Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis by Xiaoxue Wang, Longhao Cheng, Aijun Liu, Lihong Liu, Lili Gong, Guolin Shen

“…Conclusion Our findings on key metabolites and metabolic pathways provide novel insights into the exploration of diagnostic and therapeutic targets for MM. …”
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A reliable analytical procedure to determine the carbon isotopic signature of CO₂-bearing COH fluids generated in petrological experiments by L. Toffolo, L. Minopoli, E. Ferrari, S. Tumiati

“…Experiments aiming to replicate isotopic exchange between carbon reservoirs encounter significant analytical challenges due to the limited sample size and issues related to sampling, particularly when dealing with volatile species. Here we present a novel methodology that integrates a capsule-piercing device, a quadrupole mass spectrometer (QMS), and isotopic ratio mass spectrometry (IRMS) to measure the CO<span class="inline-formula">₂</span> concentration and natural-like <span class="inline-formula"><i>δ</i>¹³</span>C ratio of CO<span class="inline-formula">₂</span> in the volatile COH phase generated in petrological experiments. …”
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The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer by Yi Zhao, Hengheng Zhang, Wenwen Wang, Guoshuang Shen, Miaozhou Wang, Zhen Liu, Jiuda Zhao, Jinming Li

“…These results suggest that CD5 is likely a potential prognostic biomarker and therapeutic target, providing novel insights into the treatment and prognostic assessment of BCa.…”
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Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients by Hao Zhang, Takahiro Tsuchikawa, Satoshi Takeuchi, Kenji Hirata, Kimitaka Tanaka, Aya Matsui, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Toru Nakamura, Shintaro Takeuchi, Masataka Wada, Satoshi Hirano

“…As novel biomarkers for gastroenteropancreatic neuroendocrine tumors (GEPNET) are in demand, we aimed to validate the clinical value of the NETest in Japanese patients. …”
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Mechanically stable polymer networks incorporating polymeric ionic liquids for enhanced conductivity in solid-state electrolytes by Sezer Özenler, Nataliya Kiriy, Upenyu L. Muza, Martin Geisler, Anton Kiriy, Brigitte Voit

“…Enhancing both ionic conductivity and mechanical robustness remains a major challenge in designing solid-state electrolytes for lithium batteries. This work presents a novel approach in designing mechanically robust and highly conductive solid-state electrolytes, which involves ionic liquid-based cross-linked polymer networks incorporating polymeric ionic liquids (PILs). …”
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Enhanced detection of mild cognitive impairment in Alzheimer’s disease: a hybrid model integrating dual biomarkers and advanced machine learning by John Sahaya Rani Alex, R. Roshini, G. Maneesha, Jeetashree Aparajeeta, B. Priyadarshini, Chih-Yang Lin, Chi-Wen Lung

“…As a result, in this study, CerebroSpinal Fluid (CSF) biomarker information is combined with hippocampal volumes to differentiate between MCI and AD. For this, a novel two-stage hybrid learning model that leverages 3D CNN and the notion of a Fuzzy and Machine learning model is proposed. …”
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Genome-wide discovery of InDels and validation of PCR-Based InDel markers for earliness in a RIL population and genotypes of lentil (Lens culinaris Medik.). by K M Shivaprasad, Muraleedhar Aski, Gyan Prakash Mishra, Subodh Kumar Sinha, Soma Gupta, Dwijesh C Mishra, Amit Kumar Singh, Akanksha Singh, Kuldeep Tripathi, Ranjeet Ranjan Kumar, Atul Kumar, Shiv Kumar, Harsh K Dikshit

“…The bulks were made by pooling 20 extreme recombinant inbred lines (RILs) each, derived by crossing Globe Mutant (late flowering parent) with L4775 (early flowering parent). Finally, 734,716 novel InDels were identified, which is nearly one InDel per 5,096 bp of lentil genome. …”
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Communication between DNA polymerases and Replication Protein A within the archaeal replisome by Markel Martínez-Carranza, Léa Vialle, Clément Madru, Florence Cordier, Ayten Dizkirici Tekpinar, Ahmed Haouz, Pierre Legrand, Rémy A. Le Meur, Patrick England, Rémi Dulermo, J. Iñaki Guijarro, Ghislaine Henneke, Ludovic Sauguet

“…Using an integrative structural biology approach, combining nuclear magnetic resonance, X-ray crystallography and cryo-electron microscopy, we unveil how RPA interacts with PriSL and PolD through two distinct surfaces of the WH domain: an evolutionarily conserved interface and a novel binding site. Finally, RPA is shown to stimulate the activity of PriSL in a WH-dependent manner. …”
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A Negative Capacitance Field-Effect Transistor with High Rectification Efficiency for Weak-Energy 2.45 GHz Microwave Wireless Transmission by Hualian Tang, Ailan Tang, Weifeng Liu, Jingxiang Huang, Jianjun Song, Wenjie Sun

