A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits. by Dennis Khodasevich, Nina Holland, Lars van der Laan, Andres Cardenas

“…<h4>Conclusions</h4>We introduce a novel method for the development of DNAm-based predictors that combines the improved reliability conferred by training on principal components with advanced ensemble-based machine learning. …”
Get full text

An Effective Methodology for Diabetes Prediction in the Case of Class Imbalance by Borislava Toleva, Ivan Atanasov, Ivan Ivanov, Vincent Hooper

“…This paper proposes a novel methodology to perform classification in the case of heavy class imbalance, as observed in the PIMA diabetes dataset. …”
Get full text

Articulatory-to-Acoustic Conversion Using BiLSTM-CNN Word-Attention-Based Method by Guofeng Ren, Guicheng Shao, Jianmei Fu

“…Aiming at developing novel recognition feature and application to speech recognition, this paper presents a new method for articulatory-to-acoustic conversion. …”
Get full text

Antifungal Constituents from the Roots of Piper dilatatum Rich. by Ruilan Alves dos Santos, Clécio Souza Ramos, Maria Cláudia M. Young, Thamilles Gonçalves Pinheiro, André M. Amorim, Massuo J. Kato, Ronan Batista

“…Results indicate P. dilatatum as a candidate for the development of novel antifungal phytotherapic products as well as point out pyrone 1 as a promising hit compound in the quest for novel antifungal agents.…”
Get full text

Disentangled Contrastive Learning From Synthetic Matching Pairs for Targeted Chest X-Ray Generation by Euyoung Kim, Soochahn Lee, Kyoung Mu Lee

“…In this study, we propose a novel framework for disentangled Chest X-ray (CXR) generation that enables explicit control over person-specific and disease-specific attributes. …”
Get full text

Genome-Wide Association Studies Associated with Backfat Thickness in Landrace and Yorkshire Pigs by Young-Sup Lee, Donghyun Shin

“…These novel genes might have roles in important cellular and physiological functions related to BF accumulation. …”
Get full text

Molecular dynamics-guided reaction discovery reveals endoperoxide-to-alkoxy radical isomerization as key branching point in α-pinene ozonolysis by Huan Yang, Umberto Raucci, Siddharth Iyer, Galib Hasan, Thomas Golin Almeida, Shawon Barua, Anni Savolainen, Juha Kangasluoma, Matti Rissanen, Hanna Vehkamäki, Theo Kurtén

“…Here, we explore the oxidation of α-pinene, a critical atmospheric biogenic VOC, using a novel reaction discovery approach based on molecular dynamics and state-of-the-art enhanced sampling techniques. …”
Get full text

Characterizing suburban soil and microbial properties along a soil age chronosequence by Andie Suratt, Kavisha Behl, Wai Lam Hong, Yae Eun Yoon, Steven D. Allison

“…In particular, suburban residential neighborhoods comprise novel ecosystems with water and nutrient inputs that differ greatly from the surrounding land area. …”
Get full text

Accuracy evaluation and clinical realization of digital interproximal enamel reduction for orthodontics: a case study by Jia You, Xiangyu Zhou, Xiaofan Xia, Jianxing Zhang, Yunfeng Liu

“…Abstract Objective This study presents a novel digital interproximal enamel reduction (IER) clinical procedure, aiming to improve the effectiveness of IER processes in orthodontic treatment. …”
Get full text

Curiosity-Driven Camouflaged Object Segmentation by Mengyin Pang, Meijun Sun, Zheng Wang

“…Notably, we develop a novel curiosity-calculation operation to discover and remove curiosity, leading to accurate segmentation results. …”
Get full text

Fuzzy Filtering Method for Color Videos Corrupted by Additive Noise by Volodymyr I. Ponomaryov, Hector Montenegro-Monroy, Luis Nino-de-Rivera, Heydy Castillejos

“…A novel method for the denoising of color videos corrupted by additive noise is presented in this paper. …”
Get full text

