Tuberculosis vaccines and therapeutic drug: challenges and future directions by Yajing An, Ruizi Ni, Li Zhuang, Ling Yang, Zhaoyang Ye, Linsheng Li, Seppo Parkkila, Ashok Aspatwar, Wenping Gong

“…The hurdles in TB vaccine and therapeutic development encompass overcoming antigen diversity, enhancing vaccine effectiveness across diverse populations, and advancing novel vaccine platforms. Future initiatives emphasize combinatorial strategies, the development of anti-TB compounds targeting novel pathways, and personalized medicine for TB treatment and prevention. …”
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Frequency and Texture Aware Multi-Domain Feature Fusion for Remote Sensing Scene Classification by Russo Ashraf, Kang-Hyun Jo

“…Delving into these complexities, the Efficient Spectral Inception Former (ESIF) architecture is proposed, which introduces a novel paradigm to RS scene classification by integrating multi-domain feature fusion of the spatial, texture, and spectral (frequency) domains. …”
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Improving the Utility, Safety, and Ethical Use of a Passive Mood-Tracking App for People With Bipolar Disorder Using Coproduction: Qualitative Focus Group Study by Laurence Astill Wright, Matthew Moore, Stuart Reeves, Elvira Perez Vallejos, Richard Morriss

“…Principally, people with BD wished to use this novel technology to aid them in self-managing their BD with greater insight and a better understanding of potential triggers. …”
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Proteomic insights into dual-species biofilm formation of E. coli and E. faecalis on urinary catheters by Kidon Sung, Miseon Park, Ohgew Kweon, Angel Paredes, Alena Savenka, Saeed A Khan

“…Notably, elongated E. faecalis cells were observed in dual-species biofilms, a novel finding in mixed-species biofilm cultures. …”
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Enhancing paddy leaf disease diagnosis -a hybrid CNN model using simulated thermal imaging by Jagamohan Padhi, Kunal Mishra, Ashoka Kumar Ratha, Santi Kumari Behera, Prabira Kumar Sethy, Aziz Nanthaamornphong

“…This study introduces a novel hybrid Deep Learning approach integrating thermal imaging and model hybridization for early and precise detection of rice leaf diseases. …”
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Immune dynamics throughout life in relation to sex hormones and perspectives gained from gender-affirming hormone therapy by Ahmet Yalcinkaya, Ahmet Yalcinkaya, Rumeysa Yalcinkaya, Fabian Sardh, Fabian Sardh, Nils Landegren, Nils Landegren

“…The advent of gender-affirming hormone therapy offers a novel opportunity to study the immunological effects of sex hormones. …”
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Ultra-sparse reconstruction for photoacoustic tomography: Sinogram domain prior-guided method exploiting enhanced score-based diffusion model by Zilong Li, Jiabin Lin, Yiguang Wang, Jiahong Li, Yubin Cao, Xuan Liu, Wenbo Wan, Qiegen Liu, Xianlin Song

“…Photoacoustic tomography, a novel non-invasive imaging modality, combines the principles of optical and acoustic imaging for use in biomedical applications. …”
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A two-step method for assessing enhanced value in turnaround, spin-off, and value stocks by Nicolas Pfister, Michael J. Kendzia, Jan-Alexander Posth

“…In this event study, to test for the existence of risk-adjusted excess returns, or alpha, a novel two-step approach is proposed to assess Enhanced Value in single stocks for three different investment approaches: plain value investing, investing in spin-offs, and investing in turnaround companies. …”
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Sealless Production Ultracentrifuge and Its Magnetically Self-Bearing Openable Motors for Purification in Viral Nanotechnology by Emanuel J. Hubmann, Daniel Steinert, Thomas Nussbaumer, Johann W. Kolar

“…This article proposes a novel PUCF type with rotational speed potential towards 100 krpm with a hermetically enclosed process chamber without any rotary seals, i.e. a sealless production ultracentrifuge (SL-PUCF) omitting contamination risk. …”
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Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives by Menghua Liu, Rumeng Chen, Zhiwei Zheng, Shuling Xu, Chunyan Hou, Yining Ding, Mengling Zhang, Meihua Bao, Binsheng He, Sen Li