“…Based on the optimized NCFET, a half-wave rectifier circuit employing a novel diode connection configuration was constructed and verified through transient simulations. …”
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Ecological network construction and optimization of typical resource-based regions, and strategies for the enhancement of multiple ecosystem services: Balancing function and struct... by Shaoqing Wang, Yanling Zhao, Qiyuan Wang, He Ren, Shichao Zhu, Jiarui Cao

“…Therefore, this study proposed a new conceptual model and method for constructing ENs in resource-based regions and a novel optimization framework. The model combines ecological functions, topological characteristics and the degree of coordination between them to determine the optimization approaches for ENs under different ecological process scenarios. …”
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Hydrogen production with grid-connected electrolysis: scenario-based analysis of the EU criteria for renewable fuels by Bernhard Thaler, Gerhard Pirker, Nicole Wermuth

“…By uniquely focusing on the impact of H _2 production from the perspective of EU grid criteria, this study offers a novel assessment of how these regulations interact with the evolving energy landscape. …”
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Are Trends in Economic Modeling of Pediatric Diabetes Mellitus up to Date with the Clinical Practice Guidelines and the Latest Scientific Findings? by Roque Cardona-Hernandez, Alberto de la Cuadra-Grande, Julen Monje, María Echave, Itziar Oyagüez, María Álvarez, Isabel Leiva-Gea

“…**Discussion:** Economic models designed for assessing interventions in diabetes in pediatric patients should be based on pediatric-specific data and include novel adjuvant glucose-monitoring metrics and latest evidence on prognostic factors (C-peptide, legacy effect, age at diagnosis, socioeconomic status) to provide a more faithful reflection of the disease. …”
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High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods by Liangjun Zheng, Fengyi Yang, Chen Wang, Muhammad Zafir, Zishuo Gao, Pilong Liu, Fatma A. El-Gohary, Xin Zhao, Huping Xue

“…This study presents a novel approach for the biosynthesis of the antimicrobial peptide Kiadin by engineering a DAMP4–DPS–Kiadin fusion protein to mitigate host cell toxicity and achieve high-level expression. …”
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Davallia mariesii Moore Improves FcεRI-Mediated Allergic Responses in the Rat Basophilic Leukemia Mast Cell Line RBL-2H3 and Passive Cutaneous Anaphylaxis in Mice by Hyun Ju Do, Tae Woo Oh, Ju Hye Yang, Kwang Il Park, Jin Yeul Ma

“…These findings provide novel information on the molecular mechanisms underlying the antiallergic effects of DRE in FcɛRI-mediated allergic responses.…”
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The Reaction Extraction Combining Crystallization for Growth of Sodium Chloride in a Spray Fluidized Bed Crystallizer by Dan Zheng, Jie Yan, Jun Chen, Zeqin Wang

“…At present, the crystal size of sodium chloride prepared by a traditional crystallization process (such as stirred crystallization) is inhomogeneous, and it has a great quantity of fine grains in crystallizer. This work presents a novel approach for the growth of sodium chloride from supersaturated solutions by reaction-extractive crystallization in a spray fluidized bed crystallizer (SFBC), in which sodium sulfate solution is transformed into potassium chloride and sulphuric acid based on a reactive extraction-crystallization process using triisooctylamine (TOL) in n-octanol as the extraction system. …”
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Loss of protein C vs protein S results in discrepant thrombotic phenotypes by Chia-Jui Ku, Xinge Yu, Queena Y. Zhao, Steven J. Grzegorski, Jeffrey G. Daniel, Allison C. Ferguson, Jordan A. Shavit

“…Transcriptomic analysis and gene knockdown identified novel proc genetic interactions with adgrf7, a G protein-coupled receptor (GPCR) not previously known to be involved in coagulation. …”
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Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches by David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick, Giuseppe Licari

“…In this study, we introduce a novel in silico approach for predicting deamidation and isomerization sites in therapeutic antibodies by analyzing the structural environment surrounding asparagine and aspartate residues. …”
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Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

“…These findings suggest a novel mechanism of plasma-AM interaction in sepsis-induced ALI, offering a plausible strategy for assessing septic progression and treating lung injury.…”
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Crowdsourced Indicators of Flora and Fauna Species: Comparisons Between iNaturalist Records and Field Observations by Hyuksoo Kwon, Bumsuk Seo, Jungin Kim, Heera Lee

“…The results show citizen science data effectively quantify public preferences for scenic locations, offering a novel approach to mapping cultural ecosystem services when traditional data are unavailable. …”
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Construction of Multi-Scale Fusion Attention Unified Perceptual Parsing Networks for Semantic Segmentation of Mangrove Remote Sensing Images by Xin Wang, Yu Zhang, Wenquan Xu, Hanxi Wang, Jingye Cai, Qin Qin, Qin Wang, Jing Zeng

“…To address these challenges, we present two main contributions. (1) Using multi-source high-resolution satellite imagery from China’s new generation of Earth observation satellites, we constructed the Mangrove Semantic Segmentation Dataset of Beihai, Guangxi (MSSDBG); (2) We propose a novel Multi-scale Fusion Attention Unified Perceptual Network (MFA-UperNet) for precise mangrove segmentation. …”
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