Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics by Lorraine Gaenaelle Gé, Mathias Bogetoft Danielsen, Aaraby Yoheswaran Nielsen, Mathias Lander Skavenborg, Niels Langkjær, Helge Thisgaard, Christine J. McKenzie

“…With cobalt-57 (⁵⁷Co) serving as a surrogate radionuclide for ^55/58mCo, the novel GE11-TZTPEN construct was successfully radiolabeled with a high radiochemical yield (99%) and purity (>99%). …”
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Sentinel-1-Aided Mutual Calibration of TanDEM-X DEMs for the Estimation of Height and Volume Changes by Carolina Gonzalez, Luca Dell'Amore, Jose-Luis Bueso-Bello, Pietro Milillo, Gabriele Schwaizer, Thomas Nagler, Paola Rizzoli

“…We propose a novel method for retrieving a set of reliable natural calibration targets and for performing an effective mutual calibration of TanDEM-X time-tagged DEMs. …”
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Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance by Gabrielle C. Ngwana-Joseph, Jody E. Phelan, Emilia Manko, Jamille G. Dombrowski, Simone da Silva Santos, Martha Suarez-Mutis, Gabriel Vélez-Tobón, Alberto Tobón Castaño, Ricardo Luiz Dantas Machado, Claudio R. F. Marinho, Debbie Nolder, François Nosten, Colin J. Sutherland, Susana Campino, Taane G. Clark

“…Overall, we provide novel markers for resistance surveillance, supported by evidence of regions under recent directional selection and temporal analysis in this continually evolving parasite.…”
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Circadian Rhythms Fluctuate the Treatment Effects of Intravesical Treatments on Rat Urinary Frequency Models by Tomofumi Watanabe, Takuya Sadahira, Yusuke Tominaga, Yuki Maruyama, Naoya Nagasaki, Takanori Sekito, Kohei Edamura, Toyohiko Watanabe, Motoo Araki, Masami Watanabe

“…These findings may help establish novel therapies for urinary frequency.…”
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Unveiling the Genetic Diversity and Demographic History of <i>Coffea stenophylla</i> in Sierra Leone Using Genotyping-By-Sequencing by Paul M. Lahai, Peter O. Aikpokpodion, Alieu Mohamed Bah, Mohamed T. Lahai, Lyndel W. Meinhardt, Seunghyun Lim, Ezekiel Ahn, Dapeng Zhang, Sunchung Park

“…This species faces increasing threats from climate change, deforestation, and habitat fragmentation in its West African homeland. Using 1037 novel SNP markers derived from Genotyping-by-Sequencing (GBS), we revealed the presence of three distinct natural populations (mean Fst = 0.176) in Sierra Leone. …”
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Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

“…Based on these findings, we developed a novel prognostic model that identifies poorer prognosis in high-risk groups. …”
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Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particles by Majid Moussaei, Ebrahim Tajik, Vahid Haddadi-Asl, S. Ali Mazloumi, Helia Heydarinasab, Elahe Abdollahi, Fatemeh Haj-Sadeghi, Hanie Ahmadi, Mohammad Reza Gholizadeh

“…Development of efficient drug delivery systems remains a critical challenge in pharmaceutical applications, necessitating novel approaches to improve drug loading and release profiles. …”
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An experimental and modelling approach to proclaim sustainable machining using avocado oil-based nano-cutting fluids by Abera Ayza Anebo, Venkatesh Chenrayan, Kiran Shahapurkar, Gezahgn Gebremaryam, Jana Petrů, Manzoore Elahi M. Soudagar, Vijayabhaskara Rao Bhaviripudi, Rajakrishnan Rajagopal, Muhammad Nasir Bashir

“…The improved performance of the novel machining fluid upholds its potential to replace conventional fluids and ensure green manufacturing.…”
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Self-perceived middle-distance race pace is faster in advanced footwear technology spikes by Montgomery Bertschy, Victor Rodrigo-Carranza, Ethan W.C. Wilkie, Laura A. Healey, Jeremy Noble, Wayne J. Albert, Wouter Hoogkamer

“…Methods: We introduce a novel approach to assess the benefits of AFT spikes, consisting of a series of 200-m runs at self-perceived middle-distance race pace with 10 min recovery, and conduct 4 experiments to evaluate its validity, sensitivity, reproducibility, and utility. …”
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An Injectable Oil-Based Depot Formulation of <i>N</i>-Acyloxymethyl Prodrug of Ropivacaine for Long-Acting Local Analgesia: Formulation Development and In Vitro/In Vivo Evaluation by Xiaowei Liu, Ruihan Zhao, Peijie Xu, Jianqiang Qian, Peiyan Zhang, Xudong Xie, Yong Ling, Qimin Ge, Yong Chen

