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6421
Clinical phenotype and trio whole exome sequencing data from a patient with glycogen storage disease IV in Indonesia(NCBI)
Published 2025-02-01“…The non-specific clinical finding (phenotype) and identification of novel mutation adds the complexity of diagnosing and confirming rare disease. …”
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6422
The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy
Published 2025-02-01“…Exploration of new small-molecule toxins with unique antitumor and toxicity profiles is crucial. Tub114, a novel Tubulysin B analog with a hydrophilic ethylene glycol moiety, has been conjugated to the anti-HER2 antibody DX-CHO9, forming the ADC DX126-262. …”
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6423
Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice
Published 2023-01-01“…Cognitive function was assessed using the novel object recognition test (NORT) and Y-maze test. …”
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6424
Integrating RNA-seq and scRNA-seq to explore the prognostic features and immune landscape of exosome-related genes in breast cancer metastasis
Published 2025-12-01“…The integration of RNA-seq and scRNA-seq data highlights the predictive accuracy of the model and underscores its potential for identifying novel therapeutic targets and improving patient prognosis.…”
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6425
Circulating miRNA-125b Is a Potential Biomarker Predicting Response to Rituximab in Rheumatoid Arthritis
Published 2014-01-01“…Circulating micro(mi)RNAs represent a novel class of molecular biomarkers whose expression is altered in RA. …”
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6426
Resolving ambiguity in natural language for enhancement of aspect-based sentiment analysis of hotel reviews
Published 2025-01-01“…This article proposes a novel approach to ABSA by introducing a novel technique of word sense disambiguation (WSD) and integrating it with the Transformer architecture bidirectional encoder representations from Transformers (BERT) and graph convolutional networks (GCNs). …”
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6427
Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism
Published 2025-02-01“…Infants were presented with native (English) and novel (Japanese) speech while sleeping naturally in the scanner. …”
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6428
Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing
Published 2025-02-01“…., atomic layer deposition [ALD]) have paved the way for the modification of the surface of target substrates with thin films, nanoparticles, or other types of nanomaterials. This novel way can improve the base material's properties and enhance specific properties through adding functionalized groups to the surface. …”
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6429
Thermal performance of Falkner Skan model (FSM) for (GOMoS2)/(C2H6O2-H2O) 50:50% nanofluid under radiation heating source
Published 2025-01-01“…Hence, the current study aims to develop and investigate the novel hybrid nanofluid model (GO-MoS2)/(C2H6O2-H2O) through MRW (moving riga wedge) and SRW (static riga wedge) cases. …”
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6430
Hybrid Plant Growth: Integrating Stochastic, Empirical, and Optimization Models with Machine Learning for Controlled Environment Agriculture
Published 2025-01-01“…This study introduces a novel hybrid plant growth model integrating stochastic, empirical, and optimization approaches, using Internet of Things sensors for real-time data collection. …”
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6431
Quinoid to benzenoid transition-driven glutathione sensing: Dual-emission carbon dots and smartphone-based ratiometric fluorescence analysis
Published 2025-08-01“…This study presents a novel and sensitive method for the determination of glutathione (GSH), a crucial antioxidant and cellular protectant, using dual blue/orange-emitting carbon dots (BOCDs) and phenolphthalein (PHP). …”
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6432
Astrocytic proteins involved in regulation of the extracellular environment are increased in the Alzheimer's disease middle temporal gyrus
Published 2025-01-01“…Our study presents novel and potentially modifiable glial changes in the AD human brain that are critical to our understanding of disease pathogenesis.…”
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6433
Direct and Indirect Protein Interactions Link FUS Aggregation to Histone Post-Translational Modification Dysregulation and Growth Suppression in an ALS/FTD Yeast Model
Published 2025-01-01“…Exploiting the same model, we reveal novel connections between FUS aggregation and epigenetic dysregulation. …”
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6434
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6435
GLP-1 Gene-Modified Human Umbilical Cord Mesenchymal Stem Cell Line Improves Blood Glucose Level in Type 2 Diabetic Mice
Published 2019-01-01“…We hypothesized that human umbilical cord mesenchymal stem cells can be used as a vector to construct a novel cell line that expresses GLP-1 in vivo for a long time. …”
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6436
A Wearable System for Experimental Knee Pain During Real-World Locomotion: Habituation and Motor Adaptation
Published 2025-01-01“…We developed a novel, wearable system that couples motion sensing and electrical stimulation in real-time to study motor adaptation in new environments. …”
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6437
Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures
Published 2018-01-01“…Due to the restricted intrinsic capacity of resident chondrocytes to regenerate the lost cartilage postinjury, stem cell-based therapies have been proposed as a novel therapeutic approach for cartilage repair. …”
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6438
VP-SFDA: Visual Prompt Source-Free Domain Adaptation for Cross-Modal Medical Image
Published 2025-01-01“…Methods: We propose a novel 2-stage framework for SFUDA called visual prompt source-free domain adaptation (VP-SFDA). …”
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6439
In Situ Synthesis of Ternary Ni-Fe-Mo Nanosheet Arrays for OER in Water Electrolysis
Published 2025-01-01“…Ni-based nanomaterials have exhibited great potential for the catalysis of water splitting, which have attracted the attention of researchers around the world. Here, we prepared a novel Mo-doped NiFe-based layered double hydroxide (LDH) with a nanoarray microstructure on Ni foam. …”
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6440
Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine
Published 2025-01-01“…We explore the possibility of novel cancer biomarker candidates and novel diagnostic methods.…”
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