Structural characterization of three acidic polysaccharides from Opuntia dillenii Haw. fruits and their protective effect against hydrogen peroxide-induced oxidative stress in Huh-... by Rui Liu, Fangxin Chu, Zheng Yan, Hanqing Chen

“…Three novel acidic polysaccharide fractions (OFPP-1, OFPP-2, OFPP-3) with different m olecular weights (803.7, 555.1 and 414.5 kDa) were isolated from the peeled Opuntia dillenii Haw. fruits by alkali-extraction, graded alcohol precipitation and column chromatography. …”
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Applying Metallo‐Organic Ligand Design Principles to the Stereoselective Synthesis of a Peptide‐Based Pd2L4X4 Cage by Dr. Dominic F. Brightwell, Dr. Kushal Samanta, Dr. Jimmy Muldoon, Dr. Patricia C. Fleming, Dr. Yannick Ortin, Dr. Lina Mardiana, Dr. Paul G. Waddell, Dr. Michael J. Hall, Dr. Ewan R. Clark, Dr. Felipe Fantuzzi, Dr. Aniello Palma

“…We have successfully designed a series of polyprolines, which mimic the topology of ditopic polyaromatic ligands, to achieve the stereoselective synthesis of a novel Pd lantern cage. This cage exhibits excellent stability in water and demonstrates the stabilization of a highly reactive species in solution. …”
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Associations between Chinese Visceral Adiposity Index and the Risk of Metabolic Dysfunction-associated Steatotic Liver Disease and Liver Fibrosis: A Large Cross-sectional Study by Hui Liu, Mingming Deng, Gang Luo, Jie Chen

“…Conclusion: The CVAI was positively related to the risk of MASLD or liver fibrosis and could be a novel biomarker for predicting MASLD and fibrosis in the American population.…”
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Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6 by Huan Yi, Yan-zhao Su, Rong Lin, Xiang-qin Zheng, Diling Pan, Dan-mei Lin, Xiang Gao, Rong Zhang

“…This finding may provide a novel diagnostic and therapeutic target for improving the poor prognoses of OC patients.…”
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Kruppel-family zinc finger proteins as emerging epigenetic biomarkers in head and neck squamous cell carcinoma by Patrick Pearson, Kendra Smith, Nilita Sood, Elizabeth Chia, Alicia Follett, Michael B. Prystowsky, Simon Kirby, Thomas J. Belbin

“…Conclusions Both ZNF132 and ZNF154 represent novel clinically significant biomarkers in head and neck cancer with potential tumour suppressive properties. …”
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Developing a translational research framework for MDD: combining biomolecular mechanisms with a spiraling risk factor model by Max van Baalen, Lars van der Velden, Toon van der Gronde, Toon van der Gronde, Toine Pieters

“…Biomolecular mechanisms within the microbiota-gut-brain axis (MGBA) may significantly contribute to MDD, potentially paving the way for novel treatment approaches. However, integrating the MGBA with the psychological and environmental aspects of MDD remains challenging. …”
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A new potential of sodium anthraquinone-2-sulfonate as a corrosion inhibitor for carbon steel in 0.5 M H2SO4 by Nikolay Akatyev, Roza Kenzhegalieva, Meruyet Khapiyeva, Gauhar Uzakbay, Aruzhan Talapova, Ruben Vardanyan

“…The results highlight the novel potential of AQ2SNa as an effective corrosion inhibitor to provide an effective solution for enhancing the protection of carbon steel in acidic media. …”
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Biochemical characteristics, genetic variants and treatment outcomes of 55 Chinese cases with neonatal intrahepatic cholestasis caused by citrin deficiency by Juan Li, Jintao Duan, Shuli He, Ying Li, Meifen Wang, Chengjun Deng

“…All NICCD patients were followed up until death or at least 1 year of age.ResultsCompared to INC group, significant increase was found in levels of total bilirubin, indirect bilirubin, total bile acid, gamma-glutamyl transpeptidase, alkaline phosphatase, prothrombin time, thrombin time, international normalized ratio, alpha-fetoprotein (AFP), Vitamin D, and Vitamin E of NICCD group, while alanine aminotransferase, albumin, fibrinogen, glucose, and Vitamin A levels showed significant decrease in the NICCD group (P < 0.05). There were 7 novel variants among 19 SLC25A13 variant types. No significant differences were found between NICCD patients treated for 12 months and normal controls. …”
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Leakage of Octyl(Phenyl)--Di-Isobutylcarbamoylmethylphosphine Oxide from a Macroporous Silica-Based Chelating Polymeric Adsorption Material and its Recovery by Some Selected Porous... by Anyun Zhang, Yuezhou Wei, Harutaka Hoshi, Mikio Kumagai, Yoshikazu Koma

