The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars by Masayo Aoki, Akatsuki Kondo, Noriko Matsunaga, Azusa Honda, Yuri Okubo, Kazuaki Takabe, Rei Ogawa

“…Topical FTY720 can be a novel therapeutic option for abnormal scars that are difficult to control with corticosteroids. …”
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Unveiling the potential of spirulina algal extract as promising antibacterial and antibiofilm agent against carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study by Mohamed I. Selim, Tarek El-banna, Fatma Sonbol, Walaa A. Negm, Engy Elekhnawy

“…Abstract Carbapenem-resistant Klebsiella pneumoniae poses a severe risk to global public health, necessitating the immediate development of novel therapeutic strategies. The current study aimed to investigate the effectiveness of the green algae Arthrospira maxima (commercially known as Spirulina) both in vitro and in vivo against carbapenem-resistant K. pneumoniae. …”
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Maximal mouth opening in infants and toddlers with spinal muscular atrophy: a prospective controlled study by Jana Zang, Deike Weiss, Charlotte Dumitrascu, Julia Glinzer, Marie Wegner, Anna Strube, Jonas Denecke, Almut Niessen, Christina Pflug

“…This study presents a novel approach to measuring MMO in infants and toddlers with SMA and compares it with healthy controls. …”
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AppAuth: Authorship Attribution for Android App Clones by Guoai Xu, Chengpeng Zhang, Bowen Sun, Xinyu Yang, Yanhui Guo, Chengze Li, Haoyu Wang

“…In this paper, we propose AppAuth, a novel learning-based approach to predict the authorship of app clones. …”
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Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma by Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings

“…These data provide avenues for novel therapeutic approaches that could combine CD175- and CA19-9-targeting therapies for PDAC patients.…”
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Modelling COVID-19 in the North American region with a metapopulation network and Kalman filter by Matteo Perini, Teresa K. Yamana, Marta Galanti, Jiyeon Suh, Roselyn Kaondera-Shava, Jeffrey Shaman

“…Methods: We developed a novel metapopulation model for simulating respiratory virus transmission in the North America region, specifically for the 96 states, provinces, and territories of Canada, Mexico, and the United States. …”
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Plasmonically-enhanced reconfigurable photodetector based on graphene/Sb2S3 heterojunction by Xiaojuan Lian, Shiyu Li, Jiyuan Jiang, Wen Huang, Nan He, Xiaoyan Liu, Jie Wu, Zhou Wang, Gangyi Zhu, Lei Wang

“…To overcome these weakness, we proposed a novel photodetector based on a Gold (Au)/Graphene/Chalcogenide (Sb _2 S _3 ) hetero-junction, leveraging surface plasmonic and phase-transition effects. …”
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Genetic analyses identify circulating genes related to brain structures associated with Parkinson’s disease by Zhe Han, Yanping Zhu, Zhenhong Xia, Qing Deng, Hongjie He, Quanting Yin, Hui Zhang, Mudan Yuan, Chunhua Yang, Geng Tian, Jia Mi, Fuyi Xu

“…Our study bridges the gap between molecular genetics, neuroimaging, and PD pathology, and suggests novel targets for diagnosis and treatment.…”
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Chemical Changes Under Heat Stress and Identification of Dendrillolactone, a New Diterpene Derivative with a Rare Rearranged Spongiane Skeleton from the Antarctic Marine Sponge <i>... by Andrea Prófumo, Conxita Avila, Adele Cutignano

“…From the dichloromethane extract of sponge samples from Deception Island collected in January 2023, we isolated a novel derivative with an unusual β-lactone diterpene skeleton here named dendrillolactone (<b>1</b>), along with seven previously described diterpenes, including deceptionin (<b>2</b>), a gracilane norditerpene (<b>3</b>), cadlinolide C (<b>4</b>), a glaciolane norditerpene (<b>5</b>), membranolide (<b>6</b>), aplysulphurin (<b>7</b>), and tetrahydroaplysulphurine-1 (<b>8</b>). …”
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Student’s perception of hybrid team-based and case-based learning in undergraduate endodontics education by Lee Yuetqi, Galvin Sim Siang Lin, Rosnani Binti Mamat, Tahir Yusuf Noorani

