Protective effects of small RNAs encapsulated in Artemisia Capillaris-derived exosomes against non-alcoholic fatty liver disease by Min Xu, Longjun Ma, Hongwei Liang, Wei Tang, Shouyong Gu

“…This study aimed to evaluate the potential of Artemisia capillaris-derived exosomes (ACDEs) as a novel therapeutic approach in non-alcoholic fatty liver disease (NAFLD).MethodsThe physicochemical properties of ACDEs were isolated and characterized using differential centrifugation, and the therapeutic efficacy was evaluated in an in vivo methionine-choline-deficient (MCD) diet induced NAFLD mouse model. …”
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Deletion of bZIP Transcription Factor <i>PratfA</i> Reveals Specialized Metabolites Potentially Regulating Stress Response in <i>Penicillium raistrickii</i> by Anxin Zhang, Shu Zhang, Xinran Xu, Wen-Bing Yin

“…The manipulation of regulatory factors can guide the discovery of novel natural products (NPs).…”
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System‐failing creativity in health care by Stijn Horck, Rachel E. Gifford, Bram P. I. Fleuren, Cheryl Rathert, Tracy H. Porter, Afshan Rauf, Yuna S. H. Lee

“…Abstract Introduction Health care professionals often generate novel solutions to solve problems during day‐to‐day patient care. …”
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Identification of Houge type of X-linked syndromic mental retardation caused by CNKSR2 truncated variants by Si-Hua Chang, Jie-Yuan Jin, Yi-Qiao Hu, Run-Yan Wang, Rong Xiang, Xia Wang

“…Conclusions We identified two novel CNKSR2 variants in MRXSHG families, expanding the variant spectrum of CNKSR2, enriching MRXSHG-related phenotypes, and contributing to genetic counseling for MRXSHG patients.…”
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The Stability-Indicating Ultra High-Performance Liquid Chromatography with Diode Array Detector and Tandem Mass Spectrometry Method Applied for the Forced Degradation Study of Ritl... by Jelena Kovačić, Daniela Amidžić Klarić, Nikša Turk, Željko Krznarić, Emma Riordan, Ana Mornar

“…Ritlecitinib, a second-generation JAK3 inhibitor, is a novel therapeutic agent for alopecia areata and other autoimmune conditions. …”
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Nevoid basal cell carcinoma syndrome (Gorlin syndrome): a case report by Noura Abdul Rahman, Fatima Breim, Joud Zakour, Zainab Srouji, Silva Ishkhanian

“…Minimal side effects were observed, highlighting the potential efficacy of this novel approach in managing basal cell carcinomas associated with Gorlin–Goltz syndrome. …”
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Stock volatility as an anomalous diffusion process by Rubén V. Arévalo, J. Alberto Conejero, Òscar Garibo-i-Orts, Alfred Peris

“…In financial markets, accurately estimating asset volatility—whether historical or implied—is vital for investors.We introduce a novel methodology to estimate the volatility of stocks and similar assets, combining anomalous diffusion principles with machine learning. …”
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Research Progress on the Potential Pathogenesis of Persistent Postural–Perceptual Dizziness by Chen Qin, Ruyi Zhang, Zhihui Yan

“…Methods To better understand the pathogenesis of PPPD and to aid in the development of novel diagnostic strategies and therapies, we conducted a comprehensive narrative review of the relevant literature. …”
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Atomized Neutrophil Membrane-coated MOF Nanoparticles for Direct Delivery of Dexamethasone for Severe Pneumonia by Yixiao Yang, Lizhen Yan, Han Zhang, Chuanguang Xiao, Kai Wang

“…Methods: We designed a novel UiO66 metal-organic framework nanoparticle loaded with Dex and coated with neutrophil cell membranes (UiO66-Dex@NMP) for targeted therapy of severe pneumonia. …”
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Nutritional Quality, Potential Health Promoting Properties and Sensory Perception of an Improved Gluten Free Bread Formulation Containing Inulin, Rice Protein and Bioactive Compoun... by Alessandro Guglielmetti, Beatriz Fernandez-Gomez, Giuseppe Zeppa, Dolores del Castillo

“…The new formulation combines well-known and novel food ingredients. To validate the novel ingredients, we determined the physicochemical characterization, caffeine and chlorogenic acid contents and food safety of coffee silverskin (CSE) and husk (CHE) extracts. …”
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Bioinformation study of immune microenvironment characteristics of disulfidptosis-related subtypes in ovarian cancer and prognostic model construction by Ying Zhou, Yuhong Zhang, Yang Zhou, Yanzheng Gu, Youguo Chen, Juan Wang

