Cross-Shaped Heat Tensor Network for Morphometric Analysis Using Zebrafish Larvae Feature Keypoints by Xin Chai, Tan Sun, Zhaoxin Li, Yanqi Zhang, Qixin Sun, Ning Zhang, Jing Qiu, Xiujuan Chai

“…We propose the cross-shaped heat tensor network (CSHT-Net), a feature point detection framework consisting of a novel keypoint training method named cross-shaped heat tensor and a feature extractor called combinatorial convolutional block. …”
Get full text

An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…This first-in-human trial evaluates ESK-440, a dual inhibitor of ALK and focal adhesion kinase, as a novel strategy for cancers with resistance to ALK-targeting TKIs. …”
Get full text

Effect of ultrasonic modification on the protective activity of Flammulina velutipes polysaccharide to prevent ethanol-induced injury on GES-1 cells by Jinrong Xiao, Xin Chen, Jingsi Zhang, Yifan Wang, Lei Zhong, Qiping Zhan, Qiuhui Hu, Liyan Zhao

“…The ultrasonic modification might be an effective way to develop novel F. velutipes polysaccharides that could effectively resist the gastric injury caused by excessive alcohol consumption.…”
Get full text

Magnetic-responsive triple shape memory polymer from bio-based benzoxazine/urethane polymer alloys with iron oxide nanoparticles by Kullanard Ruenpanya, Phattarin Mora, Panagiotis Karagiannidis, Kittipon Bunyanuwat, Sarawut Rimdusit

“…Novel magnetic-responsive triple shape memory polymers (SMPs) derived from bio-based benzoxazine-urethane (V-fa/PU) polymer alloys containing iron oxide nanoparticles (Fe3O4 NPs) were developed in this work. …”
Get full text

Simultaneous Inference of Past Demography and Selection from the Ancestral Recombination Graph under the Beta Coalescent by Korfmann, Kevin, Sellinger, Thibaut Paul Patrick, Freund, Fabian, Fumagalli, Matteo, Tellier, Aurélien

“…We tackle these limitations by developing two novel and different approaches to infer multiple merger events from sequence data or the ancestral recombination graph (ARG): a sequentially Markovian coalescent (SMβC) and a graph neural network (GNNcoal). …”
Get full text

Benzo[1,2-b:6,5-b’]dithiophene-4,5-diamine: A New Fluorescent Probe for the High-Sensitivity and Real-Time Visual Monitoring of Phosgene by Yingzhen Zhang, Jun Xiao, Ruiying Peng, Xueliang Feng, Haimei Mao, Kunming Liu, Zhenzhong Liu, Chunxin Ma

“…This work is the first to report a novel fluorescent system based on the Intramolecular Charge Transfer (ICT) effect, which can rapidly detect phosgene in both solution and gas phases with high sensitivity by integrating a benzo[1,2-b:6,5-b’]dithiophene-4,5-diamine (BDTA) probe. …”
Get full text

Non-invasive blood glucose monitoring using PPG signals with various deep learning models and implementation using TinyML by Mahdi Zeynali, Khalil Alipour, Bahram Tarvirdizadeh, Mohammad Ghamari

“…In this study, we propose an innovative 1-second signal segmentation method and evaluate the performance of three advanced deep learning models using a novel dataset to estimate blood glucose levels from PPG signals. …”
Get full text

Imbalance of the Gut Microbiota May Be Associated with Missed Abortions: A Perspective Study from a General Hospital of Hunan Province by Bingsi Gao, Xingping Zhao, Xinyi Liu, Xuan Yang, Aiqian Zhang, Huan Huang, Yu-ligh Liou, Dabao Xu

“…Comprehensive insights regarding gut microbiota may facilitate improved understanding and the development of novel therapeutic and preventive strategies for MAs.…”
Get full text

A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy by Andreas Schulte, Janik Brockmann, Nina Müller, Tibor Anderlei, Jochen Büchs

“…Conclusions The developed TOM system showcases a novel approach to measuring OTR, CTR, and RQ in shaken bioreactors. …”
Get full text

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3 by Alexander J. D. Snow, Tharushi Wijesiriwardena, Benjamin J. Lane, Brendan Farrell, Polly C. Dowdle, Matilda Katan, Stephen P. Muench, Alexander L. Breeze

“…Here, functional FGFR3-TACC3 was expressed through a novel cell-free expression system in under 48 h. …”
Get full text

Development of Chitosan-Polyacrylic Acid Complex Systems for Enhanced Oral Delivery of Lactobacillus Gasseri and Bifidobacterium Bifidum Probiotics by AL-Fawares O, Alshweiat A, Abuawad A

