Predicting the hub interactome of COVID-19 and oral squamous cell carcinoma: uncovering ALDH-mediated Wnt/β-catenin pathway activation via salivary inflammatory proteins by Pradeep Kumar Yadalam, Deepavalli Arumuganainar, Prabhu Manickam Natarajan, Carlos M. Ardila

“…Abstract Understanding shared pathways and mechanisms involved in the pathogenesis of diseases like oral squamous cell carcinoma (OSCC) and COVID-19 could lead to the development of novel therapeutic strategies and diagnostic biomarkers. …”
Get full text

Mediators of Inflammation in Topical Therapy of Skin Cancers by Vlad Mihai Voiculescu, Cristina Victoria Lisievici, Mihai Lupu, Cristina Vajaitu, Carmen Cristina Draghici, Alexandra Victoria Popa, Iulia Solomon, Teona Ioana Sebe, Maria Magdalena Constantin, Constantin Caruntu

“…Taking into consideration that the immune system plays a very important role in the development of melanoma and non-melanoma skin cancers, which have a high prevalence in immunosuppressed patients and after prolonged ultraviolet radiation, the interest in developing novel therapies, in particular targeting the inflammation in cancer, has increased in the past years. …”
Get full text

An interprofessional model to improve LGBTQ+ specific cultural competence in dental and pharmacy students. by Anubhuti Shukla, Sriha Yalamanchi, Guillermo Tamayo-Cabeza, Amanda Albright, Zachary A Weber, April D Newton

“…<h4>Methodology</h4>This study is a retrospective observational study which used a novel interprofessional model of three different LGBTQ+ focused educational interventions within a group of dental and pharmacy students. …”
Get full text

Islands of genomic stability in the face of genetically unstable metastatic cancer. by Kirsten Bowland, Jiaying Lai, Alyza Skaist, Yan Zhang, Selina Shiqing K Teh, Nicholas J Roberts, Elizabeth Thompson, Sarah J Wheelan, Ralph H Hruban, Rachel Karchin, Matthew H Bailey, Christine A Iacobuzio-Donahue, James R Eshleman

“…These mutations are targetable because ~10% of them form novel tumor-specific "NGG" protospacer adjacent motif (PAM) sites targetable by CRISPR-Cas9.…”
Get full text

Wireless Secure Communication Based on Code Domain Space-Time Modulated Metasurface by Xinyu Fang, Xuezhi Zheng, Mengmeng Li, Zhiyu Li, Dazhi Ding

“…The emergence of space-time modulated metasurface (STMM) as a novel platform for signal modulation holds significant promise for wireless secure communication, particularly within modern information technologies such as Internet of things and the 5th generation and beyond. …”
Get full text

Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia by Xin Ma, Xin-Meng Wang, Guo-Zhang Tang, Yi Wang, Xue‑Chun Liu, Shuai-Deng Wang, Peng Peng, Xiu-Hong Qi, Xin-Ya Qin, Yue‑Ju Wang, Chen-Wei Wang, Jiang-Ning Zhou

“…Abstract Metabolomics provide a promising tool for understanding dementia pathogenesis and identifying novel biomarkers. This study aimed to identify amino acid biomarkers for Alzheimer’s Disease (AD) and Vascular Dementia (VD). …”
Get full text

Devaluing memories of reward: a case for dopamine by Benjamin R. Fry, Nicolette Russell, Victoria Fex, Bing Mo, Nathan Pence, Joseph A. Beatty, Fredric P. Manfredsson, Brandon A. Toth, Christian R. Burgess, Samuel Gershman, Alexander W. Johnson

“…In this series of studies, we describe a novel role for dopamine in devaluing sensory features of reward. …”
Get full text

A CNN-Based Approach for Classical Music Recognition and Style Emotion Classification by Yawen Shi

“…Meanwhile, in this study, a novel loss function has been devised to more effectively assess the model&#x2019;s performance. …”
Get full text

Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood by Klara Mareckova, Ana Paula Mendes-Silva, Martin Jáni, Anna Pacinkova, Pavel Piler, Vanessa F. Gonçalves, Yuliya S. Nikolova

“…We hypothesized that higher functional impact (FI) score of mitochondrial DNA (mtDNA) variants might contribute to premature aging and tested the relationships between a novel FI score of mtDNA variants and epigenetic and biological aging in young adulthood. …”
Get full text