“…Despite advancements in understanding DNA repair mechanisms and identifying novel therapeutic targets, additional strategies are still needed. …”
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Overcoming Data Scarcity in Wind Power Forecasting: A Deep Learning Approach With Bidirectional Generative Adversarial Network and Neighborhood Search PSO Algorithm by Shiyu Liu, Fei Chen, Zhendong Liu, Hongyan Qiao

“…To address the challenge of few sample in WPP, a novel data-enhanced WPP method is proposed, which integrates BiGAN (BiGAN) module, self-attention mechanism (SAM) and neighborhood search particle swarm optimization (NSPSO). …”
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A two-step machine learning approach for predictive maintenance and anomaly detection in environmental sensor systems by Saiprasad Potharaju, Ravi Kumar Tirandasu, Swapnali N. Tambe, Devyani Bhamare Jadhav, Dudla Anil Kumar, Shanmuk Srinivas Amiripalli

“…Using Environmental Sensor Telemetry Data, this study introduces a novel methodology that combines unsupervised and supervised machine learning approaches to detect anomalies and predict sensor failures. …”
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Numerical investigation of heat and mass transfer for unsteady multiphase flow in a vented cavity filled with hybrid nanofluid by Muhammad Ashhad Shahid, Mojtaba Dayer, Muhammad Adil Sadiq, Haris Ali, Ishak Hashim

“…The current study investigates the effect of novel combination of unsteady condition and multiphase flow effect on hybrid nanofluid (HNF) convective heat and mass transfer (CHMT) within a vented cavity. …”
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Safety-Critical Oracles for Metamorphic Testing of Deep Learning LiDAR Point Cloud Object Detectors by Simon Speth, Maximilian Trien, Dominik Kufer, Alexander Pretschner

“…We address this by introducing novel egocentric test oracles based on traffic participants&#x2019; bounding boxes shifted into or out of the ego vehicle&#x2019;s expected lane. …”
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Raman spectroscopy study of the role of dispersion and interfaces in the improvement of the mechanical properties of epoxy-TiO2 composites by María Fernández-Álvarez, Alberto Moure, Luis Angulo Delgado, Julián J. Reinosa, José F. Fernández

“…To achieve these goals, a novel dispersion method, involving three steps (high-speed stirring, high-shear mixing, and tri-cylinder rolling), was developed. …”
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Synergistic Enzybiotic Effect of a Bacteriophage Endolysin and an Engineered Glucose Oxidase Against <i>Listeria</i> by David Talens-Perales, José-Antonio Daròs, Julio Polaina, Julia Marín-Navarro

“…Two enzyme-based antimicrobials (enzybiotics) have been combined in a novel treatment against this pathogenic bacterium, resulting in a powerful synergistic effect. …”
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GFRα1 Promotes Axon Regeneration after Peripheral Nerve Injury by Functioning as a Ligand by Tomoaki Suzuki, Ken Kadoya, Takeshi Endo, Miwako Yamasaki, Masahiko Watanabe, Norimasa Iwasaki

“…These findings reveal a novel role of GFRα1 as a ligand, the molecular mechanism supporting axon regeneration by RSCs, and a novel therapy for peripheral nerve repair.…”
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Development of a New Reporter Gene System-dsRed/Xanthine Phosphoribosyltransferase-Xanthine for Molecular Imaging of Processes Behind the Intact Blood-Brain Barrier by Mikhail Doubrovin, Vladimir Ponomarev, Inna Serganova, Suren Soghomonian, Tadashi Myagawa, Tatiana Beresten, Lyudmila Ageyeva, Michel Sadelain, Jason Koutcher, Ronald G Blasberg, Juri G. Gelovani Tjuvajev

“…We report the development of a novel dual-modality fusion reporter gene system consisting of Escherichia coli xanthine phosphoribosyltransferase (XPRT) for nuclear imaging with radiolabeled xanthine and Discosoma red fluorescent protein for optical fluorescent imaging applications. …”
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A Lactobacillus consortium provides insights into the sleep-exercise-microbiome nexus in proof of concept studies of elite athletes and in the general population by Tindaro Bongiovanni, Marina Santiago, Kinga Zielinska, Jonathan Scheiman, Carolina Barsa, Ralf Jäger, Daniela Pinto, Fabio Rinaldi, Giammaria Giuliani, Tullio Senatore, Aleksandar D. Kostic

“…Here, we conducted the first large-scale investigation into the influence of a novel elite athlete-derived probiotic, consisting of a multi-strain Lactobacillus consortium, on sleep quality, exercise recovery, and gut microbiome composition in both elite athletes (n = 11) and the general population (n = 257). …”
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