Optimal configuration of a solar-powered Organic Rankine Cycle power plant utilizing thermochemical energy storage by Sofiene Mellouli, Talal Alqahtani, Salem Algarni, Abdullah A. Faqihi, Badr M. Alshammari, Lioua Kolsi

“…What makes this system unique is its integration with an ORC system-a novel approach not previously explored or examined. …”
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Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair by Yinan Xiao, Yu Wu, Qilong Wang, Mo Li, Chaolin Deng, Xiaoyang Gu

“…Proximity labeling revealed replication protein A3 (RPA3) as a novel PFKFB3-binding protein involved in HR repair. …”
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FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE₂-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells by Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno

“…We also synthesized a novel FXR agonist, <b>FLG390</b>, and compared its biological effects in osteoblast differentiation with a known FXR agonist, chenodeoxycholic acid (CDCA). …”
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Advanced artificial intelligence with federated learning framework for privacy-preserving cyberthreat detection in IoT-assisted sustainable smart cities by Mahmoud Ragab, Ehab Bahaudien Ashary, Bandar M. Alghamdi, Rania Aboalela, Naif Alsaadi, Louai A. Maghrabi, Khalid H. Allehaibi

“…Abstract With the fast growth of artificial intelligence (AI) and a novel generation of network technology, the Internet of Things (IoT) has become global. …”
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The potential uses of Galangal (Alpinia sp.) essential oils as the sources of biologically active compounds by R. Amilia Destryana, Teti Estiasih, Sukardi, Dodyk Pranowo

“…Some studies indicates that the novel technologies produce higher yield than conventional method for essential oil extraction. …”
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Insights into incompatible plasmids in multidrug-resistant Raoultella superbugs by Jiao Feng, Changxin Wu, Dongsheng Zhou, Lingfei Hu, Kai Mu, Zhe Yin

“…This study aims to elucidate the genomic features of novel incompatible plasmids in MDR Raoultella by presenting 13 complete plasmid sequences from four isolates, along with an analysis of 16 related plasmids from GenBank. …”
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Educational Needs During COVID-19: MOOCs Experiences Among Global Family Physicians by Özden Gökdemir, Halime Seda Küçükerdem, Sudip Bhattacharya, Maria Bakola, Mohammed Idris Shariff

“…This gave them capacity to save and improve the lives of countless patients infected by the novel coronavirus worldwide. Sharing their experiences with COVID-19 could be a way to cope with stress.…”
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Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 by Yongzhi Lu, Qi Yang, Ting Ran, Guihua Zhang, Wenqi Li, Peiqi Zhou, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, Jiayi Chen, Jiyun Zhang, Sidi Yang, Kunzhong Wu, Xinyu Wu, Miru Tang, Wei K. Zhang, Deyin Guo, Xinwen Chen, Hongming Chen, Jinsai Shang

“…However, the mutations causing drug resistance have been observed in RdRp and 3CLpro from SARS-CoV-2, which makes it necessary to develop antivirals with novel mechanisms. Through the application of a structure-based drug design (SBDD) approach, we discover a series of novel potent non-covalent PLpro inhibitors with remarkable in vitro potency and in vivo PK properties. …”
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Bedside hyperspectral imaging for the evaluation of microcirculatory alterations in perioperative intensive care medicine: a study protocol for an observational clinical pilot stud... by Thilo Hackert, Thomas Bruckner, Maximilian Dietrich, Sebastian Marx, Felix Nickel, Beat Peter Müller-Stich, Markus A Weigand, Florian Uhle, Thorsten Brenner, Karsten Schmidt

“…The TIVITA Tissue System is a novel HSI system that uses the visible and near-infrared spectral light region to determine tissue microcirculatory parameters. …”
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Microstructures, properties and preparations of lightweight refractory high-entropy alloys: A review by Gengchen Li, Zhibin Wu, Yajing Dong, Zhen Hu, Yuefei Jia, Shiwei Wu, Yongkun Mu, Kang Sun, Yandong Jia, Gang Wang

“…Additionally, the latest advancements in additive manufacturing technology are synthesized, exploring their implications for microstructural development and performance characteristics of these novel LRHEAs. Finally, the review identifies existing gaps in the research and offers prospects for the future development of LRHEAs, emphasizing the need for enhanced theoretical frameworks and novel manufacturing techniques to fully realize their potential in practical applications.…”
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Zellweger syndrome; identification of mutations in PEX19 and PEX26 gene in Saudi families by Abdulfatah M. Alayoubi, Ambreen Ijaz, Abdul Wali, Jamil A. Hashmi, Azizah Alharbi, Sulman Basit

