Physiology‐based pharmacokinetic model with relative transcriptomics to evaluate tissue distribution and receptor occupancy of anifrolumab by Pradeep Sharma, David W. Boulton, Lynn N. Bertagnolli, Weifeng Tang

“…The results informed the dosing of phase III studies of anifrolumab in new indications and present a novel approach to PBPK modeling coupled with relative transcriptomics in simulating pharmacokinetics of therapeutic monoclonal antibodies.…”
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Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma by Lin Wang, Xinyu Liu, Haoze Lv, Han Zhang, Rimei Lin, Shan Xu, Chaojing Zhang, Shilei Lou, Zhidong Qiu, Cong Sun, Ning Cui

“…These approaches could help uncover novel regulatory mechanisms in osteosarcoma pathways and provide a theoretical foundation for developing new drugs and identifying novel therapeutic targets.…”
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ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cells by Lijing Qin, Geng Tang, Ruirui Gui, Yanming Yang, Li Wang, Weiqiang Xu, Hongyuan Tian, Lei Yu, Xiangshan Yang, Zhicheng Wang

“…Abstract Identifying novel targets for molecular radiosensitization is critical for improving the efficacy of colorectal cancer (CRC) radiotherapy. …”
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DeepDrug as an expert guided and AI driven drug repurposing methodology for selecting the lead combination of drugs for Alzheimer’s disease by Victor O. K. Li, Yang Han, Tushar Kaistha, Qi Zhang, Jocelyn Downey, Illana Gozes, Jacqueline C. K. Lam

“…While newly approved amyloid immunotherapy has been reported, effective AD drugs remain to be identified. Here, we propose a novel AI-driven drug-repurposing method, DeepDrug, to identify a lead combination of approved drugs to treat AD patients. …”
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Genomic analysis and potential polyhydroxybutyrate (PHB) production from Bacillus strains isolated from extreme environments in Mexico by Alvaro Ríos Sosa, Lilia A. Prado Barragán, Alvaro Ríos Reyes, Elva T. Aréchiga Carvajal

“…The ability of P. dendritiformis and B. inaquosorum to synthetize PHB was also confirmed by the observations made providing novel evidence to consider these species as potential producers.…”
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Identification of important genes related to ferroptosis in early missed abortion based on WGCNA by Yulu Zeng, Jiayi Gan, Jinlian Cheng, Changqiang Wei, Xiangyun Zhu, Shisi Wei, Lihong Pang

“…This research has identified novel genes that could be targeted for the early detection and management of missed abortions.…”
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Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation and metal homeostasis. by Odette Verdejo-Torres, David C Klein, Lorena Novoa-Aponte, Jaime Carrazco-Carrillo, Denzel Bonilla-Pinto, Antonio Rivera, Arpie Bakhshian, Fa'alataitaua M Fitisemanu, Martha L Jiménez-González, Lyra Flinn, Aidan T Pezacki, Antonio Lanzirotti, Luis Antonio Ortiz Frade, Christopher J Chang, Juan G Navea, Crysten E Blaby-Haas, Sarah J Hainer, Teresita Padilla-Benavides

“…Here we show the role of a novel Cu-binding protein (Cu-BP) in mammalian transcriptional regulation, specifically on skeletal muscle differentiation using murine primary myoblasts. …”
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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…Taken together, these data functionally and chemically validate the targeting of Wnt signalling as a novel strategy to undermine the pathogenicity of juvenile F. hepatica.…”
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Automated Web Tool Measurement of Total Hip Arthroplasty Acetabular Component Inclination and Anteversion Angles by Christine Yoon, BS, Anna Eligulashvili, BS, Zeynep Seref-Ferlengez, PhD, Barlas Goker, MD, Eli Kamara, MD, Edward Mardakhaev, MD

“…Conclusions: Automated measurements obtained with a novel web tool are in strong agreement with the manually obtained ground truth measurements. …”
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Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

“…Building upon this, we created a novel bispecific antibody (anti-PD-L1/CD40 bispecific antibody, referred to as ''BA4415'') designed to activate CD40 signaling specifically in the context of PD-L1 while simultaneously blocking PD-1/PD-L1 signaling. …”
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Quantum size effects and tailoring the electron energy levels in semiconductors: comparison study on Al x Ga 1-x As and Ga x In 1-x As quantum wires by M. K. Abu-Assy, Fatin Fadhel Mahmood, Z. A. El-Wahab

