PSMA antibody, humanized PSMA.CAR10.3, or Cetuximab increases prostate cancer localization of NF-κB p50-deficient immature myeloid cells (p50-IMC) and phagocytosis by their macroph... by Mohammad A. Alzubi, Theresa Barberi, Alan D. Friedman

“…Nevertheless, this study indicates the potential clinical utility of adding a tumor-directing antibody or CAR, including the novel, fully humanized PSMA.CAR10.3, to proinflammatory p50-IMC to optimize the activation of anti-tumor immunity in prostate cancer and other malignancies, and understanding PSMA toxicity in normal but not malignant prostate epithelium may reveal a novel therapeutic opportunity.…”
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A Comprehensive Strategy for Laser Corneal Refractive Surgery during the COVID-19 Epidemic in a Tertiary Teaching Hospital in Wenzhou, China by Jia Zhang, Ioannis M. Aslanides, Vasileios Selimis, Nan-Ji Lu, Wei-Jie Liu, Hong-Xiao Jiang, Chao Zhang, Chen-Chen Xu, Qin-Mei Wang, Jia Qu, Shi-Hao Chen

“…The novel coronavirus pneumonia COVID-19 is caused by the novel coronavirus SARS-CoV-2, which is highly contagious, has a long incubation period, and can be detected in patients’ tears and conjunctival secretions. …”
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A graph neural network approach for hierarchical mapping of breast cancer protein communities by Xiao Zhang, Qian Liu

“…Conclusion The proposed graph neural network approach to analyzing breast cancer protein communities in a hierarchical structure provides a novel perspective on breast cancer prognosis and treatment. …”
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Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions by David B. Olawade, Aanuoluwapo Clement David-Olawade, Temitope Adereni, Eghosasere Egbon, Jennifer Teke, Stergios Boussios

“…Additionally, AI facilitates the discovery of novel therapeutic targets, such as neoantigens, enabling the development of personalized immunotherapies. …”
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Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis by Alexandra Noble, Rodrigo Motta, Silvia Cabras, Belen Moron Flores, Jan Nowak, Aleksandra Glapa-Nowak, Alessandra Geremia, Jack Satsangi, Emma Culver

“…Abstract Background IgG4-related cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are chronic fibro-inflammatory hepatobiliary conditions, with genetic, environmental, and immunologic risk factors, in which epigenetic alterations may provide insights into pathophysiology and novel biomarkers. This study is the first to assess methylation signatures in IgG4-SC. …”
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Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD by Charles I. V. Drummer, Fatma Saaoud, Yu Sun, Diana Atar, Keman Xu, Yifan Lu, Ying Shao, Candice Johnson, Lu Liu, Huimin Shen, Nirag C. Jhala, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We performed a panoramic analysis on both human nonalcoholic steatohepatitis (NASH) microarray data and microarray/RNA-seq data from various mouse models of nonalcoholic fatty liver disease NASH/NAFLD with total 4249 genes examined and made the following findings: (i) human NASH and NAFLD mouse models upregulate both cytokines and chemokines; (ii) pathway analysis indicated that human NASH can be classified into metabolic and immune NASH; methionine- and choline-deficient (MCD)+high-fat diet (HFD), glycine N-methyltransferase deficient (GNMT-KO), methionine adenosyltransferase 1A deficient (MAT1A-KO), and HFCD (high-fat-cholesterol diet) can be classified into inflammatory, SAM accumulation, cholesterol/mevalonate, and LXR/RXR-fatty acid β-oxidation NAFLD, respectively; (iii) canonical and noncanonical inflammasomes play differential roles in the pathogenesis of NASH/NAFLD; (iv) trained immunity (TI) enzymes are significantly upregulated in NASH/NAFLD; HFCD upregulates TI enzymes more than cytokines, chemokines, and inflammasome regulators; (v) the MCD+HFD is a model with the upregulation of proinflammatory cytokines and canonical and noncanonical inflammasomes; however, the HFCD is a model with upregulation of TI enzymes and lipid peroxidation enzymes; and (vi) caspase-11 and caspase-1 act as upstream master regulators, which partially upregulate the expressions of cytokines, chemokines, canonical and noncanonical inflammasome pathway regulators, TI enzymes, and lipid peroxidation enzymes. Our findings provide novel insights on the synergies between hyperlipidemia and hypomethylation in establishing TI and promoting inflammation in NASH and NAFLD progression and novel targets for future therapeutic interventions for NASH and NAFLD, metabolic diseases, transplantation, and cancers.…”
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Lossless and reference-free compression of FASTQ/A files using GeneSqueeze by Foad Nazari, Sneh Patel, Melissa LaRocca, Alina Sansevich, Ryan Czarny, Giana Schena, Emma K. Murray

“…Abstract As sequencing becomes more accessible, there is an acute need for novel compression methods to efficiently store sequencing files. …”
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Fingolimod exerts in vitro anticancer activity against hepatocellular carcinoma cell lines via YAP/TAZ suppression by Du Jiamin, Qian Meijia, Yuan Tao, Zhang Bo, Chen Xueqin, An Ning, He Qiaojun, Yang Bo, Ye Song, Zhu Hong

“…Overall, our current study not only identifies fingolimod as a novel YAP-targeting in hibitor, but also indicates that this clinically-approved drug could be utilized as a potential and feasible therapeutic drug for HCC.…”
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Greenness, blueness and whiteness evaluated rapid Attenuated Total Reflection/ Fourier Transform Infrared Spectroscopy method for piper nigrum Samples Coupled with multivariate ana... by Rinkal N Patel, Kunjal L Vegad, Ruchik V Mistry, Nikunj D Patel