Utility of complexity analysis in electroencephalography and electromyography for automated classification of sleep-wake states in mice by Naoki Furutani, Yuki C. Saito, Yasutaka Niwa, Yu Katsuyama, Yuta Nariya, Mitsuru Kikuchi, Tetsuya Takahashi, Takeshi Sakurai

“…This integrated model significantly enhances the accuracy of sleep stage identification, achieving an accuracy of 97.4–98.1% for novel wild-type mice, on par with the agreement level among human scorers (97.3–97.8%). …”
Get full text

BWFER-YOLOv8: An Enhanced Cascaded Framework for Concealed Object Detection by Khalid Ijaz, Ikramullah Khosa, Ejaz A. Ansari, Syed Farooq Ali, Asif Hussain, Faran Awais Butt

“…The third stage uses a novel FER-YOLOv8 architecture with a custom-designed feature extraction and regularization (FER) module and multiple regularized convolution (Conv_Reg) modules for better generalization capability. …”
Get full text

Investigating the influence of heterocyclic Schiff bases as a biofuel additive on combustion, performance and emissions by Beşir Dağ, Selman Aydın, Ramazan Şener

“…In terms of cylinder pressure, knock density and mean gas temperature, it was determined that the fuel with novel additive D90E10-AAP results in improvements to diesel. …”
Get full text

Retracted: Design of LoRa Antenna for Wearable Medical Applications by Amer Alsaraira, Omar A. Saraereh, Ashraf Ali, Samer Alabed

“…In this study, we introduce a novel arch-shaped iTDS that takes up the buccal shelf space in the mouth without constricting tongue motions. …”
Get full text

Staphylococcal SSL5 Binding to Human Leukemia Cells Inhibits Cell Adhesion to Endothelial Cells and Platelets by Annemiek M. E. Walenkamp, Jovanka Bestebroer, Ingrid G. J. Boer, Roeline Kruizinga, Henk M. Verheul, Jos A. G. van Strijp, Carla J. C. de Haas

“…Bacterial proteins provide promising tools for novel anticancer therapies. Staphylococcal superantigen-like 5 (SSL5) was recently described to bind P-selectin glycoprotein ligand-1 (PSGL-1) on leukocytes and to inhibit neutrophil rolling on a P-selectin surface. …”
Get full text

Development of broadly protective influenza B vaccines by Chunyang Gu, Lavanya Babujee, David Pattinson, Shiho Chiba, Peter Jester, Tadashi Maemura, Gabriele Neumann, Yoshihiro Kawaoka

“…These findings show the potential of our novel strategy to develop cross-lineage protective influenza B virus vaccines.…”
Get full text

A Systematic Review of Opportunities and Limitations of Innovative Practices in Sustainable Agriculture by Anita Boros, Eszter Szólik, Goshu Desalegn, Dávid Tőzsér

“…The integrative assessment in this study suggests that adopting novel, innovative practices can achieve the most significant progress toward agricultural sustainability. …”
Get full text

Amphiphiles Self-Assembly: Basic Concepts and Future Perspectives of Supramolecular Approaches by Domenico Lombardo, Mikhail A. Kiselev, Salvatore Magazù, Pietro Calandra

“…Introduction of stimulus responsive supramolecular amphiphile assembly-disassembly processes provides particularly novel approaches for impacting bionanotechnology applications. …”
Get full text

ACD-ML: Advanced CKD detection using machine learning: A tri-phase ensemble and multi-layered stacking and blending approach by Mir Faiyaz Hossain, Shajreen Tabassum Diya, Riasat Khan

“…The investigation reveals that, for the Discrete Merged dataset, the novel Tri-phase Ensemble and Multi-layer Stacking with layers interchanged achieves an accuracy of 99.5%. …”
Get full text

Advancements in energy storage applications: harnessing the potential of fish industry waste by Vishal Rajput, Bindu Naik, Vijay Kumar, Vivek Kumar, Saurav Chandra Bhatt, Sarvesh Rustagi

“…Lastly, a significant focus is placed on protein batteries, a novel concept that utilizes seafood waste as a sustainable source for energy storage. …”
Get full text

An Update on Less Invasive and Endoscopic Techniques Mimicking the Effect of Bariatric Surgery by Froukje J. Verdam, Ruben Schouten, Jan Willem Greve, Ger H. Koek, Nicole D. Bouvy

“…In the last decade, several novel less invasive techniques have been introduced and some have been abandoned again. …”
Get full text