Performance Evaluation and Site Application of a Hydrophobic Long-Chain Ester-Based CO2 Fracturing Fluid Thickener by Jianqiang Lu, Meilong Fu, Liu Xu, Qian Huang, Yan Zheng

“….), the authors have synthesized the novel hydrophobic long-chain ester thickener, studied viscosity, frictional drag, and proppant-carrying capacity of CO2 fracturing fluid and core damage by CO2 fracturing fluid by varying the temperature, pressure, and level of injection of the novel thickener and explored the thickening mechanism for this thickener in CO2. …”
Get full text

A Fatal Case of Septic Shock Secondary to Acinetobacter Bacteremia Acquired from a Platelet Transfusion by C. Nevala-Plagemann, P. Powers, M. Mir-Kasimov, R. Rose

“…Our review of the literature revealed only one other documented platelet transfusion associated fatality caused by Acinetobacter species. Novel pathogen reduction and contamination detection methods have been developed but have yet to be widely adopted in the United States.…”
Get full text

Innovative financial solutions for sustainable investments using artificial intelligence-based hybrid fuzzy decision-making approach in carbon capture technologies by Serhat Yüksel, Serkan Eti, Hasan Dinçer, Yaşar Gökalp, Gabriela Oana Olaru, Nihal Kalaycı Oflaz

“…This study’s main contribution is its creation of a novel fuzzy decision-making model by integrating AI methodology with fuzzy decision-making theory. …”
Get full text

A New Prognostic Indicator of Immune Microenvironment and Therapeutic Response in Lung Adenocarcinoma Based on Peroxisome-Related Genes by Zhen Xiong, Liwen Zhang, Wei Fan

“…Overall, we developed a novel peroxisome-related prognostic signature for LUAD patients. …”
Get full text

Development of a unique crosslinked glycosaminoglycan for soft tissue repair: Treatment of interstitial cystitis/bladder pain syndrome. by Richard W Heidebrecht, Thomas H Jozefiak, Harrison C Shain, Eugene M Skrabut, Debra Saunders, Nataliya Smith, Rheal A Towner, Robert Hurst

“…Here we report the preparation of a novel crosslinked chondroitin sulfate (~200 to 2000 kilodaltons) that is both soluble in aqueous solution and microfilterable. …”
Get full text

RATIONAL DRUG DESIGN OF POTENT V600E-BRAF KINASE INHIBITORS THROUGH MOLECULAR DOCKING SIMULATION by Bello Abdullahi Umar, Adamu Uzairu, Gideion Adamu Shallangwa, Sani Uba

“…This compound (QAP6) were further used in designing novel and potent V600E-BRAF inhibitors by attaching substituents to the quinoline ring of the compound. …”
Get full text

MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers by Yixin Yang, Christopher Alderman, Ayoub Sehlaoui, Yuan Xiao, Wei Wang

“…Since the current targeted therapies provide limited benefit to the overall response and survival, there is an urgent need for developing novel therapeutic strategy to improve the outcome of gastroenterological cancers. …”
Get full text

GPA-MDS: A Visualization Approach to Investigate Genetic Architecture among Phenotypes Using GWAS Results by Wei Wei, Paula S. Ramos, Kelly J. Hunt, Bethany J. Wolf, Gary Hardiman, Dongjun Chung

“…In order to address this challenge, in this paper, we propose a novel approach, GPA-MDS, to visualize genetic relationships among phenotypes using the GPA algorithm and multidimensional scaling (MDS). …”
Get full text

Condition Monitoring of Marine Diesel Lubrication System Based on an Optimized Random Singular Value Decomposition Model by Shuxia Ye, Bin Da, Liang Qi, Han Xiao, Shankai Li

“…Unlike traditional methods, the proposed approach eliminates the need for explicit modeling and leverages a novel optimization algorithm for data denoising. …”
Get full text