Exploring purine analogues as inhibitors against Katanin, a microtubule severing enzyme using molecular modeling approach by Vibhuti Saxena, Pruthanka Patil, Purva Khodke, Bajarang Vasant Kumbhar

“…Inhibiting katanin’s function could potentially hinder the uncontrolled growth of cancerous cells, making it an attractive target for novel anti-cancer therapies. Previous studies have shown that purine-based compounds exhibit a strong affinity for microtubule-severing enzymes. …”
Get full text

The integrated teaching practice of medical cloud dictionary development and project-based learning by Jiayi Zhang, Jiexuan Chen, Hongbin Guo, Wei Liu, Mingzhe Li

“…Abstract Objective This study examines a novel teaching model that integrates the development and use of a Medical Cloud Dictionary with project-based learning (PBL). …”
Get full text

Deciphering the fungal symphony: unveiling the fungal dynamics during the fermentation of traditional Chinese strong-flavor Daqu by Lina Zhao, Wenjing Zhang, Yuting Niu, Xiaohan Chen, Jiuyang Guo, Ying Wu, Ying Wu, Xuan Li, Shaobin Gu, Shaobin Gu, Shaobin Gu

“…Ultimately, this research presented novel perspectives for enhancing the quality and precision of liquor production by shedding light on the central role of keystone species in maintaining community stability and their adaptive responses to environmental stimuli.…”
Get full text

Network pharmacology: a crucial approach in traditional Chinese medicine research by Yiyan Zhai, Liu Liu, Fanqin Zhang, Xiaodong Chen, Haojia Wang, Jiying Zhou, Keyan Chai, Jiangying Liu, Huiling Lei, Peiying Lu, Meiling Guo, Jincheng Guo, Jiarui Wu

“…The application of network pharmacology in TCM is widespread, covering areas such as identifying the material basis of TCM efficacy, unraveling mechanisms of action, and evaluating toxicity, safety, and novel drug development. However, challenges remain, such as the lack of standardized data collection across databases and insufficient consideration of processed herbs in research. …”
Get full text

68Ga-Pentixafor PET/CT for the assessment of therapeutic outcomes following superselective adrenal arterial embolization in patients with primary aldosteronism by MengDan Li, Lili Guan, Lu Yang, WenBo Li, Zhu Xia, Min Mao, Hua Pang

“…Abstract Background Superselective adrenal artery embolization (SAAE) represents a novel therapeutic strategy for managing primary aldosteronism (PA). …”
Get full text

Circulating miR-574–5p shows diagnostic and prognostic significance and regulates oxygen-glucose deprivation (OGD)-induced inflammatory activation of microglia by targeting ATP2B2... by Xia Yin, Chunlei Zhang

“…This study evaluated miR-574–5p in discriminating ischemic stroke and predicting the severity and prognosis of patients, aiming to provide novel insights into the clinical prevention of ischemic stroke. …”
Get full text

Neutrophil extracellular traps are associated with airways inflammation and increased severity of lung disease in cystic fibrosis by Sheonagh M. Law, Gareth Hardisty, Jonathan L. Gillan, Nicola J. Robinson, Donald J. Davidson, Moira K.B. Whyte, Ian Dransfield, Robert D. Gray

“…Neutrophil extracellular traps (NETs) were measured by a novel histone-calprotectin ELISA. NET levels were compared with established measurements of airway inflammation. …”
Get full text

Sound-Induced Round Window Vibration—Experiment and Numerical Simulations of Energy Transfer Through the Cochlea of the Human Ear by Robert Zablotni, Sylwester Tudruj, Jaroslaw Latalski, Marcin Szymanski, Andrzej Kucharski, Grzegorz Zając, Rafał Rusinek

“…To evaluate the amplification of acoustic waves within the cochlea, the authors proposed a novel index defined as the ratio of the FRF of the RWM and SF, respectively. …”
Get full text

Solvothermal synthesis of polyvinyl pyrrolidone encapsulated, amine-functionalized copper ferrite and its use as a magnetic resonance imaging contrast agent. by Fatemeh Heydari, Ágnes M Ilosvai, Noémi Kovács, Domokos Máthé, Ferenc Kristály, Lajos Daróczi, Zoltán Kaleta, Béla Viskolcz, Miklós Nagy, László Vanyorek, László Forgách, Krisztián Szigeti

“…Copper ferrite nanoparticles for use as MRI contrast agents were synthesized using two different methods. A novel microwave-assisted (MW) solvothermal method was developed and compared to a conventional 12-hour synthesis (Reflux) as an eco-friendlier approach. …”
Get full text

Clinical Features and Genetic Analysis of 20 Chinese Patients with X-Linked Hyper-IgM Syndrome by Lin-Lin Wang, Wei Zhou, Wei Zhao, Zhi-Qing Tian, Wei-Fan Wang, Xiao-Fang Wang, Tong-Xin Chen

“…Eighteen unique mutations in CD40L gene were identified in these 20 patients from 19 unrelated families, with 12 novel mutations. We compared with reported mutation results and used bioinformatics software to predict the effects of mutations on the target protein. …”
Get full text

