Hospitalization outcomes in people living with HIV on Dolutegravir-based regimen in Mwanza, Tanzania: a comparative cohort by Godfrey A. Kisigo, Eric Barongo, Benson Issarow, Cody Cichowitz, Bahati Wajanga, Samuel Kalluvya, Robert N. Peck

“…Clinical trials are urgently needed to test novel interventions for improving survival in this high-risk group. …”
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Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio) by Utsa Saha, Aishee Ghosh, Adrija Sinha, Aditya Nandi, Sudakshya S. Lenka, Abha Gupta, Shalini Kumari, Anu Yadav, Mrutyunjay Suar, Nagendra Kumar Kaushik, Vishakha Raina, Suresh K. Verma

“…In this study, we investigated the efficacy of a novel biosurfactant-microplastic (BSμP) hybrid in reducing in vivo green bio-toxicity of microplastics (μP) induced by oxidative stress and apoptosis in zebrafish (Danio rerio). …”
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Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6/lpr Mice by Xiaoxie Xu, Jun Huang, Mei Zhao, Huanpeng Chen, Jinhua Mo, Xiaoqing Zhou, Qiao Su, Bolan Yu, Zhaofeng Huang

“…Our study suggested that stabilized β-catenin ameliorated some ALPS-like symptoms of lpr/lpr mice by potentiating Fas-independent signal-mediated T cell apoptosis, which might uncover a potential novel therapeutic direction for ALPS.…”
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Using magnetic dynamics to measure the spin gap in a candidate Kitaev material by Xinyi Jiang, Qingzheng Qiu, Cheng Peng, Hoyoung Jang, Wenjie Chen, Xianghong Jin, Li Yue, Byungjune Lee, Sang-Youn Park, Minseok Kim, Hyeong-Do Kim, Xinqiang Cai, Qizhi Li, Tao Dong, Nanlin Wang, Joshua J. Turner, Yuan Li, Yao Wang, Yingying Peng

“…Abstract Spin-orbit entangled materials have attracted widespread interest due to the novel magnetic phenomena arising from the interplay between spin-orbit coupling and electronic correlations. …”
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Enhancing water use efficiency and fruit quality in jujube cultivation: A review of advanced irrigation techniques and precision management strategies by Yingying Xing, Mengru Chen, Xiukang Wang

“…The review underscores the importance of novel practices such as biopolymer-based fertilizers, the intelligent integration of water and fertilizers, and IoT-based frameworks, all of which significantly enhance water use efficiency and economic productivity in jujube cultivation. …”
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Multiple optical path length reflections enhancement based on balloon-type photoacoustic cell for trace gas sensing by Ruiming Wu, Wenjun Ni, Chunyong Yang, Bingze He, Ping Lu, Sixiang Ran, Zhongke Zhao, Perry Ping Shum

“…A novel balloon-type photoacoustic cell (BTPAC) is proposed to facilitate the detection limitations of acetylene (C2H2) gas achieving ppb level. …”
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The Effects of Different Phase on Independent Visual Fields SSVEP Responses by Dalu Zheng, Songyun Xie, Xinzhou Xie, Michael Scholz, Hao Tang

“…We propose “independent visual field stimulation” (IVFS), utilizing a head-mounted display (HMD) as a novel experimental paradigm to improve the interpretability of SSVEP responses. …”
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Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis by He Cao, Zhi Cao, Yue Han, Jing Shan

“…This study aims to design a novel multi-epitope vaccine targeting HSV-1 glycoproteins B, C, D, H, and L using an immuno-informatics approach, which are essential for viral entry and pathogenesis.MethodsThe study identified epitopes for CD8+ T cells, CD4+ T cells, and B cells within the target glycoproteins. …”
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ANN-based software cost estimation with input from COCOMO: CANN model by Chaudhry Hamza Rashid, Imran Shafi, Bilal Hassan Ahmed Khattak, Mejdl Safran, Sultan Alfarhood, Imran Ashraf

“…This research aims to identify the factors that influence the software effort estimation using the constructive cost model (COCOMO), and artificial neural networks (ANN) model by introducing a novel cost estimation approach, COCOMO-ANN (CANN), utilizing a partially connected neural network (PCNN) with inputs derived from calibrated values of the COCOMO model. …”
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Low Complexity Unquantized Forward Stack Decoding Algorithm for Spinal Codes in Measurement While Drilling Communication by Xiaoyang Yu, Lei Liang, Ke Jiang, Tianwei Chen

“…Furthermore, this work integrates the non-quantized forward stack decoding with the superposition UEP-Spinal code to construct a novel MWD communication system. In simulated MWD environment, the proposed system achieved an average bit error rate (BER) of <inline-formula> <tex-math notation="LaTeX">$5.58\times 10^{-5}$ </tex-math></inline-formula>, with BER consistently below 0.1% across all intervals. …”
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Optimization Research on the Performance of the RC-DTH Air Hammer Based on Computational Fluid Dynamics by Zihao Liu, Yongjiang Luo, Wenchao He, Rui Tao, Jiangfu He, Yongliang Sun, Hongwei Chen, Qianting Hu