“…Box 206, Al-salt, 19117, Jordan, Tel +9627997622457, Email ola.alfawares@bau.edu.joIntroduction: The beneficial effects of probiotics are encountered by their low viability in gastrointestinal conditions and their insufficient stability during manufacturing, throughut the gastrointestinal transit, and storage. Therefore, novel systems are highly required to improve probiotics delivery.Methods: In this study, Lactobacillus gasseri (L), Bifidobacterium bifidum (B), and a combination of L+B were encapsulated in chitosan (CS)-polyacrylic acid (PAA) complex systems (CS-PAA). …”
Get full text

OSAD: Open-Set Aircraft Detection in SAR Images by Xiayang Xiao, Zhuoxuan Li, Xiaolin Mi, Dandan Gu, Haipeng Wang

“…To address these challenges, a novel open-set aircraft detector for SAR images is proposed, named open-set aircraft detection, which is equipped with three dedicated components: global context modeling (GCM), location quality-driven pseudolabeling generation (LPG), and prototype contrastive learning (PCL). …”
Get full text

Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage Closure by Yao Yao, Yanli Li, Qinchun Jin, Xiaoye Li, Xiaochun Zhang, Qianzhou Lv

“…Insufficient data exist regarding the investigation of the impact of novel oral anticoagulants (NOACs) on coagulation activation biomarkers in the context of left atrial appendage closure (LAAC) and device-related thrombosis (DRT). …”
Get full text

Technology Readiness Level of biodiversity monitoring with molecular methods – where are we on the road to routine implementation? by Tiina Laamanen, Veera Norros, Petteri Vihervaara, Jacqueline Jerney, Pirkko Kortelainen, Katharina Kujala, Stefan Lambert, Janne Mäyrä, Lilja Nikula, Ida Palmroos, Mikko Tolkkinen, Kristiina Vuorio, Kristian Meissner

“…Thus, implementation of novel molecular monitoring methods such as environmental DNA (eDNA) and DNA metabarcoding, are necessary. …”
Get full text

Anti-Tumor Effect of Rutin on Human Neuroblastoma Cell Lines through Inducing G2/M Cell Cycle Arrest and Promoting Apoptosis by Hongyan Chen, Qing Miao, Miao Geng, Jing Liu, Yazhuo Hu, Lei Tian, Jingkun Pan, Yi Yang

“…It supports the viability of developing rutin as a novel therapeutic prodrug for neuroblastoma treatment, as well as providing a new path on anticancer effect of Chinese traditional drug.…”
Get full text

CDPMF-DDA: contrastive deep probabilistic matrix factorization for drug-disease association prediction by Xianfang Tang, Yawen Hou, Yajie Meng, Zhaojing Wang, Changcheng Lu, Juan Lv, Xinrong Hu, Junlin Xu, Jialiang Yang

“…Subsequently, we introduce a novel multi-view contrastive learning framework, named CDPMF-DDA, which enhances the model's ability to capture drug-disease associations by incorporating diverse information representations from different views. …”
Get full text

Antibody in Lymphocyte Supernatant (ALS) responses after oral vaccination with live Shigella sonnei vaccine candidates WRSs2 and WRSs3 and correlation with serum antibodies, ASCs,... by Malabi M Venkatesan, Cassandra Ballou, Shoshana Barnoy, Monica McNeal, Jill El-Khorazaty, Robert Frenck, Shahida Baqar

“…A recently completed trial of two novel S. sonnei live oral vaccine candidates WRSs2 and WRSs3 established that both candidates were safe, well tolerated and immunogenic in a vaccine dose-dependent manner. …”
Get full text

Introducing an integrated approach for fire safety assessment in healthcare facilities by interval valued neutrosophic-AHP and Fuzzy Inference System by Samaneh Salari, Ali Karimi

“…Subsequently, three main parameters – Potential Risk Level (PRL), Acceptance Risk Level (ARL) and Protection Level (PL) – were calculated as alternatives in IVN-AHP technique using novel mathematical equations. A fuzzy inference system (FIS) was then employed to estimate the risk magnitude and subsequently classify departments within the healthcare building based on their risk level. …”
Get full text

Massively Parallel Screening of Toll/Interleukin‐1 Receptor (TIR)‐Derived Peptides Reveals Multiple Toll‐Like Receptors (TLRs)‐Targeting Immunomodulatory Peptides by Yun Lim, Tae Kyeom Kang, Meong Il Kim, Dohyeon Kim, Ji Yul Kim, Sang Hoon Jung, Keunwan Park, Wook‐Bin Lee, Moon‐Hyeong Seo

“…A comprehensive parallel screening method is developed to uncover novel TIR‐binding peptides derived from previously unexplored surfaces on a wide range of TIR domains. …”
Get full text

Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization by Yue-Yang Zhang, Pei-Dong Li, Bing-Xue Chen, Qin Wan

“…Therefore, this study aims to provide novel evidence for the development of a healthier diet-lifestyle model specifically tailored to the Chinese population. …”
Get full text