Case-Based Virtual Reality Simulation for Severe Pelvic Trauma Clinical Skill Training in Medical Students: Design and Pilot Study by Peng Teng, Youran Xu, Kaoliang Qian, Ming Lu, Jun Hu

“…ObjectiveThis study aims to introduce a novel experimental teaching methodology for severe pelvic trauma, integrating virtual reality (VR) technology as a potent adjunct to existing teaching practices. …”
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RETRACTED ARTICLE: Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients by Xiliang Zhang, Hanjie Guo, Xiaolong Li, Wei Tao, Xiaoqing Ma, Yuxing Zhang, Weidong Xiao

“…Our findings offer new insights into tumor heterogeneity, and a novel framework to personalize prognosis. Single-cell technologies are being used in this context to enhance our understanding of the complex molecular terrain of breast cancer and support more effective clinical management.…”
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Comprehensive analysis of disulfidptosis-related genes and the immune microenvironment in heart failure by Linna Zhao, Juanjuan Zhang, Juanjuan Zhang, Qiuhang Song, Cheng Dai, Yiping Qin, Aiying Li, Aiying Li

“…A recent study has linked disulfidoptosis, a novel form of cell demise, with the development of a range of diseases. …”
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Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease by H. Trimarchi, R. Canzonieri, A. Muryan, A. Schiel, A. Araoz, M. Forrester, A. Karl, F. Lombi, J. Andrews, V. Pomeranz, T. Rengel, E. Zotta

“…However, in this report we demonstrate that podocyturia antedates the classical appearance of proteinuria and could be considered as an even earlier biomarker of kidney damage. Podocyturia may be a novel indication for the initiation of therapy in Fabry disease.…”
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An Improved YOLOv8 Model for Strip Steel Surface Defect Detection by Jinwen Wang, Ting Chen, Xinke Xu, Longbiao Zhao, Dijian Yuan, Yu Du, Xiaowei Guo, Ning Chen

“…To improve the effectiveness of surface defect detection in steel strips, we propose an enhanced detection model known as YOLOv8-BSPB. First, we propose a novel pooling layer module, SCRD, which replaces max pooling with average pooling. …”
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Multi-Task Learning for Alzheimer’s Disease Diagnosis and Mini-Mental State Examination Score Prediction by Jin Liu, Xu Tian, Hanhe Lin, Hong-Dong Li, Yi Pan

“…To address this challenging problem, we propose a novel multi-task learning method, which uses feature interaction to explore the relationship between Alzheimer’s disease diagnosis and mini-mental state examination score prediction. …”
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Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models by Shengying Lin, Roy Wai-Lun Tang, Yutong Ye, Chenxi Xia, Jiahui Wu, Ran Duan, Ka-Wing Leung, Tina Ting-Xia Dong, Karl Wah-Keung Tsim

“…There is still a need to develop novel VEGF-based therapeutics against these VEGF-related diseases. …”
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SPEMix: a lightweight method via superclass pseudo-label and efficient mixup for echocardiogram view classification by Shizhou Ma, Yifeng Zhang, Delong Li, Yixin Sun, Zhaowen Qiu, Lei Wei, Suyu Dong

“…However, the current semi-supervised echocardiogram view classification faces challenges of declining accuracy due to out-of-distribution data and is constrained by complex model structures in clinical application.MethodsTo deal with the above challenges, we proposed a novel open-set semi-supervised method for echocardiogram view classification, SPEMix, which can improve performance and generalization by leveraging out-of-distribution unlabeled data. …”
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Graphene-Based, Flexible, Wearable Piezoresistive Sensors with High Sensitivity for Tiny Pressure Detection by Rui Li, Jiahao Hu, Yalong Li, Yi Huang, Lin Wang, Mohan Huang, Zhikun Wang, Junlang Chen, Yan Fan, Liang Chen

“…Here, we present a piezoresistive sensor with a novel microstructure that combines insulating and conductive properties. …”
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Large-Scale Mapping of Maize Plant Density Using Multi-Temporal Optical and Radar Data: Models, Potential and Application Strategy by Jing Xiao, Yuan Zhang, Xin Du, Qiangzi Li, Hongyan Wang, Yueting Wang, Jingyuan Xu, Yong Dong, Yunqi Shen, Sifeng Yan, Shuguang Gong, Haoxuan Hu

“…This study presents a novel approach to maize density estimation by integrating optical and radar data, addressing these challenges with a unique mapping strategy. …”
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IUPHAR themed review: The gut microbiome in schizophrenia by Srinivas Kamath, Elysia Sokolenko, Kate Collins, Nicole S.L. Chan, Natalie Mills, Scott R. Clark, Francine Z. Marques, Paul Joyce

