Tackling Microbial Resistance and Emerging Pathogens with Next-Generation Antibiotics by Kar Jing Chong, Huang Feng, Vengadesh Letchumanan, Masita Arip, Omotayo Fatokun, Lazuardi Mochamad, Chin Tat Ng, Sasikala Chinnapan, Malarvili Selvaraja

“…Consequently, multiple initiatives have been undertaken to address these phenomena, including the development of antimicrobials with novel modes of action. Without novel discoveries of newer antimicrobial agents, we may face the risk of entering a post-antibiotic era where uncomplicated infections become untreatable. …”
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Unsupervised Identification for 2-Additive Capacity by Principal Component Analysis and Kendall’s Correlation Coefficient in Multi-Criteria Decision-Making by Xueting Guan, Kaihong Guo, Ran Zhang, Xiao Han

“…In this paper, we develop a novel unsupervised method for identifying 2-additive capacities by means of Principal Component Analysis (PCA) and Kendall’s correlation coefficient. …”
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A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer by Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He

“…Here, we designed and prepared a novel aptamer-conjugated drug targeting NCL by AS1411 aptamer-human serum albumin (HSA)-the apoprotein of lidamycin (LDP)-active enediyne chromophore (AE), in order to achieve targeted treatment of esophageal cancer. …”
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Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer by Riley J. Morrow, Nima Etemadi, Belinda Yeo, Matthias Ernst

“…While there are various novel treatment strategies already underway in clinical trials, the need for further development of preclinical models of this rare but aggressive disease is paramount.…”
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Progress on the Quality of Animal/Plant Protein and Fish Surimi Mixed Gel by Xinyue ZHANG, Wenhao GENG, Miaomiao TIAN, Xin LIANG, Xinrong LI, Xinru FAN, Qiancheng ZHAO

“…The aim is to provide theoretical support for the development of novel surimi products with improved gel properties while offering guidance for further advancements.…”
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The Application of Advanced Bone Imaging Technologies in Sports Medicine by Samuel S. Tadros, Scott Epsley, Sameer Mehta, Brandon C. Jones, Hiran I. Rajapakse, Rashad Madi, Austin Alecxih, Daniel Kargilis, Chamith S. Rajapakse

“…Until recently, the evaluation of bone health and fracture risk through imaging has been limited to dual-energy X-ray absorptiometry (DXA) and plain radiographs, with a limited application in the athletic population. Several novel imaging technologies are now available for the clinical assessment of bone health, including bone injury risk and healing progression, with a potential for use in sports medicine. …”
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Research on RTD Fluxgate Induction Signal Denoising Method Based on Particle Swarm Optimization Wavelet Neural Network by Xu Hu, Na Pang, Haibo Guo, Rui Wang, Fei Li, Guo Li

“…Therefore, we proposed a novel denoising method that integrates Particle Swarm Optimization (PSO) with Wavelet Neural Networks, enhanced by a dynamic compression factor and an adaptive adjustment strategy. …”
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Insights Into Genetic Variations of the OCT1 Gene in Metformin Poor Responders Among Bangladeshi Type 2 Diabetic Patients by Rokeya Begum, Arindita Das, Md. Jahangir Alam, Gazi Nurun Nahar Sultana

“…In this study, 29 mutations of the OCT1 gene were identified; among which 5 mutations (c.412-86G>T, c.970G>C, c.1386-3088_1386-3083delGAATCA, c.1498+66G>T, and c.1653C>A) were novel. It was found that nsSNPs c.181C>T, c.1022C>T, c.493G>T, c.1207A>G, and c.970G>C (novel) as well as frameshift deletions have potential deleterious effects on OCT1 protein stability and function. …”
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Artificial Intelligence in Lymph Node Metastasis Prediction for T1 Colorectal Cancer: Promise and Challenges by Jung Ho Bae

“…In this study, we aimed to assess the efficacy and safety of a novel tapered-tip sheath system for tissue sampling from biliary strictures. …”
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Construction of AMPK-related circRNA network in mouse myocardial ischemia–reperfusion injury model by Yang Song, Yi Zhao, Xiaodi Zhang, Cheng Cheng, Haidong Yan, Daxing Liu, Dengshen Zhang

“…Results MIRI model was successfully constructed, and two AMPK related differentially expressed loops (novel_circ_043550 and novel_circ_035243) were screened out. …”
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Development of a Finite Element Model for the HAZ Temperature Field in Longitudinal Welding of Pipeline Steel by Zhixing Wang, Chengjia Shang, Xuelin Wang