“…The frequency and pathogenicity of the identified mutations were assessed using various online bioinformatics tools.Results WES identified a novel nonsense variant (c.367C > T) in the PEX19 gene in family A patients. …”
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IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma by Khuloud Bajbouj, Mahmood Y. Hachim, Rakhee K. Ramakrishnan, Huwaida Fazel, Jumana Mustafa, Shahed Alzaghari, Mahmoud Eladl, Jasmin Shafarin, Ronald Olivenstein, Qutayba Hamid

“…This study highlights the novel pathological involvement of the histone demethylase JMJD2B/KDM4B in asthmatic airway fibroblasts that are regulated by IL-13. …”
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Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review by Francesco M Marincola, Alessandra Cesano, Yana G Najjar, Davide Bedognetti, Marco Ruella, Sarah Warren, Christine Spencer, Elad Ziv, Tomas Kirchhoff, Jennifer McQuade, Tullia C Bruno, Jakob Nikolas Kather, Allison Betof Warner, Christian Hammer, Alberto Carturan, Ryan Augustin, Rhine Shen, Winson S Ho, Rongze O Lu, Luigi Barrea, Violena Pietrobon, Laura Soldati

“…Recent advancements as well as novel approaches to address the limitations of current treatments are discussed here, with a specific focus on ICI and ACT.…”
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Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives by Nikolaos Nektarios Karamanolis, Dimitris Kounatidis, Natalia G. Vallianou, Krystalia Dimitriou, Eleni Tsaroucha, Georgios Tsioulos, Ioanna A. Anastasiou, Evangelos Mavrothalassitis, Irene Karampela, Maria Dalamaga

“…Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. In this context, the repurposing of antibiotics as anti-cancer agents has emerged as an attractive prospect for investigation. …”
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Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border by Keke Wang, Hongyan Qu, Ruinan Hu, Bernard Lassègue, Douglas C. Eaton, Chang Song, Jianjun Mu, Kathy K. Griendling, Marina S. Hernandes

“…Abstract Background Polymerase delta-interacting protein 2 (Poldip2) is a novel regulator of vascular permeability that has been shown to be involved in aggravating blood–brain barrier (BBB) disruption following stroke; however, the underlying mechanisms are unknown. …”
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Experimental Operation of a Prototype 750C Advanced Chloride Molten Salt Bellows Valve by Kenneth Armijo, Aaron Overacker, Ansel Blumenthal, Jeffrey Parish, Michael Nelson, Ivica Radman, Javier Martell

“…Additionally, the design includes the employment of a novel heat pipe valve stem to facilitate enhanced passive thermal management into the valve assembly. …”
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Spermine driven water deficit tolerance in early growth phases of sweet corn genotypes under hydroponic cultivation by Tahoora Batool Zargar, Mawia Sobh, Oqba Basal, Tibor Janda, Magda Pál, Szilvia Veres

“…This study investigates the novel application of Spermine as a bio-stimulant to improve sweet corn (Zea mays L. var. saccharata) resilience under hydroponic water deficit conditions. …”
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Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma by Yihong Li, Xuejie Yang, Zhen Wei, Heng Niu, Liyang Wu, Caijing Chen, Huina Liu, Ting Cai, Huadong Fan

“…In animal experiments, besides a significant reduction in tumor volume and a delay in losing body weight, H&E staining showed a massive infiltration of neutrophils adjacent to the tumor sites, indicating this novel nanocomplex SFN@RB@SPM can synergistically augment SDT efficacy, partially by enhancing the antitumor function of innate immunity.…”
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Efficient Path Planning and Formation Control in Multi-Robot Systems: A Neural Fields and Auto-Switching Mechanism Approach by Raouf Fareh, Mohammed Baziyad, Tamer Farouk Rabie, Sofiane Khadraoui, Mohammad Habibur Rahman

“…This paper presents a novel approach to enhancing the path planning and formation control of multi-robot leader-follower systems by integrating neural fields and novel potential field modeling. …”
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Children with autistic spectrum disorder can imagine actions— what can this reveal about the Broken Mirror Hypothesis? by Jessica Galli, Jessica Galli, Laura Dusi, Gioacchino Garofalo, Gioacchino Garofalo, Alessandra Brizzi, Michela Gritti, Federica Polo, Elisa Fazzi, Elisa Fazzi, Giovanni Buccino, Giovanni Buccino

“…Children had to press the key associated to the correct frame to provide their responses.ResultsBoth groups performed similarly in the questionnaire and in the novel MI task, where they showed the same error rate. …”
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