A comprehensive method to explore inhibitory kinetics and mechanisms of an anticoagulant peptide derived from Crassostrea gigas by Shuzhen Cheng, Di Wu, Hanxiong Liu, Xianbing Xu, Beiwei Zhu, Ming Du

“…A comprehensive method was applied to evaluate the anticoagulant activity of a novel anticoagulant peptide (NAESLRK) derived from oyster (Crassostrea gigas). …”
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fragSMILES as a chemical string notation for advanced fragment and chirality representation by Fabrizio Mastrolorito, Fulvio Ciriaco, Maria Vittoria Togo, Nicola Gambacorta, Daniela Trisciuzzi, Cosimo Damiano Altomare, Nicola Amoroso, Francesca Grisoni, Orazio Nicolotti

“…In this paper, we present fragSMILES, a novel fragment-based molecular representation in the form of string. fragSMILES encode fragments in a ‘chemically-meaningful’ way via a novel graph-reduction approach, allowing to obtain an efficient, interpretable, and expressive molecular representation, which also avoids fragment redundancy. fragSMILES contributes to the field of fragment-based representation, by reporting fragments and their ‘breaking’ bonds independently. …”
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A Multivent System for Non-Invasive Ventilation: Solving the Problem of Ventilator Shortage During the COVID-19 Pandemic by Shuai Ren, Xiaohan Wang, Liming Hao, Tao Wang, Zujin Luo

“…However, the ventilator-sharing method needs to use the same ventilator settings for all the patients, which cannot meet the ventilation needs of different patients. Therefore, a novel multivent system for non-invasive ventilation has been proposed in this study. …”
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The Inhibitory Effects of Alpha 1 Antitrypsin on Endosomal TLR Signaling Pathways by Ahmed S. Elshikha, Georges Abboud, Rigena Avdiaj, Laurence Morel, Sihong Song

“…Targeting this proteolytic processing may represent a novel strategy to inhibit TLR-mediated pathogenesis. …”
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Comparison of Approaches for Stroke Prophylaxis in Patients with Non-Valvular Atrial Fibrillation: Network Meta-Analyses of Randomized Controlled Trials. by Navkaranbir S Bajaj, Rajat Kalra, Nirav Patel, Taimoor Hashim, Hemant Godara, Sameer Ather, Garima Arora, Tilak Pasala, Thomas T Whitfield, David C McGiffin, Mustafa I Ahmed, Steven G Lloyd, Nita A Limdi, Pankaj Arora

“…<h4>Background</h4>Multiple novel oral anticoagulants and left atrial appendage closure devices (WATCHMAN) have been tested against dose-adjusted vitamin K antagonists in randomized controlled trials for stroke prophylaxis in non-valvular atrial fibrillation. …”
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Endogenous Estrogen Influences Predator Odor-Induced Impairment of Cognitive and Social Behaviors in Aromatase Gene Deficiency Mice by Yaner Gao, Lei Ma, Feng Gao, Zuoli Sun, Zhengrong Zhang, Yuhong Li, Rena Li

“…TMT induced an acute impairment of novel object recognition memory and long-term social behavior impairment in WT mice, particularly in females, while Ar+/- mice showed impaired novel object recognition in both sexes and TMT-elevated social behaviors, particularly in males. …”
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From Heritage Building Information Modelling Towards an ‘Echo-Based’ Heritage Digital Twin by Hord Arsalan, David Heesom, Nigel Moore

“…These can then be converted using a novel ‘Architectural Heritage Transformer’ (AHT), which converts plain language descriptions into architectural terminology through a generated taxonomy. …”
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Penalized landmark supermodels (penLM) for dynamic prediction for time-to-event outcomes in high-dimensional data by Anya H. Fries, Eunji Choi, Summer S. Han

“…Conclusions The proposed penLM framework with novel evaluation metrics offers effective dynamic risk prediction when leveraging high-dimensional multi-source longitudinal data.…”
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hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways by Yan Yu, Chengchun Zhu, Xiao Wang, Ying Shi, Yiping Gao, Zhiyi Yu

“…This highlights the need for novel drug candidates with new mechanisms of action by targeting alternative signaling pathways. …”
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A Lightweight Mitigation Technique Against a Modified Version Number Attack in IoT Networks by Ibrahim S. Alsukayti, Mohammed Alreshoodi, Mehdi Rouissat

“…To effectively mitigate the DVN attack, a novel lightweight solution called DVN-Secure RPL (DVN-SRPL) is introduced in this paper. …”
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Developing a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir by Amy J. Mathers, Thomas J. X. Li, Qijun He, Sharvari Narendra, Nicole Stoesser, David W. Eyre, A. Sarah Walker, Katie E. Barry, Salvador Castañeda-Barba, Fenix W. Huang, Hardik Parikh, Shireen Kotay, Derrick W. Crook, Christian Reidys