“…The primary concerns in quality of piper nigrum arise due to numerous factors including adulteration, omission and partial substitution. A novel, rapid, steadfast method based on attenuated total reflectance - Fourier transform infrared (ATR-FTIR) technique with a diamond crystal was developed to evaluate samples of piper nigrum. …”
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Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors by Deepak T Patel, Peter J Stogios, Lukasz Jaroszewski, Malene L Urbanus, Mayya Sedova, Cameron Semper, Cathy Le, Abraham Takkouche, Keita Ichii, Julie Innabi, Dhruvin H Patel, Alexander W Ensminger, Adam Godzik, Alexei Savchenko

“…This illustrates an emerging strategy of exploring synergies between predictions and targeted experimental approaches in elucidating novel effector activities involved in infection.…”
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Cost-Effective Autonomous Drone Navigation Using Reinforcement Learning: Simulation and Real-World Validation by Tomasz Czarnecki, Marek Stawowy, Adam Kadłubowski

“…This study aims to develop and implement a novel approach to autonomous drone navigation using machine learning (ML) algorithms. …”
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KGRDR: a deep learning model based on knowledge graph and graph regularized integration for drug repositioning by Huimin Luo, Huimin Luo, Hui Yang, Hui Yang, Ge Zhang, Ge Zhang, Jianlin Wang, Jianlin Wang, Junwei Luo, Chaokun Yan, Chaokun Yan, Chaokun Yan

“…Moreover, case study results further validate the effectiveness of KGRDR in predicting novel drug-disease interactions.…”
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A Wavelet-Based Correlation Analysis Framework to Study Cerebromuscular Activity in Essential Tremor by Yifan Zhao, Ramon C. Laguna, Yitian Zhao, Jimmy Jiang Liu, Xiongxiong He, John Yianni, Ptolemaios G. Sarrigiannis

“…This paper proposes a novel framework to address this challenge, including an estimation of the interaction strength using wavelet cross-spectrum and phase lag index while demonstrating the statistical significance of the findings. …”
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RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties by Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz

“…Despite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges. …”
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Pigskin Treatment Using Different Food-Grade-Acids: Effects on The Physicochemical Characteristics of The By-Products by Diego Ezequiel Velazquez, Mariana Marta Sánchez, Maria Emilia Latorre

“…<p>Upcycling foods contribute to reducing food loss and waste and provide sustainable solutions to novel products. In the present work, it was studied the use of food-grade acids (Acetic(AH), Latic(AL), Citric(AC), and Ascorbic(AA) acid) to obtain pigskin by-products, acid soluble collagen (ASC) and gelatin (G). …”
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Expression of Tropomyosin 1 Gene Isoforms in Human Breast Cancer Cell Lines by Syamalima Dube, Santhi Yalamanchili, Joseph Lachant, Lynn Abbott, Patricia Benz, Charles Mitschow, Dipak K. Dube, Bernard J. Poiesz

“…The exact differences in expression of these novel isoforms and their functional properties in breast epithelial cells will require further study.…”
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Prenatal depression level prediction using ensemble based deep learning model by Abinaya Gopalakrishnan, Xujuan Zhou, Revathi Venkataraman, Raj Gururajan, Ka Ching Chan, Guohun Zhu, Niall Higgins

“…This culminated in the development of a novel EBDL model to accurately predict stress levels. …”
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Extrapolation of Metal Gate With High-K Spacer in Strained Nanosystem Channel QWB Cylindrical FET for High-Speed Applications by Rasmita Barik, Rudra Sankar Dhar, Kuleen Kumar, Yash Sharma, Amit Banerjee

“…The development of novel strain-engineered channel Cylindrical Gate-All-Around (CGAA) quantum well-barrier (QWB) field-effect transistors (FETs) using high-k gate stacks and metallic gates with varying work functions is analyzed, offering enhanced performance to meet the 1 nm technology node of IRDS 2028. …”
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X-Linked Autism Type 9 Caused by a Hemizygote Pathogenic Variant in the TMLHE Gene: Etiological Diagnosis in an Adult Male with Moderate Intellectual Disability by Verhoeven WM, Pfundt R, Engelke UF, Kluijtmans LA, Egger JI

“…Lack of TMLH enzyme activity is associated with developmental delay and autistic behaviours described as X-linked recessive autism, type 6 (OMIM&num;300872).Patient and Methods: Here, an institutionalized adult male patient with intellectual disability, autism, and challenging behaviours is presented in whom genetic analysis disclosed a novel pathogenic variant in the TMLHE gene. Extensive somatic, neurological, psychiatric, and neuropsychological investigations were performed next to examination of hematological and biochemical parameters including plasma carnitine status. …”
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CB-MNCs@ CS/HEC/GP promote wound healing in aged murine pressure ulcer model by Zhi-cheng Yang, He Lin, Guo-jun Liu, Hui Pan, Jun-lu Zhu, Xiao-hong Zhang, Feng Gao, Zhong Wang, Zhi-hao Wang

“…Cord blood mononuclear cells (CB-MNCs) are a novel type of tissue repair seed cells. However, their clinical application is restricted by low retention and survival rates post-transplantation. …”
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