamed R. Eid, Syed M. Hussain, Manuel Sánchez-Chero, Sheda Méndez Ancca, Johana Milagritos Ramírez Cerna, Carmen Luisa Aquije Dapozzo

“…In the case of S > 1, physically it is a representation of Joule and viscous dissipations. This article is novel in its sense that the influence of oblique magnetic force and second order velocity slippage on Carreau nano liquid and its numerical computation with help of the spectral relaxation method has never been done before. …”
Get full text

Fabrication of metal organic framework/Polyoxometalate-TiO2 based DSCCs with enhanced electron lifetime and reduced recombination of charge carriers sensitized with cabbage/spinach... by William Moloto, Pontsho Mbule, Edward Nxumalo, Bulelwa Ntsendwana

“…As a result, this electrode was used to fabricate a novel natural dye (chlorophyll, anthocyanin and cocktail mixture)-based DSSCs.The cocktail based mixture showed higher power conversion efficiency of 1.92 % compared to spinach based DSSCs (0.98 %) and purple cabbage (0.89 %) under 100 ​mW/cm2 light illumination with 30 ​ms of electron lifetime, which is three times and four times more than spinach and cabbage based DSSCs respectively. …”
Get full text

Design and maintenance of medical oxygen concentrators in Sub-Saharan Africa: a systematic review by Nahimiya Husen Ibrahim, James Wallace, Davide Piaggio, Leandro Pecchia

“…It highlighted a pressing need for improved healthcare infrastructure investment, context-aware OC design and novel standards and regulatory frameworks to support frugal innovation.…”
Get full text

Damage Identification in Large-Scale Structures Using Time Series Analysis and Improved Sparse Regularization by Huihui Chen, Xiaojing Yuan

“…Aiming at the existing obstacles, this study enables to propose a novel method based on time series analysis model and improved sparse regularization technique for damage identification of the large-scale structure. …”
Get full text

Estimation of D-dimer, C-reactive protein and ferritin in Covid-19 survivors in a North Indian Hospital, Lucknow, India. by Chetna Singla, Dhananjay Tiwari, Himali Jha, Mohammad Mustufa Khan, Sadaf Parveen, Roshan Alam

“… Background: Novel coronavirus disease (COVID-19), the disease caused by SARS-CoV-2, is a highly contagious disease. …”
Get full text

Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects by Takashi Kobayashi, Takaomi Kessoku, Michihiro Iwaki, Asako Nogami, Masato Yoneda, Satoru Saito, Yoshie Yamana, Yosuke Nishitani, Hiroshige Kuwahara, Atsushi Nakajima

“…The bacterial component of Lactiplantibacillus plantarum 22 A-3 ameliorates increased intestinal permeability through its anti-inflammatory effect in the intestinal tract and may be a novel treatment for leaky gut.…”
Get full text

Pegylated NIR Fluorophore-Conjugated OBHSA Prodrug for ERα-Targeted Theranostics with Enhanced Imaging and Long-Term Retention by Xiaohua Wang, Xiaofei Deng, Lilan Xin, Chune Dong, Guoyuan Hu, Hai-Bing Zhou

“…This study aims to integrate the pegylation strategy with a tumor microenvironment-responsive approach. A novel esterase-activated EPR strategy prodrug, OBHSA-PEG-DCM, was designed. …”
Get full text

Preface by CTA Editorial Board

“…For example, in 1989 together with others he was awarded by the Prize of the Council of Ministers of the USSR for the development of novel ceramic cathodes for CO2-lasers, in 2000 he was awarded the State Scholarship for Outstanding Scholars of the Russian Federation, in 2001 he was awarded the Honored Scientist of the Russian Federation title. …”
Get full text

Identification of emerging harms due to COVID-19 outbreak: a qualitative study in Iran by Sina Ahmadi, Seyed Fahim Irandoost, Neda SoleimanvandiAzar, Marzieh Nojomi, Javad Yoosefi Lebni, Arash Tehrani-Banihashemi

“…Conclusion The COVID-19 crisis has intensified existing social harms and introduced new ones, rendering previous mitigation strategies ineffective. Designing novel policies and guidelines is crucial to address these evolving challenges and reduce the adverse societal impacts of the pandemic.…”
Get full text

TAD-SIE: sample size estimation for clinical randomized controlled trials using a Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator by Sayeri Lala, Niraj K. Jha

“…Methods To remove this obstacle from the drug development cycle, we present a new algorithm called Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator (TAD-SIE) that powers a parallel-group trial, a standard RCT design, by leveraging a state-of-the-art hypothesis testing strategy and a novel trend-adaptive design (TAD). Specifically, TAD-SIE uses synthetic intervention (SI) to estimate individual treatment effects and thereby simulate a cross-over design, which makes it easier for a trial to reach target power within trial constraints (e.g., sample size limits). …”
Get full text

Constructing meaningful code changes via graph transformer by Shikai Guo, Mengxuan Li, Xin Ge, Hui Li, Rong Chen, Tingting Li

“…To solve these limitations, a novel method is proposed, named Graph Transformer for learning meaningful Code Transformations (GTCT), to provide developers with preliminary and quick feedback when developers submit code changes, which can improve the quality of code changes and improve the efficiency of code review. …”
Get full text