“…These unique features of the proposed novel architecture may open a new avenue for the future applications in photonics, spintronics and waveguides.…”
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Peran Measles-Containing-Vaccine dalam Pencegahan Coronavirus Disease 2019 (COVID-19) by Diandra Tatiana, Felicitas Anindya Utami, Yoga Devaera

“…Saat ini, penyebaran virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) atau Novel Coronavirus masih terus berkembang. Novel alphacoronavirus dan paramyxoviruses (keluarga campak) memiliki strain virus yang mirip. …”
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Multi-omic and machine learning analysis of mitochondrial RNA modification genes in lung adenocarcinoma for prognostic and therapeutic implications by Xiao Zhang, Jiatao Liu, Yaolin Cao, Wei Wang, Haoran Lin, Yue Yu

“…These findings provide novel insights into mitochondrial RNA modifications and their potential applications in personalized treatment for LUAD.…”
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Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography by Shiyi Cheng, Shuaibin Chang, Yunzhe Li, Anna Novoseltseva, Sunni Lin, Yicun Wu, Jiahui Zhu, Ann C. McKee, Douglas L. Rosene, Hui Wang, Irving J. Bigio, David A. Boas, Lei Tian

“…The emerging label-free serial sectioning optical coherence tomography (S-OCT) technique offers uniform 3D imaging capability across samples but has poor histological interpretability despite its sensitivity to cortical features. Here, we present a novel 3D imaging framework that combines S-OCT with a deep-learning digital staining (DS) model. …”
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Performance, isotherm, kinetics and mechanism of simultaneous removal of Cr(VI), Cu(II) and F ions by CeO2–MgO binary oxide nanomaterials by Rumman Zaidi, Saif Ullah Khan, Izharul Haq Farooqi, Faheem Ahmed, Abdullah Alsulami, Ameer Azam, Saleh O. Allehabi

“…Abstract This study focuses on the synthesis of a novel Cerium-Magnesium (CeO2-MgO) binary oxide nanomaterials by a simple co-precipitation process and used to remove harmful pollutants such as Cr(VI), Cu(II), and F. …”
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Endoplasmic reticulum protein TXNDC5 modulates thyroid eye disease TGF-β1-induced myofibroblast transdifferentiation by Albert Y Wu, Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai

“…Aim There remain limited therapies to treat thyroid eye disease (TED) orbital fibrosis, highlighting the urgency to develop novel targets. Transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from orbital fibroblasts are important pathogenetic factor of TED. …”
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Digital multiple health behaviour change intervention targeting online help seekers: protocol for the COACH randomised factorial trial by Hanna Henriksson, Pontus Henriksson, Marie Löf, Preben Bendtsen, Marcus Bendtsen, Katarina Åsberg, Oskar Lundgren, Jenny Blomqvist

“…Since participation is likely motivated by gaining access to novel support, the main concern is demotivation and opportunity cost if the intervention is found to only exert small effects. …”
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Event segmentation in ADHD: neglect of social information and deviant theta activity point to a mechanism underlying ADHD by Christian Beste, Veit Roessner, Astrid Prochnow, Xianzhen Zhou, Foroogh Ghorbani, Bernhard Hommel

“…The results call for a novel conceptual view of ADHD, based on event segmentation theory.…”
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Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target by Yan Li, Yan Li, Yan Li, Yuxin Zhang, Yuxin Zhang, Yuxin Zhang, Mengxia Cao, Mengxia Cao, Mengxia Cao, Tingting Yuan, Tingting Yuan, Tingting Yuan, Santao Ou, Santao Ou, Santao Ou

“…These findings underscore the important gaps that warrant further investigation to develop novel targets for the prediction or treatment of various renal diseases.…”
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64Cu-chelated InP/ZnSe/ZnS QDs as PET/fluorescence dual-modal probe for tumor imaging by Ziyu Zhao, Ayaka Otsuka, Noriko Nakamura, Toshifumi Tatsumi, Kazuhiro Nakatsui, Taiki Tsuzukiishi, Tomo Sakanoue, Kenji Shimazoe, Seiichi Ohta

“…However, to the best of our knowledge, PET/fluorescence dual-modal imaging of InP QDs has yet to be explored. Here, we developed a novel PET/fluorescence imaging probe based on radioisotope (RI) -chelated InP/ZnSe/ZnS QDs for tumor imaging. …”
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