“…<b>Objectives:</b> The development of novel long-acting injectables for local anesthetics is necessary to effectively manage the acute postoperative pain. …”
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Studying Alzheimer’s disease through an integrative serum metabolomic and lipoproteomic approach by Alessia Vignoli, Giovanni Bellomo, Federico Paolini Paoletti, Claudio Luchinat, Leonardo Tenori, Lucilla Parnetti

“…We proposed a novel approach able to sub-stratify MCI-AD patients identifying those associated with a faster rate of clinical progression.…”
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Voices from the Amazon: exploring implementor and user perceptions of non-invasive malaria diagnostics in Peru by Lauren Nussbaum, Emma Ortega, E. Jennifer Ríos López, Alfonso Simoné Vizcarra, Jhonny J. Córdova López, Serafina Calarco, Elena Marbán-Castro, Kevin Tetteh, Sonjelle Shilton, Amy C. Morrison, Vanessa Fargnoli, Valerie A. Paz-Soldán

“…Abstract Background Malaria burden remains high in some Peruvian regions, especially in the Northeast Amazon rainforest state of Loreto and the tropical coastal state of Tumbes. Novel non-invasive diagnostic tools for malaria are being developed, and formative research in malaria-endemic areas with community members and health professionals who would potentially use these devices is vital for this process. …”
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Ultrafast laser welding of transparent materials: from principles to applications by Xianshi Jia, Jinlin Luo, Kai Li, Cong Wang, Zhou Li, Mengmeng Wang, Zhengyi Jiang, Vadim P Veiko, Ji’an Duan

“…The principles of ultrafast laser welding, bottleneck problems in the welding, novel welding methods, advances in welding performance, in-situ monitoring and diagnosis, and various applications are reviewed. …”
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Modality Specific CBAM-VGGNet Model for the Classification of Breast Histopathology Images via Transfer Learning by Areesha Ijaz, Basit Raza, Iqra Kiran, Abdul Waheed, Aadil Raza, Habib Shah, Sulaiman Aftan

“…In this study, we have proposed a novel modality specific CBAM-VGGNet model for classifying H and E stained breast histopathology images. …”
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Anti-Tissue-Transglutaminase IgA Antibodies Presence Determination Using Electrochemical Square Wave Voltammetry and Modified Electrodes Based on Polypyrrole and Quantum Dots by Angela Gabriela Pãun, Simona Popescu, Alisa Ioana Ungureanu, Roxana Trusca, Alina Popp, Cristina Dumitriu, George-Octavian Buica

“…A novel electrochemical detection method utilizing a cost-effective hybrid-modified electrode has been established. …”
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Categorization of early embryonic malformations in broilers by a new classification method combining light microscopy and high-resolution Episcopic Microscopy by Yuval Cinnamon, Natalia Slutsky, Maxim Quint, Olga Genin, Dalit Sela-Donenfeld

“…However, understanding of the types and prevalence of early embryonic malformations in broiler eggs remains incomplete.Here we present a novel tool for categorizing abnormalities in 3-day-old broiler embryos through a standardized classification system. …”
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Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis by Mengyuan Li, Hang Yuan, Xiaofei Yang, Yingfeng Lei, Jianqi Lian

“…Results Here, we have delineated a novel perspective on the pathogenesis of JE by identifying an aberrant low flux in glutamine-glutamate metabolism both in vivo and in vitro, which was critical in the establishment of JEV infection and progression of JE. …”
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Refining prognostic assessment of diffuse large B-cell lymphoma: insights from multi-omics and single-cell analysis unveil SRM as a key target for regulating immunotherapy by Xiaojie Liang, Jia Guo, Baiwei Luo, Weixiang Lu, Qiumin Chen, Yeling Deng, Yunong Yang, Liang Wang

“…Herein, we aimed to integrate proliferation, stromal, and immune (PSI) features to systematically evaluate the risk stratification and explore novel therapeutic targets in DLBCL. Methods Using data from multiple researches, we comprehensively evaluated the characteristics and prognostic impact of PSI features in DLBCL, and developed a novel risk stratification model (PSI score) with a consistent cutoff value to stratify the risk of 3,229 DLBCL patients from different cohorts. …”
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Current challenges, and potential solutions to increase acceptance and long-term consumption of cultured meat and edible insects – A review by Jia Wen Xanthe Lin, Narmatha Maran, Amanda JiaYing Lim, Siew Bee Ng, Pey Sze Teo

“…Novel alternative proteins have been in the spotlight due to increased awareness and desire to improve the sustainability of global food consumption. …”
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Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis by Xiaoyu Huang, Zhouao Zhang, Zhouyi Wang, Tiancheng Luo, Mingjin Yang, Xinyan Guo, Xue Du, Tianyu Ma, Yong Zhang

“…Therefore, we aimed to identify potential novel therapeutic targets that preserve part of B cell function while inhibiting antibody-secreting cells (ASCs). …”
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