Inhibiting H3K27 Demethylases Downregulates CREB‐CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia by Juan Lazaro‐Navarro, Clara Alcon, Mathurin Dorel, Lina Alasfar, Lorenz Bastian, Claudia Baldus, Kathy Astrahantseff, Marie‐Laure Yaspo, Joan Montero, Cornelia Eckert

“…Selectively targeting epigenetic signaling may be an effective novel therapeutic approach to overcome drug resistance. …”
Get full text

KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA by Xiaowei Lu, Kui Hu, Dandan Zhang, Xuefeng Yin, Jifeng Nie, Kai Zhao

“…Conclusion Collectively, our results suggest that KLF5 regulates GBC cell proliferation, invasion, migration, angiogenesis, as well as apoptosis, via mediating PDGFA transcriptionally, which might provide a novel therapeutic strategy for treatment of human GBC.…”
Get full text

Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study by Raviraj Menon, Poornima Baby, Anil Kumar V., Sandeep Surendran, Manu Pradeep, Aiswarya Rajendran, Gaayathri Suju, Arathy Ashok

“…Logistic regression analysis indicated that chronic kidney disease (OR = 14.0), CRP >100 IU/L (OR = 6.964), and S. albumin <3 gm/dl (OR = 8.0) were risk factors associated with mortality and can guide in risk stratification. Hypoalbuminemia is a novel mortality risk factor, detected in this study, and requires further investigation to validate its utility as a prognostic marker and reveal possible therapeutic benefits in clinical correction.…”
Get full text

Genome-scale evolution in local populations of wild chimpanzees by Takashi Hayakawa, Takushi Kishida, Yasuhiro Go, Eiji Inoue, Eri Kawaguchi, Tomoyuki Aizu, Hinako Ishizaki, Atsushi Toyoda, Asao Fujiyama, Tetsuro Matsuzawa, Chie Hashimoto, Takeshi Furuichi, Kiyokazu Agata

“…Abstract Analysis of genome-scale evolution has been difficult in large, endangered animals because opportunities to collect high-quality genetic samples are limited. There is a need for novel field-friendly, cost-effective genetic techniques. …”
Get full text

Four Decades of <i>Bacillus</i> Biofertilizers: Advances and Future Prospects in Agriculture by Xinmai Wu, Yan Liu, Baolei Jia, Lili Tao, Han Li, Jingbang Wang, Ziqi Yuan, Xiaobao Sun, Yanlai Yao

“…We segmented the research timeline into three distinct phases, each marked by varying growth rates and research foci. This paper presents novel insights into the geographical and institutional distributions of research, highlighting the predominant role of developing countries in advancing <i>Bacillus</i>-based technologies. …”
Get full text

Nanopore adaptive sampling accurately detects nucleotide variants and improves the characterization of large‐scale rearrangement for the diagnosis of cancer predisposition by Sandy Chevrier, Corentin Richard, Marie Mille, Denis Bertrand, Romain Boidot

“…As we analyzed complete genes and more genes than with short‐read sequencing, we detected novel unknown variants. We randomly selected six new variants with a coverage larger than 10× and an average quality higher than 14, and confirmed all of them by Sanger sequencing, suggesting that variants detected with ONT (coverage >10× and quality score >14) could be considered as real variants. …”
Get full text

Occurrence of Isopods in Two Species of Snappers (Lutjanidae) from Northeast Brazil by André M. Alves, Marina G. Leonardo, Geza T. R. Souza, Ricardo M. Takemoto, Flávia S. de Lima, Luiz E. R. Tavares, Cláudia M. Melo, Rubens R. Madi, Verónica L. S. Jeraldo

“…In this sense, this study presents novel records of Isopoda of the families Aegidae, Cymothoidae, and Corallanidae. …”
Get full text

Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules by Yan-Chuang Han, Yoon Lim, Michael D. Duffieldl, Hua Li, Jia Liu, Nimshitha Pavathuparambil Abdul Manaph, Miao Yang, Damien J. Keating, Xin-Fu Zhou

“…Thus, we have established a novel way to efficiently induce neural stem cells (iNSC) from fibroblasts using only small molecules without altering the genome. …”
Get full text

Lumbopelvic Stability and Trunk Muscle Contractility of Individuals with Chronic Ankle Instability by Ryan S McCann, Kelly Johnson, Ashley M B Suttmiller

“… # Conclusion Deficits in TrA contractility are a novel finding among individuals with CAI. While LM contractility and lumbopelvic stability did not differ between groups, future research should continue to examine their relevance to CAI…”
Get full text

PermGuard: A Scalable Framework for Android Malware Detection Using Permission-to-Exploitation Mapping by Arvind Prasad, Shalini Chandra, Mueen Uddin, Taher Al-Shehari, Nasser A. Alsadhan, Syed Sajid Ullah

“…This paper introduces PermGuard, a scalable framework for Android malware detection that maps permissions into exploitation techniques and employs incremental learning to detect malicious apps. It presents a novel technique for constructing the PermGuard dataset by mapping Android permissions to exploitation techniques, providing a comprehensive understanding of how permissions can be misused by malware. …”
Get full text