“…In this study, a novel hybrid heat source model was developed to simulate the welding temperature field in the heat-affected zone (HAZ) of X80 pipeline steel. …”
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New Insights into the PPARγ Agonists for the Treatment of Diabetic Nephropathy by Zhanjun Jia, Ying Sun, Guangrui Yang, Aihua Zhang, Songming Huang, Kristina Marie Heiney, Yue Zhang

“…Due to the higher selectivity of these novel PPARγ agonists on the regulation of the antidiabetes-associated genes than that of the side effect-associated genes, they present fewer adverse effects than TZDs. …”
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From musk to body odor: Decoding olfaction through genetic variation. by Bingjie Li, Marissa L Kamarck, Qianqian Peng, Fei-Ling Lim, Andreas Keller, Monique A M Smeets, Joel D Mainland, Sijia Wang

“…Second, we found two linked SNPs associated with the musk Galaxolide in a novel musk receptor, OR4D6, which is also the first human OR shown to drive specific anosmia to a musk compound. …”
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Synthesis of Polydopamine Functionalized Reduced Graphene Oxide-Palladium Nanocomposite for Laccase Based Biosensor by Da-Wei Li, Lei Luo, Peng-Fei Lv, Qing-Qing Wang, Ke-Yu Lu, An-Fang Wei, Qu-Fu Wei

“…The PDA-Lac-rGO-Pd nanocomposites were further modified on electrode surface to construct novel biosensing platform. The obtained electrochemical biosensor was applied in the detection of catechol, achieving excellent analytic results. …”
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Emily and Charlotte Brontë’s Re-reading of the Byronic hero by Cristina Ceron

“…My hypothesis is that Brontë makes use of these aspects of Byron’s characters with the precise aim of setting the Gothic element as alternative narrative mode, as the subversive element inside a realistic novel. On the contrary, in spite of some juvenile experiments on the gothic, Charlotte’s reading of the Byronic hero is much more framed within the conventions of the realistic novel, and in the second section of my essay I maintain that what comes to the fore in Jane Eyre is the unsurpassed mastery the novelist shows in the combination of the realistic plot with the gothic elements and features of the protagonists. …”
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Anion-Directed Assembly of a Bimetallic Pd/Ag Nanocluster: Synthesis, Characterization, and HER Activity by Yu-Rong Ni, Rugma Thekke Pangal, Michael N. Pillay, Tzu-Hao Chiu, Samia Kahlal, Jean-Yves Saillard, C. W. Liu

“…Our findings highlight the potential of anion-directed synthesis for creating novel bimetallic NCs with tailored structures and catalytic properties.…”
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Exploratory Network Meta Regression Analysis of Stroke Prevention in Atrial Fibrillation Fails to Identify Any Interactions with Treatment Effect. by Sarah Batson, Alex Sutton, Keith Abrams

“…There are a number of different stroke prevention treatments available to include warfarin and novel oral anticoagulants. Previous network meta-analyses of novel oral anticoagulants for stroke prevention in atrial fibrillation acknowledge the limitation of heterogeneity across the included trials but have not explored the impact of potentially important treatment modifying covariates.…”
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The Anthropology of Love by Ingeborg Bachmann (“War Diary” and “The Book of Franza”) by Yulia Isapchuk

“…In particular, the «War Diary» («Kriegstagebuch», 1944–1945) and the unfinished novel «The Book of Franza» («Das Buch Franza», 1965–1966) are considered comparatively. …”
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Analyzing Adherence to Prenatal Supplement: Does Pill Count Measure Up? by Kristie E. Appelgren, Paul J. Nietert, Thomas C. Hulsey, Bruce W. Hollis, Carol L. Wagner

“…Conclusions. Based on our novel definition of adherence, pill count was not a reliable predictor of adherence to protocol, and calls into question how adherence is measured in clinical research. …”
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Always Clear Days: Degradation Type and Severity Aware All-in-One Adverse Weather Removal by Yu-Wei Chen, Soo-Chang Pei

“…To extract weather information from a single image, we propose a novel Marginal Quality Ranking Loss (MQRL) and utilize Contrastive Loss (CL) to guide weather severity and type extraction, and leverage a bag of novel techniques such as Multi-Head Cross Attention (MHCA) and Local-Global Adaptive Instance Normalization (LG-AdaIN) to efficiently restore spatial varying weather degradation. …”
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