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Selective response surface methodology for Anti Reflective Coated Nano-film filter thickness optimization in hybrid PVT system by Kundan Kumar Sharma, Prakash Chandra

“…To overcome these issues a novel Hybrid Anti Reflective Coated Nanofilm Filter is proposed in which a Polycarbonate nano-film filter is utilized since its refractive index is unaffected by temperature changes. …”
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Peptide-Based Vaccinology: Experimental and Computational Approaches to Target Hypervariable Viruses through the Fine Characterization of Protective Epitopes Recognized by Monoclon... by Matteo Castelli, Francesca Cappelletti, Roberta Antonia Diotti, Giuseppe Sautto, Elena Criscuolo, Matteo Dal Peraro, Nicola Clementi

“…Defining immunogenic domains of viral proteins capable of eliciting a protective immune response is crucial in the development of novel epitope-based prophylactic strategies. This is particularly important for the selective targeting of conserved regions shared among hypervariable viruses. …”
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Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier by Hitaishi Sharma, Kannan Badri Narayanan, Shampa Ghosh, Krishna Kumar Singh, Prarthana Rehan, Aparajita Dasgupta Amist, Rakesh Bhaskar, Jitendra Kumar Sinha

“…Hence, it is imperative to develop novel approaches that can overcome these constraints and offer efficient therapy for meningitis. …”
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circRNA_101277 Influences Cisplatin Resistance of Colorectal Cancer Cells by Modulating the miR-370/IL-6 Axis by Qing Lv, Qinghua Xia, Anshu Li, Zhiyong Wang

“…The identification of genes associated with CRC chemoresistance would thus be a beneficial approach to identifying novel treatments for this deadly disease. Methods. …”
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Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians. by Danielle Ireland, Christina Rabeler, Sagar Rao, Rudy J Richardson, Eva-Maria S Collins

“…Mental illnesses put a tremendous burden on afflicted individuals and society. Identification of novel drugs to treat such conditions is intrinsically challenging due to the complexity of neuropsychiatric diseases and the need for a systems-level understanding that goes beyond single molecule-target interactions. …”
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Molecular Characterization and Antibacterial Potential of Endophytic Fungal Isolates from Selected Mangroves along the Coastline of Kenya by Teresia Nyambura Wacira, Huxley Mae Makonde, Carren Moraa Bosire, Cromwell Mwiti Kibiti

“…Scientists have been striving to find novel bioactive compounds and drugs to overcome these obstacles. …”
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Immunological Responses and Epitope Mapping by Tuberculosis-Associated Antigens within the RD1 Region in Japanese Patients by Hideaki Nagai, Maho Suzukawa, Yumi Sakakibara, Ken Ohta, Pedro A. Reche, Koichi Suzuki, Yoshihiko Hoshino

“…Tuberculosis remains a major global health problem worldwide, and hence there is a need for novel vaccines that better induce cellular-mediated immunity (CMI). …”
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Soft-Label Supervised Meta-Model with Adversarial Samples for Uncertainty Quantification by Kyle Lucke, Aleksandar Vakanski, Min Xian

“…In addition, a novel training framework using adversarial samples is proposed to explore the decision boundary of the base model and mitigate issues related to training datasets with label imbalance. …”
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Study on the Coarsening Behavior of Interphase Precipitates and Random Precipitates in Steel Under the High-Temperature Environment of Fire by Jinghua Cong, Yongzhe Yang, Haibin Zhu, Xueliang Shang, Hongyu Wu, Zhendong Song, Xuemin Wang, Xiangyu Xu

“…This study developed a novel heat treatment protocol to concurrently achieve both interphase precipitation and random precipitation. …”
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Optimising the mechanism of electroshock treatment on the tensile behaviour of the laser melting deposited Ti55531 alloy by Chang Liu, Haoxing Wang, Jian Zhou, Yan Wen, Lechun Xie, Liqiang Wang, Lin Hua

“…In this work, the Ti55531 alloy (Ti-5Al-5V-5Mo-3Cr-1Zr) is manufactured by LMD, and a novel electroshock treatment (EST) is introduced to modify the tensile properties of LMD Ti55531. …”
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