“…The leakage behaviour of a neutral chelating agent, i.e. octyl(phenyl)- N,N -di-isobutylcarbamoylmethylphosphine oxide (CMPO), from its macroporous silica-based (CMPO/SiO 2 -P) extraction resin (a novel polymeric adsorption material developed in the MAREC process) and the recovery of CMPO by some selected polymer- and silica-based porous adsorbents were investigated by column operation in 0.01 M HNO 3 at 25°C or 50°C. …”
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Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer by Ai Sato, Kiyoshi Takagi, Mio Yamaguchi-Tanaka, Jotaro Okushima, Yuto Yamazaki, Akihiro Ito, Takashi Suzuki

“…Prostate cancer is a common malignancy in men around the world, and it is crucial to explore novel biomarkers to improve its treatment. Prostate cancer cells typically invade the surrounding stroma, and remodeling of the extracellular matrix (ECM) is a crucial step in the progress of prostate cancer. …”
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Call to Action: Lead Pharmacy into the Next Decade by Kerry K Fierke, Gardner Lepp, Bridget McGugan, Marta Brooks

“…The evolving landscape of healthcare leadership demands novel perspectives, creative applications, and open-minded evaluations. …”
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Regular Chinese Green Tea Consumption Is Protective for Diabetic Retinopathy: A Clinic-Based Case-Control Study by Qinghua Ma, Dandan Chen, Hong-Peng Sun, Ning Yan, Yong Xu, Chen-Wei Pan

“…Regular Chinese green tea consumption may be a novel approach for the prevention of DR.…”
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Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients by Ru-xing Zhao, Wen-juan Li, Yi-ran Lu, Jun Qin, Chuan-long Wu, Meng Tian, Tian-yi He, Shou-nan Yi, Dong-qi Tang, Lei Sun, Li Chen

“…The recently identified Th22 cells might play an independent role in CHD and represent a novel proxy for cardiovascular risks in diabetes.…”
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Single-Round Patterned DNA Library Microarray Aptamer Lead Identification by Jennifer A. Martin, Peter A. Mirau, Yaroslav Chushak, Jorge L. Chávez, Rajesh R. Naik, Joshua A. Hagen, Nancy Kelley-Loughnane

“…The sequence demonstrating the highest fluorescence intensity upon target addition was confirmed to bind the target molecule thrombin with specificity by surface plasmon resonance, and a novel imino proton NMR/2D NOESY combination was used to screen the structure for G-quartet formation. …”
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Advances in fear memory erasure and its neural mechanisms by Wenbo Guo, Xibo Wang, Xibo Wang, Zihan Zhou, Zihan Zhou, Yuhui Li, Yuhui Li, Yani Hou, Keyan Wang, Ruyuan Wei, Xiaoyu Ma, Hao Zhang

“…Notably, this review may guide future studies on fear memory and its underlying molecular mechanisms, which may help to develop novel treatment strategies for post-traumatic stress disorder, anxiety, and other mental disorders.…”
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Enhanced Arsenic Removal from Aqueous Solution by Fe/Mn-C Layered Double Hydroxide Composite by Yaru Wang, Yingying Gao, Zongqiang Zhu, Lihao Zhang, Ningning Zhao, Yali Fang, Yinian Zhu, Guifeng Liu

“…A novel material named Fe/Mn-C layered double hydroxide composite (Fe/Mn-C-LDH) was synthesized to remove arsenic from an aqueous solution. …”
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Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker by Karzan Ghafur Khidhir, Baban Ahmad, Dana Khdr Sabir

“…Our findings could lead to the discovery of novel diagnostic, preventive and therapeutic strategies. …”
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Exploitation of the Nutraceutical Potential of the Infesting Seaweed <i>Chaetomorpha linum</i> as a Yellow Mealworms’ Feed: Focus on Nutrients and Antioxidant Activity by Annalaura Brai, Edoardo Brogi, Franca Tarchi, Federica Poggialini, Chiara Vagaggini, Sauro Simoni, Valeria Francardi, Elena Dreassi

“…According to the Sustainable Blue Economy Communication, the Farm to Fork Strategy, and the European Green Deal, novel business models supporting the use of resources from oceans and seas are of primary importance. …”
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Differential Gene Expression Analysis in a Lumbar Spinal Stenosis Rat Model via RNA Sequencing: Identification of Key Molecular Pathways and Therapeutic Insights by Jin Young Hong, Wan-Jin Jeon, Hyunseong Kim, Changhwan Yeo, Hyun Kim, Yoon Jae Lee, In-Hyuk Ha

“…Conclusions: Our findings provide novel insights into the molecular mechanisms underlying LSS and offer potential avenues for the development of targeted therapies aimed at mitigating disease progression and improving patient outcomes.…”
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Investigation of Crinum solapurense leaves extract for antidiabetic activity and histopathological evaluation in an in-vivo experimental model by Sunayana Mali, Gaurav Jain, Jyotiram Sawale, Audumbar Mali

“…Background: This study investigates the biological activity of the newly discovered novel C. solapurense (Crinum solapurense) plant from the Solapur, Maharashtra region, addressing a literature gap on its properties. …”
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