“…To address these challenges, novel therapeutic strategies targeting the gut microbiome, encompassing probiotic supplementation, prebiotic compounds, faecal microbiota transplantation, and rationalised co-pharmacotherapy, show promise in attenuating antipsychotic-induced metabolic disruptions while enhancing therapeutic efficacy. …”
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Cooperative maximum adhesion tracking control for multi-motor electric locomotives by Leiting Zhao, Yongxiang Wang, Kan Liu, Liran Li, Jingyuan Zhan, Qingliang Liu

“…Originality/value – This study presents a novel cooperative adhesion tracking control scheme. …”
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Potential involvement of cuproptosis induced by m6A-modified autophagy gene ATG10 in KICH by Qingyun Zhu, Daiquan Fu, Zhaohui Zhu, Jian Wu, Chenxi Li, Jiajun Chen, Chuan Chen, Yanxiang Li, Yuehui Guo, Xiangqi Li

“…This study elucidates the significance of ATG10 in KICH, implicating m6A methylation and cuproptosis as novel targets for therapeutic intervention. The identification of B cells and CD8 + T cells as key immune components, along with specific amino acids, suggests that a combination of targeted immune therapies and dietary interventions could provide a multifaceted approach to KICH treatment. …”
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Inhibition of transcriptional regulation of detoxification genes contributes to insecticide resistance management in Spodoptera exigua by Bo Hu, Yuping Deng, Tao Lu, Miaomiao Ren, Kuitun Liu, Cong Rao, Hailiang Guo, Jianya Su

“…Altogether, our results demonstrate that reduced expression of detoxification genes resulting from suppression of transcriptional regulation of these genes contributes to controlling insecticide resistance, which provides a very novel and high-efficiency green resistance management strategy.…”
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Relationship between the CUBN and the MIA3 gene copy number variation and growth traits in different cattle breeds by Yue Han, Jiwei Liu, Congcong Zhang, Ming Sun, Xuanyu Li, Hongliang Liu, Shengnan Li, Yongchao Zhu, Ruidong Li, Xiaotong Luo, Yumin Zhao, Jian Wu

“…In conclusion, CUBN CNV is correlated significantly with growth traits in Chinese cattle and is a novel molecular marker that could be exploited in cattle breeding.…”
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Tracheal Resection for Critical Airway Obstruction in Morquio A Syndrome by Claire Frauenfelder, Elizabeth Maughan, Johnny Kenth, Reema Nandi, Simon Jones, Robert Walker, Bill Walsh, Nagarajan Muthialu, Iain Bruce, Richard Hewitt, Colin Butler

“…This addressing of tracheal/thoracic cage dimension mismatch represents a novel surgical treatment approach to an existing clinical paradigm and may be useful for other carefully selected individuals with MPS IVA. …”
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Innovative Damage Assessment of Endodontic Instruments Based on Digital Image Stacking by Raúl Argüello-Sánchez, Ivette Alejandra Calderón-Alday, Antonio Hernández-Morales, Benjamín Gonzalo Rodríguez-Méndez, Diego Medina-Castro, Régulo López-Callejas, Carlo Eduardo Medina-Solís

“…This study proposes a novel system that leverages digital photography and advanced image processing techniques as a viable alternative to SEM. …”
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AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells by Yuhan Gan, Linhui Zhu, Yimo Li, Ruoting Ge, Jiahe Tian, Yuxin Chen, Xiang He, Shumei Ma, Xiaodong Liu

“…This study will promote the development of novel targeted radiosensitizing drugs.…”
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A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

“…This study explored the inhibitory potential of natural compounds from <i>Lepidium meyenii</i> (Peruvian Maca) on the YAP-1 and PARP-1 protein systems to develop novel therapeutic strategies for GBM. By molecular dynamics simulations, we identified N-(3-Methoxybenzyl)-(9Z,12Z,15Z)- octadecatrienamide (DK5) as the most promising natural inhibitor for PARP-1 and stearic acid (GK4) for YAP-1. …”
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O Serogroup-Specific Touchdown-Multiplex Polymerase Chain Reaction for Detection and Identification of Vibrio cholerae O1, O139, and Non-O1/Non-O139 by Adisak Bhumiratana, Achiraya Siriphap, Nutsarin Khamsuwan, Jednipit Borthong, Kaknokrat Chonsin, Orasa Sutheinkul

“…A novel, sensitive locus-specific touchdown-multiplex polymerase chain reaction (TMPCR), which is based on two-stage amplification pertaining to multiplex PCR and conditional touchdown strategy, was used in detecting and differentiating Vibrio cholerae serogroups. …”
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