“…To assess dynamic gene movement, we introduced the ‘Composite-Sample Complex’, a novel mathematical approach to using probability to capture the directional movement of antimicrobial resistance genes. …”
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Efficacy of Rapid Salivary C-Reactive Protein Test to Assess Early Changes in Malignancy in the Oral Cavity and Its Utility in Screening for Oral Cancer by Vathsala Patil, Ravindranath Vineetha, Komal Smriti, Kalyana Chakravarthy Pentapati, Srikanth Gadicherla, Carnelio Sunitha

“…<b>Methods:</b> In this study, unstimulated saliva samples of cases (OPMDs and oral cancer) and controls (systemically healthy subjects) were used to detect CRP levels using a novel colorimetric, quantitative rapid assay kit. …”
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Network pharmacology and in silico investigation into the therapeutic potential of phytoconstituents of Peucedanum ostruthium as anti-tubercular agents by Neeru Bhanwala, Raunak Katiyar, Sumit Kumar, Ashok K. Datusalia, Gopal L. Khatik

“…Despite significant progress in biomedical research, novel treatment strategies, and preventative measures, the incidence rates of TB continue to rise. …”
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Mutational Analysis of Extranodal NK/T-Cell Lymphoma Using Targeted Sequencing with a Comprehensive Cancer Panel by Seungkyu Choi, Jai Hyang Go, Eun Kyung Kim, Hojung Lee, Won Mi Lee, Chun-Sung Cho, Kyudong Han

“…We also found mutations in 18 novel candidate genes, with molecular functions that were potentially implicated in cancer development. …”
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First Use of Superpulsed Fibre Thulium Laser-Based Contact Stone Ablation in Common Bile and Main Pancreatic Ducts by S. A. Budzinskiy, S. G. Shapovalyants, E. D. Fedorov, E. A. Vorobyeva, M. Yu. Svirin, M. G. Malyarov, P. L. Chernyakevich, E. N. Platonova

“…A clinical demonstration of the feasibility of novel superpulsed thulium fibre laser in contact intraductal lithotripsy in patients with choledocholithiasis and pancreatic lithiasis.Key points. …”
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Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity by Fei Zhao, Xiao Cong, Xiaobo Huang, Yi Zheng, Qin Zhao, Yiping Wen, Rui Wu, Senyan Du, Sanjie Cao, Feng Cong, Yiping Wang

“…Abstract Swine acute diarrhoea syndrome coronavirus (SADS-CoV), a novel HKU2-related coronavirus of bat origin, is a newly emerged swine enteropathogenic coronavirus that causes severe diarrhoea in piglets. …”
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DNA barcoding: how many earthworm species are there in the south of West Siberia? by S. V. Shekhovtsov, N. E. Bazarova, D. I. Berman, N. A. Bulakhova, E. V. Golovanova, S. V. Konyaev, T. M. Krugova, I. I. Lyubechanskii, S. E. Peltek

“…The rest of the novel clusters probably represent new earthworm species. …”
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Over-the-Scope Clip-Associated Endoscopic Muscular Dissection for Seven Cases of Small Gastric Submucosal Tumor: A Video-Based Case Series by Xin Li, Rongfen Wei, Jianfu Qin, Fei Qin, Peng Peng, Mengbin Qin, Shiquan Liu, Jiean Huang

“…To evaluate the methodology, feasibility, safety, and efficacy of a novel method called over-the-scope clip- (OTSC-) associated endoscopic muscular dissection for small GSMT. …”
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Application of a New Type of Protective Sputum Suction Device in Clinic against Cross-Infection between Medical Staff and Patients by Kang Lu, Weizhou Wu, Gaomei Jin, Haixia Yang, Xiaowei Cai, Lin Li, Zanchao Chen, Lin Ren, Baoshuan Guo, Qing-feng Xue

“…To explore the clinical application of a new type of protective sputum suction device (PSSD) in patients with tracheotomy or tracheal intubation and to evaluate the protective effect of PSSD against cross-infection between medical staffs and patients. Methods. A novel PSSD was designed which can assist closed sputum suction operation without disconnecting the ventilator. 32 patients with tracheotomy were included to study the protective effect and safety of this device. …”
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Update on the Role of Cannabinoid Receptors after Ischemic Stroke by Luciano S. A. Capettini, Silvia Q. Savergnini, Rafaela F. da Silva, Nikos Stergiopulos, Robson A. S. Santos, François Mach, Fabrizio Montecucco

“…On the other hands, the recent discoveries of novel different classes of cannabinoids and receptors have increased the complexity of this system in atherosclerosis. …”
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