“…Conclusions The positive perception of dental students encourages the potential integration of this novel approach into the dental curriculum, moving away from didactic lectures. …”
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Let us be heard: critical analysis and debate of collaborative research approaches used in implementation science research with equity-deserving populations by Sarah Madeline Gallant, Cynthia Mann, Britney Benoit, Megan Aston, Janet Curran, Christine Cassidy

“…Efforts are being made to implement novel approaches to care for this population; however, the implementation research continues to leave the voices of pregnant persons unheard, compounding the existing stigma and marginalization experienced. …”
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Effects of copper/graphene oxide core-shell nanoparticles on Rhipicephalus ticks and their detoxification enzymes by Haytham Senbill, Amr Gangan, Ahmed M. Saeed, Mohammed E. Gad, Jehan Zeb, Alaa Fahmy

“…Abstract Nanopesticides have been recently introduced as novel pesticides to overcome the drawbacks of using traditional synthetic pesticides. …”
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Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA by Tobias Solli Iveland, Lars Hagen, Mirta Mittelstedt Leal de Sousa, Nina Beate Liabakk, Per Arne Aas, Animesh Sharma, Bodil Kavli, Geir Slupphaug

“…The potential of HDACis to modulate pyrimidine metabolism and DNA damage responses offers novel strategies for improving NSCLC outcomes.…”
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Contributions to the Virtualization of the BNG by Jorge Proenca, Ricardo Figueiredo, Vasco Pereira, Tiago Cruz, Paulo Simoes

“…Similarly to other elements within the operators&#x2019; infrastructure, the BNG has faced escalating challenges due to the surge in bandwidth demand, rapid subscriber growth, and the introduction of novel services with unique requirements. As a single point of failure for subscriber-operator access, it becomes crucial to enhance management flexibility, simplify the device, and improve overall resilience. …”
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Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis by Graciela Ruíz, Heriberto A. Valencia-González, Ismael León-Galicia, Enrique García-Villa, Alejandro García-Carrancá, Patricio Gariglio

“…Our results suggest that resveratrol is effective to sensitize cervical CSC because of RAD51 inhibition, targeting high RAD51 expressing CD49f-positive cells, which supports the possible therapeutic application of RES as a novel agent to treat cancer.…”
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Subsurface geology of the Torino metropolitan area (Westernmost Po Plain, NW Italy) by Andrea Irace, Igor Marcelli, Gianfranco Fioraso, Andrea Festa, Rita Catanzariti, Brunella Raco, Matia Menichini, Giulio Masetti, Elisa Brussolo, Gianna Vivaldo, Marco Doveri

“…The map provides an updated representation of the bedrock geology below the late Early Pleistocene-Holocene Alpine-sourced fluvial blanket, relying on novel correlation of shallow water well and borehole logs. …”
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Assembly-free reads accurate identification (AFRAID) approach outperforms other methods of DNA barcoding in the walnut family (Juglandaceae) by Yanlei Liu, Kai Chen, Lihu Wang, Xinqiang Yu, Chao Xu, Zhili Suo, Shiliang Zhou, Shuo Shi, Wenpan Dong

“…In this study, we use plant species in Juglandaceae to evaluate an assembly-free reads accurate identification (AFRAID) method of species identification, a novel approach for precise species identification in plants. …”
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DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations by Jason Sheng Li, Karen Riggins, Li Yang, Chaorong Chen, Patricia Castro, Wedad Alfarkh, Neda Zarrin-Khameh, Michael E. Scheurer, Chad J. Creighton, Benjamin Musher, Wei Li, Lanlan Shen

“…Our exploratory findings in this cohort highlight epigenetic mechanisms underlying the pathogenesis of EOCRC and nominate novel biomarkers for EOCRC in underrepresented populations.…”
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Factors associated with weight loss response to GLP-1 analogues for obesity treatment: a retrospective cohort analysis by Nadia Khan, Jesse Bittman, Peter Squire, James Naude, Ali Zentner

“…Future research should assess additional variables and support the development of novel biomarkers that are associated with weight loss response.…”
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Bi-Josephson effect in a driven-dissipative supersolid by Jieli Qin, Shijie Li, Yijia Tu, Maokun Gu, Lin Guan, Weimin Xu, Lu Zhou

“…The findings of this work unveil unique Josephson physics in the supersolid phase, and show new opportunities to build novel Josephson devices with supersolids.…”
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