“…To optimize the performance of the RC-DTH air hammer, a mathematical model detailing each phase of the piston’s movement has been constructed in the present work. Simultaneously, a novel piston structure of the RC-DTH air hammer (Type B) with diverse internal flow has been proposed. …”
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Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency by Masato Wakabayashi, Yuji Kamijo, Takero Nakajima, Naoki Tanaka, Eiko Sugiyama, Tian Yangyang, Takefumi Kimura, Toshifumi Aoyama

“…We found free fatty acid accumulation, enhanced three acyl-CoA dehydrogenases, catalyzing the first reaction in the β-oxidation system and being assumed to have normal activities in these patients, and PPARα activation that was confirmed in the experiments using MK886, a PPARα specific antagonist and fenofibrate, a PPARα specific agonist. These novel findings suggest that the fatty acid accumulation and the resulting PPARα activation are major causes of the increase in the β-oxidation ability as probable compensation for fatty acid metabolism in the patients’ fibroblasts, and that enhanced cell proliferation and increased oxidative stress due to the PPARα activation relate to the development of specific clinical features such as hypertrophic cardiomyopathy, slight hepatomegaly, and skeletal myopathy. …”
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Identification of Target Genes of Antiarrhythmic Traditional Chinese Medicine Wenxin Keli by Yusi Yao, Yuhong Liu, Zhihuan Zeng, Yanqun Zhao, Tudi Li, Rong Chen, Rendan Zhang

“…These findings provide novel insight into molecular mechanisms of WXKL in reducing the incidence of ventricular arrhythmia.…”
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RUSSIA'S RELATIONS WITH THE EUROPEAN UNION AND CHINA: COMPARATIVE ANALYSIS OF MUTUAL PERCEPTION IN THE BORDER REGIONS by R. H. Simonyan, T. M. Kochegarova

“…The notorious dichotomy becomes more and more absurd, Recalling the disputes of "points" and "dull bits" from the famous novel of Jonathan Swift. The country is a completely different choice - effectiveness and development or the inefficiency and backwardness, modernization or preservation of its political and economic model, developed by reformers in 1990-ies. …”
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USP8‐Dependent Family Tyrosine Kinase Promotes the Malignant Progression of Esophageal Squamous Cell Carcinoma by Upregulating Protein Tyrosine Kinase 2 Expression by Yuechang Wu, Dubiao Xian, Yunzhong Liu, Ding Huang, Qingfeng Liu, Shubo Yang

“…Targeting this pathway may offer a novel therapeutic strategy for ESCC treatment.…”
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R-CNN Based Vehicle Object Detection via Segmentation Capabilities in Road Scenes by Bisma Riaz Chughtai, Haifa F. Alhasson, Mohammed Alnusayri, Mohammed Alatiyyah, Hanan Aljuaid, Ahmad Jalal, Jeongmin Park

“…This paper delves into advanced methodologies for detecting and classifying vehicles on roadways, addressing the limitations of traditional techniques that are often computationally intensive and data acquisition-sensitive. We propose a novel approach that leverages state-of-the-art machine learning and deep learning algorithms to enhance accuracy and efficiency. …”
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Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach by Ronghua Bei, Justin Thomas, Shiven Kapur, Mahlet Woldeyes, Adam Rauk, Jason Robarge, Jiangyan Feng, Kaoutar Abbou Oucherif

“…Our model does not need clinically observed plasma concentration-time data; this is a novel capability not previously achieved in predictive pharmacokinetic models. …”
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Thiadiazoline- and Pyrazoline-Based Carboxamides and Carbothioamides: Synthesis and Inhibition against Nitric Oxide Synthase by Fabio Arias, M. Encarnación Camacho, M. Dora Carrión, Meriem Chayah, Miguel Romero, Juan Duarte, Miguel A. Gallo

“…Their inhibitory activities against two different isoforms of nitric oxide synthase (inducible and neuronal NOS) are reported. The novel derivatives were synthesized combining the arylthiadiazoline or arylpyrazoline skeleton and a carboxamide or carbothioamide moiety, used as starting material ethyl 2-nitrobenzoates or substituted nitrobenzaldehydes, respectively. …”
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Identification and Genetic Diversity Analysis of Cinnamomum parthenoxylon (Jack) Meisn Species in Song Hinh Protection Forest, Vietnam Based on Three Chloroplast Gene Regions by Dinh Duy Vu, Mai Phuong Pham, Ngoc Huyen Dang, Xuan Dac Le, Hung Cuong Dang, Huu Thuc Nguyen, Dang Hoi Nguyen

“…Results: The nucleotide sequences of matK, rbcL, and trnH-psbA were determined to be 786bp, 513bp, and 464bp, respectively. The novel sequences have been deposited in Genbank with matK (PQ106670-PQ106689), rbcL (PQ106690-PQ106709), and trnH-psbA (PQ1066710-PQ106729). …”
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GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models by Yu Huang, Jinyong Wang, Xiling Wei, Hui Zhang, Wei Shang, Xiangling Zhang, Lanjiao Zhai, Xi Chen, Huiming Li, Suofu Qin

“…In order to develop a novel, effective treatment for cachexia, we generated a GDF15-targeting VHH nanobody, GB18–06, that was able to bind GDF15 with high affinity. …”
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